Pharmacy and Pharmaceutical Sciences Commons^™

Phosphatidylinositol 3-Kinase (Pi3k) As A Therapeutic Target In Nsclc, Christopher W. Stamatkin

Theses and Dissertations--Pharmacy

Deregulated activation of phosphatidylinositol 3-kinase (PI3K) pathway is central to many human malignancies. The functions of this pathway are critical for normal cell metabolism, proliferation, and survival. In lung cancers, the PI3K pathway activity is often aberrantly driven by multiple mutations, including EGFR, KRAS, and PIK3CA. Molecules targeting the PI3K pathway are intensely investigated as potential anti-cancer agents. Although inhibitors of the pathway are currently in clinical trials, rational and targeted use of these compounds, alone or in combination, requires an understanding of isoform-specific activity in context. We sought to identify class IA PI3K enzyme (p110a/PIK3CA, p110b/PIK3CB, p110d/PIK3CD) activities using …

A Review Of Common Drug-Drug And Food-Drug Interactions Associated With Cardiovascular Medications, Raymond Kho, Sarah Kim, Stacy Lee, Laura Tsu

Pharmacy Faculty Articles and Research

This home-study CPE activity has been developed to educate pharmacists on the common drug-drug and food-drug interactions associated with cardiovascular medications.

Simultaneous Bactericidal And Osteogenic Effect Of Nanoparticulate Calcium Phosphate Powders Loaded With Clindamycin On Osteoblasts Infected With Staphylococcus Aureus, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

S aureus internalized by bone cells and shielded from the immune system provides a reservoir of bacteria in recurring osteomyelitis. Its targeting by the antibiotic therapy may thus be more relevant for treating chronic bone infection than eliminating only the pathogens colonizing the bone matrix. Assessed was the combined osteogenic and antibacterial effect of clindamycinloaded calcium phosphate nanoparticles of different monophasic compositions on co-cultures comprising osteoblasts infected with S aureus. Antibiotic-carrying particles were internalized by osteoblasts and minimized the concentration of intracellular bacteria. In vitro treatments of the infected cells, however, could not prevent cell necrosis due to the …

Nanoparticulate Drug Delivery Platforms For Advancing Bone Infection Therapies, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

Introduction—The ongoing surge of resistance of bacterial pathogens to antibiotic therapies and the consistently aging median member of the human race signal an impending increase in the incidence of chronic bone infection. Nanotechnological platforms for local and sustained delivery of therapeutics hold the greatest potential for providing minimally invasive and maximally regenerative therapies for this rare but persistent condition.

Areas covered—Shortcomings of the clinically available treatment options, including poly(methyl methacrylate) beads and calcium sulfate cements, are discussed and their transcending using calcium-phosphate/polymeric nanoparticulate composites is foreseen. Bone is a composite wherein the weakness of each component alone is …

Programmable Folding Of Fusion Rna In Vivo And In Vitro Driven By Prna 3wj Motif Of Phi29 Dna Packaging Motor, Dan Shu, Emil F. Khisamutdinov, Le Zhang, Peixuan Guo

Pharmaceutical Sciences Faculty Publications

Misfolding and associated loss of function are common problems in constructing fusion RNA complexes due to changes in energy landscape and the nearest-neighbor principle. Here we report the incorporation and application of the pRNA-3WJ motif of the phi29 DNA packaging motor into fusion RNA with controllable and predictable folding. The motif included three discontinuous ∼18 nucleotide (nt) fragments, displayed a distinct low folding energy (Shu D et al., Nature Nanotechnology, 2011, 6:658–667), and folded spontaneously into a leading core that enabled the correct folding of other functionalities fused to the RNA complex. Three individual fragments dispersed at any …

Knowledge And Provision Practices Of Misoprostol Among Pharmacies In Senegal, Ramatoulaye Ndao, Babacar Mane, Eva Burke, Nafissatou Diop, Kate Reiss, Thoai Ngo, Katharine Footman, Maaike Van Min

Reproductive Health

In developing countries, postpartum hemorrhage and complications related to unsafe abortions are direct causes of maternal death. In Senegal, actions have been undertaken by the government to reduce this burden and significant advances have been made in these areas in recent years. However, progress is still necessary to achieve the Millennium Development Goals for the reduction of the maternal mortality rate to the target numbers by 2015. The objective of the study was to understand the knowledge about, availability of, and practices in the provision of misoprostol at pharmacies in Dakar, Senegal, to ensure correct delivery of the product. Pharmacists …

Electrostatic Charge Effects On Pharmaceutical Aerosol Deposition In Human Nasal-Laryngeal Airways, Jinxiang Xi, Xiuhua Si, Worth Longest

University Faculty Publications and Creative Works

Electrostatic charging occurs in most aerosol generation processes and can significantly influence subsequent particle deposition rates and patterns in the respiratory tract through the image and space forces. The behavior of inhaled aerosols with charge is expected to be most affected in the upper airways, where particles come in close proximity to the narrow turbinate surface, and before charge dissipation occurs as a result of high humidity. The objective of this study was to quantitatively evaluate the deposition of charged aerosols in an MRI-based nasal-laryngeal airway model. Particle sizes of 5 nm-30 μm and charge levels ranging from neutralized to …

Understanding Ligand Binding, Selectivity And Functions On The G Protein-Coupled Receptors: A Molecular Modeling Approach, Saheem Zaidi

Theses and Dissertations

The assessment of target protein molecular structure provides a distinct advantage in the rational drug design process. The increasing number of available G protein-coupled receptor crystal structures has enabled utilization of a varied number of computational approaches for understanding the ligand-receptor interactions, ligand selectivity and even receptor response upon ligand binding. The following dissertation examines the results from three different projects with varied objectives – i) structural modeling of human C-C chemokine receptor type 5 (CCR5) and assessment of the ligand binding pocket of the receptor, ii) assessment of the selectivity profile of naltrexone derivatives on the three opioid receptors …

Bullying In The Clinical Training Of Pharmacy Students, Katherine K. Knapp, Patricia A. Shane, Debra Sasaki-Hill, Keith Yoshizuka, Paul Chan, Thuy Vo

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To determine whether bullying is a significant factor in the clinical training of pharmacy students.

Methods. The literature as well as the Accreditation Council for Pharmacy Education (ACPE) Standards and American Association of Colleges of Pharmacy (AACP) surveys were reviewed for mention and/or measurement of bullying behaviors in the clinical training of pharmacy students. The authors used a Delphi process to define bullying behavior. The consensus definition was used to analyze 2,087 in-house student evaluations of preceptors for evidence of bullying behaviors. The authors mapped strings of text from in-house student comments to different, established categories of …

Pharmacy Students’ Performance And Perceptions In A Flipped Teaching Pilot On Cardiac Arrhythmias, Terri H. Wong, Eric J. Ip, Ingrid C. Lopes, Vanishree Rajagopalan

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To implement the flipped teaching method in a 3-class pilot on cardiac arrhythmias and to assess the impact of the intervention on academic performance and student perceptions.

Design. An intervention group of 101 first-year pharmacy students, who took the class with the flipped teaching method, were supplied with prerecorded lectures prior to their 3 classes (1 class in each of the following subjects: basic sciences, pharmacology, and therapeutics) on cardiac arrhythmias. Class time was focused on active-learning and case-based exercises. Students then took a final examination that included questions on cardiac arrhythmias. The examination scores of the …

Implementation Of An Accelerated Physical Examination Course In A Doctor Of Pharmacy Program, Jackie Ho, Monica K. Bidwal, Ingrid C. Lopes, Bijal M. Shah, Eric J. Ip

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To describe the implementation of a 1-day accelerated physical examination course for a doctor of pharmacy program and to evaluate pharmacy students’ knowledge, attitudes, and confi- dence in performing physical examination.

Design. Using a flipped teaching approach, course coordinators collaborated with a physician faculty member to design and develop the objectives of the course. Knowledge, attitude, and confidence survey questions were administered before and after the practical laboratory.

Assessment. Following the practical laboratory, knowledge improved by 8.3% (p,0.0001). Students’ perceived ability and confidence to perform a physical examination significantly improved (p,0.0001). A majority of students responded …

Pharmacists' Preparedness For Acute Medical Emergencies, James W. Parrett

Electronic Theses and Dissertations

Purpose/Objectives: This project studied how prepared community pharmacists are to respond to acute medical emergencies, as well as their perceived efficacy in addressing these situations. Specifically, it considered what training pharmacists have for responding to medical emergencies, what emergency medical equipment pharmacies have on-hand, the frequency that medical emergencies occur within pharmacies, and the types of emergencies encountered. It also measured self and collective efficacy of pharmacists in responding to medical emergencies within their pharmacy to determine if differences in self-efficacy or collective efficacy exist. Methods: This study utilized a cross-sectional, non-experimental, descriptive design via a self-administered, Internet-based survey distributed …

Mississippi Pharmacists' Knowledge And Attitudes About Pharmacy Compounding Safety And Regulation, Kimberly Allen

Honors Theses

Introduction: Pharmacy compounding, which is defined by The Food and Drug Administration (FDA) as a practice in which a licensed pharmacist combines, mixes, or alters ingredients in response to a prescription to create a medication tailored to the medical needs of an individual patient,1 has gained recent attention at both national and state levels. Outbreaks of adverse events associated with pharmacy compounding have led to many proposed and enacted changes in how to appropriately and best regulate traditional compounding pharmacies and those that act as manufacturers. Given such recent controversies and potential confusion as to exactly how compounding is regulated, …

Parent Satisfaction With Diabetes Technology In Children With Type 1 Diabetes Mellitus, Laura Brooke Carter

Honors Theses

Purpose: To increase glucose control, advanced technologies are being integrated into diabetes self-management in children with Type 1 Diabetes Mellitus (T1DM). Two technologies being adopted is Continuous Subcutaneous Insulin Infusion (CSII), more commonly known as insulin pumps (pumps) and Continuous Glucose Monitoring (CGM). The purpose of the study was to better understand the experiences of parents whose T1DM child is using insulin pumps and CGM devices in diabetes self-management. Methods: This study was approved by the University of Mississippi IRB. A cross-sectional study was conducted using a sample of parents in the Mid-South region of the U.S. The local chapters …

Reproductive And Multigenerational Effects Of Dietary Benzo[A]Pyrene Exposure In Zebrafish, Mallory White

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is a known carcinogen that also acts as an endocrine disruptor. Multigenerational impacts of PAH exposure are suggested in human cohort studies. To investigate mechanisms and developmental phenotypes associated with a dietary BaP exposure, zebrafish (Danio rerio) were used. We hypothesized that BaP exposure would cause: 1) phenotypic malformations in the gonad that would affect reproductive success; 2) developmental deformities in the offspring that would lead to decreased survival and ability to reproduce without additional BaP exposure; and 3) changes in gene expression that would be conserved across generations and related …

Customer Tolerance In Community Pharmacy, Philip Everett Schwab

Electronic Theses and Dissertations

Customers can have an existing relationship with a service provider where they are not satisfied with the services they receive, yet they continue to patronize the service provider. Why does this happen? Why do these customers remain as patrons of service providers that do not meet expectations and that leave these customers with low satisfaction. This dissertation presents the concept of tolerance to explain the retention of customers who are not satisfied with a service provider. Specifically, this dissertation examined the concept of customer tolerance in community pharmacy. Tolerance is an important concept for consideration because regardless of good intentions …

Evaluating Albumin Utilization In A Community-Based Hospital Post-Hetastarch Food And Drug Administration (Fda) Warning, Wilbert Fuerte, Frances Ordieres, Judy Tseng

All Publications

No abstract provided.

Implications Of Dose‐Rounding Intravenous Chemotherapy At A Community‐Based Hospital, Wilbert Fuerte, Omi Gopalani, Judy Tseng

All Publications

No abstract provided.

Management Of Breast Cancer In The Medicaid Population, Rohan Mahabaleshwarkar

Electronic Theses and Dissertations

Breast cancer is the second most comcancer and the second leading cause of cancer-related death among women. The current project examined some key issues important for effective breast cancer management in the Medicaid population. Medicaid is one the largest healthcare insurance systems in the US providing coverage to more than 60 million low-income individuals. As a part of this project, three studies were conducted. The first study determined the healthcare burden associated with breast cancer in the form of healthcare use (inpatient, outpatient, and emergency room [ER] visits) and costs associated with the condition in the Medicaid population. Significant healthcare …

Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman

Electronic Theses and Dissertations

The fruit of the American cranberry (Vaccinium macrocarpon Aiton, Ericaceae) is a comfood and a top selling dietary supplement in the U.S. Cranberry juice is traditionally used for the prevention of urinary tract infections (UTIs), many of which are caused by P-fimbriated Escherichia coli. Human urine produced after cranberry juice consumption can prevent E. coli adhesion, but the urinary metabolites responsible for this activity are currently not known. High-molecular weight components of cranberry juice, specifically proanthocyanidin oligomers (PACs), are currently believed to be responsible for the ability of cranberry juice to prevent UTIs. Cranberry PACs can prevent the adherence of …