Pharmacy and Pharmaceutical Sciences Commons^™

Cost-Effectiveness Analysis Of Aducanumab Versus Placebo For Patients With Mild Cognitive Impairment And Mild Alzheimer’S Disease, Xiaomo Xiong, Gang Lv, Jacob Jordan King, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Objectives To assess the cost-effectiveness of aducanumab at its updated price for treating patients with mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD).

Design Cost-effectiveness analysis.

Settings A five-state Markov model was constructed using 10 000 virtual patients to assess the cost-effectiveness of aducanumab from the perspective of the US healthcare system. The model employed a one-year cycle time and a lifetime time horizon. Transition probabilities and mortality rates were derived from a literature review. To address uncertainty and generalise the base case results, both one-way and probabilistic sensitivity analyses were conducted.

Participants 10 000 virtual patients with MCI …

Canadian Adolescent And Young Athletes Knowledge Of Pain-Relieving Medications, Jackie Vandertuin, Dalya Abdulla, Stephanie Lowther

Internet Journal of Allied Health Sciences and Practice

Purpose: Adolescent knowledge of pain-relieving medications (PRM) and opioids is scant, particularly from a Canadian perspective. Research indicates that athletes will often resort to PRM and opioids to manage their pain, but it is unknown whether athletes are fully informed as to its use and misuse including adverse events that may occur. The purpose of this study is to understand what elite level male athletes know about use, contraindications, and recommendations of pain-relieving medications; particularly opioids to manage their pain. Methods: Using a qualitative, grounded theory approach, we interviewed male athletes to understand their level of knowledge regarding pain-relieving medications, …

The Effects Of Cyclic Peptide [R4w4] In Combination With First-Line Therapy On The Survival Of Mycobacterium Avium, Melissa Kelley, Kayvan Sasaninia, Ali Badaoui, Ira Glassman, Arbi Abnousian, Nadia Rai, Rakesh K. Tiwari, Vishwanath Venketaraman

Pharmacy Faculty Articles and Research

Background: Mycobacterium avium (M. avium) is a nontuberculous mycobacterium (NTM) that can cause pulmonary and extrapulmonary infections mostly in immunocompromised individuals, such as those with HIV and diabetes. Traditionally, rifampicin (RIF) and azithromycin (AZ) have been used for a 12-month duration as first-line antibiotics against M. avium. Due to the increased multidrug resistance, novel ways, such as enhancement of macrophages response, are needed to provide adequate immune response required to clear M. avium infection.

Methods and findings: In this study, we aim to study the effects of using THP-1 cells, which are monocyte-like cells, to induce a …

Hexasodium Fytate (Snf472 Or Csl525) Inhibits Ectopic Calcification In Various Pseudoxanthoma Elasticum And Calcinosis Cutis Animal Models, Miguel Ferrer, Maria Pérez-Ferrer, Marc Blasco, Ida Jacobs, Qiaoli Li, Olivier Vanakker, Lisa Dangreau, Andrea López, Gianluca Malagraba, Firas Bassissi, Joan Perelló, Carolina Salcedo

Department of Biochemistry and Molecular Biology Faculty Papers

Background/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals. Hexasodium fytate (CSL525, previously known as SNF472) is a crystallization inhibitor being developed for the treatment of ectopic calcification-related disorders. Our aim was to investigate CSL525 for the treatment of soft-tissue calcification disorders in animal models of pseudoxanthoma elasticum and calcinosis cutis. Methods: In a first study, abcc6^-/- zebrafish larvae were exposed to 1 mM CSL525 for 7 days or kept under the same conditions without CSL525, and spinal mineralization was quantified. In a second study, abcc6 …

Pro: The Use Of Sugammadex Does Not Preclude The Need For Objective Neuromuscular Monitoring., J Ross Renew, Dustin D. Linn

Parkview Pharmacy Department

Based on strong evidence, optimal management of neuromuscular block should incorporate objective (or quantitative) neuromuscular monitoring with appropriately dosed antagonists such as sugammadex. Sugammadex has the unique ability to antagonize aminosteroidal-induced neuromuscular block at any level; however, neostigmine is a reasonable alternative at minimal levels. Blind or excessive administration of sugammadex does not eliminate the risk of patients having postoperative residual neuromuscular block. Significant variability exists in how patients respond both to neuromuscular blocking agents and their antagonists.

Clinical Characteristics And Outcomes Of Pediatric Staphylococcal Scalded Skin Syndrome (Ssss) At An Inner-City Tertiary Care Center, Nina Kb Gust Md, Ashley Frei Bs, Rebecca M. Adams Bs, Elika Ridelman Phd, Christina Shanti Md, Ronald Thomas Phd, Jocelyn Y. Ang Md

Medical Student Research Symposium

Introduction

Staphylococcal Scalded Skin Syndrome (SSSS) is a blistering skin condition caused by a toxin-producing staphylococcus species. Epidemiologic studies on pediatric SSSS in the United States are limited, with a reported incidence of 7.67 cases per million children and 45.1 per million infants. Immature renal function, lack of protective antibodies, and increased exotoxin target desmoglein-1 are hypothesized to increase incidence in younger children. We aimed to determine clinical and microbiological characteristics of pediatric SSSS and factors that could help predict disease severity.

Methods

A retrospective chart review was performed for admitted patients under 18 years old diagnosed with SSSS from …

Pacific Rxtracts - April 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

• FDA Approves Miudella: First New Hormone-Free IUD in Over 40 Years
• First Treatment for Cerebrotendinous Xanthomatosis Approved
• Presepsin: A New Biomarker for Assessing Cardiovascular Disease
• New Insights into Severe NOWS Prediction
• Myasthenia Gravis: Nipocalimab, a Potential Add-on Therapy
• ARF/ARDS Concern with Trimethoprim-Sulfamethoxazole in Youth
• Hormone Replacement Therapy: Beneficial for Managing Menopausal Symptoms Long-Term?
• Esketamine Shows Promise in Preventing Postpartum Depression After Cesarean Delivery
• From One Week to One Hour: FDA Approves Label Changes for Sublocade Rapid Induction in Patients with Moderate to Severe Opioid Use Disorder
• Repurposing Semaglutide: A Novel Approach to Alcohol Use Disorder
• Treating Neuropathic Pain: Pregabalin …

Profit Over Patients: Examining The Influence Of Pharmaceutical Companies On Mental Health Medication Prescriptions, Allison Beltramini

Honors Projects in Biological and Biomedical Sciences

This paper explores the relationship pharmaceutical companies have with the overprescription of mental health medication, highlighting unethical marketing practices and their impact on prescription patterns. Previous literature addresses unethical pharmaceutical company marketing strategies, relationships within the field, and cost differences. This study includes qualitative insights from professionals in the field. Interviews conducted collected information that showed the prevalence of mental health illnesses, how treatments are prescribed, and the extent of pharmaceutical influence. Initial findings suggest a significant push for medication as it is the most common treatment method for mental health illnesses. This study highlights pharmaceutical companies' profit-driven motives and …

1st Place Contest Entry: Effectiveness Of Intravesical Bcg In The Treatment Of Nonmuscle Invasive Bladder Cancer: An Umbrella Review, Gerald Obinna Ozota

Eric M. Scandrett Graduate Library Research Prize

This is Gerald Obinna Ozota's submission for the 2025 Eric M. Scandrett Graduate Research Prize, which won first place. It contains their essay on using library resources, their bibliography, and a summary of their research project on conducting a systematic literature search to identify all relevant systematic reviews and meta-analyses investigating the effectiveness of intravesical Bacillus Calmette-Guerin (BCG) on Non-muscle-invasive Bladder Cancer (NIMBC).

Gerald is a student in the Ph.D. in Pharmaceutical Sciences program at Chapman University. Their faculty mentor is Dr. Lawrence Brown.

Spring 2025 Edition, Southwestern Oklahoma State University

The Sig

Greetings, COP Community!

We are so proud of our student pharmacists and graduates. Whenever I meet alumni, I am impressed by their accomplishments. To look back and remember their first weeks of pharmacy school and to now hear about their career journey and successes reminds us of how a quality pharmacy education can positively impact the personal and professional growth of young people. It also helps us as teachers, preceptors, and mentors to remember why we have dedicated our careers to pharmacy education. The COP is 85 years young, and we continue to strive to provide a personalized educational experience …

Interprofessional Education And Collaboration In The Philippines: Current Landscape, Gaps, And Propositions, Arvie Vitente, Michael Sy, Reeva Ann Sumulong, Anna Causapin, Jocel Regino

Rehabilitation Sciences Department Faculty Articles

Interprofessional education (IPE) is a forward-looking strategy in healthcare education that unites students and professionals from various disciplines to enhance interprofessional collaboration (IPC). IPE is designed to prepare future health and social care professionals to navigate and address the complexities of modern healthcare systems. In the Philippines, despite being a developing country with a fragmented healthcare system, there have been efforts over the last 15 to 20 years to introduce and institutionalize IPE and IPC in both higher education and healthcare settings. However, significant challenges persist, including the dominance of medical professionals, inadequate regulatory mechanisms, and a lack of strong …

A Three-Year Utilization Analysis Of Branded Second-Generation Antipsychotics At A Regional Health Plan, Kamaladdin Saei, Eddie Miljkovic, Hailey Button

Doctoral External Publications

In the last 30 years,13 new antipsychotic entities have been approved by the Food and Drug Administration (FDA). Today, the majority of those are available generically.

Caplyta (lumateperone), Fanapt (Iloperidone), Rexulti (brexpiprazole), Vraylar (cariprazine), and the most recently approved, Lybalvi (olanzapine/samidorphan), continue to be available only as brand name products.

The cost of antipsychotics in 2023 was $18.04 billion USD.

It is anticipated that this market will continue to increase at about eight percent annually, reaching $37.40 billion by 2032

A Mechanistic Understanding Of The Effect Of Staphylococcus Aureus Vras Histidine Kinase Single-Point Mutation On Antibiotic Resistance, Liaqat Ali, Salima Karki, Gunavanthi D. Boorgula, Amir Mekakda, Brittnee Cagle-White, Shrijan Bhattarai, Robert Beaudoin, Aryanna Blakeney, Sanjay Singh, Shashikant Srivastava, May H. Abdelaziz

Pharmacy Faculty Publications and Presentations

Bacterial genomic mutations in Staphylococcus aureus have been detected in isolated resistant clinical strains, yet their mechanistic effect on the development of antimicrobial resistance remains unclear. Resistance-associated regulatory systems acquire adaptive mutations under stress conditions that may lead to a gain-of-function effect and contribute to the resistance phenotype. Here, we investigate the effect of a single-point mutation (T331I) in VraS histidine kinase, part of the VraSR two-component system in S. aureus. VraSR senses and responds to environmental stress signals by upregulating gene expression for cell wall synthesis. A combination of enzyme kinetics, microbiological, and transcriptomic analyses revealed the mechanistic effect …

Brain Endothelial Cells As Phagocytes: Mechanisms And Implications, Rudy T. Chang, Mark J. Fisher, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Brain microvascular endothelial cells (BECs) lining the brain capillaries form the anatomical site of the blood-brain barrier (BBB), providing a highly selective barrier to support brain homeostasis and function. While the BBB acts as a barrier to immune cells and pathogens under normal conditions, BECs can facilitate their entry into the CNS via a phagocytosis-like mechanism. A similar process is now increasingly reported for a diverse set of cargos, resulting in the categorization of BECs as “non-professional” phagocytes and redefining the conventional view that these cells are functionally non-phagocytic. This review aims to summarize research demonstrating the capacity of BECs …

Evaluation Of Lc-Uv Data For Method Validation, Maeve Scott

Case studies: Digital Education

The module was co-delivered in face-to-face mode to three Science programmes (typically 70 students) in year three, many of whom apply to industries where the learning outcome of the video is a key competency. Analytical methods used in a regulated or accredited testing environment must be validated in line with international guidelines. A science graduate who intends to work in a pharmaceutical or related industry should understand how to interpret test results to demonstrate an analytical method is reliable and fit for purpose. A screen pal video was generated to support an introduction to the theory of method validation delivered …

Short-Course Subcutaneous Alemtuzumab Induces Clinical Responses In Relapsed T-Cell Large Granular Leukemia, Miguel Ruiz, Zachary Braunstein, Eric Mclaughlin, Anjali Mishra, Pierluigi Porcu, Jonathan E. Brammer

Department of Medical Oncology Faculty Papers

No abstract provided.

Interprofessional Education And Collaboration In The Philippines: Current Landscape, Gaps, And Propositions, Arvie Vitente, Michael Sy, Reeva Ann Sumulong, Anna Karerina Causapin, Jocel Regino

Philippine Journal of Physical Therapy

Interprofessional education (IPE) is a forward-looking strategy in healthcare education that unites students and professionals from various disciplines to enhance interprofessional collaboration (IPC). IPE is designed to prepare future health and social care professionals to navigate and address the complexities of modern healthcare systems. In the Philippines, despite being a developing country with a fragmented healthcare system, there have been efforts over the last 15 to 20 years to introduce and institutionalize IPE and IPC in both higher education and healthcare settings. However, significant challenges persist, including the dominance of medical professionals, inadequate regulatory mechanisms, and a lack of strong …

April 2025, Swosu Rural Health Center

RURAL ROCKS

This is the April 2025 issue of Rural Rocks from the SWOSU College of Pharmacy.

Exploring The Impact Of Pharmacy Education On Pharmacy Residents' Confidence & Knowledge Of Gender-Affirming Hormone Therapy, Grace Thompson, Jordan Ballou, Chao Cai

Senior Theses

This thesis will examine the relationship between pharmacy school education about gender-affirming hormone therapy and the confidence and knowledge of PGY1 and PGY2 pharmacy residents at ASHP-accredited or candidate pharmacy residency programs across the United States. This cross-sectional study was completed through an analysis of de-identified survey data, including demographics, confidence-based questions, and knowledge-based questions. The study survey and thesis were compiled by reviewing the current literature regarding the perceptions of pharmacists, pharmacy residents, and student pharmacists on transgender and gender diverse topics. The survey was sent to pharmacy residents through residency program directors (RPDs) and program contacts. After considering …

Strengthening The Paediatric Clinical Trial Ecosystem To Better Inform Policy And Programmes, James A. Berkley, Judd L. Walson, Glenda Gray, Fiona Russell, Zulfiqar Ahmed Bhutta, Per Ashorn, Shane A. Norris, Ebunoluwa A. Adejuyigbe, Rebecca Grais, Bernhards Ogutu

Institute for Global Health and Development

The first WHO Global Clinical Trials Forum was convened in November, 2023 to develop a shared vision of an effective global clinical trial infrastructure. The Paediatric Clinical Trials Working Group was formed to provide perspectives, identify challenges, and propose solutions to strengthen the paediatric clinical trials ecosystem. Participants represented paediatric disciplines, including infectious diseases, nutrition, neonatology, pharmacology, oncology, neurodevelopment, public health, and policy. Childhood diseases have profound lifelong effects on health, livelihoods, and societies. Investment in early childhood results in highly cost-effective changes to lifelong health, productivity, and human capital returns. Yet, there remain substantial gaps in knowledge on the …