Pharmacy and Pharmaceutical Sciences Commons^™

State-Level Variability In Veteran Reliance On Veterans Health Administration And Potentially Preventable Hospitalizations: A Geospatial Analysis, Drew A. Helmer, Mazhgan Rowneki, Xue Feng, Chin-Lin Tseng, Danielle Rose, Orysya Soroka, Dennis Fried, Nisha Jani, Leonard M. Pogach, Usha Sambamoorthi

Faculty & Staff Scholarship

Most Veterans who use the Veterans Health Administration (VHA) also utilize private-sector health care providers. To better inform local and regional health care planning, we assessed the association between reliance on VHA ambulatory care and total and system-specific preventable hospitalization rates (PHRs) at the state level. We conducted a retrospective dynamic cohort study using Veterans with diabetes mellitus, aged 66 years or older, and dually enrolled in VHA and Medicare parts A and B from 2004 to 2010. While controlling for median age and proportion of males, we measured the association between reliance on VHA ambulatory care and PHRs at …

Photoluminescence Mechanism And Applications Of Zn-Doped Carbon Dots, Quan Xu, Wei Cai, Miaoran Zhang, Yingchun Ye, Yeqing Li, Lipeng Zhang, Yongjian Guo, Zhiqiang Yu, Siyu Li, Xun Lin, Yusheng Chen, Yan Lou, Jason Street, Meng Xu

Faculty & Staff Scholarship

Heteroatom-doped carbon dots (CDs) with excellent optical characteristics and negligible toxicity have emerged in many applications including bioimaging, biosensing, photocatalysis, and photothermal therapy. The metal-doping of CDs using various heteroatoms results in an enhancement of the photophysics but also imparts them with multifunctionality. However, unlike nonmetal doping, typical metal doping results in low fluorescence quantum yields (QYs), and an unclear photoluminescence mechanism. In this contribution, we detail results concerning zinc doped CDs (Zn-CDs) with QYs of up to 35%. The zinc ion charges serve as a surface passivating agent and prevent the aggregation of graphene p–p stacking, leading to an …

Spontaneous Dna Damage To The Nuclear Genome Promotes Senescence, T Redox Imbalance And Aging, Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhan Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Celine Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Rena A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. Mcgowan, Nadiezhda Cantu-Madellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. Larusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St, Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Neidernhofer

Faculty & Staff Scholarship

Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/Δ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/Δ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/Δ mice compared to repair-competent animals. However, the levels of DNA damage and senescent cells in Ercc1-/Δ mice never exceeded that …

Team Based Approach To Fall Prevention In Elderly Population: A Four Year Review, Britney Schwartz Bsn, Rn, Anne Yaple, Jamie Gaul Pharmd, Bcps, Jennifer Ferguson, Katelyn Hougham, Fenlei Chang Md, Phd

Parkview Pharmacy Department

Poster Presentation

“The research reported on this poster was supported by Parkview Health, Indiana University School of Medicine, and Aging & In-Home Services of NE Indiana. The investigators retained full independence in the conduct of this research”

Methods:

The Fall Prevention Clinic was established 4 years ago as an outpatient service within a community hospital.  The patient completes a series of two appointments after a physician referral is received • 1st Visit – Composed of evaluation by a multi-disciplinary team: Neurologist (Neuro),RN Care Advisor (RN), Physical Therapist (PT), Pharmacist (RPh), Occupational Therapist (OT), and Aging & In-Home Services (AIHS) …

Evaluation Of Acute Kidney Injury With Vancomycin Therapy In Adult, Sarah Ferrell Pharmd, Sarah Pfaehler Pharmd, Mba, Bcps

Parkview Pharmacy Department

Poster Presentation

Objective: To evaluate the outcomes and risk of acute kidney injury (AKI) associated with a pharmacy-driven vancomycin dosing protocol at a community hospital.

Impact Of Sepsis Order Set Updates On Carbapenem Utilization In A Community Regional Medical Center, Brandon Euen Pharmd, Michele Walters Pharmd, Bcps, Aq-Id, Luke Keller Pharmd, Bcps, Bcccp

Parkview Pharmacy Department

2018 ASHP Midyear Clinical Meeting / Anaheim, California / Poster # ADD

Background: Patients with penicillin allergies who require broad-spectrum antimicrobial therapy for the treatment of sepsis often receive a carbapenem instead of a cephalosporin due to concerns of penicillin-cephalosporin cross-reactivity. • As rates of antibiotic resistance continue to increase, institutions should prioritize efforts to preserve the efficacy of carbapenems. • Reduction of carbapenem use in institutions has been shown to lower incidence rates of carbapenem-resistant organisms . • Cephalosporins have previously demonstrated low rates of cross-reactivity in penicillin allergic patients. • As of May 29th, 2018, updates to our …

Co-Occurrence Of Tobacco Product Use, Substance Use, And Mental Health Problems Among Youth: Findings From Wave 1 (2013–2014) Of The Population Assessment Of Tobacco And Health (Path) Study, Kevin P. Conway, Victoria R. Green, Karin A. Kasza, Marushka L. Silveira, Nicolette Borek, Heather L. Kimmel, James D. Sargent, Cassandra A. Stanton, Elizabeth Lambert, Nahla Hilmi, Chad J. Reissig, Kia J. Jackson, Susanne E. Tanski, David Maklan, Andrew J. Hyland, Wilson M. Compton

United States Food and Drug Administration: Publications

Introduction: Cigarette use is associated with substance use and mental health problems among youth, but as- sociations are unknown for non-cigarette tobacco product use, as well as the increasingly common poly-tobacco use.

Methods: The current study examined co-occurrence of substance use and mental health problems across tobacco products among 13,617 youth aged 12–17 years from Wave 1 (2013–2014) of the nationally representative Population Assessment of Tobacco and Health (PATH) Study. Participants self-reported ever cigarette, e-cigar- ette, smokeless tobacco, traditional cigar, cigarillo, filtered cigar, hookah, and other tobacco product use; al- cohol, marijuana, and other drugs; and lifetime substance use, internalizing …

Trends And Economic Drivers For United States Naloxone Pricing, January T 2006 To February 2017, Matthew Rosenberg, Grace Chai, Shekhar Mehta, Andreas Schick

United States Food and Drug Administration: Publications

Anecdotal evidence indicates that naloxone prices have risen in recent years, but limited research has examined the magnitude of these increases and potential causes. We contribute nationally representative evidence to help answer each of these questions, including wholesale pricing data from a proprietary drug sales database span- ning January 2006 to February 2017. We find that all formulations of naloxone increased in price since 2006 except for Narcan Nasal Spray. These cumulative increases totaled 2281% for the 0.4 MG single-dose products, 244% for the 2 MG single-dose products, 3797% for the 4 MG multi-dose products, and 469% for the 0.4 …

2018 Apothecary, Southwestern Oklahoma State University

Apothecary

This publication is dedicated to the Southwestern College of Pharmacy faculty, staff, alumni, and students. We congratulate this year's graduating seniors and wish you success in your professional careers.

It is with great honor we present the 2018 Apothecary issue. This year’s Apothecary was made possible by the provision of generous financial contributions from many stores, businesses, and Southwestern College of Pharmacy alumni. We greatly appreciate and thank you for your continued support.

Jackrabbits Script & Scope, College Of Pharmacy And Allied Health Professions

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 4 An Expert's Ear
[Page] 6 Hitting the Road
[Page] 8 Pilot Program
[Page]10 Greatest Job in the World
[Page] 11 Keo Glidden Smith
[Page] 12 MLS White Coat Ceremony
[Page] 14 Honorary White Coat
[Page] 16 Scholarships
[Page} 18 Rural Experiences for Health Professions Students
[Page] 20 Summer Student Experiences
[Page] 24 Distinguished Alumnus
[Page] 26 Harold Bailey
[Page] 28 Carnie Allex
[Page] 30 Treating Metastatic Cancer
[Page] 32 Academic Assessment - Curriculum Report
[Page] 33 Department of Pharmacy Practice
[Page] 34 Department of Pharmaceutical Sciences
[Page] 35 2017 Highlights
[Page] 39 Avera Health Scholarships
[Page] 40 Development …

Bill Gatton College Of Pharmacy Economic Impact Report - 2018, Bill Gatton College Of Pharmacy, East Tennessee State University

Bill Gatton College of Pharmacy Miscellaneous Publications

No abstract provided.

Student Handbook 2018-2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Endocide-Induced Abnormal Growth Forms Of Invasive Giant Salvinia (Salvinia Molesta), Shiyou Li, Ping Wang, Zushang Su, Emily Lozano, Olivia Lamaster, Jason Grogan, Yuhui Weng, Thomas Decker, John Findeisen, Monica Mcgarrity

Faculty Publications

Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. The fern is known to have primary, secondary, and tertiary growth forms, which are also commonly hypothesized as growth stages. The identification of these forms is primarily based on the size and folding status of the floating leaves. However, we identified 12 forms in the greenhouse and the field. Our experiments showed that the folding of floating leaves is a reversible trait dependent on water access. The floating leaves quickly fold in response to water shortage, reducing water loss and needs, decreasing growth, …

Permeability Changes And Effect Of Chemotherapy In Brain Adjacent To Tumor In An Experimental Model Of Metastatic Brain Tumor From Breast Cancer, Afroz S. Mohammad, Chris E. Adkins, Neal Shah, Rawaa Aljammal, Jessica I. G. Griffith, Rachel M. Tallman, Katherine L. Jarrell, Paul R. Lockman

Faculty & Staff Scholarship

Abstract

Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert toxicity on cells of the central nervous system. Herein, we studied permeation changes in BAT using quantitative fluorescent microscopy and autoradiography, while the effect of chemotherapy within the BAT region was determined by staining for activated astrocytes.

Methods: Human metastatic breast cancer cells (MDA-MB-231Br) were injected into left ventricle …

Absolute Oral Bioavailability Of Creatine Monohydrate In Rats: Debunking A Myth, Eman A. Alraddadi, Ryan Lillico, Jonathan L. Vennerstrom, Ted M. Lakowski, Donald W. Miller

Journal Articles: Pharmaceutical Sciences

Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg)

The Enzymatic Activity Of Apobe3g Multimers, Yangang Pan, Karen Zagorski, Luda S. Shlyakhtenko, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization of A3G is related to the packing mechanism into virus particle and, is critical for the so-called roadblock model during reverse transcription of proviral ssDNA. The role of oligomerization for deaminase activity of A3G is widely discussed in the literature; however, its relevance to deaminase activity for different oligomeric forms of …

Flupirtine Derivatives As Potential Treatment For The Neuronal Ceroid Lipofuscinoses, Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El-Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C. Trippier, Rose-Mary Boustany

Journal Articles: Pharmaceutical Sciences

OBJECTIVE: Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease-modifying drug candidates, with potential to enhance growth, reduce apoptosis and lower ceramide in neuronal precursor PC12 cells and human NCL cell lines using enhanced flupirtine aromatic carbamate derivatives in vitro.

METHODS: Aromatic carbamate derivatives were tested by establishing growth curves under pro-apoptotic conditions and activity evaluated by trypan blue and JC-1 staining, as well as a drop in pro-apoptotic ceramide in neuronal precursor PC12 cells following siRNA knockdown of the

RESULTS: Retigabine, the benzyl-derivatized …

Ancestral Dependence On Breast Stemness And Nucleotide Excision Repair In Breast Cancer Stem Cells In Novel Human Model Systems, Omar Ibrahim

Student Theses, Dissertations and Capstones

Precocious puberty, measured by thelarche or menarche, is a well-established breast cancer risk factor. Using a unique and patented tissue engineering system we established cell lines from 48 primary cultures of normal breast tissue from reduction mammoplasties and used them as an in vitro model of thelarche, quantifying episphere formation and ductal differentiation. Differential ductal formation was observed based on ancestry. In light of African American (AA) precocious thelarche both in vivo and as we observed in vitro, we hypothesized that AA women would exhibit an increased proportion of breast stem cells, with greater potency for differentiation. Five AA cell …

Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley

Student Theses, Dissertations and Capstones

NER plays an important role in remediating DNA damage. Latimer et al., have previously shown nucleotideexcision repair (NER) to be intrinsically deficient in stage I sporadic BC by function and gene expression. Previous work performed on 12 isogenically matched stage I tumors and non-tumor adjacent (NTA) samples identified 2 types of NTA tissue with regard to functional NER. One type that represented 75% ofthe samples, had lower NER capacity, similar to the tumor (Low: Low pair). The other type had high NER relative to the tumor (High: Low pair). Two isogenic NTA/tumor cell line pairs representing these 2 types ofNTA …

Heteromerization Of G Protein-Coupled Receptors In Human Vascular Smooth Muscle Cells: Identification Of Hetero-Oligomeric Receptor Complexes Between Α1-Adrenergic Receptors, Arginine Vasopressin Recptor 1a, Chemokine (C-X-C Motif) Receptor Type 4, And Atypical Chemokine Receptor 3., Lauren J. Albee

Dissertations

G protein-coupled receptor (GPCR) heteromerization is rapidly evolving field. Traditionally, GPCRs were thought to behave has independent entities or protomers. However, that line of reasoning has since been brought into question. Currently, it appears that many, if not all, GPCRs signal and function as heteromeric receptor complexes. The roles of GPCR heteromerization are vast and can include: maturation and trafficking; dynamic regulation; allostery and cooperativity; signal transduction; and receptor internalization.

The majority of studies identifying and characterizing GPCR heteromers were performed using recombinant receptors. Only four receptor pairs have been identified and validated in native tissues. The overall objective of …