Pharmacy and Pharmaceutical Sciences Commons^™

Investigating The Role Of Traditional Chinese Herbal Medicine For Cancer Symptom Management In Older Adults: A Rapid Review, Isabelle C. Karshner

Honors Undergraduate Theses

Background: Patients with cancer often experience symptoms related to disease, complications, and treatment. One potential method of alleviating these symptoms is traditional Chinese herbal medications (TCHM). This rapid review explores the role of traditional Chinese herbal medications in treating cancer-related symptoms in older adults.

Purpose: The purpose of this rapid review is to gain and provide a better understanding of the effects of TCHM on cancer-symptom management in the older adult population. This review explores the association between TCHM and effects on cancer symptoms in older adults, including interactions, toxicity, and signs/symptoms of TCHM use that may be useful information …

Synthesis And Characterization Of Succinate Dehydrogenase Inhibitors H2/Z14 And C6/Z96 In Order To Combat Small Cell Lung Cancer, Lauren M. Graves

Honors Undergraduate Theses

The use of ubiquinone inhibitors to combat cancer is a recent development in medicinal science and procedures to efficiently synthesize these drugs remain limited. C6/Z96 and H2/Z14, two succinate dehydrogenase inhibitors, have been previously tested in vitro against NSCLC with positive results. Their similarity to ubiquinone is what makes them a strong candidate for a succinate dehydrogenase inhibitor at the ubiquinone binding site. The heterocyclic scaffolds and substituents are proposed to bind strongly through a combination of electronics, hydrogen-bonding, and fit, allowing them to bind well and prove to be more favorable than ubiquinone when competing for the Q-site. By …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a wide-spectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (−72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Association Of Acetaminophen/Butalbital/Caffeine Doses And Incidence Of Cerebral Vasospasm, Emma Cloud, Mallory Stringer, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Incidence Of Sodium Overcorrection With Acute Tolvaptan Use, Emma Cloud, Alisha B. Terry

South Atlantic Division GME Research Days 2026

No abstract provided.

Burnout Amongst Pharmacy Preceptors Across The United States, Rachel Denison, Audrey Johnson, Danielle Croegaert, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Evaluation Of Levetiracetam Use In Aneurysmal Subarachnoid Hemorrhage And Spontaneous Intracranial Hemorrhage For Seizure Prophylaxis, Taylor Dodd, Mallory Stringer, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Tirofiban Use Following Mechanical Thrombectomy With Emergent Stent Placement In Acute Ischemic Stroke, Taylor Dodd, Mallory Stringer, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Evaluation Of Insulin Dosing In A Hyperkalemia Protocol, Kayla Hedgspeth, Rohan Johnson, Eric Shaw, Stephanie Lesslie

South Atlantic Division GME Research Days 2026

No abstract provided.

Evaluation Of Phenobarbital Dosing For The Management Of Alcohol Withdrawal Syndrome, Kayla Hedgspeth, Eric Shaw, Alisha B. Terry

South Atlantic Division GME Research Days 2026

No abstract provided.

Burnout Among Pharmacy Residents, Hunter Mcdowell, Mallory Stringer, Taja Scott, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Comparison Of Oral Vancomycin Dosing Strategies For Initial, Non-Fulminant C. Difficile Infection Treatment, Hunter Mcdowell, Eric Shaw, Danielle Lott

South Atlantic Division GME Research Days 2026

No abstract provided.

Factors Associated With Successful Publication Of Pharmacy Resident Research Projects, Victoria Michel-Milian, Amy Taylor, Eric Shaw

South Atlantic Division GME Research Days 2026

No abstract provided.

Evaluating Heparin Infusions And Resultant Monitoring Parameters, Victoria Michel-Milian, Eric Shaw, Alisha B. Terry

South Atlantic Division GME Research Days 2026

No abstract provided.

Epoetin Alfa Administration In Intermittent Hemodialysis, Britany Shellhouse, Eric Shaw, Stacie Coleman

South Atlantic Division GME Research Days 2026

No abstract provided.

Evaluating The Impact Of Perioperative Antibiotic Timing On Surgical Site Infections In Hysterectomy And Colorectal Surgeries, Britany Shellhouse, Eric Shaw, Amy Taylor

South Atlantic Division GME Research Days 2026

No abstract provided.

Scholarly Productivity Of Non–Pharmacy Practice Faculty In U.S. Schools And Colleges Of Pharmacy, 2019–2023, Osama A. Shoair, Sierra Pollard, Faith Fosuhene-Apenteng, Michael Pimentel-Galvan, Abrar Elagami, May H. Abdelaziz

Pharmacy Faculty Publications and Presentations

Purpose: Scholarly productivity is central to academic advancement, institutional benchmarking, and accreditation in pharmacy education. This study evaluated the national scholarly productivity among non–pharmacy practice (NPP) faculty in U.S. schools and colleges of pharmacy and assessed variation in publication output across faculty and institutional characteristics.

Methods: A retrospective bibliometric analysis was conducted between January 2019 and December 2023. Faculty were identified using the American Association of Colleges of Pharmacy Roster of Faculty and Professional Staff and classified as biomedical and pharmaceutical sciences (BPS) or social and administrative sciences (SAS). Publications were retrieved from Web of Science and characterized …

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd

Graduate Research Posters

Background

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance …

Circulating Biomarker Results From A Phase 2 Study Of Seralutinib In Pulmonary Arterial Hypertension, Robin Osterhout, Athénaïs Boucly, Raymond L. Benza, Richard N. Channick, Kelly M. Chin, Robert P. Frantz, Anna R. Hemnes, Luke S. Howard, Vallerie V. Mclaughlin, Olivier Sitbon, Jean-Luc Vachiéry, Rotham T. Zamanian, Richard Aranda, Matt Cravets, Zhaoqing Ding, Thao Duong-Verlé, David Mattola, Robert F. Roscigno, Ravikumar Sitapara, Lawrence S. Zisman, Jean-Marie Bruey, Hossein-Ardeschir Ghofrani

Department of Medicine Faculty Publications

[Introduction] To the Editor: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by obstructive pulmonary arterial remodeling (1). Seralutinib, an investigational inhaled tyrosine kinase inhibitor, potently and selectively targets kinases relevant to PAH pathobiology including platelet-derived growth factor receptors (PDGFR) α and β, colony stimulating factor 1 receptor (CSF1R), and mast/stem cell growth factor receptor kit (c-KIT) (2). In preclinical models, seralutinib improved cardiopulmonary hemodynamics, reversed pulmonary vascular pathology and decreased right ventricular hypertrophy (3). In TORREY, a phase 2, multicenter, double-blind, randomized, placebo-controlled trial in PAH, seralutinib significantly reduced pulmonary vascular resistance (PVR) after 24 weeks with good …

Longitudinal Patterns Of Urinary Biomarkers Of Placental And Renal Function In Pregnancy And Associations With Early Pregnancy Exposure To Phthalates And Replacements, Erin E. Mcnell, Danielle R. Stevens, Barrett M. Welch, Suzanne Fenton, Antonia M. Calafat, Julianne Cook Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson

Department of Obstetrics & Gynecology Faculty Publications

Phthalates and replacements are endocrine-disrupting chemicals that may interfere with early pregnancy processes such as placentation and renal adaptation. Placental and renal biomarkers may help examine these toxicologic mechanisms. This study aims to characterize longitudinal changes in urinary protein biomarkers of placental angiogenesis (sFlt-1, PlGF, sEng) and renal function (KIM-1, NGAL, nephrin), and investigate associations with early pregnancy exposure to phthalates and replacements. Among 291 participants from the Human Placenta and Phthalates prospective cohort, urinary metabolites of eight phthalates and two replacements were quantified at up to 2 time points from 12 to 15 weeks gestation. Repeated measures were averaged …