Dentistry Commons^™

Temperature And Ph-Responsive Nano-Hydrogel Drug Delivery System Based On Lysine-Modified Poly (Vinylcaprolactam), Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E. Welland, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Background: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems.

Purpose: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed.

Methods: Poly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety …

Impact Of Two Distinct Dental Anesthesia Simulation Models On The Perception Of Learning By Students, Jadith Merino-Parra, Ricardo E. Madrazo-Meneses, Takashi Komabayashi, Bernardino I. Cerda-Cristerna

Dental Medicine Faculty Publications

We evaluated an infiltration anesthesia simulation model (IAM) and a conduction anesthesia simulation model (CAM) on the perception of learning by Mexican dental students. Our aim was to compare the perception of learning by dental students trained with two distinct dental anesthesia simulation model (DASM) with dental students who were not trained with a DASM. 3 groups participated in the study: G1 (N=12 students) learned to block the mental nerve (BMN) by participating in a theoretical lecture (stage 1) and a clinical demonstration (stage 2); G2 (N=12 students) learned the BMN by participating in the stage 1, stage 2, and …

Oral Hygiene In Intensive Care Units: A Survey On Protocol, Kayla J. Gallegos, Christine Nathe

Dental Hygiene ETDs

The purpose of this study was to learn about various Intensive Care Units’ current oral hygiene care protocols, nurses’ values, and interests in interprofessional collaboration with a dental professional. An online survey was created and intended recipients included 1,696 members of the Trauma ICU Nurses/Critical Care Medicine Facebook page. Participants were asked about their value of oral hygiene, oral hygiene education, and interest in interprofessional collaboration. Of the 1,696 nurses 34 (2%) opted to participate in this survey study. Findings from this study suggest that these nurses’ value oral health in themselves and in patients. Half of the survey participants …

An Assessment Of A Video On The Link Between Diabetes And Peridontal Disease To Educate Native American Populations., Valerie E. Long

Dental Hygiene ETDs

As the Native American population of the Navajo Nation, becomes affected with diabetes dental offices across the Navajo Reservation must ensure that evidence based research is being presented n the oral systemic link of diabetes and periodontal disease. The purpose of this study was to bring awareness to the important topic of the bi-directional link of diabetes and periodontal disease with Native American dental patients. This topic seems to not be valued during oral hygiene education time and so that addition of a culturally-specific educational video on the topic should add value to the message. This topic was investigated via …

In Vivo Effectiveness And Safety Of Probiotics On Prophylaxis And Treatment Of Oral Candidiasis: A Systematic Review And Meta-Analysis, Lijun Hu, Mimi Zhou, Andrew L. Young, Weiwei Zhao, Zhimin Yan

All Dugoni School of Dentistry Faculty Articles

BACKGROUND: To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis.

METHODS: A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned.

RESULTS: Six randomized …

Ada News - 07/08/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Dental Practice Success Vol. 6 No. 2, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Mapping The Literature Of Dental Hygiene: An Update, Carol L. Watwood, Terry Dean

DLPS Faculty Publications

Objective: This study updates Haaland’s 1999 dental hygiene mapping study. By identifying core journals and estimating database coverage, it characterizes changes in dental hygiene research and aids librarians in collection development and user education.

Method: Cited references from a three-year (2015–2017) sample of core dental hygiene journals were collected, categorized into five formats, and analyzed by format and publication year according to Bradford’s Law of Scattering. CINAHL Complete, MEDLINE, and EMBASE were surveyed to determine the indexing coverage of cited journals.

Results: The number of cited journal titles increased from 389 in 1999 to 1,675 in 2018. Core Zone 1 …

Part I: Complete Dentures And Diabetes Correlation, Ibeth Erazo

Publications and Research

Diabetes is one of the most frequent pathologies that dentists encounter, due to its high prevalence worldwide. The aim of this study is to present the correlation between diabetes and complete denture wearers, intending to emphasize the importance of proper control and denture adaptation to oral environment for this type of patient. Within the sphere of the dental office, one of the main complications to consider in this type of patient is periodontal disease, which is their most frequent complication. Other important oral manifestations considered in the research are fungal infections, xerostomia, and burning mouth syndrome. It is common for …

Effect Of Heat-Treatment Time On Bending Properties Of Cobolt-Chromium Orthodontic Wires, Melanie Hammerbeck

Master's Theses (2009 -)

Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires. Two tempers of CoCr ‘Elgiloy’ wires (Rocky Mountain Orthodontics), blue (B) and yellow (Y), were heat-treated for different durations. The groups (n=20/group/temper) included: 1) as-received (control); 2) brush-flame; 3) 480oC for 5sec; 4) 480oC for 10min; 5) 480oC for 2hr; and 6) 480oC for 5hr. Wire segments were tested by a three-point bend test. Stiffness/flexural modulus, percent recovery, and force values at select deflections were statistically compared …

Efficacy Of Invisalign Attachments: A Retrospective Study, Theresa Karras

Master's Theses (2009 -)

Objective: To compare the efficacy of Invisalign’s (Align Technology, Inc., Santa Clara, CA) optimized and conventional attachments on rotational and extrusive tooth movements.Materials and Methods: Initial, predicted, and achieved digital dental models from 100 orthodontic patients were exported from Invisalign’s ClinCheck software as stereolithography (STL) files and subsequently imported into the Slicer CMF program (open source, version 4.7.0) for superimpositions on posterior teeth with no planned movement. Rotational and extrusive measurements for both optimized and conventional attachment types were made on 382 teeth from the superimposition of the initial and predicted models (“predicted movement”) and from the superimposed initial and …

The Cytotoxicity Effect Of Silver Solder Materials On Human Periodontal Ligament Fibroblast Cells, Joseph Jeffrey Curry

Master's Theses (2009 -)

Objectives:Orthodontic appliances with silver soldering can be in the oral cavity for several years and very few studies have been done to detect the biosafety of the silver solders. The aim of this in vitro study was to compare the cytotoxicity effects of two different solder materials on Human Periodontal Ligament Fibroblast cells (HPLF).Methods:Two commonly used solder materials from two companies, (Leone and Summit) with different metal elements and percentages were studied. The solder samples were exposed to HPLF cells for 48 hours and the cytotoxicity effect of soldered materials on HPLF cells was measured via the MTT colorimetric assay …

The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis - A Micro-Ct Study, Andrei Dan Taut

Master's Theses (2009 -)

Introduction: Vibration in the form of high frequency, low magnitude acceleration has paradoxical effects on craniofacial bones – with anabolic effects under physiological conditions and catabolic effects in the presence of inflammation. The objectives of this study are to establish a murine model for periodontitis and to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature- induced experimental periodontitis.Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment …

Evaluation Of Corrosion Mechanisms In Stainless Steel Orthodontic Retainer Wires, Jamie Martin

Master's Theses (2009 -)

Title: Evaluation of Corrosion Mechanisms in Stainless Steel Orthodontic Retainer WiresAuthors: Jamie Martin, Ghada Nimeri, David BerzinsObjective:Orthodontic retainers fabricated from stainless steel wire and acrylic are prone to several types of corrosion in the oral environment, including stress, crevice, and galvanic corrosion. The aim of this study was to determine the relative effect of stress corrosion, galvanic corrosion, and crevice corrosion on stainless steel retainer wires.Methods:Three different brands of 0.032-inch stainless steel wires were tested. Six new segments (2-inch length) of each brand of wire were tested in each of four tests: 1) in an artificial saliva solution to determine …

J Mich Dent Assoc July 2019

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA’s 6,200+ members across the state. No publication reaches more Michigan dentists! This month's issue presents the 2019 MDA Award winners, outgoing MDA president Dr. Deb Peters' presidential address, and the 2019 MDA Annual Session in words and photos.

Microrna-374a, -4680, And -133b Suppress Cell Proliferation Through The Regulation Of Genes Associated With Human Cleft Palate In Cultured Human Palate Cells, Akiko Suzuki, Aimin Li, Mona Gajera, Nada Abdallah, Musi Zhang, Zhongming Zhao, Junichi Iwata

Faculty, Staff and Student Publications

BACKGROUND: Cleft palate (CP) is the second most common congenital birth defect; however, the relationship between CP-associated genes and epigenetic regulation remains largely unknown. In this study, we investigated the contribution of microRNAs (miRNAs) to cell proliferation and regulation of genes involved in CP development.

METHODS: In order to identify all genes for which mutations or association/linkage have been found in individuals with CP, we conducted a systematic literature search, followed by bioinformatics analyses for these genes. We validated the bioinformatics results experimentally by conducting cell proliferation assays and miRNA-gene regulatory analyses in cultured human palatal mesenchymal cells treated with …

The Influence Of Vitamin D Supplementation On Local And Systemic Inflammatory Markers In Periodontitis Patients: A Pilot Study, Mohamed M Meghil, Lance Hutchens, Anas Raed, Neha A Multani, Mythilypriya Rajendran, Haidong Zhu, Stephen Looney, Mahmoud Elashiry, Roger M Arce, Mark E Peacock, Yanbin Dong, Christopher W Cutler

Faculty, Staff and Student Publications

OBJECTIVES: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients.

MATERIALS AND METHODS: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D …

Stimulus-Responsive Polymeric Nanogels As Smart Drug Delivery Systems, Sakineh Hajebi, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Hossein Roghani-Mamaqani, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in non-target tissues and …

Effects Of Dental Composite Resin Monomers On Dental Pulp Cells, Thomas R. Schneider, Roxan Hakami-Tafreshi, Alexandra Tomasino-Perez, Lobat Tayebi, Doug Lobner

School of Dentistry Faculty Research and Publications

Methacrylate monomers found in many dental materials cause toxicity to dental pulp cells but the mechanism of the toxicity is poorly understood. We used cultured human dental pulp cells to test the effects of three commonly used monomers; bisphenol-A-glycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA), and triethyleneglycol dimethacrylate (TEGDMA). The order of toxicity was Bis-GMA>UDMA>TEGDMA. The toxicity correlated inversely with cystine uptake, with TEGDMA stimulating uptake and BisGMA and UDMA inhibiting uptake. Bis-GMA and UDMA induced oxidative stress, while TEGDMA did not. Toxicity correlated poorly with glutathione levels, as all compounds decreased cellular glutathione. TEGDMA is less toxic than …

Ada News - 06/17/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.