Dentistry Commons^™

Amixicile As A Novel Antimicrobial Treatment For Periodontitis: A Pilot Study In The Non-Human Primate, Macaca Mulatta, Denver J. Lyons

Theses and Dissertations

Periodontitis is an inflammatory disease with a bacterial etiology in a susceptible host. Given the bacterial etiology, a selective antimicrobial agent with minimal side effects could be a useful adjunct to traditional therapy. Amixicile is a novel antimicrobial that targets the pyruvate: ferredoxin oxidoreductase (PFOR) which is an enzyme that is critical for anaerobic bacterial metabolism. It has been found to have no effect on commensal, aerobic microbes and has little to no side-effects thus far in animal models. In this study, two nonhuman primates of the Macaca mulatta species with naturally occurring mild chronic periodontitis were studied before and …

Repeat Full Mouth Dental Rehabilitation Under General Anesthesia For Medicaid Eligible Healthy Children Who Are High Caries Risk, Lajoi E. Wiggins

Theses and Dissertations

Purpose: To evaluate the treatment of healthy children who are high caries risk and of low socioeconomic status and who require repeat full mouth dental rehabilitation (FMDR) under general anesthesia (GA).

Methods: A retrospective chart review was performed on healthy Medicaid eligible patients who were initially between 18 months - 6 years of age who underwent FMDR under GA in the OR more than once at the Virginia Commonwealth University (VCU) School of Dentistry, Department of Pediatric Dentistry from January 2008 to December 2018. Biographical information for each patient was gathered into a REDCap™ Survey. Statistical analysis, chi-squared test with …

A Comparison In Pediatric Dental Website Design From A Guardian And Pediatric Dentists’ Perspective., David M. Voth

Theses and Dissertations

Purpose: This project aims to determine which aspects of pediatric dental practice websites are preferable to the guardians of pediatric dental patients and which of these aspects are currently available to guardians on the websites of pediatric dental practices across the United States. The comparison will reveal if practice websites are meeting the needs of the guardians of pediatric dental patients. Our hope is to provide meaningful guidance to pediatric dentists designing new practice websites and to provide the guardians of pediatric dental patients with an appealing online experience during their use of the aforementioned websites. Methods: A survey with …

Accuracy Of Blx And Blt Guided Implants In The Edentulous Maxilla: An In Vivo Study, Benjamin Andrew Kordusky

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objectives: To determine the accuracy of dental implants placed using a dual scan CBCT protocol with a SLA 3D printed mucosa supported surgical guide using a flapless surgical approach with regard to sleeve position, type of implant, and regional location in the maxillary arch.

Methods: Nine patients received 4 dental implants utilizing a fully guided, flapless approach with a mucosa supported SLA surgical guide with 3 fixation pins. Implants were immediately loaded using an attachment placed in an existing Maxillary complete denture. Accuracy of implant positions were evaluated by the Treatment Evaluation module of coDiagnostiX (DentalWings, Montreal, Canada). Statistical analysis …

Fracture Resistance Of Simulated External Cervical Resorption In Anterior Teeth Restored With And Without A Fiber Post., Michelle M. Romeo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: External cervical resorption (ECR) is a destructive type of external resorption that can be difficult to treat. ECR usually begins subgingival at the cementoenamel junction of teeth and continues apically and circumferentially. This substantial loss of tooth structure may make these teeth more prone to fracture and should be addressed when treatment planning teeth with ECR. The aim of this in vitro study was to evaluate the fracture resistance of treated and non-treated teeth with simulated ECR using two different treatment modalities.

Materials and Methods: Forty-eight extracted human permanent mandibular central incisors were selected. Teeth were randomly divided into …

Multitarget Stool Dna Testing For The Prevention Of Colon Cancer: Outcomes In A Large Integrated Healthcare System, Nimish Vakil, Kristin Ciezki, Nadia Huq, Maharaj Singh

School of Dentistry Faculty Research and Publications

Background and Aims

Multitarget stool DNA (MT-sDNA) testing is used in primary care as a screening test for colon cancer. Test effectiveness and patient compliance were examined in clinical practice.

Methods

We assessed outcomes of MT-sDNA testing in a cohort study conducted in a large integrated healthcare system comprising 15 hospitals and 150 outpatient clinics using advanced electronic data capture (Clarity2 [Epic, Verona, Wisc, USA] and REDCap [Encinitas, Calif, USA]) followed by manual chart review to confirm MT-sDNA test results and to monitor the outcomes of subsequent colonoscopy.

Results

A total of 6835 MT-sDNA tests were performed over 1 year …

Hydrogen Peroxide Preconditioning Promotes Protective Effects Of Umbilical Cord Vein Mesenchymal Stem Cells In Experimental Pulmonary Fibrosis, Tayebeh Mahmoudi, Kamal Abdolmohammadi, Hamed Bashiri, Mehdi Mohammadi, Mohammad Jafar Rezaie, Fardin Fathi, Shohreh Fakhari, Mohammad Ali Rezaee, Ali Jalili, Mohammad Reza Rahmani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few available treatments. Mesenchymal stem cell therapy (MSCT), an innovative approach, has high therapeutic potential when used to treat IPF. According to recent data, preconditioning of MSCs can improve their therapeutic effects. Our research focuses on investigating the anti-inflammatory and antifibrotic effects of H₂O₂-preconditioned MSCs (p-MSCs) on mice with bleomycin-induced pulmonary fibrosis (PF).

Methods

Eight-week-old male C57BL/6 mice were induced with PF by intratracheal (IT) instillation of bleomycin (4 U/kg). Human umbilical cord vein-derived MSCs (hUCV-MSCs) were isolated and exposed to a sub-lethal concentration (15 …

Current Trends And Future Perspectives Of Oral Pathology: Indian Scenario, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

No abstract provided.

Correlation Between Number Of Mendeley Readers And Citations In Dental Sciences, Jafar Kolahi, David G. Dunning, Edward F. Rossomando

Journal Articles: College of Dentistry

No abstract provided.

West Virginia Dentists' Perception Of The Knowledge And Skills Of Two Vs. Four Year Dental Hygiene Graduates, Kaitlyn M. Mcquain

Graduate Theses, Dissertations, and Problem Reports (ETD)

The entry level for the dental hygiene profession has, historically been an associate degree. In 2016 the American Dental Hygiene Association (ADHA) approved the Bachelor’s Degree level of education as the preferred for entry level degree. This study is to determine practicing West Virginia dentists preference for the education level of their entry-level dental hygiene employees. There were 1020 surveys electronically distributed to practicing WV dentists to obtain their opinions and preferences. WVU Research Electronic Data Capture (REDCap) was used to determine response percentages and Chi-square statistics were used to compare 2017 to 2019 response rates. Between 2016-2017 and 2018-2019, …

Comparison Of Skeletal And Dentoalveolar Changes Between Two Bone-Borne Maxillary Expanders, Mohamad Sarraj

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Bone-borne maxillary expander (BBME) are designed to provide additional anchorage to widen the maxillary arch for patients who exhibit maxillary transverse deficiency. One form of BBME is the hybrid BBME which uses mini-implants (bone-borne) and posterior teeth (tooth-borne) as anchorage for maxillary expansion. The other form of BBME is absolute BBME which only uses mini-implants as anchorage. It is not clear in the literature if there is a difference in skeletal and dental changes with these two types of expanders. The objective of this study was to compare the skeletal, dentoalveolar, and periodontal changes between the hybrid and the …

Wv Dental Hygienists' Knowledge And Educational Approach For Pregnant Women, Isabella Hope Mcdaniel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Adverse pregnancy outcomes have become a concern for dental professionals caring for pregnant women with poor oral health. Pregnant women may not be aware of their increased risk of bacterial infections in their oral tissues and how it could relate to adverse pregnancy outcomes such as pre- term birth (PTB) and low birthweight babies (LBW). Dental healthcare professionals need to be well informed of risk related to poor oral health and have confidence to effectively educate pregnant women. PTB and LBW babies account for 1 million infant deaths annually. It is the responsibility of dental healthcare professionals to be …

The Visual And Spectrophotometric Effect Of External Bleaching On Omnichroma Resin Composite And Natural Teeth, Michael Brian Evans

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objective: To determine the visual and spectrophotometric effect external tooth bleaching has on natural tooth structure and OMNiCHROMA composite at various number of treatments. Variables were compared to determine if there is a detectable difference between the composite and the tooth before and after bleaching.

Methods: Preparation and restoration of 25 previously extracted teeth was completed. OMNiCHROMA composite was used. Each tooth was measured visually with a VITA shade guide and a colorimeter. Measurements were recorded before bleaching, after 5 and 10 treatments. Statistical analysis was completed and ΔE values between the composite and tooth were compared between the 3 …

Clear Aligner Therapy Vs. Traditional Brackets On Smile Arc, Sarah Elizabeth Larue

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives: More so than ever, the public is becoming exceedingly aware of esthetics, and will evaluate their treatment outcome based upon the improvement to their smile and overall enhancement of their facial appearance. Smile arc is considered to be a key component of facial esthetics. Literature has demonstrated that orthodontic treatment mechanics utilizing traditional brackets and wires can cause flattening of the smile arc and that smiles with flatter arcs are judged to be less attractive. The aim of this study was to determine whether clear aligner therapy can help to preserve or improve the smile arc …

Root Coverage Predictability In The Treatment Of Gingival Recessions On Mandibular And Anterior Teeth, Michele Agusto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Mandibular anterior teeth are most frequently affected by gingival recessions. However, data regarding mucogingival treatment aimed at root coverage in this specific location is limited.

Aim. To systematically review the literature addressing the focused question: “What is the effectiveness, efficacy and efficiency of different surgical approaches on clinical and patient-related outcomes in the treatment of buccal gingival recessions on mandibular anterior teeth?”

Material methods. Electronic (Medline, Scopus, and Cochrane databases) and hand literature searches were performed for studies including at least one arm involving the use of pedicle flaps and/or free soft tissue grafts in the …

Oral Care During Pregnancy: An Educational Intervention, Holly Redwine

EWU Masters Thesis Collection

Purpose: Interprofessional collaboration can help prevent adverse pregnancy outcomes related to poor oral health. This study was conducted to see if an educational module provided by a dental hygienist (DH) could increase the knowledge and confidence of physician assistant (PA) students with preventive oral care for the pregnant patient.

Methods: A one group mixed-method approach was used in this research. Pregnancy and oral health knowledge were assessed using a 9-item pretest and posttest survey. Participants completed the pretest, were presented an educational module, and were asked to complete an immediate posttest. A second posttest was sent via e-mail to the …

Using Motivational Interviewing And Technology To Increase Confidence In Nutritional Counseling Among Dental Hygienists: A Thesis, Heather Anderson

EWU Masters Thesis Collection

Purpose: Research shows definite connections between food choices and caries, periodontal disease, and oral cancer. Dental hygienists have the unique opportunity to educate patients on how nutrition can improve oral health. Dental hygiene students are introduced to these concepts but struggle to gain confidence to share this knowledge with patients. This study looked at an educational module on motivational interviewing (MI) and an electronic assessment tool to build student confidence with nutritional counseling.

Methods: Students participated in an educational module to review MI and introduce the electronic nutritional risk assessment and counseling tool. Prior to the module, participants completed a …

Biomedical Applications Of Zeolitic Nanoparticles, With An Emphasis On Medical Interventions, Hossein Derakhshankhah, Samira Jafari, Sajad Sarvari, Ebrahim Barzegari, Faezeh Moakedi, Milad Ghorbani, Behrang Shiri Varnamkhasti, Mehdi Jaymand, Zhila Izadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies …

In Vitro Evaluation Of Different Protocols For Preventing Microleakage Of Fissure Sealants Placed Following Saliva Contamination, Hayrunnisa Şimşek, A. Rüya Yazici, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Purpose: To evaluate the effect of different enamel conditioning protocols and their re-application on the microleakage of fissure sealants placed following saliva contamination.

Study design: The study included 156 human third molars in 16 subgroups (2×4×2) under two main groups (sealant type): Group A- hydrophobic resin sealant, 3M Clinpro^™ Sealant; Group B- hydrophilic resin sealant, Ultraseal XT Hydro. Each group was then divided according to the type of surface conditioning; 1- Er,Cr:YSSG laser etching, 2- acid-etching, 3- acid-etching+etch-and-rinse adhesive (Prime&Bond^® One Select) and 4- self-etching adhesive (Clearfil^™SE Bond). After contaminating the conditioned occlusal enamel surfaces with …

Comparison Of External Root Resorption In Orthodontic Treatment Between Self-Ligating And Conventional Bracket Systems, Nuriah Bohari, Noor Airin Koah, Rohana Ahmad

Journal of Dentistry Indonesia

The relationship between orthodontic bracket systems and external root resorption has remained debatable. Objective: This study compared the magnitude and pattern of the external root resorption of maxillary incisors as induced by self-ligating and conventional bracket systems via cone beam computed tomography and medical imaging programs. Methods: Eight participants were recruited for each bracket system. Their maxillary incisors were scanned at the beginning (T0) and 18 months into treatment (T1). Three-dimensional models of the four maxillary incisors at T0 and T1 were reconstructed using the Mimics program. The difference in root length between T0 and T1 models represented external root …