Is Opt-80 A Safe And Effective Treatment For Patients With C.Difficile Infection?,
2011
Philadelphia College of Osteopathic Medicine
Is Opt-80 A Safe And Effective Treatment For Patients With C.Difficile Infection?, Heather A. Shupp
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: Objective of this systematic review is to determine whether or not OPT-80 is a safe and effective treatment for patients with C.difficile infection.
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children,
2011
Philadelphia College of Osteopathic Medicine
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice
PCOM Physician Assistant Studies Student Scholarship
The objective of this systematic review is to determine whether or not antibiotic treatment is safe and effective in healing tympanic membrane (TM) perforation in Aboriginal children diagnosed with chronic suppurative otitis media and otitis media with effusion less than 16 years of age.
Is Extract Err731 From The Rheum Rhaponticum Effective In Relieving Menopausal Symptoms In Women Aged 45 To 55 Years Of Age?,
2011
Philadelphia College of Osteopathic Medicine
Is Extract Err731 From The Rheum Rhaponticum Effective In Relieving Menopausal Symptoms In Women Aged 45 To 55 Years Of Age?, Annette M. Merlino
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine whether ERr 731 extract from the Rheum rhaponticum plant is effective in relieving symptoms of menopausal symptoms in women aged 45 to 55 years of age
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?,
2011
Philadelphia College of Osteopathic Medicine
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?, Brian M. Kairalla
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of the systematic review is to determine whether or not chronic use of Bacopa monnieri is an effective treatment to improve memory performance in healthy and aging adults.
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?,
2011
Philadelphia College of Osteopathic Medicine
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not caffeine ingestion prior to exercise effects exercise performance in healthy adults.
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?,
2011
Philadelphia College of Osteopathic Medicine
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not white bean extract is a safe and effective treatment for weight loss.
Is Green Tea An Effective Aid In Weight Reduction?,
2011
Philadelphia College of Osteopathic Medicine
Is Green Tea An Effective Aid In Weight Reduction?, Lindsey A. Brown
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not green tea extract is effective in aiding in weight reduction.
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression,
2011
Philadelphia College of Osteopathic Medicine
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression, Lauren Cabana
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does fish oil supplementation (omega-3 PUFA) cause mood improvement in adults with depression?”
Is Vitamin E Supplementation Effective In Reducing Mortality Related To Cardiovascular Events In People With Type 2 Diabetes Mellitus?,
2011
Philadelphia College of Osteopathic Medicine
Is Vitamin E Supplementation Effective In Reducing Mortality Related To Cardiovascular Events In People With Type 2 Diabetes Mellitus?, Payal Amin
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not Vitamin E is effective in reducing the mortality related to cardiovascular event in patients with Type 2 Diabetes mellitus.
Lead Identification Of Β-Lactam And Related Imine Inhibitors Of The Molecular Caperone Heat Shock Protein 90,
2011
Technological University Dublin
Lead Identification Of Β-Lactam And Related Imine Inhibitors Of The Molecular Caperone Heat Shock Protein 90, Niamh O'Boyle, Andrew Js Knox, Trevor P. Price, D. Clive Williams, Daniela M. Zisterer, David G. Lloyd, Mary J. Meegan
Articles
Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical trials and represent a new and exciting area in the treatment of cancer. Heat shock protein 90 inhibitors have huge structural diversity, and here we present the identification of inhibitors based on β-lactam and imine templates. β-Lactam 5 and imines 12 and 18 exhibit binding to heat shock protein 90-α with IC50 values of 5.6 μM, 14.5 μM and 22.1 μM respectively. The binding affinity displayed …
Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe,
2011
Technological University Dublin
Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Niall O. Keely, Andrew Js Knox, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan
Articles
The structure-activity relationships of antiproliferative β-lactams, focusing on modifications at the 4-position of the β-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger and Reformatsky reactions. The antiproliferative activity was assessed in MCF-7 cells, where the 4-(4-ethoxy)phenyl substituted compound 26 displayed the most potent activity with an IC50 value of 0.22 μM. The mechanism of action was demonstrated to be by inhibition of tubulin. Cell exposure to combretastatin A-4 and 26 led to arrest of MCF-7 cells in the G2/M phase of the cell cycle and induction of apoptosis. Additionally, mitotic catastrophe for …
The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes,
2010
Chapman University
The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz
Mathematics, Physics, and Computer Science Faculty Articles and Research
The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating that CBD acts as a noncompetitive antagonist of 5-HT3 …
