Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Mri-Guided Breast Biopsy, Makayla Franko

Medical Imaging Senior Posters

This project explains the role MRI has in performing breast biopsies. MR imaging is used along with mammogram and ultrasound to detect and monitor lesions. Traditional imaging of the breast is explained to understand how images of the breast are obtained. The grade of the lesion and how the lesion is found indicates the type of biopsy performed. MRI provides superior visibility for lesions within the breast. MRI-guided breast biopsies are indicated in patients with lesions only visible on MRI. The equipment required for an MRI-guided breast biopsy includes the breast coil, grid, and vacuum-assisted breast biopsy apparatus. Experienced breast …

Developing A New Analytical Model For Combatting Crises: A Comprehensive Review, Seth Spire

Research Awards

As the world emerges from the COVID-19 pandemic, it is critical to reflect on the lessons learned and prepare for potential future health crises. While data analytics and artificial intelligence (AI) played a pivotal role in managing the pandemic, there is much room for improvement and further use. This study examines the current state of data science tools employed during COVID-19, evaluating their advantages, limitations, and challenges in their broader implementation. We also review literature on future directions for AI in healthcare. Our findings highlight significant challenges, including difficulties in accessing usable data and common distrust of AI models for …

Viral Factors Influencing Early Infection Events During Ex-Vivo Kshv Infection, Ramina Nabiee

Pharmaceutical Sciences (PhD) Dissertations

The enigma of Kaposi Sarcoma Herpes Virus infection, and its persistence despite a quarter century of research on the virus, has given rise to an immediate need for addressing fundamental questions about basic immunology and virology knowledge regarding this virus. Kaposi Sarcoma Herpes Virus (KSHV), also known as Human Herpesvirus 8 (HHV8), is the etiological agent of Kaposi Sarcoma (KS) and other lymphoproliferative cancers, such as Multicentric Castleman’s Disease (MCD), Primary Effusion Lymphoma (PEL), and a newly discovered rare disease called KSHV Inflammatory Cytokines Syndrome (KICS). Epidemic KS, also known as AIDS-KS, is the most common cancer in untreated HIV …

Best Practices For Clinical Evaluation Of Sacroiliac Joint Pain: An Evidence-To-Practice Review, Nicolette A. Harris, Adriana Peña, Sofia Núñez Rivera

Clinical Practice in Athletic Training

Sacroiliac joint (SIJ) pain serves as an under-recognized source of chronic low back pain. Improvement in the accuracy of a clinical SIJ pain diagnosis lends a higher likelihood of appropriate treatment measures, better patient outcomes and decreased out-of-pocket costs. Therefore, the overall purpose of this evidence to practice review was to highlight the main points of a systematic review on the clinical diagnosis of SIJ pain. Searches of five electronic databases revealed 758 studies, nonetheless only six studies met final inclusion criteria. Studies included were assessed by the authors for methodological quality using the Quality Assessment of Diagnostic Accuracy Studies …

Opioid Medication Use And Education Following Sports Medicine Procedures: An Evidence-To-Practice Review, Caitlin S. O’Mara, Michael G. Ward, Zachary K. Winkelmann

Clinical Practice in Athletic Training

According to the Centers for Disease Control (CDC), illicit and prescription drug overdoses are responsible for 128 deaths every day in the United States. In 2018, 70% of all overdose related deaths involved opioids. Efforts to minimize the opioid epidemic focus on community education, research, partnership, and healthcare support. Under the CDC guidelines, current practices include monitoring trends of drug use and drug related deaths, conducting research to recognize areas in need of improvement and to analyze effectiveness of current treatments, partner with community organizations and healthcare systems that deal firsthand with opioid users, and educate the public on drug …

Disablement Model Case Study: Running With Postural Orthostatic Tachycardia Syndrome, Jordan Fenney, Wendy Reitz, Hayley M. Ericksen

Clinical Practice in Athletic Training

A 17-year-old high school female cross-country runner and basketball player presented with syncope following long-endurance exercise. The syncope episodes started when the patient was 13 years old during a basketball game. After the first episode, the patient fainted every time she crossed the finish line of a cross-country meet. Her symptoms included increased heart rate, shortness of breath, and paresthesia in her hands and legs during exercise. The patient also experienced some dizziness when quickly sitting or standing during activities of daily living. The patient was first misdiagnosed with exercise induced asthma and prescribed a rescue inhaler to take prior …

Effect Of Tissue Flossing On Grip Strength In Collegiate Baseball Players, M A. Eilers, B J. Warner, D M. Gallegos, I Hopper, S A. Cage

Clinical Practice in Athletic Training

Context: Tissue flossing bands are a relatively new therapeutic modality that has increased in popularity in recent years. While there is evidence to suggest that tissue flossing bands can decrease pain and increase perceived range of motion, there has been little research conducted to determine the effects of tissue flossing on muscular strength and performance. Thus, the aim of this study was to assess the effects of a single tissue flossing treatment on grip strength among healthy collegiate baseball players. Methods: Twenty apparently healthy collegiate baseball players (21.4 ± 1.54 years, 181.9 ± 3.56 cm, 84.5 ± 8.56 kg) were …

Nonsurgical Management Of Unilateral, Nondisplaced Lateral Malleolus Fracture In 17-Year-Old Outside Linebacker, K Tallman, R Bautista, B Spencer

Clinical Practice in Athletic Training

Background: Ankle fractures, specifically unilateral fractures, are among the most common injuries encountered by orthopedic surgeons. Ankle fractures have an incidence of 187 out of 100,000 individuals. Current treatment options for ankle fractures are dependent on stability of the ankle mortise, determined through number of fracture sites and ligamentous integrity. The management of the fracture scan either be surgical or nonsurgical, the majority being surgical. In this case report, a 17-year-oldmaleoutside linebacker sustained a left lateral ankle injury during a regular season football game. As he attempted to make a tackle, his left foot got caught in the turf, he …

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …

Electromyographic And Mechanomyogrpahic Signal Changes With Fatigue In Adults, Rehana Koilpillai

Honors Undergraduate Theses

Surface electromyography (sEMG) and mechanomyography (MMG) are well-studied signals that can reveal information about the physiological behavior of muscles during contraction. The purpose of this study was to quantify, characterize, and analyze the electrical and mechanical muscle responses to submaximal, isometric contractions in the rectus femoris in adults. Previous studies have investigated the use of EMG to monitor muscle fatigue. However, more information appears to be needed about the use of MMG to measure muscle fatigue during submaximal isometric contraction in the rectus femoris. In this study, the utility of MMG as a measure of muscle fatigue or muscle state …

Patient Tolerance To Virtual Reality-Based Vestibular Rehabilitation: A Scoping Review, Michael Knapp, Tejal Naik

Phase 1

Introduction: Virtual reality-based therapy (VRBT) using head-mounted devices (HMDs) is being explored as a novel treatment modality for rehabilitation of vestibular disorders. We hypothesize there may exist unique risks and side effects to VRBT using HMDs in the vestibular patient population which no previous studies have directly explored. This scoping review compiles all currently published data concerning vestibular patient tolerance to this treatment modality and provides preliminary interpretation of overall risks.

Methods: An exhaustive list of search terms covering virtual reality, HMDs, vestibular disorders, side effects, and adverse events were submitted to six different databases. Returned papers were uploaded to …

Provider Perceptions Of Virtual Reality As A Therapeutic Tool, Margaret Eberts, Christine Vincent, Tejal U. Naik, Md, Virginia O'Hayer

Phase 1

Introduction: Virtual reality (VR) shows significant potential as a healthcare tool, especially in the management of anxiety disorders and pain. However, despite recent studies demonstrating the effectiveness of VR, there continues to be limited use among providers. A lack of resources and understanding of the feasibility of clinical VR use may present a significant barrier for VR implementation. Through studying the perceptions of providers using VR clinically, this study aims to understand the achievability of VR as a standardized therapy.

Methods: Researchers distributed an online, self-administered questionnaire to healthcare providers identified on VR application websites. The questionnaire consisted of five …

Provider Perceptions Of Virtual Reality As A Therapeutic Tool, Christine Vincent, Margaret Eberts, Tejal U. Naik, C. Virginia O'Hayer

Phase 1

Introduction: Virtual reality (VR) can be an effective healthcare tool, particularly applied to anxiety and pain management. Despite significant interest in VR, lack of resources and knowledge regarding feasibility are barriers to implementation. This study aims to understand the current clinical usage of VR and the achievability of VR as a standardized therapy, by assessing VR healthcare providers.

Methods: An online, self-administered questionnaire with five sections—respondent demographics, VR value, onboarding, billing, and clinical use—was distributed. Providers, identified on VR application websites, were contacted via email. Inclusion criteria was providers in the United States using VR actively or in the past …

Relationship Between Preoperative Frailty And Postoperative Outcomes After Lvad Implantation, Katherine L. Wilhelm

DNP Projects

Abstract

Background: Frailty is common in many patients with advanced heart failure, including those who undergo left ventricular assist device (LVAD) implantation. Frailty has been associated with worse outcomes after other cardiac surgeries; however, little is known about the effect of frailty on postoperative outcomes after LVAD implant.

Purpose: The purpose of this project was to evaluate whether preoperative frailty [as determined by either short physical performance battery (SPPB) score ≤ 7/12 or 6-minute walk test (6-MWT) <200 >meters] is associated with poorer postoperative outcomes after LVAD implantation than non-frailty in adults with advanced heart failure.

Setting and Sample: This project …

Effect Of Imagery And Heart Rate Variability Biofeedback Training On Selected Soccer Skills Performance, Sara Majlesi

Student Works (2020-2029)

The present study aimed to evaluate the influence of PETTLEP video imagery (Physical, Environment, Task, Timing, Learning, Emotion and Perspective), heart rate variability biofeedback (HRVB), and concurrent intervention of both on selected soccer skill performances. The objective of this study was to evaluate the effect of PETTLEP video imagery, HRVB and concurrent intervention on soccer players' reactive motor skill test (RMST), sprint time, reactive agility, passing time, and passing accuracy. Participants of this study were Malaysian high school soccer players (N=64), with mean age of 15.31±1.83, who were assigned randomly into four groups: three experimental groups and one control group. …

Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding

Theses

Parkinson’s disease is a neurodegenerative disorder, characterised by the progressive degeneration of midbrain dopaminergic neurons, and the intracellular aggregation of the α-synuclein protein in neurons throughout the nervous system. These changes result in the characteristic motor impairments in Parkinson’s disease. Current treatments are solely symptomatic and therefore there is an unmet clinical need to develop new disease-modifying therapies that can alter disease progression. For over 25 years, one proposed experimental therapy has focused on the delivery of proteins called neurotrophic factors to the brain to prevent dopaminergic neuron degeneration. However, to date, clinical trials using the most well-known neurotrophic factors …

The Influence Of Sonographer Experience On Skeletal Muscle Image Acquisition And Analysis, Joshua C. Carr, Gena R. Gerstner, Caleb C. Voskuil, Joel E. Harden, Dustin Dunnick, Kristin M. Badillo, Jason I. Pagan, Kylie K. Harmon, Ryan M. Girts, Jonathan P. Beausejour, Matt S. Stock

Human Movement Studies & Special Education Faculty Publications

The amount of experience with ultrasonography may influence measurement outcomes while images are acquired or analyzed. The purpose of this study was to identify the interrater reliability of ultrasound image acquisition and image analysis between experienced and novice sonographers and image analysts, respectively. Following a brief hands-on training session (2 h), the experienced and novice sonographers and analysts independently performed image acquisition and analyses on the biceps brachii, vastus lateralis, and medial gastrocnemius in a sample of healthy participants (n = 17). Test–retest reliability statistics were computed for muscle thickness (transverse and sagittal planes), muscle cross-sectional area, echo intensity and …

Test-Retest Reliability And Minimal Detectable Change Of The Computerized Dynamic Posturography Proprio For Adults With Chronic Traumatic Brain Injury, Guilherme Manna Cesar, Thad W. Buster, Judith M. Burnfield

Department of Mechanical and Materials Engineering: Faculty Publications

Purpose: Balance deficits after brain injury, including reactive recovery from unexpected perturbations, can persist well after rehabilitation is concluded. While traditional clinical assessments are practical, the anticipatory nature of the tasks may mask perceptible balance control. Computerized dynamic posturography can directly quantify capacity to respond to unexpected, external perturbations. This study examined the reliability of the computerized dynamic posturography assessment with the device PROPRIO® 4000 in adults with traumatic brain injury and created the minimal detectable change for its standardized test.

Methods: Ten adults (ages 21–55 years) with chronic (average 10 ± 6 years post-injury) severe (loss of consciousness 2–75 …

Synthesis, Characterization And Photophysical Properties Of Ytterbium Complexes Of Functionalized Porphyrins And Porpholactone, Beibei Liu

Masters Theses

The unique structure and superior properties of lanthanide porphyrins enable them to be used in a broad variety of applications, especially in medical diagnosis fields. This research focuses on modifying the porphyrin ligands in various places, resulting in broader absorption in the red region and strong emission in the near-infrared region for these ytterbium(III) porphyrin complexes. The design, synthesis and characterization for DMPH₂-BDP, DMPH₂-COOH, TPLH₂ ligands and YbDMP-BDP, YbDMP-COOH complexes are described. The photophysical properties of these ligands and complexes including their absorbance, fluorescence and quantum yields are also presented. Both the synthesized ligands and …

Adaptive Physics-Based Non-Rigid Registration For Immersive Image-Guided Neuronavigation Systems, Fotis Drakopoulos, Christos Tsolakis, Angelos Angelopoulos, Yixun Liu, Chengjun Yao, Kyriaki Rafailia Kavazidi, Nikolaos Foroglou, Andrey Fedorov, Sarah Frisken, Ron Kikinis, Alexandra Golby, Nikos Chrisochoides

Computer Science Faculty Publications

Objective: In image-guided neurosurgery, co-registered preoperative anatomical, functional, and diffusion tensor imaging can be used to facilitate a safe resection of brain tumors in eloquent areas of the brain. However, the brain deforms during surgery, particularly in the presence of tumor resection. Non-Rigid Registration (NRR) of the preoperative image data can be used to create a registered image that captures the deformation in the intraoperative image while maintaining the quality of the preoperative image. Using clinical data, this paper reports the results of a comparison of the accuracy and performance among several non-rigid registration methods for handling brain deformation. A …