Pharmacology Commons^™

Increasing The Solubility Of Levodopa And Carbidopa Using Ionization Approach, Kitisak Krisai, Dusadee Charnvanich, Wanchai Chongcharoen

The Thai Journal of Pharmaceutical Sciences

The aim of this study is to increase the solubility of levodopa (LD) and carbidopa (CD) to improve loading quantity of both drugs for oral pullulan thin film preparation. Solubilization technique through ionization was employed to measure the solubility .

Comparative Evaluation Of The Effects Of N-Hexane, Chloroform, And Methanol Fractions Of Ricinus Communis In Carbon Tetrachloride-Induced Hepatotoxic Rats, Matthew Obaineh Ojezele

The Thai Journal of Pharmaceutical Sciences

Background: Ricinus communis is widely used among the Nigerian populace in ethnomedicine for the treatment of liver diseases. Aim of the Study: A comparative study was carried out to evaluate the hepatoprotective activity of its n-hexane, chloroform, and.

Pharmacokinetics Of 8 Mg Galantamine Hydrobromide Prolonged-Release Capsules Under Fed And Fasting Conditions, Chuleegone Sornsuvit, Narawadee Niamhun, Parichat Salee, Darunee Hongwiset, Songwut Yotsawimonwat, Chockchai Wongsinsup

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the study was to determine the pharmacokinetics of 8 mg galantamine prolonged-release capsules under fed and fasting conditions. Materials and Methods: A randomized, open-label, single-dose, two-treatment, two-period, two-sequ.

Development And Evaluation Of Gastroretentive Formulations For Moxifloxacin Hydrochloride, Raghavendra Kumar Gunda, A. Vijayalakshmi, K. Masilamani

The Thai Journal of Pharmaceutical Sciences

Purpose: The objective of the current study is to develop gastroretentive formulation for moxifloxacin HCl (hydrochloride) using various drug release modifiers and performing in vitro and in vivo evaluations. Moxifloxacin is a novel synthetic compound ha.

Anticonvulsant Activity Of Fumaria Schleicheri Dry Extract And Sodium Valproate: Role Of Neurotrophin And Cytokine Pathways, Vadim Tsyvunin, Sergiy Shtrygol, Tetiana Gorbatch, Diana Shtrygol

The Thai Journal of Pharmaceutical Sciences

Introduction: Cytokine and neurotrophin pathways can be potential targets for principally new anticonvulsant drugs which in perspective will be probably able to solve the problem of pharmacological resistance for people sick with epilepsy and to avoid po.

Synthesis, Evaluation, And In Silico Studies Of 2-Mercapto-5-Substituted Styryl-1,3,4-Oxadiazoles As Potential Cytotoxic Agents, Anitha Kumari Vinjavarapu, Shaheen Begum, Bharathi Koganti

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the present study is to design, synthesize and evaluate 2-mercapto-5-styryl-1,3,4-oxadiazoles with an aim of developing potential cytotoxic agents and to carryout in silico studies to understand the possible interactions with .

Optimizing The Method For Quantification Of Apigenin And Quercetin In The Thai Herbal Sattakavata Formula By Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometer, Khuannara Narajeenrone, Jantanee Wattanarangsan, Kajee Pilakasiri, Pravit Akarasereenont, Suksalin Booranasubkajorn

The Thai Journal of Pharmaceutical Sciences

Introduction: Sattakavata formula (SVF) is a Thai traditional medicine from Ayurved Siriraj for a relief of joint pain. It comprises six ingredients, namely, Andrographis paniculata (Burm. F.) Wall. ex Nees (AP), Cinnamomum sp. (CN), Morus alba Linn. (MA.

Beta-Blocker And Its Neuropsychiatric Effects, Ploylarp Lertvipapath, Wikrom Warunyuwong

The Thai Journal of Pharmaceutical Sciences

Norepinephrine from locus coeruleus plays roles in memory processes and behavioral controls. Locus coeruleus change is found in the primary neurodegenerative disease. The disruption of this central adrenergic pathway could contribute to neuropsychiatric .

Ocimum Gratissimum Linn. (Lamiaceae) Protects Wistar Rats Against Inflammation And Oxidative Stress In Trinitrobenzene Sulfonic Acid-Induced Colitis, O. O. Abiodun, N. Nwadike, F. N. Ogunleye, A. S. Sosanya

The Thai Journal of Pharmaceutical Sciences

Background and Aim: The activity of methanol extract of leaf of Ocimum gratissimum a plant with anti-inflammatory, antioxidant, and anti-ulcerogenic activities in a rat model of colitis was evaluated. Experimental Procedures: Colitis was induced in 30 of.

Monodora Myristica Seed Extracts Ameliorate Crude Oil Contaminated Diet-Induced Cardiotoxicity In Rats, G. T. Esiekpe, B. O. George, O. C. Orororo, A. A. Akpede, G. E. Okevwe, E. Onotugoma, J. Oguntola

The Thai Journal of Pharmaceutical Sciences

Aim: This study investigated the ameliorative effects of Monodora myristica seed extracts in serum and heart of rats fed crude petroleum oil-polluted diet (CPOPD). ). Materials and Methods: Thirty adult Wistar rats (180 ± 5 g) were used for the study. T..

Development Of Immunofet Biosensor For Detection Of 3-Nitrotyrosine, Khine Kyi Han, Supachoke Mangmool, Korbtham Sathirakul, Kosum Chansiri, Wutthinan Jeamsaksiri, Prapimpun Wongchitrat, Montri Yasawong

The Thai Journal of Pharmaceutical Sciences

3-Nitrotyrosine (3-NT) is one of the important biomarkers for the detection of excess of oxidative and nitrosative stress in the body, and derived from peroxynitrite-induced nitration of free and protein-bound at tyrosine residues. It was increased with .

A Comparison Of Model Fitting Using Different Runs In Box–Behnken Design For Alginate Film Formulation, Nichayarach Invichian N/A, Warangkana Warisnoicharoen

The Thai Journal of Pharmaceutical Sciences

Introduction: Box–Behnken design (BBD) is a response surface method used for experimental design in several applications such as pharmaceutical and food. BBD experiment can be run using different central points (CPs) for analyzing optimal model fitting...

Protective Effect Of Croton Zambesicus Leaf Extract Against Carbon Tetrachlorideinduced Cardiac Toxicity In Rats, Rashidat Oluwafunke Ayanniyi, Hidayah Ayodeji Olumoh-Abdul, Fatimoh Idowu Ojuade, Nnaemeka Asogwa

The Thai Journal of Pharmaceutical Sciences

Background: The leaves of Croton zambesicus (CZ) Muell Arg. (Euphorbiaceae) are used as a spice for food and in traditional medicine for the management of several disease conditions, including hypertension and diabetes. The study was carried out to deter.

Cytotoxicity And Antiplasmodial Activity Of Alkaloid Extracts Prepared From Eight African Medicinal Plants Used In Nigeria, U. E. Uzuegbu, O. A. Opajobi, J. E. Utalor, C. O. Elu, I. Onyesom

The Thai Journal of Pharmaceutical Sciences

Objectives: Malaria morbidity and mortality rates are worsening, despite the dedicated commitment to eradicate the infestation, principally because of failing chemotherapy, the mainstay of treatment, and lack of registered vaccine. Therefore, the search .

Cell Lysis Methods And Coenzyme Q10 Production Of Methylobacterium Strains, Nattida Mingrapoch, Somboon Tanasupawat, Dusadee Charnvanich

The Thai Journal of Pharmaceutical Sciences

Objective: This research aimed to investigate the effect of cell lysis methods on a quantity of coenzyme Q10 (CoQ10) produced by Methylobacterium strains. Methods: Methylobacterium organophilum NBRC 15689T and Methylobacterium strain LRY1-08 were used to.

Proton Pump Inhibitors Use In Short Bowel Patients At A Thai Tertiary Hospital: A 10-Year Retrospective Observational Study, Sasisom Phadungkingtrakul, Namthip Iamkaeo, Piyathida Isutsiri, Prattana Sirisupamongkhon, Suyanee Pongthananikorn, Tippawan Siritientong

The Thai Journal of Pharmaceutical Sciences

Background: Proton pump inhibitors (PPIs) reduce the gastric acid secretion in short bowel patients. However, the absorptive areas of these patients are limited. In case of residual jejunum length <50 cm, the intravenous administration of PPIs should be .

Sex Differences In The Mechanisms That Modulate The Neurochemical Effects Of Nicotine, Kevin Uribe

Open Access Theses & Dissertations

Prior behavioral studies in our laboratory revealed that overexpression of the stress peptide, corticotrophin-releasing factor (CRF), in the mesocorticolimbic reward pathway enhanced the reinforcing effects of nicotine. The latter effect was greater in female versus male rats, suggesting that females are uniquely susceptible to the effects of stress on nicotine reinforcement. The goal of this dissertation was to examine the neurochemical mechanisms by which overexpression of CRF in the nucleus accumbens (NAc), a terminal region of the mesocorticolimbic pathway, modulates the behavioral effects of nicotine. Specifically, we examined whether nicotine-induced dopamine levels are altered by CRF overexpression via excitatory (glutamate) …

The Effect Of Waterpipe/Hookah On Platelet Function And The Impact Of Inhibition Of Gβγ Subunits On Hemostasis And Thrombogenesis, Ahmed Alarabi

Open Access Theses & Dissertations

Abstract (Hookah)

Cardiovascular diseases (CVD’s) is a major public health problem. Among CVD’s risk factors, tobacco smoking is considered the single most preventable cause of death, with thrombosis being the main mechanism of CVD’s mortality in smokers. While tobacco smoking has been on the decline, the use of waterpipe/hookah has been rising, mainly due to the perception that they are “less harmful” than regular cigarettes. Strikingly, there are few studies on the negative effects of waterpipes on the cardiovascular system, and none regarding their direct contribution to thrombus formation. We employed a waterpipe whole-body exposure protocol that mimics real‐life human …

Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz

Master's Theses

The restoration of blood flow to ischemic cerebral tissue can result in reperfusion injury, and blocking reperfusion injury can significantly aid in recovery of ischemic tissue. Bradykinin has been shown to exhibit protective effects, but does not reach protective levels during reperfusion due to inactivation by aminopeptidase P2 (APP2). Therefore, inhibiting APP2 during reperfusion is a potential therapeutic strategy to aid in the reduction of reperfusion injury, leading to the development of ST-115, an APP2 inhibitor. It was hypothesized that administration of ST-115 during ischemic stroke, and just prior to reperfusion, will result in reduced neurological injury and increased functional …

Epigenetic Regulation Of Drug Metabolizing Enzymes In Normal Aging, Mohamad M. Kronfol

Theses and Dissertations

Geriatric populations are at a higher risk for adverse drug reactions (ADRs). This may be partly due to changes in drug metabolism in old age, but the underlying mechanisms are poorly understood. Prior research in humans and mice has shown age-associated changes to the expression of several genes involved in drug metabolism. Furthermore, studies of human blood showed that epigenetic regulation of genes encoding drug metabolizing enzymes change with age. However, it is unknown if genes in the liver are similarly affected. Therefore, we hypothesize that genes encoding drug metabolizing enzymes may show differential epigenetic regulation in the liver with …