Development Of A Thai Pharmacists’ Cultural Competency Self-Assessment Scale,
2023
Chulalongkorn University
Development Of A Thai Pharmacists’ Cultural Competency Self-Assessment Scale, Auttakrit Aunkaew, Puckwipa Suwannaprom, Siritree Suttajit
The Thai Journal of Pharmaceutical Sciences
Objective: The objective of the study was to develop and evaluate a cultural competency assessment form for Thai pharmacists. Materials and Methods: The research was conducted in two phases. Phase 1 involved item development based on the Campinha-Bacote’s and the ACPP’s concept of cultural competency and the self-assessment of perceived level of cultural competence questionnaire. Seven experts assessed the content validity and face validity. The revised scale was tested for comprehension among 12 pharmacists using the think-aloud technique. Phase 2 constituted the scale development and scale evaluation. The Thai pharmacist cultural competency self-assessment (TPCCS) scale developed from Phase I was …
Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation,
2023
Chulalongkorn University
Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation, Ishwar Bhat K, Afiya Abdul Aziz, Abhishek Kumar, Vijaya Bhaskar K, Vijay Kumar M
The Thai Journal of Pharmaceutical Sciences
Cancer remains a major class of morbidity and mortality despite basic and clinical research and trials of promising new therapies. In the current era, many drugs are marketed with flavonoid nucleus. Based on this information, this study aims to synthesize and screen flavones for their anticancer activity. Docking studies for cytotoxic activity of flavonoid derivatives targeting tankyrase enzyme were performed. A new series of flavonoid derivatives were prepared from chalcones. Chalcones were prepared between substituted benzaldehyde and 2-hydroxy acetophenone in the presence of potassium hydroxide as catalyst. The flavone derivatives were characterized based on IR, 1H NMR, and Mass spectral …
Preclinical Study On Hepatoprotective Potential And Antioxidant Status Analysis Of The Fruit Extract Of Rivina Humilis L. (Red Pigeon Berry) In Rats,
2023
Chulalongkorn University
Preclinical Study On Hepatoprotective Potential And Antioxidant Status Analysis Of The Fruit Extract Of Rivina Humilis L. (Red Pigeon Berry) In Rats, Raju Asirvatham, Dinu George, P. A. Daisy, Dawn V. Tomy, G. Boby Johns
The Thai Journal of Pharmaceutical Sciences
Hepatoprotective and antioxidant potential of hydromethanolic extract of Rivina humilis L. fruit (HMERH) was studied using the carbon tetrachloride (CCl4) and paracetamol (PCM) induced hepatotoxicity in Wistar rats. In both models, rats were divided into five groups having six rats in each. Group I received distilled water. Group II, disease control, Group III received 100 mg/kg of Silymarin. Group IV and Group V received 500, 1000 mg/kg of HMERH. All groups except Group II received treatment twice daily for 7 days. CCl4 (1.5 mL/kg, PCM (2 g/kg), p.o) were administered after the last dose. The degree of liver protection against …
Nutritional & Colorectal Health,
2023
University of Kentucky
Nutritional & Colorectal Health, Tariq A. Alam, Brittany R. Rice, Sara B. Police
Journal of Pharmacology & Nutritional Sciences
Kentucky has the highest incidence and mortality rate of all site cancers, and Kentuckians residing in the Appalachian region often have worse outcomes, where cancer is a leading cause of death. Focusing on colorectal cancer (CRC) specifically, Kentucky ranks first nationwide for incidence (50 cases per 100,000 people) and fifth for mortality (about 17 deaths per 100,000 people). The Kentucky Colon Cancer Screening Program increased screening rates and reduced mortality since its launch. Yet, CRC remains a leading cause of death for Kentuckians. Risk factors for CRC include increasing age as well as a history of inflammatory bowel disease (IBD) …
Vegetable Oil-Based Cannabis: Its Cannabinoid Profiling And Photoprotective Effect On Uva-Irradiated Human Skin Keratinocytes,
2023
Chulalongkorn University
Vegetable Oil-Based Cannabis: Its Cannabinoid Profiling And Photoprotective Effect On Uva-Irradiated Human Skin Keratinocytes, Nur Alfan Muhammad Zen, Kwanlada Kobtrakul, Petlada Khositanon, Kittipong Sanookpan, Visarut Buranasudja, Sornkanok Vimolmangkang
The Thai Journal of Pharmaceutical Sciences
Vegetable oils serve as affordable, non-toxic, and eco-friendly solvents for plant extraction. Chemical fingerprinting shows that vegetable oil-based cannabis has a cannabinoid profile similar to that of organic solvent-based cannabis. All samples possess antioxidative effects as they contain several cannabinoids and other unidentified compounds, with rice bran oil-based sample exhibiting the strongest effect. Tetrahydrocannabinol (THC) and cannabidiol (CBD) content in sesame oil-based and perilla seed oil-based cannabis differed significantly from that in virgin coconut oil (VCO)-based cannabis. In addition, THC and CBD content in all vegetable oil-based samples prepared using the heating and frying method differed significantly from that in …
Developmental Pharmacokinetics Of Indomethacin In Preterm Neonates: Severely Decreased Drug Clearance In The First Week Of Life.,
2023
Children's Mercy Kansas City
Developmental Pharmacokinetics Of Indomethacin In Preterm Neonates: Severely Decreased Drug Clearance In The First Week Of Life., Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney M. Nolte, Kim T. Gibson, J Steven Leeder, Tamorah Lewis
Manuscripts, Articles, Book Chapters and Other Papers
Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care unit setting have become younger, smaller, and less mature (more preterm) at the time of treatment. To develop a pharmacokinetics (PK) model to aid future dosing, we designed a prospective cohort study to characterize indomethacin PK in a dynamically changing patient population. A population PK base model was created using NONMEM, and a covariate model was developed in a primary development cohort and subsequently …
The Impact Of Pharmacogenetics On Oral Fluid Steady State Drug Testing Results,
2022
CUNY John Jay College
The Impact Of Pharmacogenetics On Oral Fluid Steady State Drug Testing Results, Aliya D. Lewis
Student Theses
Pharmacogenetics refers to the relationship between phenotypic variation in metabolism and response to certain drugs. The interface of pharmacogenetics and forensic toxicology is not well explored. A major component of the opioid metabolic pathway has to do with a family of cytochromes called cytochrome P450 (CYP450). CYP450 refers to a general family of enzymes capable of catalyzing the oxidative biotransformation of lipophilic substances, CYPs are further categorized into families and sub-families (Roller, 2015; Zanger & Schwab, 2013). The gene CYP2D6 belongs to the CYP2 family which is responsible for the biotransformation of xenobiotics. This study looked at the effect of …
Morphine-Induced Tolerance Is Reduced By The Consumption Of A Ketogenic Diet, But Not A High Fat/High Carbohydrate Diet,
2022
University of Texas at El Paso
Morphine-Induced Tolerance Is Reduced By The Consumption Of A Ketogenic Diet, But Not A High Fat/High Carbohydrate Diet, Nina Beltran
Open Access Theses & Dissertations
Opioid drugs like morphine are used medicinally for pain relief, but also have abuse liability that can lead to opioid use disorder (OUD), which contributes to nearly 70% of drug overdose deaths in the United States. Another rising health concern is the global obesity epidemic, and new evidence suggests that obesity and OUD might converge to impact individuals. For example, high body mass index (BMI) is associated with greater reports of pain among women. Further, opioid overdose risk is increased among individuals diagnosed with obesity, suggesting a potential relationship that might convey enhanced vulnerability among some populations. Given the high …
A Case Of Transverse Myelitis Secondary To Covid-19 Infection,
2022
Nova Southeastern University
A Case Of Transverse Myelitis Secondary To Covid-19 Infection, Rahul Borra, Neal T. Patel, Raheel Shaikh, Mayur S. Parmar, Sujatha Borra
HPD Articles
Infection with COVID-19 (SARS-CoV-2) is associated with a variety of generalized and specific symptoms, including neurological complications of both the peripheral and central nervous systems. In this case report, we present the case of a previously healthy 55-year-old woman who was diagnosed with transverse myelitis following a previous infection with COVID-19. MRI showed progressive demyelination of the cervical and thoracic spinal cord, and cerebrospinal fluid (CSF) showed increased levels of protein and red blood cells and no markers of infection, including negative polymerase chain reaction (PCR) for COVID-19 antibodies. The patient was treated with a course of methylprednisolone, multiple treatments …
Investigation Of Human N-Acetyltransferases (Nat1 And Nat2) Genetic Polymorphisms In Susceptibility To Aromatic Amine And Alkylaniline Genotoxicity.,
2022
University of Louisville
Investigation Of Human N-Acetyltransferases (Nat1 And Nat2) Genetic Polymorphisms In Susceptibility To Aromatic Amine And Alkylaniline Genotoxicity., Mariam Habil
Electronic Theses and Dissertations
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT1 and NAT2 genotypes. We hypothesize that different NATs alleles will impact levels of N-acetylation, HPRT mutations, DNA damage and oxidative stress induced by carcinogens. NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and NAT1*4, NAT1*14B, NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of benzidine, β-naphthylamine (BNA), and 4, 4’-methylene bis (2-chloroaniline) (MOCA) as aromatic amines and 3,4-dimethylaniline (3,4-DMA) as one of alkylanilines and their associated toxicity. Our …
Acknowledgment Of Reviewers,
2022
Taiwan Food and Drug Administration
Inorganic Arsenic Speciation Analysis In Food Using Hplc/Icp-Ms: Method Development And Validation,
2022
Division of Research and Analysis, Taiwan Food and Drug Administration, Ministry of Health and Welfare
Inorganic Arsenic Speciation Analysis In Food Using Hplc/Icp-Ms: Method Development And Validation, Yu-Cheng Lai, Yi-Chen Tsai, Yu-Ning Shin, Ya-Chun Chou, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang
Journal of Food and Drug Analysis
Arsenic (As) compounds can be classified as organic or inorganic, with inorganic arsenic (iAs) having significantly higher toxicity than organic As. As may accumulate in food materials that have been exposed to As-contaminated environments. Thus, the “Sanitation Standard for Contaminants and Toxins in Foods” published by the Ministry of Health and Welfare set the standard limits for iAs content in rice, seaweed, seafood, and marine oils to safeguard public health. Therefore, a robust analytical method must be developed to selectively and quantitatively determine iAs content in rice, seaweed, seafood, and marine oils. Herein, we reported and verified the method of …
Optimization Of Quechers And High Performance Liquid Chromatography-Fluorescence Detection Conditions To Assess The Impact Of Preparation Procedures On Eu Priority Pahs In Coffee Samples And Their Pahs Consumption Risk,
2022
Department of Food Science, National Taiwan Ocean University, Taiwan
Optimization Of Quechers And High Performance Liquid Chromatography-Fluorescence Detection Conditions To Assess The Impact Of Preparation Procedures On Eu Priority Pahs In Coffee Samples And Their Pahs Consumption Risk, Ying-Chun Wan, Zwe-Lin Kong, Yu-Hsuan Chao, Chia-Fang Teng, Deng-Jye Yang
Journal of Food and Drug Analysis
The good performance conditions for determination of EU priority PAHs in coffee samples were established to evaluate the effects of roasting degree on the PAHs in coffee beans and the brewing methods on the PAHs transfer from coffee beans to their brews. The consumption risk of the PAHs in coffee products was also assessed. The PAHs levels of the roasted coffee beans were in the order: 923.65 ng/g (dark roast) > 132.20 ng/g (medium roast) > 69.28 ng/g (light roast). Compared with general brewing with the drip bag (PAHs content, 0.30–0.62 ng/mL in coffee brews), the coffee machine brewing (set at 4 …
Effect Of Sterilization Conditions On The Formation Of Furan And Its Derivatives In Canned Foods With Different Substrates,
2022
Department of Food Science, Fu Jen University
Effect Of Sterilization Conditions On The Formation Of Furan And Its Derivatives In Canned Foods With Different Substrates, Wen-Xuan Tsao, Bing-Huei Chen, Tsai-Hua Kao
Journal of Food and Drug Analysis
This study explored the effects of sterilization conditions on the formation of furan and its 10 derivatives in canned foods with a sterilizing value (F0) at 4. The contents of furans were determined by SPME arrow-GC-MS/MS, along with the furan precursors analyzed for elucidating the possible mechanism of furan formation. Results revealed that the total furan contents rose substantially in canned meat paste, tomato mackerel, chicken puree, tomato paste, pineapple slice, pineapple juice and carrot juice following sterilization. However, the total furan content did not change significantly ( p > 0.05) in canned oily mackerel, but decreased significantly ( p < 0.05) in canned apple puree after sterilization. With the exception of apple puree and pineapple slice, all the other canned foods showed a higher total furan content under low-temperature-long-time condition than that under high-temperature-short-time condition. Following heating, only the furan level showed a large increase in chicken puree, meat paste and tomato mackerel, whereas in canned fruit- and vegetable-based foods, the contents of furan and furfural showed a pronounced increase. The levels of alkylated furans were higher in sterilized samples containing high level of amino acid, while that of oxygenated furans were higher in sterilized samples containing high level of reducing sugar.
Simple And Rapid Detection Of Ractopamine In Pork With Comparison Of Lspr And Lfia Sensors,
2022
Department of Biological science and Bioengineering, Inha University, Incheon 22212, Republic of Korea
Simple And Rapid Detection Of Ractopamine In Pork With Comparison Of Lspr And Lfia Sensors, Min Ji Lee, Sheik Aliya, Eun-Seon Lee, Tae-Joon Jeon, Mi-Hwa Oh, Yun Suk Huh
Journal of Food and Drug Analysis
This study developed a simple and rapid strategic technique to detect ractopamine (chemical growth-promoting agent) in pork. Two highly sensitive and specific gold nanoparticle-based portable sensors, i.e., localized surface plasmon resonance (LSPR) sensors, and lateral flow immunoassay (LFIA) strips were developed to detect veterinary drug residues in food products, that have detrimental effects on humans. Optimization studies were conducted on several sensor devices to improve sensitivity. Each sensor comprised functionalized gold nanoparticles conjugated with ractopamine antibodies. The LSPR sensor chip achieved excellent detection sensitivity = 1.19 fg/mL and was advantageous for quantitative analysis due to its wide dynamic range. On …
Recent Trends In Analysis Of Mycotoxins In Food Using Carbon-Based Nanomaterials,
2022
Department of Food Science, Fu Jen Catholic University
Recent Trends In Analysis Of Mycotoxins In Food Using Carbon-Based Nanomaterials, Bing-Huei Chen, Baskaran Stephen Inbaraj
Journal of Food and Drug Analysis
Mycotoxins (MYTs), a class of low molecular weight secondary metabolites produced by filamentous fungi in food and feed, pose serious global threat to both human health and world economy. Due to their mutagenic, teratogenic, carcinogenic and immunosuppressive effects, the International Agency for Research on Cancer has classified various MYTs under Group 1 to 3 category with aflatoxins being designated under Group 1 category (carcinogenic to humans). Also, the presence of MYTs in trace amounts in diverse food matrices necessitates exploration of highly sensitive methods for onsite analysis. Although conventional chromatographic methods are highly sensitive, they are expensive, tedious and cannot …
Recent Advances In Immunoassay-Based Mycotoxin Analysis And Toxicogenomic Technologies,
2022
Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Recent Advances In Immunoassay-Based Mycotoxin Analysis And Toxicogenomic Technologies, Winnie-Pui-Pui Liew, Mohd-Redzwan Sabran
Journal of Food and Drug Analysis
The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay technologies. Advance immunoassay technologies integrated in mycotoxin analysis enable simultaneous detection of multiple mycotoxins and enhance the outcomes’ quality. It highlights toxicogenomic as novel approach for hazard assessment by utilizing computational methods to map molecular events and biological processes. …
Analysis Of Highly Polar Pesticides In Foods By Lc-Ms/Ms,
2022
Department of Chemistry, National Taiwan Normal University
Analysis Of Highly Polar Pesticides In Foods By Lc-Ms/Ms, Wan-Rou Liao, Kuan-Lu Wu, Kun-Hao Chiang, Chieh-En Teng, Sung-Fang Chen
Journal of Food and Drug Analysis
Highly polar pesticides (HPP) are a group of pesticides that are characterize as low Log Kow. Many high-throughput multi-residue analysis methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of such polar pesticides have been proposed. In this article, we summarize the various sample preparation methods including quick polar pesticides (QuPPe), dispersive solid phase extraction (dSPE), solid phase extraction (SPE) and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe), especially for QuPPe, which are mainly used for the determination of HPP in foods. In addition, we summarize LC-based separation methodologies that are currently used for the analysis …
Recent Advances In The Analysis Of Polycyclic Aromatic Hydrocarbons In Food And Water,
2022
Department of Food Science, Fu Jen Catholic University
Recent Advances In The Analysis Of Polycyclic Aromatic Hydrocarbons In Food And Water, Bing-Huei Chen, Baskaran Stephen Inbaraj, Kuo-Chiang Hsu
Journal of Food and Drug Analysis
Polycyclic aromatic hydrocarbons (PAHs), a class of harmful and persistent organic contaminant, are widely distributed in the environment and eventually accumulated in water and food. Also, they are formed in different varieties and varying amounts during processing of food depending on the food composition, cooking method and processing condition. According to the International Agency for Research on Cancer (IARC), various PAHs are classified under Group 1 to 3 category, with Group 1 designated as carcinogenic to humans, Group 2A as probable carcinogen, Group 2B as possible carcinogen and Group 3 as noncarcinogenic. Therefore, it is imperative to develop rapid and …
Preface,
2022
Department of Food Science, Fu Jen Catholic University, New Taipei City, Taiwan
