Drug Therapy Problems In Asthma
Identified During Pharmacist-Led
Educational Interventions,
2021
Chulalongkorn University
Drug Therapy Problems In Asthma Identified During Pharmacist-Led Educational Interventions, Kosisochi Chinwendu Amorha, Mathew Jegbefume Okonta, Chinwe Victoria Ukwe
The Thai Journal of Pharmaceutical Sciences
Background: Drug therapy problems (DTPs) interfere with desired goals of therapy. This study evaluated DTPs in asthma identified during a pharmacist-led intervention in the asthma clinics of two Nigerian hospitals. Methods: This intervention study was conducted in the asthma clinics, University of Nigeria Teaching Hospital and Lagos University Teaching Hospital. Eligible participants were patients with asthma recruited into a pharmacist-led intervention study and followed up for 6 months. The Pharmaceutical Care Network Europe – Drug-related Problem Classification V6.2 in English (PCNE-DRP V6.2) was utilized to evaluate the DTPs. Results: Seventy-eight patients with asthma participated. A total of 158 DTPs were …
Analgesic, Anti-Inflammatory, And Antihyperuricemic Activities Of A Thai
Herbal Remedy,
2021
Chulalongkorn University
Analgesic, Anti-Inflammatory, And Antihyperuricemic Activities Of A Thai Herbal Remedy, Tipsuchon Aiamsa-Ard, Thidarat Phetmanee
The Thai Journal of Pharmaceutical Sciences
Introduction: Moa Chub’s gout formulation (MCHGF), a traditional Thai herbal remedy, is used for the treatment of pain and swelling related to gout. Objective: This study aimed to determine MCHGF’s analgesic, anti-inflammatory, and antihyperuricemic effects. Materials and Methods: The analgesic activity of MCHGF was studied in mice using an acetic acid-induced writhing test and the hot-plate method. The anti-inflammatory activity of MCHGF was evaluated in rats using carrageenan-induced paw edema. The antihyperuricemic activity of MCHGF was tested in vivo using the model of potassium oxonate-induced hyperuricemia mice. MCHGF doses of 50, 100, and 200 mg/kg/day were used in this study. …
Fruits Of Averrhoa Carambola
Inn Protects Wistar Rats Against Indomethacin And Pylorus Ligation-
Induced Ulcers,
2021
Chulalongkorn University
Fruits Of Averrhoa Carambola Inn Protects Wistar Rats Against Indomethacin And Pylorus Ligation- Induced Ulcers, Nireeksha G. Kulal, C. S. Shastry, Sharad Chand, Sawan Mukund Ghetia
The Thai Journal of Pharmaceutical Sciences
Background: Peptic ulcer disease is one among the major cause of hospitalization in the gastroenterology department. Objective: The study was conducted to evaluate the gastroprotective and anti-ulcerogenic activity of Averrhoa carambola L. aqueous extract and its ghritha formulation on rat models. Materials and Methods: The antiulcer activity of A. carambola L. fruit extract was assessed by inducing ulcer using indomethacin and using pylorus ligation-induced ulcer models. The drug activity was compared to standard drugs omeprazole 30 mg/kg and sucralfate at a dose of 100 mg/kg. The parameters such as gastric pH, gastric acid volume, total acidity, free acidity, and ulcer …
In Vivo And In Silico Anti-Arthritic
Studies Of Chlorogenic Acid From The
Rhizome Of Lasia Spinosa (L.) Thwaites
(Araceae),
2021
Chulalongkorn University
In Vivo And In Silico Anti-Arthritic Studies Of Chlorogenic Acid From The Rhizome Of Lasia Spinosa (L.) Thwaites (Araceae), M. Arya Lakshmi, D. S.N.B.K Prasanth, K. Gana Manjusha, B. Ganga Rao
The Thai Journal of Pharmaceutical Sciences
Aim: The aim of the study was to examine the anti-arthritic function of methanol extract of Lasia spinosa (MELS) and chlorogenic acid (CA) in the rats of Freund’s complete adjuvant (FCA) mediated arthritis by in vivo and In silico studies. Materials and Methods: The MELS was subjected to acute oral toxicity in rats and tested against FCA induced arthritis in rats. Large-scale isolation and chromatographical analysis with spectral review verified that CA is responsible for the pharmacological effects reported. The efficacy of MELS and CA against CFA-induced arthritis was subsequently tested for hematological, biochemical, and in vivo anti-oxidant parameters in …
Investigation Of Drug Reaction With
Eosinophilia And Systemic Syndrome
And Its Management In A Tertiary Care
Hospital Of South India,
2021
Chulalongkorn University
Investigation Of Drug Reaction With Eosinophilia And Systemic Syndrome And Its Management In A Tertiary Care Hospital Of South India, S. Shridhar, B. Suresh, S. Ojha, S. Seshadri, Mallayasamy Surulivelrajan, S. Elstin Anbu Raj, V. Rajesh
The Thai Journal of Pharmaceutical Sciences
Introduction: Drug reaction with eosinophilia and systemic syndrome (DRESS) is also known as drug hypersensitivity syndrome or drug-induced hypersensitivity syndrome, is a rare, potentially life-threatening drug reaction that affects multiple organ systems simultaneously. Objective: The objective of the study was to investigate the DRESS syndrome and its management in a tertiary care hospital in the department of medicine. Materials and Methods: A retrospective evaluation of 227 medical records was conducted among the patients admitted in medicine units. Causality assessment was carried out using Naranjo’s scale and two specific scoring systems. RegiSCAR 1 was utilized to confirm the diagnosis of DRESS …
Polymer As Precipitation Inhibitor Of Weak Base Drug: An Update And Brief Review,
2021
Chulalongkorn University
Polymer As Precipitation Inhibitor Of Weak Base Drug: An Update And Brief Review, Viviane Annisa, Syaiful Choiri, Teuku Nanda Saifullah Sulaiman, Agung Endro Nugroho
The Thai Journal of Pharmaceutical Sciences
Precipitation due to supersaturation phenomenon and intraluminal solubilization behavior is mainly faced on reducing bioavailability, particularly for weak base drugs. Incomplete and extend of absorption can be avoided by modification of drug-excipient interaction namely polymers. This interaction is proposed to stabilize the amorphous form of drug through reducing nucleation followed by crystal growth. Therefore, polymers can be utilized to inhibit the precipitation phenomenon through their interaction with poorly water-soluble and weak base drugs. However, until to date, there was no recent updates on the use of polymer for precipitation inhibitor of weak base drug. This review discussed the brief and …
Non-Destructive Analysis Of Glycyrrhizin
In Ummaruekvati Dispensatory Thai Traditional Medicine,
2021
Chulalongkorn University
Non-Destructive Analysis Of Glycyrrhizin In Ummaruekvati Dispensatory Thai Traditional Medicine, Thanattaporn Charoenkittrakul, Chanamate Noi-Ang, Prathan Luecha, Jomjai Peerapattana
The Thai Journal of Pharmaceutical Sciences
Ummaruekvati is an antitussive traditional medicine. It contains licorice as the main ingredient and the major chemical component is glycyrrhizin. The conventional method for quantitative analysis of glycyrrhizin content in licorice is by high-performance liquid chromatography, which is destructive of the sample, time consuming, high cost, and has many steps in the sample preparation process. In this study, a rapid and non-destructive near-infrared spectroscopy (NIR) method was applied for quantitative analysis of glycyrrhizin content in Ummaruekvati dispensatories. A partial least squares chemometric method with various data pre-treatments was performed to establish the calibration model. The best calibration model was obtained …
Monitoring Of Crystalline Transition During Wet Granulation Process Using
Probe Type Low Frequency Raman Spectrometer,
2021
Chulalongkorn University
Monitoring Of Crystalline Transition During Wet Granulation Process Using Probe Type Low Frequency Raman Spectrometer, Kanako Fukui, Yota Suzuki, Kazuki Haneishi, Varin Titapiwatanakun, Hiroshi Hisada, Tatsuo Koide, Toshiro Fukami
The Thai Journal of Pharmaceutical Sciences
In recent years, real time analysis has been widely studied using various Process Analytical Technology tools particularly in the quality control of drug products. In this study, we investigated the improvement of sensitivity and the reduction of measurement time using a low frequency (LF) Raman spectrometer equipped with a new light source for in situ monitoring of crystalline transformation of active pharmaceutical ingredients (API) during wet granulation process. Three model drugs were chosen to assess the system sensitivity, hydrate transition, and cocrystal dissociation. LF Raman spectra showed the specific peaks for crystalline indomethacin and theophylline which were typical and well …
In-Line Prediction Of Secondary Drying
Time From Measured Ice Nucleation Temperature During Lyophilization Process,
2021
Chulalongkorn University
In-Line Prediction Of Secondary Drying Time From Measured Ice Nucleation Temperature During Lyophilization Process, Tharavich Supakatisant, Narueporn Sutanthavibul, Oran Kittithreerapronchai
The Thai Journal of Pharmaceutical Sciences
Purpose: To propose an approach to find optimal secondary drying time (tSD) specifically for each lyophilized batch by predicting residual moisture at the beginning of secondary drying (Cs0) using measured ice nucleation temperatures (TN) obtained in-line. Materials and Methods: Value of Cs0 was determined by minimizing the residual error between measured (Tp SD,mea) and calculated (Tp SD,cal) product temperatures during secondary drying. Value of TN was determined by using product temperatures during freezing (TP Fr). Then, the correlation between Cs0 and TN was conducted and resulted in the Cs0 prediction equation. This equation was used with developed mathematical simulation to …
Inhibition Of Viper Venom-Induced
Toxicity By Moringa Oleifera Leaves
Extracts,
2021
Chulalongkorn University
Inhibition Of Viper Venom-Induced Toxicity By Moringa Oleifera Leaves Extracts, Asha B. Thomas, Snehal Karanjkhele, Nitin Salvi, Lata Kothapalli, Aaftab Shaikh, Seema Kamble
The Thai Journal of Pharmaceutical Sciences
Snakebite, a medical emergency, is a socially significant but neglected issue in India. Antivenom serum therapy that is currently used against venomous snakebites is expensive and showed severe side effects. Traditional claims reported the use of Moringa oleifera to treat snakebite in rural India. To scientifically validate these claims, in the present investigation, the antivenom potential of the extracts of M. oleifera was investigated. The extracts effectively neutralized Russell’s viper venom-induced lethality (LD50: 10.9 μg) at 10 μg/mice and 300 μg/mice (ED50), respectively. Both extracts neutralized venom-induced hemolysis (50–100 μg). Inhibitory concentrations against phospholipase A2 activity exhibited by aqueous and …
Probable Selective Compounds For
Inhibition Of Sars-Cov-2 Infection: A Review,
2021
Chulalongkorn University
Probable Selective Compounds For Inhibition Of Sars-Cov-2 Infection: A Review, Nagaraju Rajendraprasad
The Thai Journal of Pharmaceutical Sciences
The world is severely facing the pandemic COVID-19 Corona viral disease. Many people died and more than five millions are fighting for their life in the world. The viral candidate has become to play villain role for the real life due to non-availability of medication. In this background attempt is made to present a review report on the probable and effective compounds to inhibit the viral activity of SARS-CoV-2. The works on the use of plant-based and synthetic compounds to suppress the viral functioning is summarized. Wherever possible, the mechanism of action with the results and effect of dose are …
Development And Validation Of High-
Performance Liquid Chromatography
Method For Estimation Of Seratrodast In
Spiked Human Plasma,
2021
Chulalongkorn University
Development And Validation Of High- Performance Liquid Chromatography Method For Estimation Of Seratrodast In Spiked Human Plasma, Sandeep S. Sonawane, Priyanka T. Shinde, Gayatri S. Joshi, Sanjay J. Kshirsagar
The Thai Journal of Pharmaceutical Sciences
In the work presented, an high-performance liquid chromatography method was developed and validated for the estimation of seratrodast (SER) in spiked human plasma, using flurbiprofen as an internal standard (IS). The drug and IS were extracted from pooled human plasma sample using 5 mL of tert-butyl methyl ether with 200 μL of 1% v/v formic acid. Both SER and IS were well separated and resolved from each other and plasma interferents using 20 mM phosphate buffer (pH 3.0) with acetonitrile in the proportion of 30: 70% v/v, in an isocratic mode at 1 mL/min on a C18 column and detection …
Moss Bryum Weigelii Spreng Improves
Survival In Septic Rats Induced By Cecal
Ligation And Puncture,
2021
Chulalongkorn University
Moss Bryum Weigelii Spreng Improves Survival In Septic Rats Induced By Cecal Ligation And Puncture, Ho Viet Hieu, Surendra Babu Lagu, Vinay Bharadwaj Tatipamula
The Thai Journal of Pharmaceutical Sciences
The present study investigated the phytochemical, high-performance thin-layer chromatography (HPTLC) profiling, total phenolic content, antibacterial activity, acute toxicity studies, hemodynamic parameters, myeloperoxidase (MPO) activity and serum procalcitonin (PCT) levels of hydroalcoholic extract of Bryum weigelii (HE-Bw), and its effects on cecal ligation and puncture (CLP) induced sepsis in mice. The preliminary phytochemical screening showed that HE-Bw contains alkaloids, terpenoids, flavonoids, phenolics, and tannins. The HPTLC analysis of HE-Bw identified three unknown components with different Rf values and area percentage. The total phenolic amount for HE-Bw was equivalent to 211.6 ± 0.8 mg of gallic acid per 100 g of dried …
Treatment Outcomes And Their Predictive Factors In Patients Withenterobacter Spp.,
Serratia Spp.,Citrobacter Spp.,
Providencia Spp., I-Indole-Positive
Proteus Spp., Andmorganella Spp, Bloodstream Infection,
2021
Chulalongkorn University
Treatment Outcomes And Their Predictive Factors In Patients Withenterobacter Spp., Serratia Spp.,Citrobacter Spp., Providencia Spp., I-Indole-Positive Proteus Spp., Andmorganella Spp, Bloodstream Infection, Wichai Santimaleeworagun, Dhitiwat Changpradub, Sudaluck Thunyaharn, Piraporn Juntanawiwat, Patsachon Kungsahadhum6, Phornusa Leartamornsakulchai, Waramporn Seubsai, Pratewee Satavetin
The Thai Journal of Pharmaceutical Sciences
The present study examined the treatment outcomes and factors related to mortality in patients with Enterobacter spp., Serratia spp., Citrobacter spp., Providencia spp., I-indole-positive Proteus spp., and Morganella spp. (ESCPIM) bloodstream infections and determined the susceptibility of ESCPIM pathogens to antimicrobial compounds. This retrospective study was performed at a university hospital in Thailand, using records from March 2017 to December 2018. Fifty-six patients with ESCPIM bacteremia were included. Approximately, half the patient cohort (55.4%) was infected with Enterobacter spp. The in-hospital mortality rate was 23.2%. Of the 56 patients studied, 20 patients (35.7%) had received a carbapenem treatment regimen, whereas …
In Vitro And In Vivo Effects Of
Zanthoxylum Limonella (Dennst.) Alston. Crude Extracts And Volatile Oil On Blood Glucose Reduction,
2021
Chulalongkorn University
In Vitro And In Vivo Effects Of Zanthoxylum Limonella (Dennst.) Alston. Crude Extracts And Volatile Oil On Blood Glucose Reduction, Attarat Pattanawongsa, Chaweewan Klongsiriwet, Peerarat Thaina, Aunchalee Prammano, Nattaphop Maneechai, Phitchapha Saengphrom, Gorawit Yusakul, Maleeruk Utsintong
The Thai Journal of Pharmaceutical Sciences
Introduction: Complimentary medicines have been long investigated as new and alternative therapeutic options for treating type 2 diabetes mellitus because the current drugs are associated with adverse drug reactions. The antidiabetic potential of the Zanthoxylum genus has been demonstrated previously. However, Zanthoxylum limonella (Dennst.) (ZL) has not been evaluated in any clinical trials. Objectives: This study aimed to examine the inhibition of α-glucosidases in vitro and in vivo using ZL fruit extracts, thereby determining the reduction in blood glucose levels using oral glucose and sucrose tolerance tests. Results and Discussion: The water extract of ZL fruits showed the greatest inhibition …
Simultaneous Estimation Of Ivacaftor
And Tezacaftor In Rat Plasma By Liquid Chromatography Coupled With Tandem-Mass-Spectrometry: Application To Pharmacokinetic Studies,
2021
Chulalongkorn University
Simultaneous Estimation Of Ivacaftor And Tezacaftor In Rat Plasma By Liquid Chromatography Coupled With Tandem-Mass-Spectrometry: Application To Pharmacokinetic Studies, M. Satya Venkata, A. Lakshmana Rao, M. William Carey
The Thai Journal of Pharmaceutical Sciences
Background: Ivacaftor and Tezacaftor belong to the CFTR potentiator class, in combination approved to manage cystic fibrosis. Objective: To establish a sensitive LC-MS/MS approach for the synchronized analysis of Ivacaftor and Tezacaftor and its appliance to rat pharmacokinetic investigation. Methodology: Method is developed with protein precipitation by acetonitrile and Ivacaftor-d4, Tezacaftor-d4 are used as internal standards. Separation is done on an Eclipse plus C18 analysis column (100 mm × 4.6 mm 1.8 μm) with a mobile phase consisting of 0.1% trifluoroacetic acid: acetonitrile (ratio 60:40, v/v, and pH 2.5) and flow stream of 1.0 mL/min at ambient temperature. Results: The …
Gas Chromatography-Flame Ionization
Detector Analysis Of Amb-Fubinaca From
Criminal Evidences In Vietnam,
2021
Chulalongkorn University
Gas Chromatography-Flame Ionization Detector Analysis Of Amb-Fubinaca From Criminal Evidences In Vietnam, Anh Tuan Nguyen, Dang Tien Nguyen, Duy Toan Pham
The Thai Journal of Pharmaceutical Sciences
Synthetic cannabinoids are currently the largest group of new psychoactive substances. Among them, one of the most recent compounds in Vietnam is AMB-Fubinaca. No quantitative method has been officially implied for AMB-Fubinaca in criminal evidences, thus, making the police investigations burdensome. This study, for the 1st time, aimed to develop and validate the gas chromatography with flame ionization detector (GC-FID) method to determine and quantify AMB-Fubinaca in criminal evidences found in the South of Vietnam from 2016 to 2018. Chromatography separation was achieved on diphenyl dimethyl polysiloxane GC column (30 m × 0.32 mm × 0.25 μm) with a total …
Effect Of The Hydrophilic-Lipophilic Balance Values Of Non-Ionic Surfactants On Size And Size Distribution And Stability Of Oil/Water Soybean Oil
Nanoemulsions,
2021
Chulalongkorn University
Effect Of The Hydrophilic-Lipophilic Balance Values Of Non-Ionic Surfactants On Size And Size Distribution And Stability Of Oil/Water Soybean Oil Nanoemulsions, Kamonwan Singpanna, Dusadee Charnvanich
The Thai Journal of Pharmaceutical Sciences
Objective: This study aims at investigating the effect of the hydrophilic-lipophilic balance (HLB) of non-ionic surfactants on physical property and stability of nanoemulsions. Materials and Methods: The nanoemulsions were prepared using the Microfluidizer. The oil phase consisted of 10% w/w soybean oil and 5% w/w surfactant(s). Types of nanoemulsions were confirmed by dilution test. The average droplet size and size distribution (polydispersity index [PDI]) were measured by dynamic light scattering Zetasizer Nano ZS™. The screening physical stability was done by centrifugation. Only the formulations with no phase separation were further evaluated for physical stability. Results: All nanoemulsions were single phase …
Systematic Development By The Design-Of-Experiment Approach And Physicochemical Evaluations Of The Optimized Self-Microemulsifying Astaxanthin Delivery System,
2021
Chulalongkorn University
Systematic Development By The Design-Of-Experiment Approach And Physicochemical Evaluations Of The Optimized Self-Microemulsifying Astaxanthin Delivery System, Mo Mo Ko Zin, Veerakiet Boonkanokwong
The Thai Journal of Pharmaceutical Sciences
A self-microemulsifying delivery system (SMEDS) containing astaxanthin (AST) was developed and optimized using a mixture design and its desirability function. Independent factors studied in the experimental design were the amounts of castor oil, Cremophor® RH 40, and Tween® 80 in a formula. The measured response variables included droplet size, polydispersity index (PDI), zeta potential, active ingredient content, and transmittance of microemulsions obtained from the AST SMEDS formulations. The desirability function was then adjusted to optimize the formulation. The optimized AST SMEDS was composted of 19.59% castor oil, 62.34% Cremophor® RH 40, and 18.03% Tween® 80, and the resulting self microemulsions …
Antiplasmodial Activity Of Hyptis Pectinata Extract And Its Analog Against 3d7 Plasmodium Falciparum Through
Caseinolytic Protease Proteolytic (Clpp)
Inhibition,
2021
Chulalongkorn University
Antiplasmodial Activity Of Hyptis Pectinata Extract And Its Analog Against 3d7 Plasmodium Falciparum Through Caseinolytic Protease Proteolytic (Clpp) Inhibition, Meiny Suzery, Bambang Cahyono, Nur Dina Amalina, Cahyo Budiman, Ibnu Bayu, Mukhammad Asy’Ari, Widayat
The Thai Journal of Pharmaceutical Sciences
Hyptolide and epoxy hyptolide were successfully isolated and synthesized from Hyptis pectinata extract that potential to cure malaria diseases. The previous studies showed that these compounds contained lactone groups associated with antibacterial and anticancer activities. However, the antimalarial activity remained unclear. This study aimed to investigate the antiplasmodial activity of H. pectinata extract, hyptolide, and epoxy hyptolide. These compounds were tested in vitro for antiplasmodial activity against chloroquinesensitive 3D7 strain of Plasmodium falciparum. Thin blood smears were used to assess the levels of parasitemia and growth inhibition of the isolates and the ClpP inhibition was analyzed under well diffusion assay. …
