Short-Term Antenatal Corticosteroid Increases Risk Of Respiratory Morbidity In Late Preterm Infants,
2021
Chulalongkorn University
Short-Term Antenatal Corticosteroid Increases Risk Of Respiratory Morbidity In Late Preterm Infants, Nithipun Suksumek, Pithi Chanvorachote, Amuchou Soraisham, Abhay Lodha, Albert Akierman, Carlos Fajardo
The Thai Journal of Pharmaceutical Sciences
Background/Aim: Although antenatal corticosteroid (ANCS) is beneficial for preventing respiratory distress in preterm infants, the effect of ANCS on late preterm infants (LPI) is still unknown. This study aimed at investigating the effect of ANCS on respiratory morbidity of LPI. Materials and Methods: In matched cohort study, LPI of mothers who received ANCS (ANCS group) at 24–34 weeks of GA were matched with LPI of no ANCS (non-ANCS group) by gestational age and birth weight. Results: During 2 years, the ANCS group was 10.6% (191/1,810) in LPI and only 177 neonates met the criteria for inclusion and were ANCS group. …
An Updated Review: The Year 2020 And Coronavirus Disease-19 Pandemic,
2021
Chulalongkorn University
An Updated Review: The Year 2020 And Coronavirus Disease-19 Pandemic, Kanwal Ashiq, Mayyda Asif Bajwa, Sana Ashiq, Mehwish Qayyum, Rabia Khokhar, Samreen Tanveer
The Thai Journal of Pharmaceutical Sciences
The recent scenario with an outbreak of novel coronavirus has led to dramatic upsurge in mortality and morbidity rates all around the globe. The objective of consolidated article is to provide an updated insight on coronavirus disease (COVID-19) based on the current literature, and it is anticipated that it may serve as a perspective reference in future studies. Scopus, Science Direct, MEDLINE, PubMed, and Google Scholar databases were used to search the literature. For the current review, both research and review articles issued in the English language were considered. The mode of Corona virus disease transmission is through direct contact …
Group-Based Quantitative Structure And
Activity Relationship On Benzothiazole
Derivatives For Development Of Potent
Anti-Cancer Compounds,
2021
Chulalongkorn University
Group-Based Quantitative Structure And Activity Relationship On Benzothiazole Derivatives For Development Of Potent Anti-Cancer Compounds, Amit S. Tapkir, Sohan S. Chitlange, Ritesh P. Bhole
The Thai Journal of Pharmaceutical Sciences
To develop potent anticancer compounds using benzothiazole scaffolds group-based quantitative structure and activity relationship (GQSAR) analysis was performed on 41 reported benzothiazole derivatives for identification of structural fragments. Benzothiazole dataset was fragmented into two fragments (R1 and R2). GQSAR models were generated using multiple linear regression. GQSAR analysis revealed the presence of hydrophobic groups on R1 will potentiate anticancer activity. The generated models are giving insight into the benzothiazole structural requirements which will be optimized for design of anticancer drugs.
Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application,
2021
Chulalongkorn University
Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application, P. S. Singh, Suraj N. Mali, N. R. Sangale, Amit P. Pratap
The Thai Journal of Pharmaceutical Sciences
Introduction: Chitosan, a biopolymer with 97% degree of deacetylation, was used herein, to synthesize an amino sugar anionic surfactant of varied alkyl chain length, using a microwave-assisted synthesis. We were also examined their properties in aqueous form. Objectives: The objectives of the study were to increase the surface activity and water solubility of chitosan derivatives. Materials and Methods: Structural features and crystallinity were confirmed using Fourier transform infrared, ¹H-nuclear magnetic resonance, and X-ray diffraction. The chitosan by itself was found to have weak surface-active properties since it has no hydrophobic segment. Results: The microwave-assisted synthesized sugar amino-based anionic surfactant, synthesis …
Anti-Inflammatory Activity Of New 1,3,4-Oxadiazole Derivatives,
2021
Chulalongkorn University
Anti-Inflammatory Activity Of New 1,3,4-Oxadiazole Derivatives, Banylla Felicity Dkhar Gatphoh, Natasha Naval Aggarwal, Hemanth Kumar, B. C. Revanasiddappa
The Thai Journal of Pharmaceutical Sciences
A new series of 1,3,4-oxadiazole derivatives (3a-j) were synthesized by reacting p-toluic benzhydrazide (1) and substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate as catalyst and dichloromethane as a solvent medium. The structures of the new compounds were assigned based on IR, 1H-NMR, and mass spectral data and further evaluated for their in vitro anti-inflammatory potential using various protein denaturation methods following bovine serum and egg albumin assay. Some tested compounds 3e, 3f, and 3i displayed moderate anti-inflammatory activity compared to the standard diclofenac sodium.
Evaluation Of Modified Pennisetum Glaucum Starch As A Suspending Agent In Metronidazole Benzoate Suspension,
2021
Chulalongkorn University
Evaluation Of Modified Pennisetum Glaucum Starch As A Suspending Agent In Metronidazole Benzoate Suspension, Nkemakolam Nwachukwu, Kenneth Chinedu Ugoeze, Dorathy Rokalke Igoni
The Thai Journal of Pharmaceutical Sciences
The properties of modified starch derived from Pennisetum glaucum (PT) seed as a suspending agent in metronidazole benzoate suspension was evaluated. Matured PT seeds were steeped for 72h, wet milled and the slurry washed with water through a muslin cloth to obtain native PT starch (NPS) which was dried at 60°C. NPS slurry was heated (70°C), cooled (40°C), and submerged in 3.5%w/v sodium hypochlorite for 10 min, washed with 95%v/v alcohol till neutral to litmus. The modified starch (MPS) was dried (50°C), classified (180μm). NPS and MPS were characterized using standard methods. Metronidazole benzoate (MTBZ) suspensions were formulated using 2.5%w/v, …
Evaluation Of Psychometric Properties
Of The Thai Sf-12v2 In The General Thai Population,
2021
Chulalongkorn University
Evaluation Of Psychometric Properties Of The Thai Sf-12v2 In The General Thai Population, Krittaphas Kangwanrattanakul
The Thai Journal of Pharmaceutical Sciences
Background: This study investigated the psychometric properties of the Thai Short Form-12 Health Survey (SF-12v2) and reported SF-12v2 scale scores based on the general Thai population’s age and gender. Methods: Multistage sampling was used to recruit 1200 general Thai participants. For all SF-12v2 scales, item description, ceiling/floor effects, convergent validity for item-scale and SF-12v2 and EQ-5D correlations, known-group validity, exploratory factor analysis (EFA), test-retest reliability, and responsiveness were studied. Results: Ceiling effect was observed for all scales (5.8–72.6%). Floor effect was detected for all scales except for social functioning, role emotion, and mental health. Item-scale correlation coefficients ranged from 0.65 …
Effect Ethyl Acetate Extract Oflasiodiplodia Pseudotheobromae
Industrial Biotechnology Research Laboratory Os-64 On Growth And Cell Morphology Of A Foodborne Bacterium,Bacillus Cereus,
2021
Chulalongkorn University
Effect Ethyl Acetate Extract Oflasiodiplodia Pseudotheobromae Industrial Biotechnology Research Laboratory Os-64 On Growth And Cell Morphology Of A Foodborne Bacterium,Bacillus Cereus, Mohd Taufiq Mat Jalil, Darah Ibrahim
The Thai Journal of Pharmaceutical Sciences
Background: A foodborne bacterium, Bacillus cereus is one of the common food contaminants that could cause food poising with several sickness symptoms to humans. Objective: This study was undertaken to evaluate the effect of ethyl acetate extract of endophytic fungus, Lasiodiplodia pseudotheobromae Industrial Biotechnology Research Laboratory (IBRL) OS-64 towards a test bacterium, B. cereus with emphasis on bacterial growth reduction and cell morphological changes. Materials and Methods: The ethyl acetate (fermentative broth) and methanolic (fungal biomass) extracts were screened for their antibacterial activity against test bacteria via agar disc diffusion assay. Results: The results demonstrated that there is a significant …
Inhibitory Effects Of Manosa Alliacea
In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its
Confirmation By In-Silico Strategy,
2021
Chulalongkorn University
Inhibitory Effects Of Manosa Alliacea In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its Confirmation By In-Silico Strategy, D. S.N.B.K. Prasanth, Sk. Aminabee, A. Lakshmana Rao, Chakravarthi Guntupalli, Alavala Rajasekhar Reddy, Umasankar Kulandaivelu, S. N. Koteswara, P. Rajeshwari
The Thai Journal of Pharmaceutical Sciences
For the assessment of the curative effect of Manosa alliacea on Freud’s adjuvant (FA) arthritis on Swiss albino rats. Methanol extract from M. alliacea (MEMA) was administered orally at 200 mg/kg and 400 mg/kg, 28 days after FA immunization. For control and treatment groups, paw volume, body weight, hematological parameters, X-ray, and histological tests were measured. In addition, reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the levels of various inflammatory markers. In vitro, DPPH and H2O2 tests were used to evaluate the antioxidant capability. MEMA decreased paw volume and paw thickness, bodyweight considerably (P < 0.05, 0.01, 0.001), compared to hematological anomalies of arthritis control. X- rays tests and histological tests did not reveal significant structural changes in the rat ankle joints administered with MEMA. The levels of expression tumor necrosis factor - α, NF-Kβ, IL-1β, and COX-2 were significantly suppressed in the treatment groups. The in-silico study has shown that a number of chemical components in the plants under study can effectively bind to various inflammatory targets. That is why we say M. alliacea is a good source for treating rheumatoid arthritis.
Assessment Of The Phytoconstituents And Optimal Applicable Concentration Of Aqueous Extract Of Azadirachta
Indica Leaves For Wound Healing In Male Wistar Rats,
2021
Chulalongkorn University
Assessment Of The Phytoconstituents And Optimal Applicable Concentration Of Aqueous Extract Of Azadirachta Indica Leaves For Wound Healing In Male Wistar Rats, Kenneth Chinedu Ugoeze, Princewill Chukwuebuka Aja, Nkemakolam Nwachukwu, Bruno Chukwuemeka Chinko, Jude Nnabuife Egwurugwu
The Thai Journal of Pharmaceutical Sciences
Background/Aim: Plant-based medicinal agents containing phytoconstituents like extracts of Azadirachta indica leaves has been reported to heal wounds. This study evaluated the phytoconstituents and determined the optimal concentration of the aqueous extract of Azadirachta indica leaves (AEAIL) affecting wound healing in male Wistar rats. Materials and Methods: AEAIL was evaluated for phytoconstituents using GC-FID. Wounds (diameter ≈1.5cm) was excised on the dorsum of 35 rats (7 groups, n = 5). Groups 1- 6 were treated topically with 0.5, 1.5, 3.0, 5.0, 10.0 and 20.0% w/v of AEAIL respectively. Group 7 was treated with distilled water as the control. Wound contractions …
Cost-Effectiveness Analysis Of Manidipine Versus Amlodipine As An Add-On To Renin-Angiotensin System Blockers In Hypertensive Patients With Diabetes Mellitus And Proteinuria,
2021
Chulalongkorn University
Cost-Effectiveness Analysis Of Manidipine Versus Amlodipine As An Add-On To Renin-Angiotensin System Blockers In Hypertensive Patients With Diabetes Mellitus And Proteinuria, Kamolpat Chaiyakittisopon, Wiwat Thavornwattanayong, Jadesada Lertsirimunkong, Supitchaya Senbut
The Thai Journal of Pharmaceutical Sciences
Objectives: Diabetes and hypertension are the most common causes of chronic kidney disease. Calcium channel blockers are beneficial in blood pressure reduction while also stall kidney degeneration. The aim of this study was to compare the cost-effectiveness of manidipine to amlodipine as an add-on to renin-angiotensin system blockers (RASBs) to slow down kidney degeneration in hypertensive patients with diabetes mellitus and proteinuria. Methods: A lifetime Markov decision model was used to evaluate total costs and quality-adjusted life-years (QALYs) from published data on clinical outcomes and Thai data on cost and humanistic outcomes. This study adopted a societal perspective. Results: The …
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin,
2021
Chulalongkorn University
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin, Penpimon Charoenkanburkang, Tisana Kaewruethai, Pornchai Rojsitthisak, Jittima Amie Luckanagul
The Thai Journal of Pharmaceutical Sciences
Introduction: The aim of this work is to formulate and study the thermoresponsive system with hyaluronic acid (HA) as a polysaccharide backbone grafted with poly-(N-isopropylacrylamide) (pNIPAM) for stabilization of highly sensitive molecule. Methods: The nanogel forming polymer was synthesized through EDC/NHS coupling reaction. The HA grafted pNIPAM (HA-g-pNIPAM) can be self-assembled to form gel particle. The synthesized HA-g-pNIPAM polymers were characterized by 1H NMR. Size, influence of media to forming nanogel, thermoresponsive behavior and influence of HA-g-pNIPAM nanogel network on curcumin loading capacity and stability were investigated by dynamic light scattering (DLS) and UV-VIS spectrophotometry. Result and Discussion: The results …
The Physico-Chemical And Filler-Binder-
Disintegrant Properties Of Improved
Hydrophilic Powder Derived From The
Fibre Of Ipomoea Batatas Tuber In Paracetamol Tablet,
2021
Chulalongkorn University
The Physico-Chemical And Filler-Binder- Disintegrant Properties Of Improved Hydrophilic Powder Derived From The Fibre Of Ipomoea Batatas Tuber In Paracetamol Tablet, Kenneth Chinedu Ugoeze, Nkemakolam Nwachukwu, Chukwudum Ejike Okeke
The Thai Journal of Pharmaceutical Sciences
Objectives: The physico-chemical and filler-binder-disintegrant properties of improved hydrophilic powder (HP) derived from the fibre of Ipomoea batatas tuber in a paracetamol tablet was studied.Materials and Methods: A 200 g of the powdered fibre was blended with 600 ml of 0.125 N NaOH and washed with deionized water until neutral, then stirred in 200 ml of 0.50 N HCl, washed until neutral. It was precipitated with 96 % v/v ethanol, dried in a desiccator, pulverized to 250 μm and coded as HP. It was characterized and applied as a filler-binder-disintegrant in paracetamol tablet by wet-granulation and direct- compression beside avicel® …
Subacute Toxicity Study And Clinical
Trials For Ziziphus Spina-Christi Leaves
Extract As An Anti-Dandruff Shampoo,
2021
Chulalongkorn University
Subacute Toxicity Study And Clinical Trials For Ziziphus Spina-Christi Leaves Extract As An Anti-Dandruff Shampoo, Abdulkarim K.Y. Alzomor, Wafa M. Al-Madhagi, Nahlah M. Sallam, Haytham Mojamel, Mostafa M. Alawar, Abdulfattah G. Al-Hetari
The Thai Journal of Pharmaceutical Sciences
In light of recent developments in the scientific and technological world, herbs are widely used as remedial agents. This study was aimed to formulate and evaluate the safety and the efficacy of herbal antidandruff shampoo from Ziziphus spina-christi (Sidr) leaves extract, which is used traditionally for several medical and cosmetic purposes. Sidr leaves were extracted by maceration using ethanol as a solvent. The antifungal activity of the plant extract was tested against M. furfur. In-vivo study of the extract has been evaluated with daily oral doses (50, 100, and 200 mg/kg) for 28 days for tested rats, followed by, evaluation …
Cramming On Potato Starch As A
Novel Superdisintegrant For Depiction
And Characterization Of Candesartan
Cilexetil Fast Dissolving Tablet,
2021
Chulalongkorn University
Cramming On Potato Starch As A Novel Superdisintegrant For Depiction And Characterization Of Candesartan Cilexetil Fast Dissolving Tablet, Venkata Deepthi Vemuri, Swathi Nalla, Gollu Gowri, Nalini Mathala
The Thai Journal of Pharmaceutical Sciences
Background: In the current investigation, a strive became finished to synthesis a novel polymer, starch tartrate by treating potato starch with tartaric acid and utilize it as superdisintegrant for designing candesartan cilexetil (CC) fast-dissolving tablets. Starch tartrate was synthesized from potato starch and evaluated for phytochemical tests, physicochemical properties, and acute toxicity studies. CC tablets have been prepared by usage of a direct compression approach. Results: Acute toxicity studies on novel polymer indicated that there are no physiological changes in the rat behavior and were healthy. Formulated CC tablets were gone through pre- compression parameters, post-compression parameters, and stability studies. …
Hptlc-Densitometric And Tlc-Image Analysis Method For Determination Of Alkaloids Crebanine And Dicentrine In
Stephania Venosa Tuber And Their Commercial Products,
2021
Chulalongkorn University
Hptlc-Densitometric And Tlc-Image Analysis Method For Determination Of Alkaloids Crebanine And Dicentrine In Stephania Venosa Tuber And Their Commercial Products, Savita Chewchinda, Sumet Kongkiatpaiboon
The Thai Journal of Pharmaceutical Sciences
This study was aimed to develop and validate HPTLC densitometric and image analysis method for the quantification of crebanine and dicentrine in S. venosa tuber and their commercial products in Thailand. HPTLC analysis was performed on an aluminum sheet of silica gel using dichloromethane:ethyl acetate:methanol (21:6:3, v/v/v) as a mobile phase. The densitometric scanning was performed at the wavelength 290 nm, while image analysis was visualized after post-derivatization with Dragendorff’s reagent and processed by the ImageJ processing software. The proposed methods showed acceptable validation parameters. The content of crebanine and dicentrine in S. venosa tuber and their commercial product was …
Digoxin Potentiates The Anticonvulsant
Effect Of Carbamazepine And Lamotrigine Against Experimental Seizures In Mice,
2021
Chulalongkorn University
Digoxin Potentiates The Anticonvulsant Effect Of Carbamazepine And Lamotrigine Against Experimental Seizures In Mice, Vadim Tsyvunin, Sergiy Shtrygol, Diana Shtrygol, Mariia Mishchenko, Ihor Kapelka, Andriy Tara
The Thai Journal of Pharmaceutical Sciences
Introduction: The worldwide high amount of multidrug-resistant epilepsy patients makes it urgent to find new approaches to treating, including the use of combinations of classic anticonvulsants with drugs that have an exclusively original mechanism of action, in particular digoxin. Objective: The aim of this work was to investigate the influence of low-dose cardiac glycoside digoxin on the anticonvulsant effect of carbamazepine and lamotrigine. Methods: Basic models of pentylenetetrazole- induced seizures and electroinduced paroxysms (maximal electroshock) in mice were used. Classic anticonvulsants were administered intragastrically in conditionally effective and sub-effective doses at 30 min, digoxin – subcutaneously at a dose of …
High Dietary Salt Intake Alleviates Fasting Blood Glucose In Streptozotocin-Induced Diabetic Male Wistar Rats,
2021
Chulalongkorn University
High Dietary Salt Intake Alleviates Fasting Blood Glucose In Streptozotocin-Induced Diabetic Male Wistar Rats, Jerome Ndudi Asiwe, Kenneth Kelechi Anachuna, Emuesiri Goodies Moke, Kamaldeen Olalekan Sanusi, David Ehikhuemen Okonofua, Oghenerukevwe Omeru, Adesoji Adedipe Fasanmade
The Thai Journal of Pharmaceutical Sciences
Objectives: Hypertension and type 2 diabetes are common comorbidities. Studies have shown that hypertension is twofold as common in diabetic patients compared with non-diabetics. Excessive intake of dietary salt has reportedly caused increase in blood pressure. This study investigated the effects of high dietary salt intake on diabetic rats. Materials and Methods: Twenty-eight animals were randomly selected into four groups (n = 7). Group 1 (normal control), fed with standard rats’ feed; Group 2 (diabetic control), streptozotocin-induced diabetic rats fed with normal diet; Group 3 (salt control), fed with 8% salt (high salt) diet; Group 4 (test group), streptozotocin-induced diabetic …
Anti-Senescence Activity Of Indonesian
Black Pepper Essential Oil (Piper
Nigrum L.) On Ovarian Cho-K1 And Fibroblast Nih-3t3 Cells,
2021
Chulalongkorn University
Anti-Senescence Activity Of Indonesian Black Pepper Essential Oil (Piper Nigrum L.) On Ovarian Cho-K1 And Fibroblast Nih-3t3 Cells, Nadzifa Nugraheni, Faradiba Nur Ahlina
The Thai Journal of Pharmaceutical Sciences
Background: Cellular senescence or cell aging is a progressive process caused by an increase in free radicals so that cells cannot proliferate. Black pepper essential oil (BPEO) contains terpenoid compounds that perform the antioxidant activity to inhibit cell aging. Aims: This study aims to explore the potential of BPEO as an anti-senescence agent to maintain body fitness through in vitro methods on ovarian CHO-K1 and fibroblast NIH-3T3 cells. Subjects and Methods.: BPEO was obtained by hydrodistillation, then identified the compounds by gas chromatography–mass spectrometry. The cytotoxicity of BPEO was evaluated using the 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay. The senescence was …
Statistical Optimization And Evaluation
Of Flavoxate Hcl Gastro Retentive
Floating Tablets,
2021
Chulalongkorn University
Statistical Optimization And Evaluation Of Flavoxate Hcl Gastro Retentive Floating Tablets, Raghavendra Kumar Gunda, Prasada Rao Manchineni, Rajini Sudireddy
The Thai Journal of Pharmaceutical Sciences
Purpose: The objective of the current study is to develop gastroretentive formulation for flavoxate HCl using polymers of natural and semisynthetic origin in appropriate composition. Flavoxate HCl, a smooth muscle relaxant, mainly used for treating urinary incontinence, urgency of urination. Materials and Methods: Floating tablets of flavoxate HCl were prepared using variable amounts of hydroxypropyl methylcellulose (HPMC) K100M and Lannea coromandelica gum (LCG) with effervescent mixtures as per 32 factorial design by direct compression technique. Amount of release modifiers need to get sustained drug release was labeled as factors. On the other hand, time taken for drug dissolution were labeled …
