The Analgesic And Anticonvulsant Effects Of Piperine In Mice,
2013
King Saud University
The Analgesic And Anticonvulsant Effects Of Piperine In Mice, I A. Bukhari, M S. Alhumayyd, A L. Mahesar, A H. Gilani
Department of Biological & Biomedical Sciences
Piperine, is the major active principal of black pepper. In traditional medicine, black pepper has been used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy. This study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice. The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhing, tail flick assay, pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures models. The intraperitoneal (i.p.) administration of piperine (30, 50 and 70 mg/kg) significantly inhibited (P<0.01) the acetic acid-induced writhing in mice, similar to the effect of indomethacin (20 mg/kg i.p.). In the tail flick assay, piperine (30 and 50 mg/kg, i.p.) and morphine (5 mg/kg, i.p.) caused a significant increase (P<0.01) in the reaction time of mice. Pre-treatment of animals with naloxone (5 mg/kg i.p.), reversed the analgesic effects of both piperine and morphine in the tail flick assay. Piperine (30, 50 and 70 mg/kg, i.p.) and standard drugs, valproic acid (200 mg/kg, i.p.), carbamazepine (30 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) significantly (P<0.01) delayed the onset of PTZ-and PIC-induced seizures in mice. These findings indicate that piperine exhibits analgesic and anticonvulsant effects possibly mediated via opioid and GABA-ergic pathways respectively. Moreover, piperine being the main constituent of black pepper, may be contributing factor in the medicinal uses of black pepper in pain and epilepsy
The Effects Of Acute Nicotine Administration On Memory Formation And Neural Activity In The Hippocampus, Perirhinal Cortex, And Medial Septum: Implications For Neurodegenerative Disorders,
2013
Connecticut College
The Effects Of Acute Nicotine Administration On Memory Formation And Neural Activity In The Hippocampus, Perirhinal Cortex, And Medial Septum: Implications For Neurodegenerative Disorders, Matthew Wishnoff
Behavioral Neuroscience Honors Papers
Within the general public, nicotine is commonly thought of as a harmful molecule due to its role in tobacco addiction. However, nicotinic stimulation of the cholinergic system has also been shown to enhance cognitive functioning. This enhancement is thought to be caused by an increase in the release of the neurotransmitter, acetylcholine (ACh), which is responsible for mediating a variety of cognitive processes, such as REM sleep and memory formation. Recent research by Melichercik and colleagues shows that systemic nicotine administration enhances memory acquisition for both object location and object recognition memory in rats, as assessed by a modified version …
Statistical Optimization Of Mesalamine Pulsatile Release Ph Dependent Coated Pellets For Possible Ileo-Cecal Targeting,
2013
Chulalongkorn University
Statistical Optimization Of Mesalamine Pulsatile Release Ph Dependent Coated Pellets For Possible Ileo-Cecal Targeting, Hemant H. Gangurde, Mayur A., S. Tamizharasi, T. Sivakumar
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Permaganometric Determination Of Sumatriptan Succinate In Pure Drug And Pharmaceutical Formulation,
2013
Chulalongkorn University
Permaganometric Determination Of Sumatriptan Succinate In Pure Drug And Pharmaceutical Formulation, K.N. Prashanth, K. Basavaiah, M.S. Riaghu
The Thai Journal of Pharmaceutical Sciences
Based on the reduction of permanganate by sumatriptan succinate (STS) in acidic medium, two simple, sensitive and cost-effective methods were described for the determination of STS in bulk drug and in formulation. In titrimetry (method A), STS was oxidized by a known excess of potassium permanganate (KMnO₄) in H₂SO₄ medium followed by determination of unreacted permanganate by titration with ferrous ammonium sulphate. In spectrophotometry (method B), STS was treated with a measured excess of permanganate in acid medium and the unreacted oxidant was measured at 545 nm. The molar combining ratio in titrimetry and the optimum assay conditions were studied. …
Antibacterial Activitry Of Crude Extracts From Edible Mushrooms Pleurotus Citrinopileatus And Tricholoma Crassum Berk,
2013
Chulalongkorn University
Antibacterial Activitry Of Crude Extracts From Edible Mushrooms Pleurotus Citrinopileatus And Tricholoma Crassum Berk, Prontep Chomcheon, Bancha Kheawkum, Pornsinee Sriwiset, Suphak Dulsamphan, Chalernkieat Dulsamphan
The Thai Journal of Pharmaceutical Sciences
The purpose of this research was to study antibacterial activity of crude extracts derived from the culture broths of two edible mushrooms, Pleurotus citrinopileatus and Tricholoma crassum Berk, cultivated in submerged fermentation. Potato dextrose broth (PDB) and yeast extract sucrose broth (YES) were used as culture media. Each culture filtrate was extracted and evaporated to yield a crude extract. Antibacterial activities against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 were determined by paper disc diffusion assay. Crude extract (1 mg) of P. citrinopileatus culturing PDB showed the widest inhibition zones against E. coli ATCC 25922 (34.47 ± 0.50 …
In Vitro Stimulatory Effect Of Grandiflorenic Acid Isolated From Wedelia Trilobata (L.) Leaves On L929 Fibroblast Cells,
2013
Chulalongkorn University
In Vitro Stimulatory Effect Of Grandiflorenic Acid Isolated From Wedelia Trilobata (L.) Leaves On L929 Fibroblast Cells, Neelam Balekar, Titpawan Nakpheng, Teerapol Srichana
The Thai Journal of Pharmaceutical Sciences
Wedelia trilobata (L.) has been used in traditional medicine in the Caribbean and Central America for stubborn wounds, sores, swelling and arthritic painful joints. The aim of the study was to evaluate the activity of grandiflorenic acid obtained from le...
Evaluation Of The Wound Healing Potential Of Albizzia Lebbeck (L.) Bark,
2013
Chulalongkorn University
Evaluation Of The Wound Healing Potential Of Albizzia Lebbeck (L.) Bark, Neelam Balekar, Dinesh Kumar, Rajesh Kumar Upadhyay
The Thai Journal of Pharmaceutical Sciences
The present study was performed to substantiate the traditional claim of the wound healing activity of stem bark of Albizzia lebbeck Linn. in rats. The effects of aqueous and ethanolic extracts of stem bark of A. lebbeck (5% and 10% w/v topically and 250...
Development And Validation Of Hptlc Densitometric Method For Simultaneous Determination Of Antazoline Hydrochloride And Tetryzoline Hydrochloride In Eye Drop And Its Application As Stability Indicator,
2013
Chulalongkorn University
Development And Validation Of Hptlc Densitometric Method For Simultaneous Determination Of Antazoline Hydrochloride And Tetryzoline Hydrochloride In Eye Drop And Its Application As Stability Indicator, Anbessa Bekele Ariaya Hymete, Adnan A. Bekhit
The Thai Journal of Pharmaceutical Sciences
A sensitive, selective, precise, accurate and stability indicating high-performance thin layer chromatographic (HPTLC)-densitometric method for analysis of antazoline hydrochloride and tetryzoline hydrochloride was developed. The method employed HPTLC al...
Association Of Abcb1 Polymorphism With Lamotrigine-Resistant Epilepsy In Thais,
2013
Chulalongkorn University
Association Of Abcb1 Polymorphism With Lamotrigine-Resistant Epilepsy In Thais, Korakot Buathet, Yotin Chinvarun, Somchai Towanabut, Pornpimol Kijsanayotin
The Thai Journal of Pharmaceutical Sciences
Along with clinical and environmental factors, genetic variability in P-glycoprotein (P-gp) encoded by the ATP-binding cassette (ABC)B1 gene may influence inter-individual variability in antiepileptic drug response by limiting drug absorption and brain a...
Eudragit Rs 100 Nanosuspensions For The Controlled Ophthalmic Delivery Of Diclofenac Sodium,
2013
Chulalongkorn University
Eudragit Rs 100 Nanosuspensions For The Controlled Ophthalmic Delivery Of Diclofenac Sodium, Swamy N.G.N., Zaheer Abbas, Santosh Kumar I.H.
The Thai Journal of Pharmaceutical Sciences
The aim of this study was to prepare and characterize diclofenac sodium-loaded Eudragit RS 100-based nanosuspensions for controlled ophthalmic delivery in the management of ocular inflammatory conditions with an intention to provide long-term extraocular...
Author Index, Keyword Index,
2013
Chulalongkorn University
Author Index, Keyword Index, N/A
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antioxidant Activities And Phytochemicals Of Edible Flowers,
2013
Chulalongkorn University
Antioxidant Activities And Phytochemicals Of Edible Flowers, Jeerawat Sawatpipat., Vatin Phunsawat, Piyanuch Rojsanga, Pongtip Sithisarn
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Comparative Studies On Antioxidant Activities, Total Phenolics And Anthocyanin Content Of Four Native Fruits,
2013
Chulalongkorn University
Comparative Studies On Antioxidant Activities, Total Phenolics And Anthocyanin Content Of Four Native Fruits, Tanwarat Kaisongkram, Saranya Laovitthayanggoon, Kusol Iamsub, Vilailuk Chuennangchee, Penpan Srithong, Chuleratana Bangchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antileukemic Activity And Secondary Metabolites Of An Endophytic Fungus Phomopsis Sp. From Artemisia Annua,
2013
Chulalongkorn University
Antileukemic Activity And Secondary Metabolites Of An Endophytic Fungus Phomopsis Sp. From Artemisia Annua, Punvisa Ngankaranatikarn, Taksina Chuanasa, Nongluksna Sriubolmas, Khanit Suwanborirux
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Identification Of Factic Acid Bacteria And Yeasts From Fermented Rice Product (Khao-Khab),
2013
Chulalongkorn University
Identification Of Factic Acid Bacteria And Yeasts From Fermented Rice Product (Khao-Khab), Somboon Tanasupawat, Wongsakorn Phongsopitanun, Wanlapa Lorliam, Naphatrapi Luangsakul, Lawan Chatanon
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Preliminary Study Of Syzygium Aroma Ticum (L.) On Analgesic Activity In Rats,
2013
Chulalongkorn University
Preliminary Study Of Syzygium Aroma Ticum (L.) On Analgesic Activity In Rats, Kanvarat Sueksakit, Krittiya Thisayakorn, Vichein Khueynok, Kanjana Sriyam, Nopparat Buddhakala
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effects Of Topical Administration Of Nymphaeae Lotus Flower Extract On Uva-Induced Photoinflammation In Mice,
2013
Chulalongkorn University
Effects Of Topical Administration Of Nymphaeae Lotus Flower Extract On Uva-Induced Photoinflammation In Mice, Krittiya Thisavakorn., Ubon Rerk-Am, Sinn Tangstirapakdee, Vichein Khueynok, Kanchana Sriyam, Darunee Pahusi, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effect Of Morus Alba Stem Extract On Nitric Oxide Production In Lipopolysaccharide-Induced Raw 264.7 Macrophage Cells,
2013
Chulalongkorn University
Effect Of Morus Alba Stem Extract On Nitric Oxide Production In Lipopolysaccharide-Induced Raw 264.7 Macrophage Cells, Nattapom Soonthomsit., Warinkarn Hemstapat, Pongsak Utaisincharoerv, Tasana Pitaksuteepong
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Chemical Profile Analysis And Anti-Inflammatory Activity Of Polar Fraction From Soybeans (Glycine Max,
2013
Chulalongkorn University
Chemical Profile Analysis And Anti-Inflammatory Activity Of Polar Fraction From Soybeans (Glycine Max, Siripen Jarikasem, Amornrat Khayungarnnawee, Sarinthip Muensaen
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Aligned Electrospun Chitosan/Poly S-Caprolactone Blended Scaffold: Anti-Inflammatory Effect,
2013
Chulalongkorn University
Aligned Electrospun Chitosan/Poly S-Caprolactone Blended Scaffold: Anti-Inflammatory Effect, Natthan Charemsriwilaiwat, Louise Carney, Brendan Robb, Praneet Opanasopit, Theerasak Rojanarata, Sandra Downes
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
