387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease,
2015
Weill Cornell Medical College
387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul
HPD Articles
The deposition of amyloid β-peptides (Aβ), cleavage products of the amyloid precursor protein (APP) by β- and γ-secretases, in brain represents a pathological hallmark of Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers have an increased risk to develop AD and an earlier age of onset, whereas carriers of the ε2 allele have reduced risk and a delayed age of onset. APOE is also a major determinant of brain Aβ and amyloid burden in humans and in several transgenic mouse models of AD (E4>E3>E2). We have previously reported that lentivirus-mediated intraparenchymal gene delivery of APOE2 significantly reduces …
Beta-Lactam Antimicrobial Dosing Optimization In Obese Patients Compared To Non-Obese Patients Using Population Pharmacokinetic/Pharmacodynamic Approach,
2015
Purdue University
Beta-Lactam Antimicrobial Dosing Optimization In Obese Patients Compared To Non-Obese Patients Using Population Pharmacokinetic/Pharmacodynamic Approach, Eun Kyoung Chung
Open Access Dissertations
Obesity is a significant global health problem and has been associated with altered pharmacokinetics and pharmacodynamics of many drugs. However, little is known regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, and cefepime. The objective of this study is to evaluate the population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, meropenem, and cefepime in hospitalized obese patients in order to determine dosing regimens that provide similar exposures between obese and non-obese patients. ^ For piperacillin/tazobactam, a retrospective analysis was conducted using prospectively collected serum concentration-time data from two previous studies (Study …
Elucidation Of Pharmacologically Manipulated Responding In The Delay Discounting Task In High Alcohol Preferring Mice,
2015
Purdue University
Elucidation Of Pharmacologically Manipulated Responding In The Delay Discounting Task In High Alcohol Preferring Mice, Meredith Halcomb
Open Access Dissertations
Impulsive behavior is the hallmark of many psychopathologies. Uncovering the neurobiological mechanisms driving impulsivity is paramount in the development of through the delay discounting (DD) task in both human and animal models. The present study is an examination of the predictive validity of the two primary types of DD procedures in animals, the Adjusting Amounts (AA) and within session Increasing Delays (ID) tasks. Methods:Subjects were administered either1.25 mg/kg d-amphetamine (AMP), 1.5 g/kg ethanol (EtOH) or saline and tested in either the AA or ID method for 15 days to evaluate drug effects on impulsive behavior. Results: Stimulant administration resulted …
Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine,
2015
University of Nebraska-Lincoln
Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li
Department of Psychology: Faculty Publications
Neurotensin is an endogenous neuropeptide closely associated with the mesolimbic dopaminergic system and shown to possess antipsychotic-like effects. In particular, acute neurotensin receptor activation can inhibit conditioned avoidance response (CAR), attenuate phencyclidine (PCP)-induced prepulse inhibition (PPI) disruptions, and reverse PCP-induced hyperlocomotion. However, few studies have examined the long term effects of repeated neurotensin receptor activation and results are inconsistent. Since clinical administration of antipsychotic therapy often requires a prolonged treatment schedule, here we assessed the effects of repeated activation of neurotensin receptors using an NTS1 receptor selective agonist, PD149163, in 3 behavioral tests of antipsychotic activity. We also investigated whether …
Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment,
2015
Wayne State University
Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment, Kelly Marie Mcgregor
Wayne State University Dissertations
Antidepressant drugs are widely used but their mechanism of action remains only partially understood. One leading hypothesis holds that a key effect of chronic treatment with a Selective Serotonin Reuptake Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to assess the effects of the classic SSRI fluoxetine on 5-HT1A receptor-mediated autoinhibition. We conducted these experiments in mice expressing the light-sensitive ion channel Channelrhodopsin (ChR) in 5-HT neurons to facilitate their …
Short Native Α-Helical Cationic Antimicrobial Peptides: Promising Alternative Antibiotics,
2015
Chulalongkorn University
Short Native Α-Helical Cationic Antimicrobial Peptides: Promising Alternative Antibiotics, Jiraphun Jittikoon
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Synthesis And Characterization Of Sodium Alginate Conjugate: Preparation And Evaluation Of Transdermal Patches Of Losartan Potassium Using Sodium Alginate Conjugate,
2015
Chulalongkorn University
Synthesis And Characterization Of Sodium Alginate Conjugate: Preparation And Evaluation Of Transdermal Patches Of Losartan Potassium Using Sodium Alginate Conjugate, Satheesha Babu Bk, Srinivasa Rao K
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Relationship Between Carbamazepine Concentrations In Serum And Saliva Of Thai Epileptic Patients,
2015
Chulalongkorn University
Relationship Between Carbamazepine Concentrations In Serum And Saliva Of Thai Epileptic Patients, Piyaporn Kaewdoung, Chartchai Puripokai, Chartchai Puripokai, Mayuree H. Tantisira, Somsong Laanwprasert
The Thai Journal of Pharmaceutical Sciences
This study aims to examine and verify the correlation between serum and saliva carbamazepine concentrations in Thai epileptic patients. The subjects were patients aged 15-60 years old who were under treatment with carbamazepine. Carbamazepine concentrati...
Development And Validation Of A Stability-Indicating Ultra-Performance Liquid Chromatographic Method For The Determination Of Rifampicin In Bulk Drug And Capsules,
2015
Chulalongkorn University
Development And Validation Of A Stability-Indicating Ultra-Performance Liquid Chromatographic Method For The Determination Of Rifampicin In Bulk Drug And Capsules, N. Swamy, K. Basavaiah, P. Vamsikrishna, G. Krishnamurthy
The Thai Journal of Pharmaceutical Sciences
A rapid method based on ultra-performance liquid chromatography (UPLC) was developed and validated for the specific determination of anti-tuberculosis drug rifampicin (RIF) in bulk form and capsules. The UPLC determination was carried out on a reversed-p...
Synthesis Of Novel Fused Heterocyclic Pyrazolo-Pyridazine Derivatives As Antimicrobial Agents,
2015
Chulalongkorn University
Synthesis Of Novel Fused Heterocyclic Pyrazolo-Pyridazine Derivatives As Antimicrobial Agents, M. Alam, M. S. Zaman, K. Arora, A. Ahmad, S. A. Khan, A. Husain
The Thai Journal of Pharmaceutical Sciences
A series of pyrazolo-pyridazine derivatives (4a-j) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antimicrobial agents. In the first step, 6-substituted phenyl-2,3,4,5- tetrahydropyridazin-3-one (2a,b) w...
Application Of Proteoglycans From Fish Cartilage For The Acceleration Of Burn Wound Healing,
2015
Chulalongkorn University
Application Of Proteoglycans From Fish Cartilage For The Acceleration Of Burn Wound Healing, Sitthiphon Bunman, Pornanong Aramwit, Noppadol Larbcharoensub, Pasarapa Towiwat
The Thai Journal of Pharmaceutical Sciences
Cartilage contains a variety of proteoglycans (PGs) that can accelerate wound healing. The aim of this study was to evaluate the efficacy of proteoglycans extracted from fish cartilage for the acceleration of burn wound healing. Second degree burn wounds...
Evaluation Of Anti-Anxiety Activity Of Melissa Parviflora (Benth.) In Rats,
2015
Chulalongkorn University
Evaluation Of Anti-Anxiety Activity Of Melissa Parviflora (Benth.) In Rats, Kundan Singh Bora, Aruna Dubey
The Thai Journal of Pharmaceutical Sciences
Melissa parviflora Benth. (Family: Lamiaceae) has been traditionally used as a tranquillizer, relaxants, nervine and sleeping aids throughout the world. The plant is reported to relieve tension and stress reactions, and widely valued for its calming prop...
In Vitro Biological Activities Of Black Pepper Essential Oil And Its Major Components Relevant To The Prevention Of Alzheimer’S Disease,
2015
Chulalongkorn University
In Vitro Biological Activities Of Black Pepper Essential Oil And Its Major Components Relevant To The Prevention Of Alzheimer’S Disease, Pattamapan Lomarat, Kittisak Sripha, Phanida Phanthong, Worawan Kitphati, Krit Thirapanmethee, Nuntavan Bunyapraphatsara
The Thai Journal of Pharmaceutical Sciences
Black pepper oil and its major components were investigated for the biological activities related to the prevention of AD. The inhibition of acetylcholinesterase (AChE) and β-amyloid aggregation, anti-inflammatory and antioxidant activities were examine...
Phytofabrication Of Silver Nanoparticles Using Horse Gram (Dolichos Biflorus L.) Seed Extract And Assessment Of Its Bactericidal And Antioxidant Activities,
2015
Chulalongkorn University
Phytofabrication Of Silver Nanoparticles Using Horse Gram (Dolichos Biflorus L.) Seed Extract And Assessment Of Its Bactericidal And Antioxidant Activities, Mahadevan Vijayalakshmi, Thangavel Rajagopal, Jeyachandran Vijayakumar, Ponnirul Ponmanickam
The Thai Journal of Pharmaceutical Sciences
The silver nanoparticles synthesized by phytofabrication method receive bigger attention due to their fascinating properties. This study deals with the green mediated synthesis of silver nanoparticles using seed extract of horse gram (Dolichos biflorus L...
Screening Of Patients Receiving Selegiline From Methamphetamine Abusers Using The Urinary Amphetamine/Methamphetamine Ratio,
2015
Chulalongkorn University
Screening Of Patients Receiving Selegiline From Methamphetamine Abusers Using The Urinary Amphetamine/Methamphetamine Ratio, Nunthika Kaewpunya, Wichian Tungtananuwat, Akravudh Viriyavejakul, Patramon Yongpanich, Nantana Thong-Ra-Ar, Chanchai Hosanguan, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
Methamphetamine (MA), the major metabolite of selegiline excreted in urine, can cause false positive interpretation of patient receiving selegiline as a MA user based on the routine non-chiral separation method. This study aims to compare the ratio of am...
Protein-Protein Docking And Molecular Dynamics Simulations Elucidated Binding Modes Of Fubi-P62 Uba Complex,
2015
Chulalongkorn University
Protein-Protein Docking And Molecular Dynamics Simulations Elucidated Binding Modes Of Fubi-P62 Uba Complex, Sumet Chongruchiroj, Panida Kongsawadworakul, Veena Nukoolkarn, Montree Jaturanpinyo, Wichit Nosoong-Noen, Jiraporn Chingunpitak, Jaturong Pratuangdejkul
The Thai Journal of Pharmaceutical Sciences
The cytosolic Fau protein, a precursor of antimicrobial peptide, composes of ubiquitin-like domain FUBI at Nterminus and ribosomal protein rpS30 at C-terminus. Fau has been important in killing of intracellular Mycobacterium tuberculosis infection throug...
In Silico Docking And Pharmacophoric Analysis Of 3-Indolyl Pyridine Derivatives Toward Cyclooxygenase-2,
2015
Chulalongkorn University
In Silico Docking And Pharmacophoric Analysis Of 3-Indolyl Pyridine Derivatives Toward Cyclooxygenase-2, Sukumar Bepary, Ge Hyeong Lee, Hee Jong Lim, In Kwon Youn
The Thai Journal of Pharmaceutical Sciences
A series of 3-indolyl pyridine derivatives having anti-inflammatory activities were docked into the indomethacin binding pocket of cyclooxygenase-2 enzyme. In this in silico study, the possible orientations of the molecules in the binding site of the rec...
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 1: Conditions Facilitating The Integration,
2015
Chulalongkorn University
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 1: Conditions Facilitating The Integration, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich
The Thai Journal of Pharmaceutical Sciences
The purpose of this study was to gain a greater understanding of the physicians’ experiences in the conditions facilitating physicians to integrate Thai traditional medicine (TTM) into their current practice. A qualitative grounded theory method was de...
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 2: Raising Consciousness, The Process Of Integration From Physicians' Experiences,
2015
Chulalongkorn University
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 2: Raising Consciousness, The Process Of Integration From Physicians' Experiences, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich
The Thai Journal of Pharmaceutical Sciences
The main purpose of the study was to gain deeper insight on physicians’ experiences in the integration process of Thai traditional medicine (TTM) into their practice. A grounded theory method was used to gain an understanding of the core process from p...
Hptlc Method For Simultaneous Estimation Of Ramipril And Losartan Potassium In Pharmaceutical Dosage Form: Development And Validation Consideration,
2015
Chulalongkorn University
Hptlc Method For Simultaneous Estimation Of Ramipril And Losartan Potassium In Pharmaceutical Dosage Form: Development And Validation Consideration, Darshana A. Parmar, Dinesh V. Thakkar, Rashmin B. Patel, Mrunali R. Patel
The Thai Journal of Pharmaceutical Sciences
This paper describes validated high-performance thin-layer chromatography (HPTLC) methods for simultaneous estimation of ramipril (RAM) and losartan potassium (LOS) in pure powder and formulation. The HPTLC separation was achieved on an aluminum-backed l...
