The Role Of Renal Replacement Therapy In The Management Of Pharmacologic Poisonings,
2016
University of Kentucky
The Role Of Renal Replacement Therapy In The Management Of Pharmacologic Poisonings, Aibek E. Mirrakhimov, Aram Barbaryan, Adam Gray, Taha Ayach
Internal Medicine Faculty Publications
Pharmacologic toxicities are common and range from mild to life-threatening. The aim of this study is to review and update the data on the role of renal replacement therapy (RRT) in the management of various pharmacologic poisonings. We aim to provide a focused review on the role of RRT in the management of pharmacological toxicities. Relevant publications were searched in MEDLINE with the following search terms alone or in combination: pharmacologic toxicity, hemodialysis, hemofiltration, renal replacement therapy, toxicology, poisonings, critical illness, and intensive care. The studies showed that a pharmacologic substance should meet several prerequisites to be deemed dialyzable. These …
Simple And Rapid Spectrophotometric Method For Quality Determination Of Roselle (Hibiscus Sabdariffa),
2016
Chulalongkorn University
Simple And Rapid Spectrophotometric Method For Quality Determination Of Roselle (Hibiscus Sabdariffa), Tasamaporn Sukwattanasinit, Jankana Burana-Osot, Uthai Sotanaphun
The Thai Journal of Pharmaceutical Sciences
A simple and rapid spectrophotometric method has been developed to determine the quality of roselle (Hibiscus sabdariffa). The absorbance at 530 nm (coloring intensity) and the ratio between the absorbances at 380 and 530 nm (degradation index) of its 5...
Exploration Of The Srx-Prx Axis As A Small-Molecule Target,
2016
University of Kentucky
Exploration Of The Srx-Prx Axis As A Small-Molecule Target, Murli Mishra
Theses and Dissertations--Toxicology and Cancer Biology
Lung cancer is a leading cause of cancer-related mortality irrespective of gender. The Sulfiredoxin (Srx) and Peroxiredoxin (Prx) are a group of thiol-based antioxidant proteins that plays an essential role in non-small cell lung cancer. Understanding the molecular characteristics of the Srx-Prx interaction may help design the strategies for future development of therapeutic tools. Based on existing literature and preliminary data from our lab, we hypothesized that the Srx plays a critical role in lung carcinogenesis and targeting the Srx-Prx axis or Srx alone may facilitate future development of targeted therapeutics for prevention and treatment of lung cancer. First, …
Structural Characterization And Therapeutic Utility Of The Proton-Coupled Folate Transporter,
2016
Wayne State University
Structural Characterization And Therapeutic Utility Of The Proton-Coupled Folate Transporter, Michael Roy Wilson
Wayne State University Dissertations
Folate is a B9 vitamin essential to DNA synthesis. The proton-coupled folate transporter (PCFT) is a newly discovered proton/folate symporter with an acidic pH optimum and broad expression across a variety of solid tumor types, with limited expression in normal tissues. Several antifolate molecules have been developed as cancer therapeutics, although these classical antifolates display numerous off-target effects due to transport by the ubiquitous reduced folate carrier (RFC). In this dissertation, we determine the roles of multiple PCFT structure/function domains, and develop PCFT-specific antifolates to target solid tumors. We utilize substituted cysteine accessibility methods (SCAM) to identify a novel reentrant …
Molecular Docking Study Of Tyrosinase Inhibitors Using Arguslab 4.0.1 : A Comparative Study,
2016
Chulalongkorn University
Molecular Docking Study Of Tyrosinase Inhibitors Using Arguslab 4.0.1 : A Comparative Study, Prasan Tangyuenyongwatana, Nathjanan Jongkon
The Thai Journal of Pharmaceutical Sciences
We conducted a docking study with ArgusLab 4.0.1, a free molecular docking software, on tyrosinase inhibitors comparing with AutoDock 4 and AutoDock VINA. In this study, hydroxyl substituted 2-phenyl-naphthalenes (a group of modified structure based on o...
Tlc-Densitometric Method For Quantitation Of Lurasidone Hydrochloride In Nanoemulsion, Microemulsion, For Equilibrium Solubility And Ex Vivo Diffusion Studies.,
2016
Chulalongkorn University
Tlc-Densitometric Method For Quantitation Of Lurasidone Hydrochloride In Nanoemulsion, Microemulsion, For Equilibrium Solubility And Ex Vivo Diffusion Studies., Rashmin B. Patel, Khyati B. Vekaria, Mrunali R. Patel
The Thai Journal of Pharmaceutical Sciences
A new TLC-densitometric method has been successfully developed for quantitation of Lurasidone hydrochloride (LURHA) in pharmaceutical formulations. LURHA was well separated from sample matrix and degradation product using TLC plate; precoated with silica...
Mucus Secretion Stimulation: A Mechanism In Gastroprotective Effect Of Zingiber Officinale,
2016
Chulalongkorn University
Mucus Secretion Stimulation: A Mechanism In Gastroprotective Effect Of Zingiber Officinale, Gaewbpragaan Chantharangsikul, Worawan Kitpati, Noppamas Soonthornchareonnon, Achariya Sailasuta, Arunporn Itharat, Wisuda Suvitayavat
The Thai Journal of Pharmaceutical Sciences
There are several studies on the gastroprotective effect of Z. officinale, however, the nature of this effect has not been fully elucidated. The present study investigated the gastroprotective activity and underlying mechanism of the 95% ethanolic extrac...
Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method,
2016
Chulalongkorn University
Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method, Pavena Kumnerdnon, Pornchai Rojsitthisak, Nuansri Niwattisaiwong, Uthai Sotanaphun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul
The Thai Journal of Pharmaceutical Sciences
The aim of the study was to develop a reversed phase-high performance liquid chromatography (RP-HPLC) analytical method for monitoring three analytical markers, gallic acid, vanillic acid and ferulic acid, in Phikud Navakot extract (NVK-E), using the sta...
Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles,
2016
Chulalongkorn University
Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles, Padala Narasimha Murthy, Meduri Vimala Devi, Sudhir Kumar Sahoo, Anjan Kumar Mahapatra, Madhusmruti Khandai
The Thai Journal of Pharmaceutical Sciences
Suspensions are one of the most important and popular dosage forms. A large number of drugs are formulated in the form of suspensions and are available commercially. Stability studies of suspensions are very important to enable the patient to receive t...
Herbs Used As A Cure For Rheumatiod Arthritis: A Review,
2016
Chulalongkorn University
Herbs Used As A Cure For Rheumatiod Arthritis: A Review, Santhosh Aruna Mamidi
The Thai Journal of Pharmaceutical Sciences
Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and interna...
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood,
2016
Chulalongkorn University
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood, Kannikar Chatsantiprapa, Tip-Arpa Sophon, Jintana Sattayasai
The Thai Journal of Pharmaceutical Sciences
BisphenolA (BPA), a monomer estrogenic chemical of many plastic products has controversial biological effects. This study assessed the effects at 0.05 mg/kg BW/day (Tolerable Daily Intake, TDI) and 0.5 mg/kg BW/day (10TDI), in male and female mice contin...
Outcomes Of Pharmaceutical Care Services In Promoting Rational Drug Use,
2016
Chulalongkorn University
Outcomes Of Pharmaceutical Care Services In Promoting Rational Drug Use, Wanna Sriviriyanupap, Roungtiva Muenpa
The Thai Journal of Pharmaceutical Sciences
Pharmacists provide pharmaceutical care service in order to support rational drug use. However, still lack of evidence to show its outcomes. Therefore, this cross-sectional descriptive study and qualitative study were conducted to evaluate the outcomes o...
Calotropis Procera: A Phytochemical And Pharmacological Review,
2016
Chulalongkorn University
Calotropis Procera: A Phytochemical And Pharmacological Review, Neelam Balekar
The Thai Journal of Pharmaceutical Sciences
Medicinal plants are used from the ancient time as the major sources of drugs.The fact is that we can obtain many of the presently available drugs, either directly in the extract form or in the modified synthetic form. Naturally, plants have ability to s...
Effect Of Fat Content On Characteristics Of Ice Cream Fortified With Calcium And Vitamin D3,
2016
Chulalongkorn University
Effect Of Fat Content On Characteristics Of Ice Cream Fortified With Calcium And Vitamin D3, Rossarin Tansawat
The Thai Journal of Pharmaceutical Sciences
Calcium and vitamin D play important roles in bone homeostasis. Several studies reported inadequate intakes of these two nutrients in many population groups. Food fortification is one way to solve the problem. The objective of this study was to develop...
Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises,
2016
Chulalongkorn University
Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises, Wattanapong Luechoowong, Ruangthip Tantipidoke, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Objective: This qualitative study is conducted to explore the knowledge acquisition techniques from five successful food enterprises at the new entry of community business. Methods: Five successful community food producers were purposively selected unde...
Stilbenoids From The Stem Of Diospyros Collinsae, The First Evidence For The Production Of Stilbene Derivatives In Ebenaceous Plants,
2016
Chulalongkorn University
Stilbenoids From The Stem Of Diospyros Collinsae, The First Evidence For The Production Of Stilbene Derivatives In Ebenaceous Plants, Buntita Bumroong, Witchuda Thanakijcharoenpath
The Thai Journal of Pharmaceutical Sciences
Two stilbenoids, diptoindonesin D (1) and diptoindonesin G (2), were isolated from the stem of Diospyros collinsae Craib (Ebenaceae), together with four triterpenoids, namely friedelin, lupeol, betulin and betulinic acid. Their structures were determined...
Exploring Key Factors Affecting The Competitiveness Of Thailand’S Cosmetic Industry,
2016
Chulalongkorn University
Exploring Key Factors Affecting The Competitiveness Of Thailand’S Cosmetic Industry, Neeranard Jinachai, Win Winit-Watjana, Puree Anantachoti
The Thai Journal of Pharmaceutical Sciences
The Thai cosmetic industry has continuously grown, but relevant factors impacting on the industry remained un-assessed. This study was intended to explore key factors affecting the country competitiveness. The Diamond model was adapted as the conceptual ...
Anaphylactic Shock Caused By A Selective Allergy To Ceftriaxone: A Case Report,
2016
Chulalongkorn University
Anaphylactic Shock Caused By A Selective Allergy To Ceftriaxone: A Case Report, Wichai Santimaleeworagun
The Thai Journal of Pharmaceutical Sciences
Ceftriaxone has been wildly used due to once daily dosing. However, case with anaphylaxis secondary to ceftriaxone has been documented and the other β-lactam might be caution. We reported an 89 year-old patient who had history of type I hypersensitivity...
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain,
2016
Chulalongkorn University
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri
The Thai Journal of Pharmaceutical Sciences
Objectives: Allium cepa has been used extensively for culinary purposes as well as in traditional system of medicine. A number of varieties of A. cepa are available commercially with varietal differences in phytoconstituents and biological activities. Ho...
Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets,
2016
Chulalongkorn University
Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets, Sateesh Kumar Vemula, Selamu Kebamo, Balisa Mosisa, Biniam Paulos
The Thai Journal of Pharmaceutical Sciences
An effort was made in the present study to prepare flurbiprofen matrix tablets to improve the therapeutic efficacy by increasing therapeutic drug concentrations in lower intestine i.e., site-specific release to colon. The current experiment was aimed to ...
