Brain Responses To Biological Motion Predict Treatment Outcome In Young Children With Autism,
2016
George Washington University
Brain Responses To Biological Motion Predict Treatment Outcome In Young Children With Autism, D. Yang, Kevin Pelphrey, D. Sukholdolsky, M. Crowley, E. Dayan, +6 Additional Authors
Pharmacology and Physiology Faculty Publications
Autism spectrum disorders (ASDs) are common yet complex neurodevelopmental disorders, characterized by social, communication and behavioral deficits. Behavioral interventions have shown favorable results—however, the promise of precision medicine in ASD is hampered by a lack of sensitive, objective neurobiological markers (neurobiomarkers) to identify subgroups of young children likely to respond to specific treatments. Such neurobiomarkers are essential because early childhood provides a sensitive window of opportunity for intervention, while unsuccessful intervention is costly to children, families and society. In young children with ASD, we show that functional magnetic resonance imaging-based stratification neurobiomarkers accurately predict responses to an evidence-based behavioral treatment—pivotal …
Sensory Hypo-Excitability In A Rat Model Of Fetal Development In Fragile X Syndrome,
2016
George Washington University
Sensory Hypo-Excitability In A Rat Model Of Fetal Development In Fragile X Syndrome, Julia Berzhanskaya, Marnie Phillips, Jing Shen, Matthew Colonnese
Pharmacology and Physiology Faculty Publications
Fragile X syndrome (FXS) is characterized by sensory hyper-sensitivity, and animal models suggest that neuronal hyper-excitability contributes to this phenotype. To understand how sensory dysfunction develops in FXS, we used the rat model (FMR-KO) to quantify the maturation of cortical visual responses from the onset of responsiveness prior to eye-opening, through age equivalents of human juveniles. Rather than hyper-excitability, visual responses before eye-opening had reduced spike rates and an absence of early gamma oscillations, a marker for normal thalamic function at this age. Despite early hypo-excitability, the developmental trajectory of visual responses in FMR-KO rats was normal, and showed the …
Effect Of Westernization On Oral Health Among College Students Of Udaipur City, India,
2016
Pacific Dental College and Hospital
Effect Of Westernization On Oral Health Among College Students Of Udaipur City, India, Piyush Pujara, Neeraj Sharma, Rujul Jayeshkumar Parikh, Maitri Shah, Shachi Parikh, Vivek Vadera, Manpreet Kaur, Isha Makkar, Mayur Parmar, Pratik Rupakar, Shrikant Patel
HPD Articles
BACKGROUND: There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health, especially in adults. The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City, Rajasthan. METHODS: A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City, Rajasthan, India, from March 2013 to May 2013. Eight hundred students were selected based on a two-stage random sampling procedure. Westernization was assessed by a …
Enhancing Access To Alcohol Use Disorder Pharmacotherapy And Treatment In Primary Care Settings: Adapt-Pc.,
2016
George Washington University
Enhancing Access To Alcohol Use Disorder Pharmacotherapy And Treatment In Primary Care Settings: Adapt-Pc., Hildi J Hagedorn, Randall Brown, Michael Dawes, Eric Dieperink, Donald Hugh Myrick, Elizabeth M Oliva, Todd H Wagner, Jennifer P. Wisdom, Alex H S Harris
Health Policy and Management Faculty Publications
BACKGROUND: Only 7.8 % of individuals meeting diagnostic criteria for alcohol use disorder (AUD) receive treatment in a given year. Most individuals with AUDs are identified in primary care (PC) settings and referred to substance use disorders (SUD) clinics; however, only a minority of those referred attend treatment services. Safe and effective pharmacological treatments for AUD exist, but they are rarely prescribed by PC providers. The objective of this study is to refine, implement, and evaluate an intervention to integrate pharmacological AUD treatment options into PC settings. This paper provides a detailed description of the intervention design and the evaluation …
Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors,
2016
Northern Michigan University
Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter
Journal Articles
The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug dis- crimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands …
Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells,
2016
Wayne State University
Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells, Asmita Pant
Wayne State University Dissertations
Non-alcoholic fatty liver disease is emerging as one of the most common liver disorders worldwide and is characterized by accumulation of triglycerides (TGs) in liver. The endogenous isoprenoid farnesol reduces hepatic TG levels in rodents, and this effect appears to involve at least two nuclear receptors, peroxisome proliferator-activated receptor α and farnesoid X receptor (FXR). However, farnesol’s effects on human hepatic lipid metabolism are currently unknown. The objective of this study is to evaluate how farnesol treatment would affect hepatic lipid accumulation and metabolism in a cellular model of human hepatic steatosis that was created by incubating the hepatocyte-like HepaRG …
Mucus Secretion Stimulation: A Mechanism In Gastroprotective Effect Of Zingiber Officinale,
2016
Chulalongkorn University
Mucus Secretion Stimulation: A Mechanism In Gastroprotective Effect Of Zingiber Officinale, Gaewbpragaan Chantharangsikul, Worawan Kitpati, Noppamas Soonthornchareonnon, Achariya Sailasuta, Arunporn Itharat, Wisuda Suvitayavat
The Thai Journal of Pharmaceutical Sciences
There are several studies on the gastroprotective effect of Z. officinale, however, the nature of this effect has not been fully elucidated. The present study investigated the gastroprotective activity and underlying mechanism of the 95% ethanolic extrac...
Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method,
2016
Chulalongkorn University
Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method, Pavena Kumnerdnon, Pornchai Rojsitthisak, Nuansri Niwattisaiwong, Uthai Sotanaphun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul
The Thai Journal of Pharmaceutical Sciences
The aim of the study was to develop a reversed phase-high performance liquid chromatography (RP-HPLC) analytical method for monitoring three analytical markers, gallic acid, vanillic acid and ferulic acid, in Phikud Navakot extract (NVK-E), using the sta...
Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles,
2016
Chulalongkorn University
Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles, Padala Narasimha Murthy, Meduri Vimala Devi, Sudhir Kumar Sahoo, Anjan Kumar Mahapatra, Madhusmruti Khandai
The Thai Journal of Pharmaceutical Sciences
Suspensions are one of the most important and popular dosage forms. A large number of drugs are formulated in the form of suspensions and are available commercially. Stability studies of suspensions are very important to enable the patient to receive t...
Herbs Used As A Cure For Rheumatiod Arthritis: A Review,
2016
Chulalongkorn University
Herbs Used As A Cure For Rheumatiod Arthritis: A Review, Santhosh Aruna Mamidi
The Thai Journal of Pharmaceutical Sciences
Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and interna...
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood,
2016
Chulalongkorn University
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood, Kannikar Chatsantiprapa, Tip-Arpa Sophon, Jintana Sattayasai
The Thai Journal of Pharmaceutical Sciences
BisphenolA (BPA), a monomer estrogenic chemical of many plastic products has controversial biological effects. This study assessed the effects at 0.05 mg/kg BW/day (Tolerable Daily Intake, TDI) and 0.5 mg/kg BW/day (10TDI), in male and female mice contin...
Outcomes Of Pharmaceutical Care Services In Promoting Rational Drug Use,
2016
Chulalongkorn University
Outcomes Of Pharmaceutical Care Services In Promoting Rational Drug Use, Wanna Sriviriyanupap, Roungtiva Muenpa
The Thai Journal of Pharmaceutical Sciences
Pharmacists provide pharmaceutical care service in order to support rational drug use. However, still lack of evidence to show its outcomes. Therefore, this cross-sectional descriptive study and qualitative study were conducted to evaluate the outcomes o...
Calotropis Procera: A Phytochemical And Pharmacological Review,
2016
Chulalongkorn University
Calotropis Procera: A Phytochemical And Pharmacological Review, Neelam Balekar
The Thai Journal of Pharmaceutical Sciences
Medicinal plants are used from the ancient time as the major sources of drugs.The fact is that we can obtain many of the presently available drugs, either directly in the extract form or in the modified synthetic form. Naturally, plants have ability to s...
Effect Of Fat Content On Characteristics Of Ice Cream Fortified With Calcium And Vitamin D3,
2016
Chulalongkorn University
Effect Of Fat Content On Characteristics Of Ice Cream Fortified With Calcium And Vitamin D3, Rossarin Tansawat
The Thai Journal of Pharmaceutical Sciences
Calcium and vitamin D play important roles in bone homeostasis. Several studies reported inadequate intakes of these two nutrients in many population groups. Food fortification is one way to solve the problem. The objective of this study was to develop...
Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises,
2016
Chulalongkorn University
Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises, Wattanapong Luechoowong, Ruangthip Tantipidoke, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Objective: This qualitative study is conducted to explore the knowledge acquisition techniques from five successful food enterprises at the new entry of community business. Methods: Five successful community food producers were purposively selected unde...
Stilbenoids From The Stem Of Diospyros Collinsae, The First Evidence For The Production Of Stilbene Derivatives In Ebenaceous Plants,
2016
Chulalongkorn University
Stilbenoids From The Stem Of Diospyros Collinsae, The First Evidence For The Production Of Stilbene Derivatives In Ebenaceous Plants, Buntita Bumroong, Witchuda Thanakijcharoenpath
The Thai Journal of Pharmaceutical Sciences
Two stilbenoids, diptoindonesin D (1) and diptoindonesin G (2), were isolated from the stem of Diospyros collinsae Craib (Ebenaceae), together with four triterpenoids, namely friedelin, lupeol, betulin and betulinic acid. Their structures were determined...
Exploring Key Factors Affecting The Competitiveness Of Thailand’S Cosmetic Industry,
2016
Chulalongkorn University
Exploring Key Factors Affecting The Competitiveness Of Thailand’S Cosmetic Industry, Neeranard Jinachai, Win Winit-Watjana, Puree Anantachoti
The Thai Journal of Pharmaceutical Sciences
The Thai cosmetic industry has continuously grown, but relevant factors impacting on the industry remained un-assessed. This study was intended to explore key factors affecting the country competitiveness. The Diamond model was adapted as the conceptual ...
Anaphylactic Shock Caused By A Selective Allergy To Ceftriaxone: A Case Report,
2016
Chulalongkorn University
Anaphylactic Shock Caused By A Selective Allergy To Ceftriaxone: A Case Report, Wichai Santimaleeworagun
The Thai Journal of Pharmaceutical Sciences
Ceftriaxone has been wildly used due to once daily dosing. However, case with anaphylaxis secondary to ceftriaxone has been documented and the other β-lactam might be caution. We reported an 89 year-old patient who had history of type I hypersensitivity...
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain,
2016
Chulalongkorn University
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri
The Thai Journal of Pharmaceutical Sciences
Objectives: Allium cepa has been used extensively for culinary purposes as well as in traditional system of medicine. A number of varieties of A. cepa are available commercially with varietal differences in phytoconstituents and biological activities. Ho...
Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets,
2016
Chulalongkorn University
Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets, Sateesh Kumar Vemula, Selamu Kebamo, Balisa Mosisa, Biniam Paulos
The Thai Journal of Pharmaceutical Sciences
An effort was made in the present study to prepare flurbiprofen matrix tablets to improve the therapeutic efficacy by increasing therapeutic drug concentrations in lower intestine i.e., site-specific release to colon. The current experiment was aimed to ...
