Pharmacology, Toxicology and Environmental Health Commons^™

Ecological Risk Assessment Should Be Value-Relevant But Not Value-Biased, Peter Calow, Valery E. Forbes

Valery Forbes Publications

To be useful in informing environmental management decisions, ecological risk assessments (ERAs) need to be expressed in value-relevant terms (USEPA 2009). Making decisions about accepting more or less ecological resources for more or less economic and social gain depends upon public values. ERAs have been criticized for not delivering value-relevant results and for therefore not being useful as a basis for management decisions (Gibbs 2010). We agree that ERAs need to be value-relevant, but we also must be explicit about what constitutes science and what constitutes values in this process. In a recent editorial, Backhaus et al. (2010) discuss the …

Using Photoactive Vitamin Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agents To Treat Chronic Wounds, Rahul A. Khanke

All Capstone Projects

The objective of the proposed study is to develop new materials and methods to manage microbial growth in chronic wounds using phototherapy. Chronic wounds are considered as a worldwide health problem. The most common chronic wounds can be classified into three categories: venous ulcers, diabetic ulcers, and pressure ulcers. Venous ulcers, which usually occur in the legs, account for about 70% to 90% of chronic wounds and can become infected easily. Venous ulcers are sores that develop after veins in the legs have been damaged. These ulcers can penetrate deeply into the skin. Occasionally, if a venous ulcer persists for …

Trace Metal Concentrations Across Trophic Levels In Cotton Fields Of Xinjiang Province, China, Jessica Quinn

All Student Theses and Dissertations

Trace metals become concentrated in urban and peri-urban soils with the use of agricultural practices and industrial emissions. Fertilizers, liming, sewage sludge, and irrigation water contain metals which accumulate in agricultural fields and pose a risk to humans and wildlife. Coal plants and brickyards release metals into the atmosphere which are deposited on soil and plant surfaces. This research quantifies the concentrations of nine trace metals in three different soil types. A total of 116 rodents were sampled in cotton fields and a desert. Cotton plants and triplicate soil samples were collected with each rodent capture. Soil samples were analyzed …

Tactical Research Fund – Asfb 2009 Workshop, Department Of Fisheries

Fisheries Occasional Publications

Biodiversity of aquatic ecosystems – What to measure and monitor for fisheries and ecosystem management FRDC Project No. 2008/353.

Morphological Analysis Based On A Fractional Dynamic Model For Hyphal Growth, Jonathan Blackledge, Dan Barry

Conference papers

The development of methods capable of accurately characterising the morphology of filamentous microbes represents a significant challenge to biotechnologists. This is because the productivity of many industrial fermentation processes is heavily dependent on the morphological form adopted by an organism. It is therefore of significant value if a quantitative model and associated metric(s) for morphological forms determined by complex phenotypes can be determined non-invasively, e.g. through image analysis. Specific interest is in the quantification of the branching behaviour of an organism. This is due to the link between branching frequency, biomass and metabolite production. In this paper we present a …

Curated Exhibit: Absolute Poison, Laura J. Hall

Posters and Presentations

The Absolute Poison exhibit, curated by Laura J. Hall, MFA, delved into the fascinating and deadly world of poisons. From the ancient Sumerian goddess Gula, to Shakespeare’s Hamlet, and the infamous cyanide-laced Tylenol case of 1982, poisons have long held a place in our collective imagination. The exhibit explored the history, symbolism, and cultural impact of poisons, featuring materials such as Albrecht Dürer’s Adam and Eve with its skull and crossbones motif symbolizing death. On display from September 2010 to August 2011 at the UNM Domenici Center, the exhibit examined how poisons have shaped narratives of danger and mystery. September …

Particle Size On Respiratory Protection Provided By Two Types Of N95 Respirators On Agricultural Settings, Jacob Cho Kyungmin, M. Susan Jones, Gordon Jones, Roy Mckay, Sergey A. Grinshpun, Alok Swivedi, Rakesh Shukla, Umesh Singh, Tiina Reponen

Nursing Faculty Publications

The objective of this study was to compare size-selective workplace protection factors (WPFs) of an N95 elastomeric respirator (ER) and an N95 filtering facepiece respirator (FFR) in agricultural environments. Twenty-five healthy farm workers ranging in age from 20 to 30 years voluntarily participated in the study. Altogether eight farms were included representing three different types: two horse farms, three pig barns, and three grain handling sites. Subjects wore the ER and FFR while performing their daily activities, such as spreading hay, feeding livestock, and shoveling. Aerosol concentrations in an optical particle size range of 0.7–10 µm were determined simultaneously inside …

Specific, Reversible Cytostatic Protection Of Normal Cells Against Negative Effects Of Chemotherapy, Benjamin B. Mull

Dissertations and Theses (Open Access)

Chemotherapy is a common and effective method to treat many forms of cancer. However, treatment of cancer with chemotherapy has severe side effects which often limit the doses of therapy administered. Because some cancer chemotherapeutics target proliferating cells and tissues, all dividing cells, whether normal or tumor, are affected. Cell culture studies have demonstrated that UCN-01 is able to reversibly and selectively arrest normal dividing cells; tumor cells lines do not undergo this temporary arrest. Following UCN-01 treatment, normal cells displayed a 50-fold increase in IC50 for camptothecin; tumor cells showed no such increased tolerance.

We have examined the response …

Chloroacetamid Spray Drift And Leaf Tatters In Hackberry, Ariana P. Miller

School of Natural Resources: Dissertations, Theses, and Student Research

During the last decade, leaf tatters has been reported in white oak and hackberry across several Midwestern states. Herbicide spray drift studies have shown that chloroacetamides can induce leaf tatters. The objectives of this research were to: 1) identify vulnerable bud developmental stages in hackberry and 2) determine if different commercial chloroacetamides affect severity of leaf tatters. In 2008, a preliminary spray drift experiment was conducted on mature trees from a former hackberry provenance test stand. Acetochlor (Harness), S-metolachlor (Dual II Magnum), and dimethenamid (Outlook) were applied at concentrations approximating 27%, 54%, 81%, or 108% of the recommended field rate. …

Hiv And Hepatocellular And Esophageal Carcinomas Related To Consumption Of Mycotoxin-Prone Foods In Sub-Saharan Africa, Jonathan H. Williams, Jessica A. Grubbs, Jerry W. Davis, Jia-Sheng Wang, Pauline E. Jolly, Nii-Ayi Ankrah, William O. Ellis, Evans Afriyie-Gyawu, Natalie M. Johnson, Abraham G. Robinson, Timothy D. Phillips

Environmental Health Sciences: Faculty Publications

Background: Promotion of the HIV epidemic by aflatoxin is postulated but not yet established. Sub-Saharan populations commonly consume food contaminated by mycotoxins, particularly aflatoxins (predominantly found in peanut, maize, rice, and cassava) and fumonisins, which occur primarily in maize. Aflatoxin promotes hepatocellular cancer, and fumonisin may promote esophageal cancer.

Objectives: This analysis was undertaken to test the hypotheses that consumption of mycotoxin-prone staple foods is 1) related to the incidence of HIV infection in Africa and 2) related to “signature” cancer rates confirming exposure to aflatoxins and fumonisins.

Design: World Health Organization data for causes of death and the Food …

A Comparative Study Of Three Growing Media And Four Plant Groups Under Extensive Green Roof Conditions In San Luis Obispo, Ca, Todd Alan Nelson

Master's Theses

ABSTRACT A Comparative Study of Three Growing Media and Four Plant Groups Under Extensive Green Roof Conditions in San Luis Obispo, California Todd A. Nelson Green roof growing media and plant species are critical factors when deciding on the best materials for a project. Growing media must be chosen in accordance with load bearing capacities of structures and water requirements of the plant material. Plant species must be able to thrive in the climate of the green roof and withstand a green roof’s harsh environment. The objectives of this research were: (1) to determine which of three extensive green roof …

Analysis Of Anthropogenic Effects On Topsoil Throughout The California Polytechnic State University Campus In San Luis Obispo, Brooke L. Hamilton

Earth and Soil Sciences

Soils reflect the health of a landscape, and in many cases carry the burden of anthropogenic activity, continually changing in characteristics such as pH, soil texture, soil structure, carbon:nitrogen ratios (C:N), and chemical composition. In a study sampling six different soils on the California Polytechnic State University campus in San Luis Obispo, these five soil characteristics were tested for and the results were determined. Soil samples consist of the top 5-10 cm of soil profiles, with sample sites varying according to degree of human contact; the locations the samples were taken from are as follows: (1) Walters Creek Ranch pasture, …

Hypoxia And Fetal Programming Of Cardiovascular Dysfunction, Qin Xue

Loma Linda University Electronic Theses, Dissertations & Projects

Human epidemiological studies have shown a clear association of adverse intrauterine environment and an increased risk of ischemic heart disease in later adult life. Of all the stresses to which the fetus is subjected, perhaps the most important and clinically relevant is that of hypoxia. The goal of this project is to test the hypothesis that chronic hypoxia during gestation adversely affects fetal cardiovascular development and impairs cardiac function in offspring. In the first part of project, we tested the hypothesis that chronic hypoxia adversely regulates contractility of fetal pulmonary arteries and veins in sheep residing at high altitude (3,801 …

Poisonous Rangeland Plants In San Luis Obispo County, Sara Litten, Amanda Ou

Animal Science

Poisonous Rangeland Plants in San Luis Obispo County is a comprehensive educational guide to rangeland plants that are toxic to domestic livestock. This guide begins with an exploration of how the biological systems are affected by the poisonous plant toxins. The biochemistry behind these toxins is included in the discussion. Next, reference material for fourteen plants that inhabit San Luis Obispo County is provided. This information includes specific toxins found in poisonous plants, affected animals, symptoms of poisoning, stages of growth, lethal dose, and distribution of the plant in California. This section of the guide is filled with helpful photos …

Quantifying Legacy Effects Of Managed Disturbance On Sagebrush Steppe Resilience And Diversity, Julie Ripplinger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Land-use legacies can affect landscapes for decades to millennia. A long history of shrub management exists in the sagebrush steppe of the Intermountain West where shrub-removal treatments, a type of managed disturbance, have been implemented for over 50 years to reduce sagebrush cover. The assumption behind managed disturbances is that they will increase forage for domestic livestock and improve wildlife habitat. However, the long-term effects of managed disturbance on plant community composition and diversity are not well understood. We investigated the legacy effects of three common types of managed disturbance (chemical, fire, and mechanical treatments) on plant community diversity and …

Xenoestrogen-Specific Mechanisms Of Developmental Reprogramming Correlate With Gene Expression And Tumor Development, Kristen L. Greathouse

Dissertations and Theses (Open Access)

Environmental exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental reprogramming. We have shown that neonatal exposure to the xenoestrogen diethylstilbestrol (DES) can developmentally reprogram the reproductive tract in genetically susceptible Eker rats giving rise to complete penetrance of uterine leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the mechanism that is responsible for the developmental reprogramming of gene expression was through …

Effects Of Long-Term Pioglitazone Treatment On Peripheral And Central Markers Of Aging, Eric M. Blalock, Jeremiah T. Phelps, Tristano Pancani, James L. Searcy, Katie L. Anderson, John C. Gant, Jelena Popovic, Margarita G. Avdiushko, Don A. Cohen, Kuey-Chu Chen, Nada M. Porter, Olivier Thibault

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. While TZD's actions in AD models help to elucidate the mechanisms underlying their potentially beneficial effects in AD patients, little is known about the functional consequences of TZDs in animal models of normal aging. Because aging is a common risk factor for both AD and …

Adaptivearc And The Future Of The Energy Industry, Trevor Chase

Earth and Soil Sciences

No abstract provided.

A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, Jacqueline Florette Jackson

Health Services Research Dissertations

Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern Africa, Egypt, Saudi Arabia, Yemen and Madagascar, proving it to be a virus able to invade ecologically diverse regions (Gaff, 2007). The potential introduction of Rift Valley fever into the United States suggests the potential for human infection and major economic disruption. It is important to understand the role environmental variables have played in historical outbreaks …

Verapamil Inhibits The Glucose Transport Activity Of Glut1, Larry L. Louters, Nathan Stehouwer, Janelle Rekman, Andrew Tidball

University Faculty Publications and Creative Works

Calcium channel blocker toxicity has been associated with marked hyperglycemia responsive only to high-dose insulin therapy. The exact mechanism(s) of this induced hyperglycemia has not been clearly delineated. The glucose transporter GLUT1 is expressed in a wide variety of cell types and is largely responsible for a basal level of glucose transport. GLUT1 also is activated by cell stress. The specific purpose of this study was to investigate the effects of the calcium channel blocker verapamil on the glucose uptake activity of GLUT1 in L929 fibroblasts cells. Dose-dependent effects of verapamil on glucose uptake were studied using L929 fibroblast cells …