Pharmacology, Toxicology and Environmental Health Commons^™

Tissue Specific Effects Of Adipose Stem Cells (Asc) In A Melanoma Tumor Environment, Drew Michael Nedderman

Browse all Theses and Dissertations

This study determined the tissue-specific effect of adipose stem cells (ASC) within a melanoma environment for development of a cell-based melanoma therapy. Analysis included a subcutaneous B16-F1 melanoma model using thirty-one C57BL/6 wild-type mice. Melanoma xenografts were treated with cell-based therapies of CFDA-SE-labeled human fibroblasts HF20x (control), non-differentiated ndASC or hematopoietic-differentiated HdASC. No tumor regression was observed in presence of cell-based therapies, thus, the HdASC group demonstrated an increase in tumor growth accompanied with an up-regulated macrophage response, and increased angiogenesis. In addition, this group demonstrated a decrease in Melan-A tumor marker and interferon-γ expression suggesting that ASC-supported tumor angiogenesis …

Perubahan Tahap Kerintangan Dalam Nyamuk Culex Quinquefasciatus, Aedes Aegypti Dan Aedes Albopictus Terhadap Insektisid Malathion, Permethrin Dan Temephos., Hidayati Hamdan

Student Works (2010-2019)

In this study, selective pressure bioassay test against malathion, permethrin and temephos had been carried out at the larval stage of Cx. quinquefasciatus, Ae. aegypti and Ae. albopictus. Meanwhile, only selection pressure against malathion and permethrin was taken for the adults. The rate of resistance had reduce 52.68 and 13,130 fold in the malathion and permethrin strains of Cx. quinquefasciatus larvae while for the adults, a reduction of 6.14 and 10.37 fold had been observed. A reduction of 4.97, 64.16 dan 51.0 fold had been observed for the Ae. aegypti larvae while 2.74 and 4.48 fold in their adults. Treatment …

Special 301 And Access To Medicine In The Obama Administration, Sean Flynn

Scholarly Articles in Law Reviews & Journals

I. Introduction

This article examines the history and current use of the Special 301 program to restrict access to generic medicines in developing countries, specifically the 2009 and 2010 reports released under the Obama Administration. The news for access to medicines advocates is not good overall. Both reports continue the previous Administration’s policies of using Special 301 to promote Trade-Related Aspects of Intellectual Property Rights (“TRIPS”) policies (“TRIPS-plus”) endangering access to medicines for millions of people worldwide. These policies violate not only the Obama Administration’s pledges to promote access to affordable medications in developing countries, but also U.S. commitments under …

Antidepressant Stimulation Of Cdp-Diacylglycerol Synthesis Does Not Require Monoamine Reuptake Inhibition, Ashiwel S. Undieh, Marwa A. Aboukhatwa

Publications and Research

Background: Recent studies demonstrate that diverse antidepressant agents increase the cellular production of the nucleolipid CDP-diacylglycerol and its synthetic derivative, phosphatidylinositol, in depression-relevant brain regions. Pharmacological blockade of downstream phosphatidylinositide signaling disrupted the behavioral antidepressant effects in rats. However, the nucleolipid responses were resistant to inhibition by serotonin receptor antagonists, even though antidepressant-facilitated inositol phosphate accumulation was blocked. Could the neurochemical effects be additional to the known effects of the drugs on monoamine transmitter transporters? To examine this question, we tested selected agents in serotonin-depleted brain tissues, in PC12 cells devoid of serotonin transporters, and on the enzymatic activity of …

Biopharmaceuticals: An Overview, Bhupinder Singh Sekhon

The Thai Journal of Pharmaceutical Sciences

Biopharmaceuticals drugs structurally mimics compounds found within the body and are produced using biotechnologies. These have the potential to cure diseases rather than merely treat symptoms, and have fewer side effects because of their specificity, fo...

Antitumour Activities Of Some Schiff Bases Derived From Benzoin, Salicylaldéhyde, Amino Phenol And 2,4 Dinitrophenyl Hydrazine, M. Jesmin, M.M. Ali, J.A. Khanam

The Thai Journal of Pharmaceutical Sciences

Three schiff bases PDH [N-(1-phenyl-2-hydroxy-2phenyl ethyledine)-2', 4' dinitrophenyl hydrazine], PHP [N-(1 -phenyl, 2-hydroxy-2-phenyl ethylidine)-2' hydroxy phenyl imine] and HHP [N-(2-hydroxy benzylidine)-2' hydroxy phenyl imine] have been studied ag...

Antioxidant And Neuroprotective Effects Of Standardized Extracts Of Mangifera Indica Leaf, Kanistha Kawpoomhae, Monrudee Sukma, Tanasait Ngawhirunpat, Praneet Opanasopit, Areerut Sripattanaporn

The Thai Journal of Pharmaceutical Sciences

Standardized methanol and aqueous extracts of Mangifera indica L. (mango) leaf were analyzed for antioxidant and neuroprotective activities. Antioxidant activities were evaluated by 2, 2-azinobis 3-ethylbenzothiazoline 6-sulfonate (ABTS), 1,1-diphenyl-2-...

Conjugation Of Some Nsaids With 5-Phenyl-2-Aminothiazole For Reduced Ulcerogenicity, Abhilasha Verma, Nirupam Das, Meenakshi Dhanawat, Sushant K. Shrivastava

The Thai Journal of Pharmaceutical Sciences

Analgesic drugs containing free acidic group were reacted with N, N' carbonyldiimidazole to prepare the acylimidazole derivatives. They were further reacted with 5-phenyl-2-amino thiazole nucleus to obtain the corresponding amides. All the compounds were...

Comparative Study Of Extraction, Purification And Estimation Of Bromelain From Stem And Fruit Of Pineapple Plant, S. S. Gautam, S. K., V. Dash, Amit K. Goyal, G. Rath

The Thai Journal of Pharmaceutical Sciences

Bromelain is a major proteinase, isolated from pineapple (Ananas comosus). In the plant, bromelain is accumulated in the entire plant to different extent and properties depending on its source. The objective of present study was to compare the amount and...

Patients’ Opinion And Practice Toward Unused Medication Disposal In Malaysia : A Qualitative Study, Redhwan Ahmed Al-Naggar, Adel Alareefi

The Thai Journal of Pharmaceutical Sciences

This study was conducted to explore the opinion and practice toward disposal of unused medication among patients in Malaysia. An in-depth interview conducted during the period from December 2009 until February 2010. A total of 28 patients participated in...

Anticonvulsant Activity Of Methanolic Extract Of Clerodendron Infortunatum Linn, In Swiss Albino Mice, Sudipta Das, Pallab K., Goutam Pramanik, Siva P. Panda, Samit Bera

The Thai Journal of Pharmaceutical Sciences

The present study was designed to investigate the anticonvulsant and sleep potentiation effect of methanolic extract of C lerodendron info rtun atum Linn. (MECI) leaves in Swiss albino mice. The anticonvulsant effect of the MECI (250, 500 mg/kg body weig...

Use Of Charge Transfer Complexation Reaction For The Spectrophotometric Determination Of Bupropion In Pharmaceuticals And Spiked Human Urine, Kanakapura Basavaiah, Sameer A. M.

The Thai Journal of Pharmaceutical Sciences

This is the first report on use of two visible spectrophotometric methods for the determination of bupropion hydrochloride (BUPH) in pharmaceuticals and spiked human urine. Bupropion is a second-generation antidepressant agent which is also used in the m...

Sensitive Ultraviolet Spectrophotometric Determination Of Quetiapine Fumarate In Pharmaceuticals, K. Basavaiah, N. Rajendraprasad, P.J. Ramesh, K.B. Vinay

The Thai Journal of Pharmaceutical Sciences

Quetiapine fumarate (QTF) is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives indicated for the treatment of schizophrenia. It is a selective monoaminergic antagonist with high affinity for the serotonin type 2 (5HT2), an...

Synthesis And Evaluation Of Azetidinone Analogues Of Combretastatin A-4 As Tubulin Targeting Agents, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Orla Bergin, Seema M. Nathwani, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan

Articles

The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds are also substituted at position 3 of the β-lactam ring with an aryl ring. A number of analogues showed potent nanomolar activity in human MCF-7 and MDA-MB-231 breast cancer cell lines, displayed in vitro inhibition of tubulin polymerization and did not cause significant cytotoxicity in normal murine breast epithelial cells. 4-(4-Methoxyaryl)-substituted compound 32, 4-(3-hydroxy-4-methoxyaryl)-substituted compounds 35 and 41 and …