Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms,
2014
University of Kentucky
Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms, Bradley J. Newsome
Theses and Dissertations--Chemistry
Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) pose significant health risks and enduring remediation challenges. Engineered nanoparticles (NPs) provide a novel platform for sensing/remediation of these toxicants, in addition to the growing use of NPs in many industrial and biomedical applications, but there remains concern for their potential long-term health effects. Research highlighted herein also represents a transdisciplinary approach to address human health challenges associated with exposure to PCBs and NPs. The objectives of this dissertation research are two-fold, 1) to develop effective methods for capture/sensing and remediation …
Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation,
2014
Chulalongkorn University
Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn
The Thai Journal of Pharmaceutical Sciences
Hemin (iron (III)-protoporphyrin IX) is found that it is elevated in the plasma of thalassemic patients and is a possible cause of oxidative stress-promoting atherosclerosis. Deferiprone (L1), an iron chelator, can prevent free radical formation catalyze...
Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine,
2014
Chulalongkorn University
Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers
The Thai Journal of Pharmaceutical Sciences
Modifications on C8 position of purine base have been studied for their effects on B-DNA to Z-DNA conversion. The 8-bromo and 8-carboxyphenyl adduct are among the most potent Z-DNA facil tators and hence arc aimed to be utilized for Z-DNA based probe lor...
Federal V. State Effectiveness: An Analysis Of The Endangered Species Act And Current Potential Attempts At Reform,
2014
Pepperdine University
Federal V. State Effectiveness: An Analysis Of The Endangered Species Act And Current Potential Attempts At Reform, Nicholas Primo
Pepperdine Policy Review
In November 2013, several Congressional leaders drafted a new bill to reform the Endangered Species Act of 1973 (ESA). While the Endangered Species Management Self-Determination Act (ESMSDA) was the first major attempt at updating the crucial U.S. environmental policy in decades, it also inflamed environmentalist defenders of the original bill. More importantly, it raised several questions as to whether state or federal-oriented approaches to endangered species protection and environmental policy more broadly is ultimately more effective. This article analyzes the original 1973 ESA, followed by an analysis of the ESMSDA currently being considered. It will discuss the various strengths and …
Non-Additive Toxicity Of Bi-Metal Mixtures To Fathead Minnows,
2014
Loyola University Chicago
Non-Additive Toxicity Of Bi-Metal Mixtures To Fathead Minnows, Natalie Rae Lynch
Master's Theses
Much research has been conducted to assess the toxicity of metals to aquatic organisms. Most of the research has focused on the toxicity of individual metals. Recently, attention has been paid to metal mixture toxicity because metals are usually present as mixtures in contaminated environments. The literature review indicates that metal mixtures may be additive, synergistic, or antagonistic to freshwater species. However, the data is not consistent and is dependent on the metal and organisms. The goal of this research is to use a systematic experimental design to characterize the toxicity of Cu, Zn, Cd and Ni mixtures to Pimephales …
The Performance Of Simple Artificial Floating Wetland Communities And Their Effects On Aquatic Nutrient Levels And Algal Abundance,
2014
University of North Florida
The Performance Of Simple Artificial Floating Wetland Communities And Their Effects On Aquatic Nutrient Levels And Algal Abundance, Bradley L. Sleeth
UNF Graduate Theses and Dissertations
Harmful algal blooms are exponential increases in autotrophic microorganisms that proliferate in such a way that the surrounding environment, the local economy and the health of regional populations are negatively affected. Among the causes of these blooms are anthropogenic inputs of excess nitrogen and phosphorus into the environment through overfertilization. Floating treatment wetlands (FTW) have emerged as a novel method of reducing the negative impacts of these nutrient inputs by using artificial rafts to float normally emergent wetland plants on the surface of water bodies to assimilate excess nutrients. Because their use is so new, only limited research has been …
Comparative Study Of Postmortem Blood, Urine And Vitreous Humor Methamphetamine,
2014
Chulalongkorn University
Comparative Study Of Postmortem Blood, Urine And Vitreous Humor Methamphetamine, Rungtip Narapanyakul, Wichian Tungtananuwat, Patramon Yongpanich, Theerin Sinchai, Nantana Thong-Ra-Ar, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
Methamphetamine (MA) is a highly addictive and toxic central nervous system stimulant. Urine samples are used as evidences of MA abuse under the Narcotics Laws, whereas blood samples are specimens for investigation of MA poisoning. However, both specimen...
Evaluation Of Antioxidant And Free Radical Scavenging Activities Of Different Fractions Of Pterospermum Suberifolium Leaf Extract,
2014
Chulalongkorn University
Evaluation Of Antioxidant And Free Radical Scavenging Activities Of Different Fractions Of Pterospermum Suberifolium Leaf Extract, Dibyajyoti Saha, Swati Paul
The Thai Journal of Pharmaceutical Sciences
The study was aimed an evaluating the antioxidant activities of the various leaf extracts (ethyl acetate, n- butanol and chloroform) of Pterospermum suberifolium by using various in vitro antioxidant assays. The total polyphenols were also determined spe...
Determination Of Retinol And Alpha-Tocopherol In Avocado Nanoemulsion With Monolithic Column,
2014
Chulalongkorn University
Determination Of Retinol And Alpha-Tocopherol In Avocado Nanoemulsion With Monolithic Column, Wisanu Thongchai
The Thai Journal of Pharmaceutical Sciences
A high performance liquid chromatographic procedure was developed for separation of retinol and a-tocopherol from avocado oil. The extraction methods were studied to extract of oil from avocado sample. This method was developed and validated for various ...
A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration,
2014
Chulalongkorn University
A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration, Rohit. H. Khatri, Rashmin. B. Patel, Mrunali R. Patel
The Thai Journal of Pharmaceutical Sciences
This paper describes a validated high-performance liquid chromatographic (HPLC) method for simultaneous estimation of clindamycin (CLI) and adapalene (ADA) in pure powder and gel formulation. The HPLC separation was achieved on a Luna C18 (2) (250 x 4.6 ...
Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring,
2014
Chulalongkorn University
Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring, Jareerut Kongrit, Yotin Chinvarun, Nuansri Niwattisaiwong, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
This study aims to verify the correlation between serum and saliva topiramate concentrations in Thai patients with epilepsy. Twenty-six subjects were patients aged 17-56 years old who were under treatment with topiramate. Their blood and saliva samples w...
Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis,
2014
Chulalongkorn University
Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis, Jankana Burana-Osot, Panadda Phattanawasin, Sununta Srisopon, Praveen Kumar Ashok, Baokang Huang, Uthai Sotanaphun
The Thai Journal of Pharmaceutical Sciences
Kot-chula-lumpa is a crude drug of Thai traditional medicine for fever remedy. To authenticate its botanical origin, gas chromatogram of its non-polar constituents was analysed and compared with those of authentic samples by using chemometric tools. Fing...
Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients,
2014
Chulalongkorn University
Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients, Salinthip Aphichartphunkawee, Yotin Chinvarun, Pornpimol Kijsanayotin
The Thai Journal of Pharmaceutical Sciences
The aim of this study was to investigate the association of genetic variants in UGT1A6 19T>G, 541A>G and 552A>C together with non-genetic variant with VPA dose and plasma concentrations in Thai epileptic patients. Eighty four Thai epileptic patients who ...
Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization,
2014
Chulalongkorn University
Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization, Anjan Kumar Mahapatra, Supriya Samoju, Ruchita Kumari Patra, Padala Narasimha Murthy
The Thai Journal of Pharmaceutical Sciences
The study was aimed to improve solubility or dissolution characteristics of dronedarone hydrochloride by preparing its inclusion complexes (ICs) with ß-cyclodextrin (ß-CD) and hydroxypropyl ß-cyclodextrin (HP ß-CD). The phase solubility behavior of d...
Plant Produced Therapies For Ebola Infection,
2014
Chulalongkorn University
Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul
The Thai Journal of Pharmaceutical Sciences
Ebola virus (EBOV) causes severe haemorrhagic fever in humans with high fatality rate up to 90 %. There is currently no approved drug or vaccine for human use. and treatment relies almost exclusively co supportive therapy. However, there are several pote...
Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions,
2014
Chulalongkorn University
Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions, Isariya Techatanawat, Chutima Manamuti, Jaturavit Vattanarongkup, Polsak Teerawonganan, Ekawan Yoosakul, Wiwat Supasena, Bancha Chuasuwan, Piengthong Narakorn, Ponanee Puranaoti
The Thai Journal of Pharmaceutical Sciences
Abacavir is an antiretroviral drug that can be prescribed in single dose or in fixed-dose combination formulations to make adherence easier. Due to this advantage, a generic product of abacavir of GPO has been developed with lower price and would be bene...
Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration,
2014
Chulalongkorn University
Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami
The Thai Journal of Pharmaceutical Sciences
A simple, specific and robust stability indicating high performance liquid chromatographic (HPLC) method for estimation of bamifylline hydrochloride was developed and validated. Bamifylline hydrochloride was separated and quantitated on Inertsil ODS-3V c...
Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases,
2014
Chulalongkorn University
Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
Urine and blood samples are normally used to determine methamphetamine (MA) level in forensic and clinical toxicology for assessment of illicit MA use. In cases in which both samples are unavailable or contaminated, hair root has been proposed as an alte...
Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy,
2014
Chulalongkorn University
Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat
The Thai Journal of Pharmaceutical Sciences
Tree-Phon-Thad remedy is used as an antipyretic and anti-inflammatory agent by traditional practitioners in Thailand, and includes roots of Zingiber zerumbet (Kra-Thue), Zingiber montamum (Plai) and Cymbopogon nadus (Ta-Krai-Hom). In this study, the anti...
Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects,
2014
Chulalongkorn University
Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects, Kannikar Chatsantiprapa, Cameron Hurst, Kaewjai Thepsuthammarat, Nutcharee Thapunkaw, Wilaiwan Khrisanapant
The Thai Journal of Pharmaceutical Sciences
To investigate if chili consumption as a food ingredient in a fried rice meal would have any real acute pharmacological effects on autonomic nervous system (ANS) and metabolic system (MS), a randomized, cross-over, intervention trial was conducted in 33 ...
