Pharmacology, Toxicology and Environmental Health Commons^™

The Establishment Of A Fibroblastic Cell Line From Yellow Perch (Perca Flavescens) And Its Potential Applications In Toxicology, Katelin W. Spiteri

Theses and Dissertations (Comprehensive)

This thesis describes the establishment, characterization and potential toxicological applications of YPF5, a yellow perch cell line. YPF5 is a fibroblastic cell line derived from the caudal fin of yellow perch. This cell line has been maintained for over 2 years. Cultures have been passaged over 60 times, and successfully cryopreserved and thawed. YPF5 is grown at room temperature in Leibovitz-15 (L-15) media, supplemented with 10% fetal bovine serum and 3% penicillin-streptomycin. The origin of YPF5 has been confirmed as Perca flavescens through “DNA Barcoding” and reaffirmed through Karyotyping (2n = 48) as per literature reported karyology for percidae including …

Evaluation Of Analgesic Activity Of Hydroalcoholic Extract Of Ipomoea Staphylina, Soumyadeep Ghosh, M Firdous

The Thai Journal of Pharmaceutical Sciences

This study has been attempted to evaluate analgesic property of hydroalcoholic extract of leaves of Ipomoea staphylina. Analgesic activity was evaluated by abdominal writhing, formalin-induced paw licking method and Eddy's hot plate test in mice. The hyd...

In Silico Prediction Of Interaction Between Flavonoids Of Propolis Of Honey Bee And Anthrax Protective Antigen, Shahin Gavanji, Mohsen Doostmohammadi, Behrouz Larki

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to check the interaction between four ligands (Acacetin, Chrysin, Naringenin and Caffeic Acid Phenethyl Ester) and protective antigen. These ligands are the main flavonoids of propolis of honey. Bioinformatics checking was done ...

Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul

The Thai Journal of Pharmaceutical Sciences

Ebola virus (EBOV) causes severe haemorrhagic fever in humans with high fatality rate up to 90 %. There is currently no approved drug or vaccine for human use. and treatment relies almost exclusively co supportive therapy. However, there are several pote...

Synthesis And Biological Screening Of Some Thienyl And Phenyl Pyrazoline Derivatives As Antimalarial Agent, Abdu Tuha, Adnan A. Bekhit, Yimer Seid

The Thai Journal of Pharmaceutical Sciences

Malaria is a common parasitic disease of the developing world and drug resistance has hindered their efficient control. Pyrazole derivatives were synthesized using aldol condensation and subsequent cyclization reactions. The compounds were synthesized in...

Comparison Of Eight Published Models For Estimating Vancomycin Clearance From Creatinine Clearance In Thai Adult Patients, Aim-On Pradoo, Thitima Wattanavijitkul, Darunee Chotiprasitsakul, Duangchit Panomvana

The Thai Journal of Pharmaceutical Sciences

This prospective study was performed to determine the best published model for estimating vancomycin clearance from creatinine clearance (CLcr) in Thai adult patients with CLcr greater than or equal to 30 ml/min. Data from 36 adult patients, who were giv...

Molecular Mechanisms Of Chemotherapeutic Resistance In Lung Cancer, Piyaparisorn Wongvaranon, Varisa Pongrakhananon, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Lung cancer mortality is mainly due to the high rate of chemotherapeutic resistance frequently found in lung cancer patients. In order to develop the novel strategies for effective treatment, the molecular basis regarding adaptive machineries of lung can...

Comparative Study Of Postmortem Blood, Urine And Vitreous Humor Methamphetamine, Rungtip Narapanyakul, Wichian Tungtananuwat, Patramon Yongpanich, Theerin Sinchai, Nantana Thong-Ra-Ar, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Methamphetamine (MA) is a highly addictive and toxic central nervous system stimulant. Urine samples are used as evidences of MA abuse under the Narcotics Laws, whereas blood samples are specimens for investigation of MA poisoning. However, both specimen...

Understanding The Medication Experiences Of Thai Patients Attending A Medication Therapy Management Clinic, Phantipa Sakthong, Win Winit-Watjana, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

The study aimed to explore Thai patients' medication experiences in five domains, i.e., attitudes, understanding, expectations and wants, concerns, and convenience of medicine use. This cross-sectional descriptive study was carried out using a qualitativ...

Identification And Antimicrobial Activity Of Streptomyces Strains From Thai Mangrove Sediment, Wongsakorn Phongsopitanun, Khanit Suwanborirux, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Two actinomycete strains, D2-1 and D2-2, were isolated from mangrove sediment sample collected from Samut Song Kram province, Thailand. On the screening of antimicrobial activity, the crude extracts of fermentation broth of both strains exhibited activit...

Gigantol-Induced Apoptosis In Lung Cancer Cell Through Mitochondrial-Dependent Pathway, Sopanya Charoenrungruang, Pithi Chanvorachote, Boonchoo Sritularak, Varisa Pongrakhananon

The Thai Journal of Pharmaceutical Sciences

Lung cancer is identified as a major cause of cancer-related death. Death in this cancer associates with the acquisition of apoptosis avoidance mechanism. Apoptosis, a programmed cell death mechanism, plays an important role on normal cell development an...

Molecular Binding Modes Of Diarylheptanoids From Curcuma Comosa On The Er-Ss Receptor, Nathjanan Jongkon, Prasan Tangyuenyongwatana

The Thai Journal of Pharmaceutical Sciences

Curcuma comosa Roxb. is a medicinal plant that belongs to the Zingiberaceae family. The plant has been used in traditional Thai medicine for the treatment of postpartum uterine bleeding. The major compounds found in this plant are diarylheptanoids, which...

Balancing Accountability For Adverse Drug Reactions Under American Product Liability Law: Lessons For Thailand?, Sakda Thanitcul, Matthew Lim Braslow

The Thai Journal of Pharmaceutical Sciences

Drugs that are powerful enough to cure disease are powerful enough to do potential harm. This common saying among physicians is the central point of this paper. When harm to a patient does occur, the sense of society requires that where and when appropri...

Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami

The Thai Journal of Pharmaceutical Sciences

A simple, specific and robust stability indicating high performance liquid chromatographic (HPLC) method for estimation of bamifylline hydrochloride was developed and validated. Bamifylline hydrochloride was separated and quantitated on Inertsil ODS-3V c...

Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Urine and blood samples are normally used to determine methamphetamine (MA) level in forensic and clinical toxicology for assessment of illicit MA use. In cases in which both samples are unavailable or contaminated, hair root has been proposed as an alte...

Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat

The Thai Journal of Pharmaceutical Sciences

Tree-Phon-Thad remedy is used as an antipyretic and anti-inflammatory agent by traditional practitioners in Thailand, and includes roots of Zingiber zerumbet (Kra-Thue), Zingiber montamum (Plai) and Cymbopogon nadus (Ta-Krai-Hom). In this study, the anti...

Short-Term Safety And Efficacy Of Fish-Oil Emulsions On The Prevention Of Parenteral Nutrition-Associated Liver Disease In Surgical Neonates: A Randomized Controlled Trial, Jrarat Ariyawangso, Chankit Puttilerpong, Suntaree Ratanachu-Ek, Maitree Anuntkosol

The Thai Journal of Pharmaceutical Sciences

Surgical neonates requiring prolonged parenteral nutrition (PN) are at risk for parenteral nutrition-associated liver disease (PNALD) that contributes to an increase in morbidity and mortality in surgical infants. Current lipid emulsions used with neonat...

Investigation Of Pyrrolizidine Alkaloids In Foods Using Liquid Chromatography Mass Spectrometry, Caroline Griffin

Theses

Pyrrolizidine Alkaloids (PAs) are known plant toxins which can cause hepatic veno-occlusive disease (HVOD) in both humans and livestock when ingested. Although PAs are primarily known for their hepatotoxicity they also induce genotoxicity, carcinogenicity and pneumotoxicity. PAs are consumed through plants as food, for medicinal purposes, or as contaminants of agricultural crops. Aside from ingesting the plants directly PA exposure may occur through the consumption of honey produced by bees that visit PA-containing plants or by drinking milk produced by animals that have consumed PA-containing plants. Possible PA contamination in our food chain is a potential health risk.

To assess …

Effects Of Nanosilver And Silver Nitrate Exposure On Fathead Minnows (Pimephales Promelas) And Zebrafish (Danio Rerio), Adam D. Hawkins

Electronic Theses and Dissertations

Silver nanoparticles (AgNPs) due to their unique antimicrobial properties are among the most widely utilized nanoparticle. Because of the nature of the products that utilize AgNPs, environmental release of AgNPs is inevitable. At greatest risk is the aquatic ecosystem due to known toxicity of the Ag + ion to aquatic organisms. Our goal was to use two fish models, fathead minnows (Pimephales promelas; FHMs) and zebrafish ( Danio rerio; ZFs), to study the effects of AgNPs on gill histopathology, Na+/K+-ATPase immunoreactivity, mucus production, bioaccumulation, particle uptake characterization, gill gene expression, and lethality in varying water parameters in comparison to the …

Impact Of Zinc Oxide Nanoparticles On Green Pea Plant & Seed Quality And Effects On Physiological Traits Of Green Peas, Corn, And Zucchini By Silver Nanoparticles, Arnab Mukherjee

Open Access Theses & Dissertations

The production and use of numerous engineered nanomaterials (ENMs) have increased exponentially over the past decade. Nanoparticles (NPs), ENMs possessing diameter between 1-100 nm, (NPs), are widely used in many applications. Worldwide consumption of NPs has increased their possible release into the environment. This, in turn, has elevated the extent of the potential impacts of NP exposure to living and non-living organisms. This is why the assessment of the impact of NPs on different environmental components, especially on plants, the producer in the food web, has become a very important aspect of nano-ecotoxicology. However, studies focusing on phytotoxicity and effects …