Pharmacology, Toxicology and Environmental Health Commons^™

The International Scientific Association For Probiotics And Prebiotics (Isapp) Consensus Statement On The Definition And Scope Of Prebiotics, Glenn R. Gibson, Robert W. Hutkins, Mary Ellen Sanders, Susan L. Prescott, Raylene A. Reimer, Seppo J. Salminen, Karen Scott, Catherine Stanton, Kelly S. Swanson, Patrice D. Cani, Kristin Verbeke, Gregor Reid

Department of Food Science and Technology: Faculty Publications

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective …

A Multibiomarker Analysis Of Pollutant Effects On Atlantic Stingray Populations In Florida’S St. Johns River, John Whalen

UNF Graduate Theses and Dissertations

The goal of this study was to examine the potential health effects of organochlorine (OC) and polycyclic aromatic hydrocarbon (PAH) exposure on Atlantic stingray populations in Florida’s St. Johns River (SJR). Special emphasis was placed on identifying OC- and/or PAH-related effects in stingrays from areas of the lower (LSJR) and middle (MSJR) basins shown to possess elevated levels of these compounds, as well as characterizing baseline levels of pollutant exposure in the SJR shipping channel, which may be subjected to dredging in the near future, potentially resuspending and redistributing contaminated sediments and increasing pollutant-associated effects. To accomplish this, we measured …

Transferrin Receptor Targeted Delivery Of Sirna For Gene Therapy, Yuran Xie

Wayne State University Dissertations

Gene therapy is thought to be a solution for various difficult to treat diseases such as cancer. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence disease related gene have been exploit in different diseases. However, lack of safe and efficient siRNA delivery systems limits the application of siRNA therapy in clinic. Transferrin receptor (TfR) is an essential transmembrane receptor involved in iron uptake. TfR universally express in most cells/ tissues but upregulated in certain cells, for example, many cancer cells and activated T cells (ATCs). To overcome the biological barriers and increase siRNA delivery efficiency, in …

Protein Phosphatase 2a Interactions In Islet And Human Skeletal Muscle In Diabetes, Divyasri Damacharla

Wayne State University Dissertations

Type 2 Diabetes is a metabolic disorder associated with insulin resistance and consequent high blood glucose levels. Under normal conditions, in response to high blood glucose levels, pancreatic beta cells produce insulin. The secreted insulin is dis-tributed to tissues thereby stimulating insulin stimulated glucose uptake. However, maximum glucose disposal takes place in skeletal muscle. Thus, studying beta cells and skeletal muscle in respect to diabetes is crucial. Protein Phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases belonging to PhosphoProteinPhospha-tase (PPP) family. It constitutes about 80% of all serine/threonine phosphatases. It is regulated by numerous regulatory subunits as well …

Role Of Mitochondrial Beta-Oxidation In Ethanol Response: A Candidate Gene Study Using Caenorhabditis Elegans, Harini Pallikarana Tirumala

Theses and Dissertations

Alcohol use disorder (AUD) is the fourth leading cause of preventable death in the United States, and the fifth leading risk factor for premature death and disability, globally. There are currently very few treatment options for AUD and there is a need for effective preventive and treatment strategies for this condition. AUD risk has a significant hereditary component, with the contribution of genetic factors being estimated to be about 50%. The Davies-Bettinger laboratory uses C. elegans as a model organism to study the contribution of genetic factors in modulating neuronal responses to ethanol. In this project, we examined the role …

Knockout Of Sphingosine Kinase 1 Attenuates Renal Interstitial Fibrosis In Unilateral Ureteral Obstruction (Uuo) Model, Xiwen Zhang

Theses and Dissertations

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite and an important signaling molecule that plays a significant role in fibrosis. S1P synthesis is catalyzed by sphingosine kinases (SphKs), which phosphorylate sphingosine into S1P. The present study tested the hypothesis that SphK1-S1P signaling pathway participates in the kidney damage in unilateral ureteral obstruction (UUO) model. Wild type and SphK1 knockout mice were subjected to UUO for 7 days or 14 days and then four groups of kidneys were collected: wild type control group (WT-C), wild type UUO group (WT-UUO), SphK1-/- control group (KO-C) and SphK1-/- UUO group (KO-UUO). The mRNA level of …

Systematic Extraction And Characterization Of ?-Glucan From The Industrial Brewing Yeast (Saccharomyces Cerevisiae) Waste Material And The Immunomodulatory Studies On Tnf-? And Il-6 Cytokine Balance Of The Mouse Macrophage Cell Lines, Theeraya Krisdaphong

The Thai Journal of Pharmaceutical Sciences

Objectives: The aim of this investigation was to create value to the industrial waste production by systematic extraction and purification of ?-glucan from the industrial brewing yeast (Saccharomyces cerevisiae) waste material. In addition, the immunolo..

Extra Precision Docking Studies Of Novel Luteolin Analogues For The Inhibition Of Tankyrase Ii- “A Theoretical Based Approach Towards Novel Cancer Target, Aravinda Pai, Jayashree B.S., Sanchari Basu-Mallik, Richard Lobo

The Thai Journal of Pharmaceutical Sciences

Luteolin, a natural bio-flavonoid is known to possess variety of pharmacological activity, particularly tumour growth inhibition. Reports are available to substantiate the interaction of luteolin with Tankyrase II, one of the key enzymes responsible for .

Clinical Outcomes Of A Pharmaceutical Care Service In Lithium Clinic Adjunct To Standard Care Compared With Standard Care Alone In Patients With Bipolar Disorder: 10 Years Naturalistic Retrospective Cohort Study, Orabhorn Suanchang, Vithaya Kulsomboon, Yupadee Sirisinsuk, Norrawee Phoomchan, Charnwit Skawatananont

The Thai Journal of Pharmaceutical Sciences

Objective: To compare the long-term clinical outcomes of bipolar patients following lithium maintenance therapy between patients who received standard care plus pharmaceutical care service (lithium clinic group) and patients who received standard care al.

Isocratic Ultra-Performance Liquid Chromatographic Assay Of Quetiapine Fumarate In Pharmaceuticals, N Rajendra Prasad, Kanakapura Basavaiah

The Thai Journal of Pharmaceutical Sciences

An isocratic and reversed phase ultra-performance liquid chromatographic (RP-UPLC) method has been developed for the determination of quetiapine fumarate (QTF)) in bulk drug and in its tablets. The method was developed using AQUITY UPLC HSS T3 (2.1 x 50.

Stability-Indicating Method To Determine Bioactive Nucleosides In Crude Drugs, Extracts, And Products From Cordyceps Sinensis And Cordyceps Militaris, Boonta Chutvirasakul

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to develop a stability indicating method to determine bioactive nucleosides including uridine, guanosine, adenosine, and cordycepin in crude drugs, extracts, and products from Cordyceps Sinensis and Cordyceps Militaris by gradie.

A Medicines Terminology Governance Model For Thailand, Anuchai Theeraroungchaisri, Ratsapan Phuksaritanon, Boonchai Kijsanayotin

The Thai Journal of Pharmaceutical Sciences

At present, Thailand does not have a national governance system for developing a health data standard and coding system, especially drug codes and medicine terminology. There is no single responsible organization and also no mechanism for cooperation amo.

From Yosemite To A Global Market: How Patagonia, Inc. Has Created An Environmentally Sustainable And Socially Equitable Model Of Supply-Chain Management, Mary-Clare Bosco

Pomona Senior Theses

There is an urgent pressure of the time (2016) to re-evaluate our patterns of consumption to adapt to changing climates and reduce waste and pollution. Because an immediate restructuring of global production strategies is not likely any time soon, industrial innovators are finding new ways of redesigning supply-chain management in efforts to move towards environmentally sustainable business in which all manufacturing practices are transparent. Patagonia, Inc. is a testament to the often-debated question of economic value in green business practices, and this thesis acts as an outline as to how they arrived at such an impressive presence in the business …

Identification Of “Kratom” (Mitragyna Speciosa) Alkaloids In Commercially Available Products, Julia Grzymkowski, Michelle R. Peace, Justin Poklis

UROP Posters

“Kratom” is the common name for the botanical mitragyna speciosa. It is a tree native to Southeast Asia in which leaves contain the psychoactive alkaloids mitragynine and 7-hydroxymitragynine. Kratom is often ingested as teas, chewed, or smoked. It acts as a stimulant in small doses and as an opioid in large doses. Overdoses can result in vomiting, seizures, and death. Recently the Drug Enforcement Agency (DEA) placed Kratom on Schedule 1, but, due to public outcry, it was almost immediately removed.

Eleven kratom based products were obtained from various tobacco shops, “headshops” and via the internet including: Choice brand …

Dredging Land Reclamation Causing Mucus Development In Massive Spherical Corals In The Spratly Islands, South China Sea: The Effects On China’S Fishing Industry, Tiffany K. Ho

UROP Posters

Images from Asia Maritime Transparency Initiative depicted huge masses of white coral mucus secreted from coral reefs in the Spratly Islands of the South China Sea, an area where several land reclamation projects are occurring. The purpose of this research was to understand how increased sedimentation levels from the dredging land reclamation method affects mucus development in massive corals, such as Acropora, located in these reefs. Journal articles that focused on the biology of coral mucus, bacterial communities associated with coral tissue, mucus, and seawater, coral mortality from different environment impacts, coral coverage of reefs in Spratly Islands, and symbiotic …

Virtual Screening For Novel 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors: A Shape-Based Search Approach, Prasan Tangyuenyongwatana, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

A virtual screening study with ArgusLab 4.0.1 was performed on 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), the second enzyme in the methyl erythritol phosphate pathway in isoprenoids production which is present in malarial parasite Plasmodium .

Chemical Compositions And Repellent Activity Of Eucalyptus Tereticornis And Eucalyptus Deglupta Essential Oils Against Culex Quinquefasciatus Mosquito, Rini Pujiarti, Rini Pujiarti

The Thai Journal of Pharmaceutical Sciences

Eucalyptus oils have distinctive smell that not preferably by mosquito and able to repellent mosquito. This research was evaluated chemical compositions and repellent activity of Eucalyptus tereticornis and Eucalyptus deglupta oils against C. quinquefasc.

Time-Kill Study Of The In Vitro Antimicrobial Activity Of Tedizolid Against Methicillin-Resistant Staphylococcus Aureus, Tanawat Nunart, Tanitta Chatsuwan, Wanchai Treyaprasert

The Thai Journal of Pharmaceutical Sciences

To evaluate the in vitro antimicrobial activity of tedizolid against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) by time-kill curve experiments. Four bacterial strains were used in methicillin susceptibility tests, including M.

Effects Of Family Pharmacy Intervention On Clinical Outcomes In Primary Care Settings In Thailand, Wiwat Thavornwattanayong, Namfon Sribundit

The Thai Journal of Pharmaceutical Sciences

Background Despite pharmaceutical care had positive effect on improving patient health, currently data fact sheet illustrate slightly increasing of uncontrolled diabetes and uncontrolled hypertension among Thai elderly. Family pharmacist applied more ef..

Vanillin Increases Stem Cell Signal And Cell Adhesion In Keratinocytes, Supak Taboonpong, Chayanin Kiratipaiboon, Preeyaporn Plaimee Phiboonchaiyanan, Premjit Junthongjin, Pornlert Trithossadech, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Keratinocyte stem cells residing in the basal layer of the epidermis are thought to function in the process of the epidermis renewal and maintain the barrier property of the skin. This study has explored for the first time that vanillin, a natural compou.