Pharmacology, Toxicology and Environmental Health Commons^™

Paediatric Fixed Drug Eruption: A Case Report Of Ofloxacin As The Culprit, Ambika Nand Jha, Varsha Ratan Gaikwad, Rabia Alam, Shivanshu Sharma, Ashok Kumar Gupta

Chulalongkorn Medical Journal

Ofloxacin, a second-generation fluoroquinolone, is a relatively rare but documented cause of fixed drug eruption (FDE), a localized cutaneous hypersensitivity reaction marked by recurrent, well-demarcated erythematous patches or macules that may develop into blisters upon re-exposure to the offending agent. The underlying mechanism is immune-mediated, involving T-cell activation, cytokine release, and keratinocyte apoptosis. A 5-year-old boy weighing 15 kg was prescribed Ofloxacin syrup (7.5 ml twice daily) and Paracetamol suspension (5 ml twice daily) for suspected enteric fever. Within two days, he developed several annular erythematous lesions on his hands and back, associated with intense itching, raising suspicion of a …

A 12,800-Year-Old Layer With Cometary Dust, Microspherules, And Platinum Anomaly Recorded In Multiple Cores From Baffin Bay, Christopher R. Moore, Vladimir A. Tselmovich, Malcolm A. Lecompte, Allen West, Stephen J. Culver, David J. Mallinson, Mohammed Baalousha M.Sc, Ph.D., James P. Kennett, William M. Napier, Michael Bizimis, Victor Adedeji, Seth R. Sutton, Gunther Kleteschka, Kurt A. Langworthy, Jesus P. Perez, Timothy Witwer, Marc D. Young, Jordan Jeffreys, Richard C. Greenwood, James A. Malley

Faculty Publications

The Younger Dryas Impact Hypothesis (YDIH) posits that ~12,800 years ago Earth encountered the debris stream of a disintegrating comet, triggering hemisphere-wide airbursts, atmospheric dust loading, and the deposition of a distinctive suite of extraterrestrial (ET) impact proxies at the Younger Dryas Boundary (YDB). Until now, evidence supporting this hypothesis has come only from terrestrial sediment and ice-core records. Here we report the first discovery of similar impact-related proxies in ocean sediments from four marine cores in Baffin Bay that span the YDB layer at water depths of 0.5–2.4 km, minimizing the potential for modern contamination. Using scanning electron microscopy …

Comparative Expression Of Cgmp-Dependent Protein Kinase G (Pkg) From Plasmodium And Toxoplasma, Tsopmo Asaah

Theses, Dissertations and Culminating Projects

Malaria and Toxoplasmosis are life threatening diseases to humans. The search for a cure and control of these diseases is still one of the major challenges of scientists worldwide. In this research we focused on two Malaria species; Plasmodium bergei² (Pb) and Plasmodium falciparum¹ (Pf) and also on Toxoplasma gondii. Part of the life cycle of these organisms is regulated by the enzyme cyclic GMP-dependent protein kinase G (PKG)⁴. This is our drug target in this research. We believe that inhibiting this enzyme will be a great step in fighting these diseases. In this research, we devised a comparative study …

Analysis Of An Ethanol Sensitive Bmp-Nkx2.3-Fgf Signaling Pathway In Pouch Morphogenesis., Hieu Dai Le Vo

Electronic Theses and Dissertations

Craniofacial malformations lie at the heart of Fetal Alcohol Spectrum Disorders (FASD). While there is growing evidence for a genetic component to FASD, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in facial development. Bone Morphogenetic Protein (Bmp) signaling pathway dependent pouch formation is a key mechanism in facial development. We have previously shown that multiple Bmp mutants are sensitized to ethanol-induced facial defects. However, ethanol does not directly impact Bmp signaling. This suggests that downstream effectors, like nkx2.3 and Fibroblast Growth Factor (Fgf) signaling, may mediate the impact of ethanol on Bmp mutants. Here, I …

Mixture Effects On Metal Accumulation In The Asian Clam, Corbicula Fluminea, Mark A. Huff

Electronic Theses and Dissertations

Field collected Corbicula fluminea were exposed to trace level copper, lead, and zinc with the aim of examining the preferential accumulation between the soft tissue and shell. Metal levels were based on those in a permitted industrial effluent. At 1X effluent and 2X effluent exposure levels, copper was found to preferentially accumulate in the clam soft tissue, lead was found to preferentially accumulate in the clam shell, and zinc was found to excrete back into the diluent after preferentially accumulating in the clam soft tissue. When exposed as a mixture at 1X effluent levels, copper and lead were found to …

Impact Of S-Phase Kinase Protien 2 Blockades On Hematopoetic Stem Cell Metabolism, Nicole Elmaraghy

Electronic Theses, Projects, and Dissertations

Hematopoietic stem and progenitor cells (HSPCs) quiescence is vital for the success of bone marrow transplantation, as it preserves long term self- renewal and prevents premature exhaustion (Takubo et al., 2013; Wilson et al., 2008). However, bone marrow transplant (BMT) failure remains a clinical challenge, often due to lack of long-term engraftment and insufficient stress reliance. Both of these characteristics are tightly linked to disrupted stem cell quiescence and metabolic imbalance (Anso et al., 2017; Vannini et al., 2016). One key player is S-phase kinase protein (SKP2), an E3 ubiquitin ligase that targets cell cycle inhibitors, like p27, for proteosome …

Hierarchy In Sensation: Exploring The 40 Hz Auditory Steady State Synchrony In The Primary Auditory And Prefrontal Association Cortices, Deepshila Gautam

Electronic Theses and Dissertations

Auditory processing begins in the cochlea and ascends through brainstem relays to the cortex, where sound features with increasing complexity are encoded. The 40 Hz auditory steady-state response (ASSR) reflects induced gamma synchrony shaped by local cortical circuit dynamics. Disrupted 40 Hz ASSR is a consistent finding in schizophrenia, linked to N-methyl-D-aspartate receptor (NMDAR) hypofunction in inhibitory interneurons, making it a promising translational biomarker. While multiple ASSR generators have been identified, it is not known if these are redundant or represent unique activity. This dissertation investigates regional differences in 40 Hz ASSR across two principal generators: the primary auditory cortex …

3,5-Dihydroxy-4-Isopropylstilbene (Tapinarof) Is A Partial Aryl Hydrocarbon Receptor Agonist In Fish, Conner A. Dicks

All Theses

The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is essential in regulating development, immune homeostasis, and drug and xenobiotic metabolism. Activation of the AHR by specific ligands results in its translocation to the nucleus where it induces a myriad of gene products, including cytochrome P450 (CYP) drug metabolizing enzymes (e.g., CYP1A1) and other components of the chemical defensome, as well as inflammatory control. Interestingly, the AHR can bind a wide variety of endogenous and xenobiotic ligands which are able to induce unique downstream effects dependent on cell type, inflammatory context, and ligand stability. The AHR is …

From Rifles To Running Shoes: How Outdoor Recreation Trends Are Reshaping Conservation Efforts, Lane James Arthur

All Graduate Theses and Dissertations, Fall 2023 to Present

Parks and protected areas (PPAs) serve a dual purpose: they conserve wildlife and natural habitats while providing spaces for people to enjoy outdoor recreation. However, balancing conservation with recreation can be challenging, especially as outdoor activities continue to grow and evolve. In Utah, Wildlife Management Areas (WMAs) are set aside to protect important wildlife habitats and provide opportunities for hunting and fishing. Recently, these areas have seen an increase in activities such as mountain biking, trail running, and dog walking, some of which take place in areas which prohibit recreational activity in effort to protect wildlife. These shifts in recreation …

Methodology For Environmental Toxicology: Assessing Feeding And Rearing Strategies In Largemouth Bass (Micropterus Nigricans) Larvae, Amber Hitchins, Hannah Mcneese, Deise Cruz, Andrew Todd, Maria Sepúlveda, Tyler Hoskins

Discovery Undergraduate Interdisciplinary Research Internship

Poly- and perfluoroalkyl substances (PFAS) are an anthropogenic group of chemicals known for their persistence in the environment and their potential to bioaccumulate. PFAS can bioaccumulate in largemouth bass (Micropterus nigricans), yet the effects of exposure on bass larvae are unknown. While largemouth bass are commonly raised for aquaculture, techniques for rearing bass which enable controlled experiments at known densities, a necessity for toxicity studies, are poorly understood. Furthermore, the live prey typically used in existing approaches are not suitable for PFAS studies due to high background concentrations. The objective of this project was to assess different venues …

Mecanismos De Participación En Temas Ambientales En Colombia, Martha Rocío Castro Rodríguez, Felipe Ramírez Cortázar, Sara Milena Niño Montero

Ciencias Agropecuarias

Mecanismos de participación en temas ambientales en Colombia es un producto editorial, de divulgación y apropiación social del conocimiento, desarrollado en el proyecto de investigación “Participación política en ciudades de Colombia, Italia y Guatemala: un estudio mixto sobre su relación con la anomia y la autoeficacia política en jóvenes”, en el marco de la V convocatoria interna - periodo 2023-1 UCundinamarca Generación Siglo 21.

Hubungan Ketersediaan Fasilitas Jamban Sehat Di Rumah Tangga Terhadap Kejadian Diare Pada Balita Menurut Analisis Data Sdki Tahun 2017 Di Wilayah Pedesaan Papua, Edgina Dhafia Callista, Arina Qonita, Bonyca Verlina, Pratiwi Pamarta Endah Jatmika

Jurnal Nasional Kesehatan Lingkungan Global

Diarrhea is a disease that commonly affects toddlers and is one of the top causes of death among children aged 1–59 months. In pedesaan areas, diarrhea remains a serious public health issue, with recorded cases reaching as high as 17,811. Purpose of this study is to explore the relationship between the availability of healthy toilet facilities in households and the incidence of diarrhea among toddlers. The research used a cross-sectional study design, utilizing secondary data obtained from the 2017 Indonesian Demographic and Health Survey (SDKI). A total of 222 samples that met the predetermined inclusion criteria were selected through random …

Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung

Theses and Dissertations

Regulatory toxicology depends primarily on animal testing, which limits throughput, mechanistic interpretability, and applicability to human-relevant endpoints. This dissertation presents computational approaches that integrate publicly available bioactivity data with machine learning to support chemical safety evaluation. Oral carcinogenicity was modeled using curated chemicals from the US Environmental Protection Agency’s Integrated Risk Information System (IRIS) and activity data from over 1,900 PubChem assays. Quantitative structure-activity relationship (QSAR) models trained on statistically prioritized assays demonstrated strong predictive performance and were applied to rank the carcinogenic potential of more than 16,000 compounds. Hepatotoxicity was evaluated using a hybrid modeling approach that combined structural …

Effect Of Mercury Dose Variation On Growth And Nitrate Reductase Activity In Aquarius Palifolius (Nees & Mart.) Christenh. & Byng, Tsurayya Nurhanifah, Dwi Umi Siswanti

Makara Journal of Science

Mercury, a byproduct of mining, can harm the environment. One method to reduce this impact is through phytoremediation. This study used the Mexican sword (Aquarius palifolius), a plant with the potential to absorb and accumulate mercury. The aim of this study was to examine the effect of mercury stress on nitrate reductase activity, which plays a role in plant productivity, and to assess its impact on growth parameters, including plant height growth rate, leaf length, and number of leaves. Three-month-old A. palifolius plants obtained from rice fields in Sleman were treated with mercury at doses of 0, 14, …

Living Heritage, Resilience And Ethically Informed Infrastructures In Malawi, Martha B. Lerski, Frank Puluputu Mwale

Publications and Research

Rooted in a rural community’s needs, this paper explores how historically, and ethically informed infrastructures can support community engagement towards identification, documentation, and dissemination of local, traditional, and indigenous knowledge relating to climate change. The paper examines climate adaptation and sustainability issues through the lenses of community organizing and Library & Information Science best practices. It draws on a growing body of literature identifying a role for expanded epistemological and subject discipline perspectives. While the impacts of climate on material culture are increasingly recognized, intangible, and biocultural heritage have not received as much attention. Living heritage traditions and knowledge systems …

Utilization Of Bixin-Loaded Polycaprolactone Nanoparticles To Ameliorate E-Cigarette-Induced Damage To Human Bronchial Epithelial Cells, Sophia R. Claymore

USF Tampa Graduate Theses and Dissertations

Electronic cigarettes (e-cigs) have increased in popularity and usage over the last few decades. E-cigs are generally composed of a liquid containing nicotine flavoring chemicals, a battery, a vaporization chamber, and a coil that heats the liquid upon inhalation of the mouthpiece. E-cigs were initially introduced as a healthy alternative to cigarette smoking. However, recent research has demonstrated that e-cigs elicit comparable cytotoxic and dangerous effects to conventional cigarettes. Bixin has been introduced in recent research as a candidate for therapeutic applications due to its innate anticancer, antioxidative, and anti-inflammatory characteristics. Nanoparticles (NPs) have emerged over the past few decades …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

Yiqi Yangyin Tongluo Prescription Targets Lncrna Vim-As1 To Regulate Foxk2/Mtor To Promote Autophagy And Inhibit Renal Tubular Epithelial Cell Apoptosis, Rucui Yu, Ruiying Wu, Tingting Chen, Jingwei Xu

Journal of Food and Drug Analysis

Diabetic nephropathy (DN) is one dominating reason for death in diabetic patients, and its incidence is high. It has been reported that Yiqi Yangyin Tongluo prescription (YYTP) can relieve inflammation, and it owns better clinical effects in the treatment of DN. However, the molecular mechanisms of YYTP in the treatment of DN still keep unclear, and deeply investigations are needed. In this study, it firstly was manifested that YYTP can repress the lncRNA VIM-antisense 1 (VIM-AS1) expression in high glucose (HG)-evoked HK-2 cells. Overexpression of VIM-AS1 roll-backed the inhibitive impacts of YYTP on cell apoptosis in HG-triggered HK-2 cells. Additionally, …

Evaluating The Cost-Effectiveness Of Atezolizumab-Bevacizumab In Advanced Hepatocellular Carcinoma: Insights From Taiwan, Tsung-Wei Chang, Wei-Chiao Chang, Wan-Hsuan Chou, Wei-Pin Chang, Chun-Nan Kuo

Journal of Food and Drug Analysis

Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectable hepatocellular carcinoma. Despite its clinical benefits, the high cost associated with this treatment poses a substantial challenge in routine practice in Taiwan. This study aims to assess the cost-effectiveness of atezolizumab plus bevacizumab in comparison to sorafenib monotherapy. This study utilized partitioned survival analysis and extrapolated survival over a 20-year horizon to conduct a cost-effectiveness analysis from the perspective of the National Health Insurance Administration. Efficacy and utility data …

Ping-Chong-Jiang-Ni Formula Effectively Inhibits Migration And Invasion Of Endometriosis 12z Cell Line Via Trip13, Jiahua Peng, Shuzhen Liu, Yunxiang Xie, Min Xiao, Chichiu Wang, Ruining Liang

Journal of Food and Drug Analysis

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that PCJNF inhibits the proliferation and induces the apoptosis of ectopic endometrial stromal cells (EESCs) by modulating the JNK signaling pathway. In our most recent study, published in January 2024, we found that PCJNF effectively alleviates EMs-associated pain by reducing inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF). Furthermore, PCJNF down-

regulates the expression of transient receptor potential vanilloid 1 (TRPV1), phosphorylated TRPV1 (p-TRPV1), and protein …