In Vitro Metabolic Profiling Of Methylenedioxy-Substituted Synthetic Cathinones For Enhanced Detection In Urine Sample Analysis,
2025
Department of Forensic Science, Central Police University, Taoyuan City, Taiwan, R.O.C.
In Vitro Metabolic Profiling Of Methylenedioxy-Substituted Synthetic Cathinones For Enhanced Detection In Urine Sample Analysis, Ya-Ling Yeh, Chin-Lin Hsieh, Yi-Jia Huang, Yu-Hsiang Chang, Sheng-Meng Wang
Journal of Food and Drug Analysis
Synthetic cathinones are a widely abused class of new psychoactive substances that pose significant challenges in forensic toxicology owing to their complex metabolic pathways and lack of verified reference standards. This study investigated the in vitro metabolism of nine methylenedioxy-substituted synthetic cathinones, including methylone and eight structural isomers, which were categorized into three groups: Group 1 (dimethylone, ethylone, and butylone), Group 2 (dibutylone, pentylone, and eutylone), and Group 3 (N-ethylpentylone and dipentylone). Pooled human liver microsomes, cytosol, and uridine diphosphate glucuronic acid were used to identify phase Ⅰ and Ⅱ metabolites by liquid chromatography–quadrupole time-of-flight mass spectrometry. Key pathways included …
Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis,
2025
Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu
Journal of Food and Drug Analysis
Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …
Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response,
2025
Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China
Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response, Huimin Pei, Mengyuan Zhao, Hongyue Wang, Xindi Zhang, Caihong Shi, Xiangrong Zhang
Journal of Food and Drug Analysis
Jiao Sanxian (JSX) consists of three traditional Chinese medicine including charred hawthorn, malt and Liu Shen Qu, they are also from Chinese medicine homologous food. It is commonly used to relieve functional dyspepsia (FD). The present study aims to explore the mechanism of JSX (granule), with the addition of prebiotics for the treatment of FD using mice model. The network pharmacology and molecular docking were used to forecast therapeutic targets for JSX. Based on the protein-protein interaction (PPI) results, thirteen targets exhibited strong interactions with each other. The results of network pharmacology and molecular docking revealed therapeutic activity of JSX …
Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan,
2025
Taiwan Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan
Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan, Shirley Pan, Jia-Chuan Hsu, Kuo-Teng Hung, Ching-Jung Ho
Journal of Food and Drug Analysis
Products containing live microorganisms may be classified as food or drugs depending on their intended use; live biotherapeutic products (LBPs) with therapeutic claims are defined as medicinal products containing live bacteria or yeasts intended to prevent or treat disease. Based on their characteristics, LBPs are classified as biological drugs and must be registered as biological drugs before they can enter the Taiwanese market. As research into the microbiota and its role in health and disease continues to advance, LBPs are expected to play an increasingly important role in medicine and biotechnology. With the growing popularity of microbial applications in recent …
Aspergillosis: A Comprehensive Review Of Pathogenesis, Drug Resistance, And Emerging Therapeutics,
2025
Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab 140111, India
Aspergillosis: A Comprehensive Review Of Pathogenesis, Drug Resistance, And Emerging Therapeutics, Amanpreet Singh, Jeewanjot Singh, Sandeep Kumar
Journal of Food and Drug Analysis
Aspergillosis stands as a primary opportunistic fungal infection which mainly results from Aspergillus fumigatus events that have gained more importance because of its multiple infection patterns and developing antifungal resistance. Healthcare providers identify two main ends of the aspergillosis spectrum which include allergic responses and invasive systemic infections that affect mainly immunocompromised subjects. This review presents a detailed summary for understanding the epidemiology of aspergillosis along with its risk factors as well as pathogenesis and host immune response and diagnostic difficulties. The analysis puts significant weight on increasing azole and echinocandin resistance that has become worse because of agricultural and …
Consumer Choice And Indoor Air Quality,
2025
Portland State University
Consumer Choice And Indoor Air Quality, Crystal Jadach
Civil and Environmental Engineering Undergraduate Honors Theses
Outdoor air pollution has drastically improved for everyone since the passage of the clean air act. However, indoor air quality is not monitored or enforceable in the United States. Yet, the EPA estimates that people of developed nations spend approximately 90% of their time indoors. Candles, a common ambiance setting choice for many household consumers, have been well characterized as a source of volatile organic compounds (VOCs). VOCs can have a wide variety of negative effects on human health. A benchtop and pilot scale study were used to characterize the difference in the accumulation and displacement of total volatile organic …
Targeting Detoxifying Enzymes In The Lymphatic Filariasis Vector: An In Silico Study On Curcumin, Camphor, And Menthol,
2025
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia
Targeting Detoxifying Enzymes In The Lymphatic Filariasis Vector: An In Silico Study On Curcumin, Camphor, And Menthol, Rizal Subahar, Rawina Winita, Surya Dwira, Gulshan Fahmi El Bayani
Indonesian Journal of Medical Chemistry and Bioinformatics
Vector control remains a critical component in the prevention of lymphatic filariasis, a disease transmitted by insect vectors. Natural compounds such as curcumin, camphor, and menthol are being explored for their bio-insecticidal properties due to their potential to inhibit key detoxification and neurological enzymes in insects, including acetylcholinesterase (AChE), glutathione S-transferase (GST), and cytochrome P450 oxidases (CYP450). A molecular docking study using SwissDock was conducted to evaluate the interaction of curcumin, camphor, and menthol with AChE, GST, and CYP450 enzymes. Binding affinity (ΔG), hydrogen bonding, and active site interactions were analyzed to assess the inhibitory potential of each compound. Curcumin …
Pesticides As Multiple Stressors To Bivalves And Echinoderms,
2025
Portland State University
Pesticides As Multiple Stressors To Bivalves And Echinoderms, Alexandra Gabrielle Tissot
Dissertations and Theses
Pesticides are ubiquitous in aquatic environments, alongside numerous contaminants and other stressors that can result in combined exposure to target and non-target organisms. Nevertheless, traditional toxicity studies quantify the effects of these compounds at an individual level, and to a narrow range of traditional test organisms. Through this dissertation, I explored the presence and effects of commonly detected pesticides of concern in the Pacific Northwest in order to realistically quantify potential effects from combined stressors. In Chapter 2, I demonstrated my background knowledge on these select pesticides (atrazine, bifenthrin, diuron, indaziflam, and imidacloprid), including their chemical and physical properties. Using …
Fda Approves Lecanemab-Irmb Maintenance Dosing For Early Alzheimer’S Disease Treatment,
2025
Ohio Northern University
Fda Approves Lecanemab-Irmb Maintenance Dosing For Early Alzheimer’S Disease Treatment, Jordyn Linfield, Giang Nguyen, Ashley Jacob, Andrew Johnson, Maria Nguyen, Sara Ha, Joshua Honaker, Samantha Mccord, Kelly Kroustos
Pharmacy and Wellness Review
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and is associated with progressive and irreversible cognitive decline that begins with memory lapses leading to physical and functional impairment. The conventional therapies that have been used for the treatment from Alzheimer's Disease include acetylcholinesterase inhibitors and memantine, but additional therapy options are being developed. Lecanemab, brand name Lequembi, is currently a Food and Drug Administration (FDA) approved humanized monoclonal antibody for the treatment of Alzheimer’s disease and indicated for mild cognitive impairment (MCI) or mild dementia. While there is impactful aid for treatment, lecanemab has three significant adverse reactions, which …
The Possible Cardioprotectiveeffect Of Empagliflozin During Endotoxemia In Mice Model,
2025
Master student in Department of pharmacology and toxocology - from Kufa university /faculty of pharmacy, Iraq.
The Possible Cardioprotectiveeffect Of Empagliflozin During Endotoxemia In Mice Model, Safwa Miqdad Al-Killidar, Bashaer M. Muhammad-Baqir
Maaen Journal for Medical Sciences
Background:Sepsis is a major complication for seriously ill people with shock, major infections, serious burns, or severe trauma. Inflammation imbalance is the primary underlying cause of sepsis progression and persists continuously over the entire sepsis course. Empagliflozin is an orally administered medication for diabetes that selectively inhibits sodium-glucose cotransporter 2 to improve kidney elimination of glucose. It has been discovered that sodium-glucose cotransporter 2 exhibit anti inflammation and multiple effects, suggesting that they may be beneficial and prevent infections. Aim of study:This study was undertaken to assess Empagliflozin's cardioprotective efficacy in septic mice through its potent anti- inflammatory …
The Role Of G6pd Variants And 3d Genomic Structure In The Development Of Pulmonary Hypertension,
2025
New York Medical College
The Role Of G6pd Variants And 3d Genomic Structure In The Development Of Pulmonary Hypertension, Christina M. Signoretti Ph.D.
NYMC Student Theses and Dissertations
Pulmonary hypertension is an under-recognized global health epidemic which is estimated to affect 1% of the population. It is associated with sustained mean pulmonary artery pressure greater than 20 mmHg, pulmonary artery remodeling, smooth muscle and endothelial cell proliferation and subsequent increased right ventricle hypertrophy due to increased afterload. Glucose-6-phosphate dehydrogenase (G6PD) is one of the key enzymes in the pentose phosphate pathway and has been previously linked to the development of pulmonary hypertension. G6PD deficiency is the most common human enzymopathy which affects approximately 400 million people worldwide and is a result of agricultural and epidemiological evolution in different …
Evaluating The Protective Role Of Epo-R76e In Oxidative Stress-Induced Cell Death In Retinal Pigment Epithelium,
2025
University of South Florida
Evaluating The Protective Role Of Epo-R76e In Oxidative Stress-Induced Cell Death In Retinal Pigment Epithelium, Jemima Alam
USF Tampa Graduate Theses and Dissertations
Age-Related Macular Degeneration (AMD) causes dysfunction and loss of Retinal pigment epithelium (RPE). The degeneration and death of RPE cells causes irreversible visual impairment. Oxidative stress is a widely accepted triggering factor for RPE dysfunction. A hormone called Erythropoietin (EPO) is responsible to facilitate the erythropoiesis process, prevents progenitor cells from apoptosis and protects photoreceptors downregulating retinal degeneration. In this study, we aim to elucidate the role of EPO in downregulating oxidative stress in RPE. It is hypothesized that EPO will have a positive impact on suppressing oxidative stress and ferroptosis-mediated RPE degeneration due to its vital role in apoptosis …
Exposure To Second-Hand Smoke In Homes And Respiratory Symptoms Among Non-Smoking Adults In Depok, Indonesia 2025,
2025
Department of Environmental Health, Faculty of Public Health, University of Indonesia, Depok, Indonesia
Exposure To Second-Hand Smoke In Homes And Respiratory Symptoms Among Non-Smoking Adults In Depok, Indonesia 2025, Faraz Ali, Budi Hartono
Journal of Indonesian Health Policy and Administration
Second-hand smoke (SHS) exposure in the home environment has become a public health emergency, especially in countries with very high smoking rates, such as Indonesia. SHS exposure has already presented evidence of symptoms of the respiratory category, like a cough and shortness of breath. This study aimed to assess the association between exposure to SHS at home and the presence of respiratory symptoms among non-smoking adults in Depok, Indonesia. Convenience sampling was adopted for enrolling 108 non-smoking adults aged 18-30 who were jointly exposed to SHS in their homes for a cross-sectional study. Data aggregations of gatherings were performed using …
Evaluation Of Schoenoplectus Californicus In An Artificial System For E. Coli Removal,
2025
Texas A&M-San Antonio
Evaluation Of Schoenoplectus Californicus In An Artificial System For E. Coli Removal, Kimia Ahmadiyehyazdi
Masters Theses (Archived)
Green technologies and nature-based solutions like constructed wetlands have be come more popular due to their environmentally friendly approach to remediation, low cost of construction, and maintenance. Also, they have shown efficiency in removing a wide range of contaminants. However, choosing a suitable aquatic plant for this system is one of the questions that should be answered wisely. Schoenoplectus californicus– Giant Bulrush is an aquatic plant that was tested in this controlled constructed wetland, and the final concentration of the targeted microbial contamination, which is E. coli, was reduced remarkably. Also, for this study, soil was removed from the …
Misused And Misunderstood: Examining The Inappropriate Use Of Stimulant Medications,
2025
Nationwide Children's Hospital
Misused And Misunderstood: Examining The Inappropriate Use Of Stimulant Medications, Connor Dains, Madilyn Paphanchith, Makayla Eversole, Chaehyeon Jin, Minhwan Yang, Joshua Honaker, Samantha Mccord, Kayla Petkus
Pharmacy and Wellness Review
Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by inattention, hyperactivity, and impulsivity. The American Academy of Pediatrics (AAP) endorses stimulant medications as the first-line treatment option. When combined with behavioral therapy, this pharmacologic class can improve focus, executive functioning, and the overall quality of life. While stimulant prescriptions can have a positive effect when used as directed, there is concern for the potential of provider overprescription and patient misuse related to these medications. Consequently, the Food and Drug Administration (FDA) revised the boxed warning and prescribing information for stimulant medications. Healthcare providers must educate …
Variability In Methotrexate Metabolites In A Cohort Of Jia Patients,
2025
Children's Mercy Kansas City
Variability In Methotrexate Metabolites In A Cohort Of Jia Patients, Nuria Lara Castillo, Mara Becker, Marc Sudman, Susan Thompson, Laura Ramsey
Research Days
Background: Methotrexate (MTX) is the cornerstone disease-modifying anti-rheumatic drug for the treatment of Juvenile Idiopathic Arthritis (JIA). While most patients receiving MTX have a favorable outcome, approximately 30% do not respond, and several experience toxic events, suggesting interindividual difference. Furthermore, evaluation of MTX response takes several months, with the risk of missing the early “window of opportunity” for treatment. Predicting MTX response prior to administration would greatly benefit these patients and their treating physicians by saving valuable time during the early stages of the disease onset. MTX is a folate antagonist and, similar to folate, it undergoes polyglutamation inside the …
Assessing One-Year Health Impacts From Wildfires In Rural Communities: Roles For Extension In Promoting Wildfire Preparedness And Recovery,
2025
Oregon State University
Assessing One-Year Health Impacts From Wildfires In Rural Communities: Roles For Extension In Promoting Wildfire Preparedness And Recovery, Marc T. Braverman, Sandi Cleveland Phibbs, Emily Jane Davis, Amanda Rau, Elijah Penner
Journal of Extension
Wildfires can produce health impacts that persist for years in affected communities. This article describes an Extension-led study of health impacts in rural Oregon communities one year after a destructive wildfire. Data collection included key informant interviews (n=36), an online survey (n=80), and three focus group interviews with survivors (n=23). Mental health, exposure to contaminants, physical stress, food insecurity, and other issues were frequently identified health concerns. Survivors’ difficulties in dealing with housing displacement significantly exacerbated health challenges. We describe potential roles for Extension in addressing wildfire risk and mitigating health impacts, including a description of the Oregon Fire Program.
Exploring Sustainable Biopolyesters: Synthesis From 1,4-Butanediol And Aliphatic Diacids,
2025
Pittsburg State University
Exploring Sustainable Biopolyesters: Synthesis From 1,4-Butanediol And Aliphatic Diacids, Vinashkumar Jayantibhai Chaudhari
Electronic Theses & Dissertations
In this thesis, we applied 1,4-butanediol, which is an emerging biobased and low-cost monomer, was synthesized with a series of aliphatic dicarboxylic acids, namely succinic acid, adipic acid, and sebacic acid using melt polycondensation to Biobased polyesters. The resulting polymers poly(butylene succinate) (PPeS), poly(butylene adipate) (PPeA), and poly(butylene sebacate) (PPeSe) chemical structures were analysis through Fourier transfer infrared spectroscopy(FT-IR), 1H nuclear magnetic resonance (NMR) revealed the elimination of side reactions in the obtained polyesters. Differential scanning calorimetry (DSC) was employed to analyze physical properties, and the impact of dicarboxylate chain length and long short diol on crystalline structure and …
Plastic In The Pack: Assessing Microplastic Risk To Urban Coyotes (Canis Latrans) In The San Francisco Bay Area,
2025
University of San Francisco
Plastic In The Pack: Assessing Microplastic Risk To Urban Coyotes (Canis Latrans) In The San Francisco Bay Area, Elaina E. Herrmann
Master's Projects and Capstones
Microplastics are an emerging concern worldwide. However, their impact on terrestrial mammals, such as Canis latrans (coyotes), has yet to be extensively studied. Coyotes are unique in their ability to adapt to urban environments and have recently begun bridging the gap between marine and terrestrial food webs. This research examines the potential sources and impact of microplastic exposure in urban coyotes in the San Francisco Bay Area and possible food web impacts through literature synthesis and Geographic Information System (GIS) mapping. This research examined potential mechanisms for direct and trophic microplastic uptake by coyotes resulting from the anthropogenic, terrestrial, and …
Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair,
2025
CUNY John Jay College
Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair, Samantha C. Mulkeen
Student Theses
Hair testing is increasing in popularity in toxicology because of its long window of detection and ease of collection and sample storage. However, it has its limitations largely due to external contamination of drugs. In particular, cocaine (COC) is a common offender of this as it has several routes of consumption. Analyzing metabolites of COC may be the key to distinguishing between consumption and external contamination. The aim of the present study was to develop a quick, easy, and sensitive method for the detection and quantification of COC, benzoylecgonine (BE), norcocaine (NCOC), cocaethylene (CE), anhydroecgonine methyl ester (AEME), meta-hydroxy-cocaine (m-OH-COC), …
