Repurposing Dihydroartemisinin As A Novel Anticancer Agent Against Colorectal Cancer Stem Cells,
2025
School of Pharmacy, National Taiwan University, Taipei 10050, Taiwan
Repurposing Dihydroartemisinin As A Novel Anticancer Agent Against Colorectal Cancer Stem Cells, Meng-Han Wu, Chieh-Ju Sung, Fan-Lu Kung, Jih-Hwa Guh, Yu Su, Lih-Ching Hsu
Journal of Food and Drug Analysis
Colorectal cancer (CRC) is one of the leading causes of cancer-related death globally and discovering novel therapeuticagents to treat the disease, and prevent cancer metastasis and recurrence is an urgent medical need. Cancer stem cells(CSCs) capable of self-renewal and differentiation are generally considered the cause of tumor metastasis, recurrenceand chemoresistance. Hence, targeting CSCs may be a promising strategy for the treatment of cancer. GATA6, a zincfinger transcription factor, contributes to tumorigenesis in CRC and is related to cancer stemness. GATA6-overexpressing stable clones OE4 and OE6 derived from HCT116 cells were previously established and exhibitedincreased stemness properties. In this study, we …
Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models,
2025
Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease Prevention and Control, Yunnan University of Chinese Medicine, Kunming,650500, China
Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models, Si-Si Han, Li-Yun Song, Peng-Tao Liang, Yin-Ying Wang, Yi Ying, Li Li, Jia-Li Yuan, Zhong-Shan Yang
Journal of Food and Drug Analysis
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by various pathologicallesions and an imbalance in the microflora. The Yi-Qi-Xuan-Fei Formula (YQXF) is a clinically effective formula withpharmacological potential to delay the progression of COPD. This study aims to explore the relationship between thetherapeutic mechanism of YQXF and the microflora in COPD. Our study found that YQXF reduces inflammatory injuryand inflammatory cell infiltration in lung tissue, repairs the intestinal mucosal barrier, and enhances immune function.Additionally, YQXF regulates the pulmonary and intestinal flora by increasing the abundance of Alloprevotella, Rose-buria, Oscillibacter, and Lactobacillus, while reducing the abundance of …
Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery,
2025
Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar (140111) Punjab, India
Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma
Journal of Food and Drug Analysis
Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …
The Rhythm Of Decline: Circadian Disruption In Neurodegeneration,
2025
Department of pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111
The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh
Journal of Food and Drug Analysis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology involving genetic,environmental, and metabolic factors. Among these, circadian rhythm disruption has emerged as a crucial but under-explored contributor to disease progression. The circadian system, regulated by the suprachiasmatic nucleus (SCN),controls essential physiological functions such as the sleep-wake cycle, metabolism, and neuroendocrine signaling.Disruption of this system has been increasingly linked to key pathological features of AD, including amyloid-betaaccumulation, tau hyperphosphorylation, and neuroinflammation. This review critically examines the mechanistic roleof circadian misalignment in AD by analyzing studies on sleep disturbances, SCN degeneration, metabolic dysregu-lation, clock gene polymorphisms (BMAL1, CLOCK, PER, …
Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach,
2025
Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111,
Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar
Journal of Food and Drug Analysis
Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …
In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine,
2025
Department of pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111
In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar
Journal of Food and Drug Analysis
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss,oxidative stress, neuroinflammation, and a-synuclein aggregation. Despite advances, current treatments only offersymptomatic relief without altering disease progression. This review aims to evaluate the therapeutic potential of plant-derived phytochemicals in PD through evidence from both in vivo and in vitro experimental models. Key findingsindicate that rodent models (e.g., MPTP, rotenone) and neuronal cell lines (e.g., SH-SY5Y) help replicate PD pathologyand mechanistic insights. Phytochemicals such as baicalein, morin, ferulic acid, and bacopa demonstrate neuroprotectiveeffects via antioxidant, anti-inflammatory, and mitochondrial-stabilizing pathways. Nanotechnology and brain orga-noids further improve translational relevance. In conclusion, …
Global Research Trends On Avocado Oil And Its Fatty Acid Composition: A Bibliometric Review,
2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Global Research Trends On Avocado Oil And Its Fatty Acid Composition: A Bibliometric Review, Ahmad Kamrullah Aras, Abdul Rohman
Journal of Food and Drug Analysis
The high content of unsaturated fatty acids in avocado oil (Persea americana) has prompted in-depth exploration across research subjects. This study uses bibliometric analysis to assess global research trends on avocado oil and its fatty acid composition from 2004 to 2024. The search string retrieved 255 articles from the Scopus database and then analyzed using R BibliometriX and VOSviewer software. These tools analyze descriptive structures and collaborative patterns and create network data maps. For comparison, we separated the data into two research periods, namely 2004-2013 and 2014-2024. There was a significant increase in the number of publications, with …
In Vivo Efficacy Of A Broad-Spectrum Antiviral Combination Against Yellow Fever In A Hamster Model,
2025
Utah State University
In Vivo Efficacy Of A Broad-Spectrum Antiviral Combination Against Yellow Fever In A Hamster Model, Abbie E. Weight, Hunter Stanger, Robert J. Geraghty, Laurent F. Bonnac, Justin G. Julander
Animal, Dairy, and Veterinary Science Student Research
Yellow fever virus (YFV) recurrently causes severe outbreaks in tropical regions of South America and Africa and an average of 30 to 40 thousand deaths worldwide each year. An effective vaccine is available but the coverage of the population in countries at risk is not optimal. No antivirals are currently approved for YFV treatment. Herein, we describe the evaluation of 6-MMPr, a de-novo-purine-nucleotide biosynthesis inhibitor, as a potentiator for enhanced activity of the broad-spectrum antiviral drug favipiravir in a hamster model of yellow fever. Administration of 6-MMPr was well-tolerated and a combination of favipiravir and 6-MMPr did not cause …
Mechanistic Rationale For Toxic Aerosol Formation From Vaping And Dabbing With A Focus On Ketene Formation From Semi-Synthetic Cannabinoids,
2025
Portland State University
Mechanistic Rationale For Toxic Aerosol Formation From Vaping And Dabbing With A Focus On Ketene Formation From Semi-Synthetic Cannabinoids, Kaelas Ryan Munger
Dissertations and Theses
Cannabis vaping is a relatively new route of administration that is increasingly common among youth and young adults. Cannabis vaping has been associated with cases of acute lung injury, especially among youth, and most often involves the heating and aerosolization of high-potency products having cannabinoid concentrations of ~ 50 % - 98 % w/w. Proponents argue that vaping is safer than smoking due to the characteristically lower temperatures and fewer plant materials. However, the extreme cannabinoid concentrations, along with non-natural formulations having undisclosed additives, require studies of the health effects of these products. Despite the popularity of cannabis concentrate vaping, …
Exploring The Relative Effects Of Natural Gas And Biogas Cooking On Indoor Air Quality In Residential Kitchens,
2025
Dickinson College
Exploring The Relative Effects Of Natural Gas And Biogas Cooking On Indoor Air Quality In Residential Kitchens, Wande Benka-Coker, Kailey Sipe, Dinela Dedic, Alexander Jones, Bramley Hawkins, Emily Lyons, Matt Steiman, Megan L. Benka-Coker
Health Sciences Faculty Publications
Indoor air pollution from gas stove combustion remains a public health concern, given links to adverse cardiorespiratory health effects, yet few studies have characterized or compared the air quality impacts of different gas-based cooking fuels. We investigated kitchen-level concentrations of nitrogen dioxide (NO2) and fine particulate matter (PM2.5) concentrations in four homes in Central Pennsylvania that used natural gas and/or biogas fueled stoves. We conducted time-resolved kitchen monitoring and assessed pollutant concentrations during cooking and non-cooking periods. We applied linear mixed-effect regression models with kitchen-level random effects and time-varying covariates to estimate the influence of fuel type on indoor air …
Synthesis, Pharmacokinetic Studies, And Metabolite Analysis Of Meridianin C In Rats Using A Validated Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry Method,
2025
Jilin Medical University, Jilin, China.
Synthesis, Pharmacokinetic Studies, And Metabolite Analysis Of Meridianin C In Rats Using A Validated Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry Method, Liangyu Xu, Zhaogen Wu, Karna Ramachandraiah, Guihun Jiang, Guozhe Zhang
School of Graduate Studies Faculty Publications
Introduction: Meridianin C (MC) is a marine-derived indole alkaloid that has demonstrated kinase inhibitory and anti-tumor activities. Despite its diverse biological properties, no previous reports have systematically evaluated the in vivo quantitative analysis of MC and its metabolites. Methods: In this study, MC was synthesized following a previously reported procedure with slight modifications. A sensitive, accurate, and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method was developed to simultaneously detect MC and its five major metabolites (MC-1-N-O-GluA, MC-1-N-O-SO3H, MC-2′-N-O-GluA, MC-2′-N-O-SO3H, and MC-O-GluA-didehydration) in rat plasma. Rats received a single oral dose of MC (100 mg/kg), and pharmacokinetic analysis was …
Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models,
2025
University of South Florida
Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models, Salma S. Abdelmaboud
USF Tampa Graduate Theses and Dissertations
Traumatic brain injury (TBI) is a leading cause of long-term neurological impairment, with aging significantly increasing vulnerability and worsening outcomes. Older individuals experience greater cognitive and motor deficits after TBI and often show diminished responses to therapeutic interventions. Both aging and TBI independently promote heightened neuroinflammation and cognitive dysfunction, increasing susceptibility to poor recovery. This study investigated the therapeutic potential of small extracellular vesicles (sEVs) derived from human adipose-derived stem cells (hASCs) to promote neurological recovery and modulate neuroinflammation in a mouse model of TBI. Male C57BL/6 mice aged 3, 15, and 20 months underwent controlled cortical impact (CCI) and …
Exploring Potential Impacts Of Polyethylene Mesh And Polypropylene Rope Leachate On Bay Scallop (Argopecten Irradians) Survival And Growth,
2025
University of Massachusetts Boston
Exploring Potential Impacts Of Polyethylene Mesh And Polypropylene Rope Leachate On Bay Scallop (Argopecten Irradians) Survival And Growth, Katherine R. Johnson
Graduate Masters Theses
The bay scallop (Argopecten irradians), a commercially and ecologically significant bivalve along the Eastern coast of the United States, has faced severe population declines due to various anthropogenic impacts. At the same time, the proliferation of plastics, particularly in maritime industries, has introduced new threats to marine environments through both physical pollution and chemical leaching. This study aimed to assess the acute toxicological effects of leachates from two commonly used plastic products, polyethylene Netron and polypropylene rope, on A. irradians larvae. Experiments were conducted in June–July 2023 at the Nantucket Shellfish Hatchery. Leachates were prepared by incubating 0.5, …
Enhancing Cataract Surgery Outcomes: Optimal Use Of Pre- And Post-Operative Eye Drops,
2025
Nova Southeastern University
Enhancing Cataract Surgery Outcomes: Optimal Use Of Pre- And Post-Operative Eye Drops, Keith Skolnick M.D., Anu Valiaveedu
Mako: NSU Undergraduate Student Journal
Many preoperative and postoperative cataract patients struggle with comprehending the use of prescription medication as directed. Language barriers and low health literacy levels are major factors contributing to improper use of prescriptions. To increase patients comprehension, the Fort Lauderdale Eye Institute employed an educational intervention consisting of a live presentation and an instructional video. Results found that 44% of patients were hesitant to ask questions to clinical staff, 32% felt overwhelmed, and nearly 70% lacked confidence in using their prescribed eye drops. Following the intervention, 91% of patients reported increased confidence in their medications, and most indicated that the video …
Muscarinic Acetylcholine Receptor 1: Implications For Precision Medicine And Rett Syndrome Therapeutics,
2025
Loyola University of Chicago Graduate School
Muscarinic Acetylcholine Receptor 1: Implications For Precision Medicine And Rett Syndrome Therapeutics, Mackenzie Smith
Dissertations
Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutations in the gene coding for methyl-CpG binding protein 2 (MeCP2). Currently, there is no cure for RTT and few effective treatment options to address the social, cognitive, motor, and respiratory symptoms that patients face. With the goal of identifying novel targets, our lab performed RNA-sequencing experiments in human autopsy samples and found decreased levels of the M1 muscarinic acetylcholine receptor. We have established that potentiation of this receptor in a Mecp2+/- mouse model of RTT rescues social, cognitive, and respiratory phenotypes, providing support for using drugs that act on …
Evaluation Of South Carolina’S Extension And Outreach Agents’ Knowledge Of Harmful Algal Bloom Management And The Impacts Of One-Day Training,
2025
Clemson University
Evaluation Of South Carolina’S Extension And Outreach Agents’ Knowledge Of Harmful Algal Bloom Management And The Impacts Of One-Day Training, George Strickland, Debabrata Sahoo, Michael Vassalos, Heather Nix, Sarah White
Journal of Extension
Harmful algal blooms (HABs) impact livestock producers. Most Extension agents have limited knowledge about HAB management. Our study goal was to assess agent readiness and training on HABs. We used data from in-person surveys of South Carolina (SC) Extension personnel. We examined how training influenced HAB knowledge using pre/post-tests. Training improved agent knowledge of HAB management, but water resource agents learned more. The results of this study can be used to identify Extension training shortfalls and drive policy to better prepare agents throughout the state. Further research should involve prioritizing additional extension topics and assessing knowledge in a similar manner.
The Characterization Of Per- And Polyfluoroalkyl Substances (Pfas) In Nebraska Drinking Water And Human Health Impacts,
2025
University of Nebraska Medical Center
The Characterization Of Per- And Polyfluoroalkyl Substances (Pfas) In Nebraska Drinking Water And Human Health Impacts, Sarah Tucker
Theses & Dissertations
Per- and polyfluoroalkyl substances (PFAS) are synthetic compounds that have been detected in water sources of urban and rural environments with evidence of adverse human health effects from exposure. Humans are primarily exposed through ingestion of contaminated water and food. PFAS exposure has been linked to negative multi-system health outcomes (liver, kidneys, cardiovascular, reproductive, and immune). PFAS occur as persistent mixtures in environmental media with decades long consequences to water quality. While national agencies have launched large-scale PFAS water quality monitoring studies, limited data exists for contamination of rural water in Nebraska, especially private wells. The aims of this study …
Impact Of Urban Fine Particulate Matter Exposure On Cardiovascular Health,
2025
University of Mississippi Main Campus
Impact Of Urban Fine Particulate Matter Exposure On Cardiovascular Health, Shelby P. Briggs
Honors Theses
Air pollution, particularly exposure to fine particulate matter (PM2.5), poses a growing threat to cardiopulmonary health. PM2.5 consists of microscopic particles smaller than 2.5 microns in diameter and originates from industrial combustion, transportation, and urban dust. These particles are classified as xenobiotics and are capable of bypassing respiratory defenses to enter systemic circulation, where they cause oxidative stress, inflammation, and cardiovascular dysfunction. This study examines the effects of PM2.5 on cardiovascular function using a murine model. Male C57BL/6 mice were divided into control (saline), subchronic (10 µg), and chronic (100 µg) groups and were exposed weekly for 11 weeks via …
Effect Of Histidine Tag On The Enzymatic Activity Of Pseudolysin And Its Interaction With The Streptomyces Metalloprotease Inhibitor (Smpi) Protein,
2025
Stephen F Austin State University
Effect Of Histidine Tag On The Enzymatic Activity Of Pseudolysin And Its Interaction With The Streptomyces Metalloprotease Inhibitor (Smpi) Protein, Adewale Adeboye Adewole
Electronic Theses and Dissertations
Pseudolysin (PLN) protein is a major virulent factor in Pseudomonas aeruginosa infection. PLN belongs to the family of zinc-dependent metalloproteases. It is naturally inhibited by a smaller protein called streptomyces metalloprotease inhibitor (SMPI), secreted by Streptomyces nigrescens. Previous and current studies demonstrate that the interaction between PLN and SMPI offers unique mechanistic insights for drug development against infections caused by P. aeruginosa. This study investigated the effect of N-terminal Histidine (His) tag on the enzymatic activity of PLN and its interaction with SMPI. His-tagged PLN and SMPI proteins were expressed in bacteria and purified by affinity chromatography …
Effects Of Oil Spill Response Agents On Scleractinan Corals Acropora Cervicornis And Porites Divaricata,
2025
Nova Southeastern University
Effects Of Oil Spill Response Agents On Scleractinan Corals Acropora Cervicornis And Porites Divaricata, Austin Blakeslee
All HCAS Student Capstones, Theses, and Dissertations
Coral reefs are biodiverse coastal ecosystems at risk of exposure to spilled oil; spills reaching shorelines can damage corals, mangroves, and many other species in nearshore shallow-water tropical environments. Efforts to remediate such spills have evolved over the years through the introduction of various chemical response agents that efficiently and effectively control the spread of oil. Chemical herding agents and dispersants, which can contain and control the oil spread, are promising additions to the spill response toolbox as potential alternatives to other response methods. These response agents are designed to be biodegradable and minimize potential harm to aquatic ecosystems. However, …
