What Role Does Age-Associated Neuroplasticity Play In The Efficacy Of Cochlear Implantation?,
2020
Touro College
What Role Does Age-Associated Neuroplasticity Play In The Efficacy Of Cochlear Implantation?, Jacob Fliegelman
The Science Journal of the Lander College of Arts and Sciences
Bilateral, profound-severe, congenital deafness causes widespread structural and functional changes of the auditory system. In humans, the consequences of these changes are extensive and often include detriments to language acquisition and auditory perception. Fortunately, early intervention methods, such as cochlear implantation, can significantly mitigate inevitable auditory deficiencies. This review begins by briefly addressing early stages of brain development and associated anatomical discrepancies observed in congenitally deaf subjects. Considering the deleterious effects of congenital deafness, neuroplasticity, the ability of the brain to rewire itself, is of paramount importance in reversing the auditory impairments. Hence, its incorporation into the methods required for …
Total Cellular Atp Production Changes With Primary Substrate In Mcf7 Breast Cancer Cells.,
2020
Department of Natural Sciences and Mathematics, Dominican University of California
Total Cellular Atp Production Changes With Primary Substrate In Mcf7 Breast Cancer Cells., Maggie Louie, Justin Ton, Maurice L. Brady, Diem T. Le, Jordon N. Mar, Chad A Lerner, Akos A Gerencser, Shona A. Mookerjee
Natural Sciences and Mathematics | Faculty Scholarship
Cancer growth is predicted to require substantial rates of substrate catabolism and ATP turnover to drive unrestricted biosynthesis and cell growth. While substrate limitation can dramatically alter cell behavior, the effects of substrate limitation on total cellular ATP production rate is poorly understood. Here, we show that MCF7 breast cancer cells, given different combinations of the common cell culture substrates glucose, glutamine, and pyruvate, display ATP production rates 1.6-fold higher than when cells are limited to each individual substrate. This increase occurred mainly through faster oxidative ATP production, with little to no increase in glycolytic ATP production. In comparison, non-transformed …
Variations On A Theme: Intricacies Of Unanchored Poly-Ubiquitin Signaling And Toxicity,
2020
Wayne State University
Variations On A Theme: Intricacies Of Unanchored Poly-Ubiquitin Signaling And Toxicity, Jessica Renee Blount-Pacheco
Wayne State University Dissertations
Ubiquitin is an 8.5 kDa post-translational modifier involved in essentially all eukaryotic cellular processes. Through a process called ubiquitination, ubiquitinating enzymes chemically attach ubiquitin to substrate proteins to control their fates, resulting in anything from their recruitment into signaling pathways to their proteasomal degradation, with a plethora of possibilities in between. Ubiquitin molecules can also be attached to one another, resulting in poly-ubiquitin chains with various effects depending on the number of ubiquitin molecules and the specific amino acid residues used to link them together. While most poly-ubiquitin in the cell exists as conjugated species, there are also untethered poly-ubiquitin …
Novel Post-Translational Modification And Function Of Fus: The Relevance To Amyotrophic Lateral Sclerosis,
2020
University of Kentucky
Novel Post-Translational Modification And Function Of Fus: The Relevance To Amyotrophic Lateral Sclerosis, Alexandra Arenas
Theses and Dissertations--Toxicology and Cancer Biology
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the preferential death of motor neurons. Approximately 10% of ALS cases are familial and 90% are sporadic. Fused in Sarcoma (FUS) is a ubiquitously expressed RNA binding protein implicated in familial ALS and frontotemporal dementia (FTD). FUS is ubiquitously expressed in cells and has a variety of functions in the nucleus and cytoplasm. FUS mutations in the nuclear localization sequence (NLS) causes mislocalization of FUS in the cytoplasm, where it can undergo liquid-liquid phase separation and become stress granules or protein inclusions. Although FUS inclusion bodies can be found in …
Management Recommendations For Jacoby Creek Land Trust’S Off-Channel Pond Site At The Kotke Ranch And Nature Preserve,
2020
Humboldt State University
Management Recommendations For Jacoby Creek Land Trust’S Off-Channel Pond Site At The Kotke Ranch And Nature Preserve, Marcos Adrian Sosa Morales, Maeve Flynn, Auston Tague
Environmental Science & Management Senior Capstones
Now more than ever there is a need for conservation easements within California because of ongoing degradation, urbanization, clear cutting and loss of habitat to ecosystems due to wildfires. The Jacoby Creek Land Trust (JCLT) is in need of a restoration and conservation plan regarding constructed off-channel ponds along Jacoby Creek. One of the ponds is flourishing and supporting different types of fishes during their migration. The other pond, our project location, is struggling to meet the JCLT’s project objectives. The pond is overgrown with European grasses due to the surrounding grazing land and has yet to see the pond's …
Analysis Of Bacterial Dna And Water Quality: Surface Water Sampling At Gardner-Webb University,
2020
Gardner-Webb University
Analysis Of Bacterial Dna And Water Quality: Surface Water Sampling At Gardner-Webb University, Celsea Reeder
Undergraduate Honors Theses
Part 1 of this experiment was to explore the bacterial types within the surface water on the campus of Gardner-Webb University, located in Boiling Springs, NC. Two water samples were collected from four locations on campus, including the boiling spring, Lake Hollifield, and an adjacent creek. Using the Zymo Research “Quick-DNA™ Fungal/Bacterial Miniprep Kit,” the bacterial DNA within these samples was isolated and sent to Psomagen, Inc. for analysis. The resulting DNA sequences were analyzed through BLAST, and subsequently interpreted. For the second part of this experiment, one surface water sample was taken from the boiling spring, and another …
Teriparatide,
2020
Ege University Faculty of Medicine
Human Papilloma Virus Vaccine,
2020
Nova Southeastern University
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
HPD Articles
No abstract provided.
Reserpine,
2020
Nova Southeastern University
Fosinopril,
2020
Nova Southeastern University
Fluorescein,
2020
Nova Southeastern University
Dornase Alfa,
2020
Nova Southeastern University
Flucytosine,
2020
Richmond University Medical Center
Lisinopril,
2020
Haysmed, The University of Kansas Health System
Lisinopril, Edgardo Olvera Lopez, Mayur S. Parmar, Venkata Satish Pendela, Jamie M. Terrell
HPD Articles
No abstract provided.
Indinavir,
2020
Nova Southeastern University
Lamivudine,
2020
Nova Southeastern University
Lamivudine, Katherine Taylor, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.
Sodium Oxybate,
2020
Nova Southeastern University
Sodium Oxybate, Alvio Dominguez, Lucia Soca Gallego, Mayur S. Parmar
HPD Articles
No abstract provided.
Pralidoxime,
2020
Sharda University, Sharda Hospital
Tolterodine,
2020
Nova Southeastern University
Assessing Embalmer Exposure To Bioaerosols And The Associated Health Risk,
2020
Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST)
Assessing Embalmer Exposure To Bioaerosols And The Associated Health Risk, Geneviève Marchand, Loïc Wingert, Stéphane Hallé, Maximilien Debia
Rapports de recherche scientifique
Plusieurs manipulations réalisées sur les corps des défunts par les thanatopracteurs produisent des bioaérosols qui peuvent contenir des agents pathogènes infectieux. La ventilation générale est souvent le seul moyen utilisé dans les laboratoires de thanatopraxie pour maîtriser les bioaérosols. Toutefois, il n’y a pas de recommandations précises pour sa mise en application. De plus, peu d'études abordent les expositions professionnelles aux bioaérosols dans le domaine de la thanatopraxie tant quantitativement (niveau d’exposition) que qualitativement (identification et classification selon les groupes de risque). L’objectif de cette étude était d’évaluer l’exposition des thanatopracteurs aux bioaérosols afin d’apprécier les risques potentiels sur leur …
