Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health,
2020
University of Kentucky College of Public Health
Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa Mcalister, Lindell E. Ormsbee, Dawn Brewer
Journal of Appalachian Health
Environmental health literacy (EHL) is an emerging, multidisciplinary field that promotes understanding of how environmental exposures can affect human health. After discussing the regional relevance of environmental health knowledge and skills, this article describes three ongoing Appalachian projects that are focused on measuring and building EHL.
Impacts Of The Deepwater Horizon Oil Spill On Reproduction And Ontogeny Of Gulf Killifish (Fundulus Grandis),
2020
Louisiana State University and Agricultural and Mechanical College
Impacts Of The Deepwater Horizon Oil Spill On Reproduction And Ontogeny Of Gulf Killifish (Fundulus Grandis), Charles Alexander Brown
LSU Doctoral Dissertations
On April 20, 2010, the Deepwater Horizon oil spill released an estimated 779 million liters of Macondo-252 crude oil into the Gulf of Mexico, making it the largest marine oil spill in history. Over a thousand kilometers of marshland that many species of fish use as a spawning grounds and nurseries was oiled, exposing breeding adult fish and their offspring to oil. My dissertation investigates the impacts of the Deepwater Horizon oil spill and associated remediation efforts on the reproduction and ontogeny of a sentinel ecotoxicological species, the Gulf killifish (Fundulus grandis). Concerns were raised regarding use of …
Neurodevelopment Outcome Of Neonates Treated With Intraventricular Colistin For Ventriculitis Caused By Multiple Drug-Resistant Pathogens-A Case Series,
2020
Aga Khan University
Neurodevelopment Outcome Of Neonates Treated With Intraventricular Colistin For Ventriculitis Caused By Multiple Drug-Resistant Pathogens-A Case Series, Kashif Hussain, Muhammad Sohail Salat, Gul Ambreen, Javaid Iqbal
Department of Biological & Biomedical Sciences
Background: Multiple-drug-resistant Gram-negative bacteria (MDR-GNB)-associated neonatal ventriculitis is a life-threatening complication that needs timely diagnosis and effective treatment with broad-spectrum antimicrobials in critical-care settings. Inadequate penetration of antibiotics through the blood-brain barrier also demands an intraventricular (IVT) route of administration. This study reports mortality and neurodevelopmental sequelae of neonates till 18 months of age, who received IVT-colistin for treating MDR-GNB associated ventriculitis.
Methods: In a case series of seven neonates with ventriculitis due to MDR-GNB at NICU of Aga Khan University Hospital, Pakistan, between June 2015 and 2018, we reviewed IVT-colistin therapy in critically ill neonates. Treatment outcomes were assessed …
Analysis Of Organochlorine Pesticides Levels In Irrigation Water From Various Water Sources Across Egypt,
2020
The American University in Cairo AUC
Analysis Of Organochlorine Pesticides Levels In Irrigation Water From Various Water Sources Across Egypt, Omar Tarek Khairy
Theses and Dissertations
Organochlorine pesticides are extensively used in agriculture to cope with the world’s increasing population and demands for nutrition. This class of pesticides poses a serious risk to human health upon chronic exposure to elevated levels. Determination of organochlorine pesticides levels in water has been extensively covered in literature in Egypt and other parts of the world. The need for up-to date data and statistical information regarding the levels of organochlorine pesticides in water is ever increasing. These compounds, although a lot have been prohibited from use decades ago, can still be detected in trace levels in water due to their …
Xuebijing Injection Maintains Grp78 Expression To Prevent Candida Albicans–Induced Epithelial Death In The Kidney,
2020
Tianjin University of Traditional Chinese Medicine
Xuebijing Injection Maintains Grp78 Expression To Prevent Candida Albicans–Induced Epithelial Death In The Kidney, Ting Shang, Qilin Yu, Tongtong Ren, Xin-Tong Wang, Hongyan Zhu, Jia-Ming Gao, Guixiang Pan, Xiumei Gao, Yan Zhu, Benjamin Feng, Ming-Chun Li
Peer Reviewed Articles
Sepsis and septic shock threaten the survival of millions of patients in the intensive care unit. Secondary fungal infections significantly increased the risk of mortality in sepsis patients. Chinese medicine Xuebijing injection (XBJ) has been routinely used as an add-on treatment to sepsis and septic shock in China. Our network pharmacology analysis predicted that XBJ also influences fungal infection, consisting with results of pioneer clinical studies. We conducted in vivo and in vitro experiments to verify this prediction. To our surprise, XBJ rescued mice from lethal Candida sepsis in a disseminated Candida albicans infection model and abolished the colonization of …
Does Preimplantation Genetic Testing Increase The Risk Of Adverse Clinical Outcomes?,
2020
Touro College
Does Preimplantation Genetic Testing Increase The Risk Of Adverse Clinical Outcomes?, Robyn Weiss
The Science Journal of the Lander College of Arts and Sciences
Before 1990, options were limited for couples who were at risk for transmitting a genetic disease or a structural chromosomal abnormality to their children. Couples traditionally underwent invasive procedures such as amniocentesis and chorionic villus sampling, after which termination was offered if the fetus was found to be affected. Many couples chose not to have children at all. Since then, technological advances have allowed preimplantation genetic testing (PGT) to be offered to these couples. Couples who choose PGT undergo in-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI), where the oocyte is injected by a single sperm and is then implanted …
Natural Sources And Bioactivities Of 2,4-Di-Tert-Butylphenol And Its Analogs,
2020
Shenyang University
Natural Sources And Bioactivities Of 2,4-Di-Tert-Butylphenol And Its Analogs, Fuqiang Zhao, Ping Wang, Rima D. Lucardi, Zushang Su, Shiyou Li
NCPC Publications and Patents
2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, …
Mechanisms Of Dopamine-Induced Methamphetamine Neurotoxicity,
2020
Marshall University
Mechanisms Of Dopamine-Induced Methamphetamine Neurotoxicity, Melinda L. Asbury
Theses, Dissertations and Capstones
Methamphetamine (MA) neurotoxicity is particularly evident in the striatum where it causes extensive dopamine (DA) release and results in neurodegeneration. To identify specific signaling pathways and macromolecules involved in postsynaptic DA-induced striatal toxicity we used a SK-N-MC cell model that mimics postsynaptic D1 receptor-expressing striatal neurons. The cells were treated for 6-24 h with 0-50 µM DA. The concentration was chosen to impart physiological relevance to the study as it mirrors [DA] found within the striatum following MA exposure. We show that 25-50 µM DA resulted in protein changes consistent with nitro(oxidative) stress as well as enhanced cleavage of caspase …
Omega-3 Fatty Acids,
2020
Nova Southeastern University
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.
Iron Dextran,
2020
Nova Southeastern University
Is Fecal Microbiota Transplantation A Safe And Effective Treatment For Gastrointestinal Diseases?,
2020
Touro College
Is Fecal Microbiota Transplantation A Safe And Effective Treatment For Gastrointestinal Diseases?, Shaindel Pinsky
The Science Journal of the Lander College of Arts and Sciences
Fecal microbiota transplantation (FMT) is a method of transferring feces from an individual with a healthy microbiome to a patient whose healthy gut bacteria is deficient. While this method is not a new one, it is constantly being explored and studied to determine if it can be an effective way to treat patients with different bowel diseases. The main target of most of these studies are patients with recurrent Clostridium difficile infections. Many studies were done to determine if the method is safe, and which method is most effective, as well as who can be a good donor or recipient …
Is Pnc-27 And Pnc-28 The Best Way To Cure Cancer?,
2020
Touro College
Is Pnc-27 And Pnc-28 The Best Way To Cure Cancer?, Miriam Silberstein
The Science Journal of the Lander College of Arts and Sciences
Immunotherapeutic agents have been researched for many decades as an alternative treatment for cancer. Current research demonstrates that immunotherapy is safer than radiotherapy or chemotherapy. This is attributed to immunotherapy’s mechanism of utilizing the body’s own defense system, as opposed to absorbing harmful chemicals. Two forms of immunotherapy that have been effective in curing cancer without the added danger of chemical toxicity are PNC-27 and PNC-28. These peptides were created by a supercomputer at SUNY Downstate Medical Center in New York in 2000. PNC-27 and PNC-28 work with the MDM2 -P53 tumor suppressor complex. It acts as a competitive inhibitor …
Full Issue: Volume 13, Number 2,
2020
Touro College and University System
Full Issue: Volume 13, Number 2
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 13, number 2 of The Science Journal of the Lander College of Arts and Sciences
Causes And Mechanisms Of Crohn’S Disease,
2020
Touro College
Causes And Mechanisms Of Crohn’S Disease, Chana Weis
The Science Journal of the Lander College of Arts and Sciences
Crohn’s disease and ulcerative colitis are the two most prevalent inflammatory bowel diseases (IBDs) in Jewish and Caucasian populations, affecting as many as one in 250 individuals. Nevertheless, the underlying causes of both disorders are not yet fully understood and remain unknown. However, current evidence suggests that the exaggerated inflammatory response, more commonly referred to as IBD, is believed to arise from dysregulation of the gastrointestinal (GI) immune system in genetically predisposed individuals who are exposed to environmental triggers. Recent advances have identified multiple IBD susceptibility genes; however, only a few environmental determinants of IBD have been consistently identified. The …
Treating Carcinomas Through Integrin Α6Β4 Modification And Inhibition,
2020
Touro College
Treating Carcinomas Through Integrin Α6Β4 Modification And Inhibition, Pearl Singer
The Science Journal of the Lander College of Arts and Sciences
Integrin α6β4 is a membrane protein which is expressed in both normal and cancerous epithelia. In normal cells, it is involved in adhesion to the basal membrane. In carcinomas, however, it takes on cell signaling roles related to survival and migration. Due to its key role in cancer progression, it is now being considered as a therapeutic target. This paper examines how we can affect integrins, with a specific focus on integrin α6β4, to reinforce their ability to prevent migration of cancer cells and progress toward metastasis.
Which Hypothesis Best Explains The Development Of Cancer?,
2020
Touro College
Which Hypothesis Best Explains The Development Of Cancer?, Ariel M. Mayer
The Science Journal of the Lander College of Arts and Sciences
There are three theories of cancer development analyzed in this review. The first theory is the immunological theory, which states that cancer is a result of the immune system failing to detect a cancerous cell in which results in uncontrolled cell growth. The second theory is the somatic mutation theory, which states that genetic mutations are a direct cause cancer. The third theory is the stem cell theory which states that cancer results from an uncontrolled stem cell. The difference in each theory helps guide a clinician’s judgment in how to treat cancer. If a clinician believes in the immunological …
The Biocompatibility Of Various Dental Materials,
2020
Touro College
The Biocompatibility Of Various Dental Materials, Amy Noble
The Science Journal of the Lander College of Arts and Sciences
Dentistry is a continuously evolving field with new materials and technologies constantly innovated. The oral cavity presents a harsh environment in which restorative and implant materials must be able to withstand. Aside for meeting the appropriate physical and chemical standards, it is important that dental materials be biocompatible. Biocompatibility relates to the material’s ability to function in the body without causing harm to living tissue. It is necessary to analyze the materials being used and determine whether they interact with the body in a detrimental manner. This will enable dental professionals to choose the most beneficial material to utilize for …
Uterine Transplantation: A Review Of Some Of The Factors That Account For The Success Or Failure Of This Experimental Procedure,
2020
Touro College
Uterine Transplantation: A Review Of Some Of The Factors That Account For The Success Or Failure Of This Experimental Procedure, Rachel Stern
The Science Journal of the Lander College of Arts and Sciences
Those who suffer from infertility, either due to a congenital or acquired cause and cannot or are opposed to other means, such as surrogacy or adoption, to have a child, are potential candidates for uterine transplantation. Uterine transplantation is a form of allograft transplantation, meaning that it is a transplant of tissue from a donor who is genetically different from the recipient. Additionally, it is a vascularized transplant, including donor blood vessels that will be sutured to the vasculature of the recipient (Testa et al. 2017). This procedure has been attempted around the globe with varying levels of success ranging …
What Is The Future Of Organoids?,
2020
Touro College
What Is The Future Of Organoids?, Michelle Freilich
The Science Journal of the Lander College of Arts and Sciences
The term organoid refers to a miniature version of any organ of the body. An organoid is artificially produced in vitro from stem cells or tissue that possess the ability to recapitulate and form the three-dimensional structure of the organ they were once a part of. Scientists have learned to create a culture for the organoid that mimics its original micro cellular environment, allowing the 3-D structure to self-organize and develop into miniature organs. The purpose of this paper is to explore the many advancements of organoid technology, and how this progress has benefited the medical field. Organoid technology allows …
Effects Of High Fat Diets,
2020
Touro College
Effects Of High Fat Diets, Esther Abady
The Science Journal of the Lander College of Arts and Sciences
With obesity on the rise, and subsequently numerous diseases, many people are looking for newer ways to counter the effects of the influx of fatty, high sugar and unhealthy foods they are consuming. The most common and widely used method is a diet plan. The key to both a healthy and effective diet is knowing what the diet does to the body. There are short term diets which have adverse effects if kept for too long and long-term diets which are aimed for a healthy lifestyle. Every diet is based on the increased and decreased consumption of different macronutrients and …
