Performance Of Mechanical Filters Used In General Ventilation Against Nanoparticles,
2020
Energy and Environment Group, Department of Building, Civil and Environmental Engineering, Concordia University
Performance Of Mechanical Filters Used In General Ventilation Against Nanoparticles, Clothilde Brochot, Pooya Abdolghader, Fariborz Haghighat, Ali Bahloul
Études primaires
With an equal mass, nanoparticles (NP) have a higher toxicity than particles with the same chemical composition but with larger surface area. However, the toxicological knowledge concerning NP is still insufficient to establish limit values of exposure. To seek the lowest exposure level, filtration is a simple and effective way to capture particles, including NP. According to ANSI/ASHRAE 52.2 standard, ventilation filters efficiency is tested for particles ranging from 0.3 to 10.0 μm. Performances of entire filters for NP are still very limited and particle size of 300 nm (0.3 μm) is commonly used as the most penetrating particle size …
Development Of Novel Analytical Methods For Detection And Determination Of Tamoxifen In Oral Fluid And Discrimination Between Regioisomeric Aromatase Inhibitors For Doping Control Purposes,
2020
Eastern Kentucky University
Development Of Novel Analytical Methods For Detection And Determination Of Tamoxifen In Oral Fluid And Discrimination Between Regioisomeric Aromatase Inhibitors For Doping Control Purposes, Brooke A. Sutton
Online Theses and Dissertations
The use of SERMs (Selective Estrogen Receptor Modulators) – most notably the drug Tamoxifen – has significantly increased among athletes over the past decade to enhance athletic performance and/or negate certain side effects of using anabolic steroids. This “doping” is always banned by WADA (World Anti-Doping Agency) for all athletes, but SERMs can naturally increase testosterone production so they are a tempting alternative to using steroids or androgenic supplements that can cause significant health problems (e.g. acne, breast development, frequent urge to urinate, low libido, etc.). Similarly, the use of AIs (Aromatase Inhibitors) has also increased among athletes for identical …
Hear Me Roar,
2020
University of Montana, Missoula
Hear Me Roar, Abigail R. Seethoff
Graduate Student Theses, Dissertations, & Professional Papers
Hear Me Roar, a compilation of personal essays interspersed with short forms, grapples with the nuances of compliance versus autonomy in the context of the male gaze, beauty standards, and pop culture. The collection also explores what it means to treasure something—another person, an object—and how to express and deepen that affection.
Environmental Contaminants, Parasitism, And Neoplasia In White Perch Morone Americana From Chesapeake Bay, Usa,
2020
West Virginia University
Environmental Contaminants, Parasitism, And Neoplasia In White Perch Morone Americana From Chesapeake Bay, Usa, Mark Arnold Matsche
Graduate Theses, Dissertations, and Problem Reports (ETD)
White perch are an abundant demersal fish species in freshwater and oligohaline habitats of the Chesapeake Bay. An avoidance of salinity > 12-15 ppt generally restricts the distribution and movements of fish to within tributaries in the mid to lower Bay, which over time has resulted in the formation of at least three separate stocks in Chesapeake Bay. Sub-populations of white perch that are partially isolated may serve as sentinels of the conditions or stressors in the tributaries in which they reside. Fish are exposed to a variety of environmental contaminants and other anthropogenic stressors that can vary in magnitude based …
Non-Invasive Method For Leptin Supplementation In Zebrafish (Danio Rerio),
2020
The University of Akron
Non-Invasive Method For Leptin Supplementation In Zebrafish (Danio Rerio), Regan Mcnamara
Williams Honors College, Honors Research Projects
I tested the hypothesis that recombinant leptin protein can be introduced to zebrafish in vivo through non-invasive soaking in a solution containing the protein. One way to study various molecules’ effects in vivo is through intraperitoneal or intracerebroventricular injections during the embryonic or larval stage, which is invasive, difficult to administer, and can have a high mortality rate. 48 hours post fertilization (hpf) zebrafish were soaked in a His-tagged recombinant leptin protein solution at 10 nM and 100 nM concentrations (produced by Genscript). After soaking, zebrafish larvae were washed extensively to remove all recombinant protein on their exterior before homogenization. …
Development Of A Method For The Detection And Quantification Of Various Benzodiazepines And Z-Drugs In Human Blood And Qualitative Identification In Urine Samples Using Liquid Chromatography Mass Spectrometry (Lc-Ms/Ms),
2020
The University of Akron
Development Of A Method For The Detection And Quantification Of Various Benzodiazepines And Z-Drugs In Human Blood And Qualitative Identification In Urine Samples Using Liquid Chromatography Mass Spectrometry (Lc-Ms/Ms), Haley Michel
Williams Honors College, Honors Research Projects
This method developed in the toxicology department at the Cuyahoga County Medical Examiner’s Office (CCMEO) detects 40 benzodiazepines and metabolites along with several z-drugs in blood and urine by liquid chromatography tandem mass spectrometry. A sample amount of 0.5 mL was used to detect analytes in postmortem drug facilitated sexual assault and impaired driving cases. Twenty-nine analytes met criteria for quantification while the remaining 14 were used as qualitative indicators. Bias and precision results for quality controls met criteria, staying within ±15% except for clonazolam and etizolam which were within ±20%. Quantitative reporting criteria which included dilution integrity was met …
Multiple Genotoxic Agents Activate Atr Kinase Signaling In Quiescent Human Cells,
2020
Wright State University
Multiple Genotoxic Agents Activate Atr Kinase Signaling In Quiescent Human Cells, Mariyyah Ahmed O. Madkhali
Browse all Theses and Dissertations
The ATR protein kinase is activated in response to DNA damage and other forms of genotoxic stress caused by both environmental carcinogens and anti-cancer drugs. However, much of our understanding of ATR kinase function is limited to proliferating cells in which DNA replication stress is the primary signal for ATR activation and where the major regulatory targets of ATR signaling are proteins involved in DNA synthesis and cell cycle progression. Here we have used HaCaT keratinocytes maintained in a non-replicating, quiescent state in vitro to examine how cell killing by different genotoxic agents is impacted by cell growth status and …
Role Of Exercise In Macrophage Polarization Of Perivascular Adipose Tissue And Adipose Tissue Inflammation In Hypertensive Mice Model,
2020
Wright State University
Role Of Exercise In Macrophage Polarization Of Perivascular Adipose Tissue And Adipose Tissue Inflammation In Hypertensive Mice Model, Venkata Sai Usha Sri Polaki
Browse all Theses and Dissertations
Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. It can lead to severe health complications and increase the risk of heart disease, stroke, and sometimes death. Perivascular adipose tissue (PVAT) is known as the adipose tissue (AT) surrounding all the blood vessels and plays a critical role in the pathogenesis of the vascular disease. In vascular pathologies, PVAT increases in volume and becomes dysfunctional, with altered cellular composition and molecular characteristics. Macrophages have been found to accumulate in PVAT during hypertension, which might be involved …
Identification Of New Metabolic Mutations In The Fission Yeast Schizosaccharomyces Pombe That Sensitize The Cell To Hydroxyurea,
2020
Wright State University
Identification Of New Metabolic Mutations In The Fission Yeast Schizosaccharomyces Pombe That Sensitize The Cell To Hydroxyurea, Alaa Mahdi
Browse all Theses and Dissertations
Cancer is a life-threatening illness and innovative research is therefore required to fuel the development of new anti-cancer therapies. As an anti-proliferative drug, hydroxyurea (HU) has been used in the treatment of various neoplastic and non-neoplastic diseases such as sickle cell anemia, psoriasis, and viral infections. HU is a well-known inhibitor of ribonucleotide reductase (RNR), an enzyme that generates dNTPs for DNA replication and repair. In our genetic screen in fission yeast looking for mutants with defects in checkpoint response, we also found a set of mutants that are highly sensitive to HU but with a functional checkpoint response. It …
Effects Of Creatine And Nicotinamide On Experimentally Induced Senescence In Dermal Fibroblasts,
2020
Wright State University
Effects Of Creatine And Nicotinamide On Experimentally Induced Senescence In Dermal Fibroblasts, Avinash Satyanarayan Mahajan
Browse all Theses and Dissertations
Dermal fibroblasts provide structural support by producing collagen and other structural/support proteins beneath the epidermis. Fibroblasts also produce Insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptors (IGF-1Rs) on keratinocytes to activate signaling pathways that regulate cell proliferation and cellular responses to genotoxic stressors like ultraviolet B radiation found in sunlight. Our group has determined that the lack of IGF-1 expression due to fibroblast senescence in the dermis of geriatric individuals is correlated with an increased incidence of skin cancer in geriatric patients. The present studies were designed to test the hypothesis that pro-energetics like creatine monohydrate and nicotinamide …
Host Abundance Correlates With Gulf War Illness Symptom Persistence Via Nlrp3-Mediated Neuroinflammation And Decreased Brain-Derived Neurotrophic Factor,
2020
University of South Carolina
Host Abundance Correlates With Gulf War Illness Symptom Persistence Via Nlrp3-Mediated Neuroinflammation And Decreased Brain-Derived Neurotrophic Factor, Diana Kimono, Dipro Bose, Ratanesh K. Seth, Ayan Mondal, Punnag Saha, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Nancy Klimas, Saurabh Chatterjee
Faculty Publications
Neurological disorders are commonly reported among veterans who returned from the Gulf war. Veterans who suffer from Gulf War illness (GWI) complain of continued symptom persistence that includes neurological disorders, muscle weakness, headaches, and memory loss, that developed during or shortly after the war. Our recent research showed that chemical exposure associated microbial dysbiosis accompanied by a leaky gut connected the pathologies in the intestine, liver, and brain. However, the mechanisms that caused the symptoms to persist even 30 years after the war remained elusive to investigators. In this study, we used a rodent model of GWI to investigate the …
Humans, Wildlife, And Our Environment: One Health Is The Common Link,
2020
Berryman Institute/Utah State University
Humans, Wildlife, And Our Environment: One Health Is The Common Link, Terry A. Messmer
Human–Wildlife Interactions
One Health has become more important in recent years because interactions between people, animals, plants, and our environment have dramatically changed. This Back Page article discusses One Health during the COVID-19 pandemic.
Seasonal Temperature Changes In Three Midwestern Wastewater Streams And The Effects On Fish Assemblages And Physiology,
2020
Eastern Illinois University
Seasonal Temperature Changes In Three Midwestern Wastewater Streams And The Effects On Fish Assemblages And Physiology, Ryan William Sparks
Masters Theses
Midwestern United States undergo extreme temperature and precipitation fluctuations throughout the year, which leads to changing habitats within Illinois river systems. Wastewater treatment facilities have long been used to treat sewage and reduce the organic products in sewage before releasing it into aquatic environments. Wastewater treatment facilities must maintain optimal conditions, especially temperature, for reproduction and growth of facilitated bacteria that break down organic materials in wastewater. The objectives for this study were to determine the thermal effects of wastewater treatment facilities on receiving waters; and secondly, to investigate the influence of these wastewater facilities on fish abundance and assemblages. …
A Biophysical Investigation Of Stability, Ligand Binding, And Iron State Of Cyp102a1,
2020
University of Kentucky
A Biophysical Investigation Of Stability, Ligand Binding, And Iron State Of Cyp102a1, Catherine A. Denning-Jannace
Theses and Dissertations--Chemistry
Cytochrome P450s (CYPs) are cysteine ligated Fe-heme monooxygenases that are found in all domains of life. In mammals, they have a role in xenobiotic metabolism and steroid synthesis, making them a fundamental requirement for survival. In addition, their ability to perform a variety of chemical reactions on an array of substrates makes CYPs highly sought for biotechnical applications such as wastewater remediation, production of potential drug candidates, and creation of drug metabolites. By mutating specific amino acids, these enzymes can be engineered to change their substrate binding profiles and achieve stereo- and regio-specific chemistry. While these mutations are essential to …
Development Of Health-Related Quality Of Life Questionnaire For Patients On Continuous Drug Use,
2020
Chulalongkorn University
Development Of Health-Related Quality Of Life Questionnaire For Patients On Continuous Drug Use, Wanna Tangpakdeerat, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Background: Health-Related Quality of Life (HRQoL) instruments has become as a principal indicator of the effectiveness of medication treatment especially in case of lifelong therapy. Objectives: The purposes of the study were to develop a quality of lif.
Cell Viability Enhancing And Cellular Protection Activity Of Vitex Glabrata R.Br. Crude Fruits Extract On Tk6 And L929 Cell Lines,
2020
Chulalongkorn University
Cell Viability Enhancing And Cellular Protection Activity Of Vitex Glabrata R.Br. Crude Fruits Extract On Tk6 And L929 Cell Lines, Saraphorn Intarasam, Thatchaphon Meemin, Mesayamas Kongsema, Kantimanee Pradermwong
The Thai Journal of Pharmaceutical Sciences
Studying the plant-based traditional medicine is a starting point for the advancement of modern studies. Vitex glabrata (VG) or Khai-Noa is a medicinal plant in Thailand, which fruits have been used by Thai ancients to improve cognition and enhance memor.
Spectrophotometric Estimation Of Linagliptin Using Ion-Pair Complexation And Oxidative Coupling Reactions – A Green Approach,
2020
Chulalongkorn University
Spectrophotometric Estimation Of Linagliptin Using Ion-Pair Complexation And Oxidative Coupling Reactions – A Green Approach, Sunitha Gurrala, Panikumar Durga Anumolu, Sahitya Menkana, Nikitha Gandla, Keerthi Toddi
The Thai Journal of Pharmaceutical Sciences
Background: Two specific spectrophotometric methods (visible region) have been established using water as a solvent and validated for the analysis of linagliptin in API and pharmaceutical dosage forms. Materials and Methods: Method-A is established on th.
Pharmacy Workforce In Myanmar Public Sector,
2020
Chulalongkorn University
Pharmacy Workforce In Myanmar Public Sector, Lwin Nyein Aye, Puree Anantachoti
The Thai Journal of Pharmaceutical Sciences
Objective: Pharmacist shortage in Myanmar was recognized, but previous local study was unavailable. This study aimed to analyze Myanmar’s pharmacist workforce situation focusing on public sector. Materials and Methods: Mixed method combining secondary ...
Knowledge, Attitude And Practices (Kap) Towards Diet And Health Among International Students In Dublin: A Cross-Sectional Study,
2020
Peking University, Beijing, China
Knowledge, Attitude And Practices (Kap) Towards Diet And Health Among International Students In Dublin: A Cross-Sectional Study, Xiyao Liu, Haoyue Chen, Qianling Zhou, Huifeng Zhang, Phensiri Asawasirisap, John Kearney
Articles
International students may have difficulties in dietary acculturation. This study aimed to evaluate the knowledge, attitude and practices (KAP) of diet and health during the acculturation of international students. A cross-sectional survey was conducted among a convenience sample of 473 international students in Dublin. Knowledge, attitude and practices towards diet and health were evaluated by a questionnaire with open- and closed-ended questions. It was found that 45.3% of participants had a broad concept of a healthy diet, while few knew its specific contents. Furthermore, 75.3% of participants could explain the term functional food, and among them, 62.1% knew the appropriate …
Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study,
2020
Chulalongkorn University
Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study, Ravindra Kamble, Manasi Kulkarni, Swati Korake, Abhishek Pawar, Krishnat Dhekale
The Thai Journal of Pharmaceutical Sciences
Aim: This work was aimed to develop a carrier system of poly(lactic-co-glycolic acid) (PLGA) by using polyethylene glycol (PEG) for longer action in various diseases by preparing a di-block copolymer by using Risperidone (RSP) as a drug. Methodology: PLG.
