Model-Based In-Vitro Pk/Pd Profiling Of Novel Synthetic Allosteric Effectors Of Hemoglobin (Aeh) As Potential Sickle Cell Disease (Scd) Therapeutics,
2020
VCU, School of Pharmacy
Model-Based In-Vitro Pk/Pd Profiling Of Novel Synthetic Allosteric Effectors Of Hemoglobin (Aeh) As Potential Sickle Cell Disease (Scd) Therapeutics, Xiaomeng Xu
Theses and Dissertations
Introduction: Allosteric effectors of hemoglobin (AEH) represent a class of synthetic aromatic aldehydes that transiently form covalent interactions (Schiff-base) with hemoglobin (Hb) to form Hb-AEH adduct, preventing the HbS polymerization and sickling of red blood cells (RBC). The overall objective of this research was to aid in the optimization of novel AEH by understanding their target-site disposition of AEH in relevant biological matrices, e.g., HbA solution, whole blood (WB) and human liver cytosol (HLC), a surrogate of aldehyde dehydrogenase (ALDH)-mediated oxidative metabolism.
Methods: A “universal” HPLC-UV/Vis assay method was developed for the quantitation of HbA-AEH adduct for chemically …
Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes,
2019
University of Nebraska Medical Center
Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng
Theses & Dissertations
Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …
Computational Studies And Design Of Pparγ And Glut1 Inhibitors,
2019
University of Nebraska Medical Center
Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud
Theses & Dissertations
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. PPARγ is a target for insulin-sensitizing drugs, and it plays a significant function in prostate cancer. PPARγ antagonists have anti-proliferative effects in a broad range of hematopoietic and epithelial cell lines. The ligand binding domain (LBD) of PPARγ is large and has orthosteric and allosteric binding sites. Several PPARγ-ligand co-crystal structures show two bound molecules, one to the orthosteric pocket and a second to the allosteric …
Sustainable Solutions, Fall/Winter 2020, Issue 41,
2019
University of Louisville
Sustainable Solutions, Fall/Winter 2020, Issue 41
Sustain Magazine
No abstract provided.
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22,
2019
University of Louisville
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Sustain Magazine
No abstract provided.
Sustainable Communities, Fall/Winter 2010, Issue 21,
2019
University of Louisville
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustain Magazine
No abstract provided.
Sustainable Building, Spring/Summer 2009, Issue 20,
2019
University of Louisville
Sustainable Building, Spring/Summer 2009, Issue 20
Sustain Magazine
No abstract provided.
Environmental History, Fall/Winter 2009, Issue 19,
2019
University of Louisville
Environmental History, Fall/Winter 2009, Issue 19
Sustain Magazine
No abstract provided.
Student Research, Spring/Summer 2008, Issue 18,
2019
University of Louisville
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17,
2019
University of Louisville
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Sustain Magazine
No abstract provided.
Climate Change, Spring/Summer 2007, Issue 16,
2019
University of Louisville
Our Energy Future, Fall/Winter 2007, Issue 15,
2019
University of Louisville
Land Conservation, Spring/Summer 2006, Issue 14,
2019
University of Louisville
Land Conservation, Spring/Summer 2006, Issue 14
Sustain Magazine
No abstract provided.
Pollution And Heart Disease, Fall/Winter 2006, Issue 13,
2019
University of Louisville
Pollution And Heart Disease, Fall/Winter 2006, Issue 13
Sustain Magazine
No abstract provided.
Green Cities, Spring/Summer 2005, Issue 12,
2019
University of Louisville
Global Sustainability, Fall/Winter 2005, Issue 11,
2019
University of Louisville
Global Sustainability, Fall/Winter 2005, Issue 11
Sustain Magazine
No abstract provided.
Environmental Justice, Spring/Summer 2004, Issue 10,
2019
University of Louisville
Environmental Justice, Spring/Summer 2004, Issue 10
Sustain Magazine
No abstract provided.
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9,
2019
University of Louisville
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9
Sustain Magazine
No abstract provided.
Urban Ecology, Spring/Summer 2003, Issue 8,
2019
University of Louisville
Urban Regeneration, Fall/Winter 2003, Issue 7,
2019
University of Louisville
