Nutrition Commons^™

Regulation Of Obesity And Metabolic Complications By Gamma And Delta Tocotrienols, Lu Zhao, Xiefan Fang, Maurice R. Marshall, Soonkyu Chung

Department of Nutrition and Health Sciences: Faculty Publications

Tocotrienols (T3s) are a subclass of unsaturated vitamin E that have been extensively studied for their anti-proliferative, anti-oxidative and anti-inflammatory properties in numerous cancer studies. Recently, T3s have received increasing attention due to their previously unrecognized property to attenuate obesity and its associated metabolic complications. In this review, we comprehensively evaluated the recent published scientific literature about the influence of T3s on obesity, with a particular emphasis on the signaling pathways involved. T3s have been demonstrated in animal models or human subjects to reduce fat mass, body weight, plasma concentrations of free fatty acid, triglycerides and cholesterol, as well as …

Effects Of Short-Term Dynamic Constant External Resistance Training And Subsequent Detraining On Strength Of The Trained And Untrained Limbs: A Randomized Trial, Pablo B. Costa, Trent J. Herda, Ashley A. Herda, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Short-term resistance training has been shown to increase isokinetic muscle strength and performance after only two to nine days of training. The purpose of this study was to examine the effects of three days of unilateral dynamic constant external resistance (DCER) training and detraining on the strength of the trained and untrained legs. Nineteen men were randomly assigned to a DCER training group or a non-training control group. Subjects visited the laboratory eight times, the first visit was a familiarization session, the second visit was a pre-training assessment, the subsequent three visits were for training sessions (if assigned to the …

Association Of Individual And Community Factors With C-Reactive Protein And 25-Hydroxyvitamin D: Evidence From The National Health And Nutrition Examination Survey (Nhanes), Weiwen Chai, Jessie X. Fan, Ming Wen

Department of Nutrition and Health Sciences: Faculty Publications

Many individual and community/neighborhood factors may contribute to inflammation and vitamin D deficiency leading to the development of chronic diseases. This study examined the associations of serum Creactive protein (CRP) and 25-hydroxyvitamin D [25(OH)D] levels with individual and community/neighborhood (tract-level or county-level) factors using a nationally representative sample from 2001–2006 National Health and Nutrition Examination Survey (NHANES). Data from the 2001–2006 waves of the continuous NHANES was merged with the 2000 census and other neighborhood data sources constructed using geographic information system. Associations between multilevel factors and biomarker levels were assessed using multilevel random-intercept regression models. 6643 participants aged 19–65 …

Four Weeks Of High- Versus Low-Load Resistance Training To Failure On The Rate Of Torque Development, Electromechanical Delay, And Contractile Twitch Properties, N.D.M. Jenkins, Terry J. Housh, S.L. Buckner, H.C. Bergstrom, C. M. Smith, Kristen C. Cochrane, E.C. Hill, Amelia A. Miramonti, Richard J. Schmidt, G. O. Johnson, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

The purpose of this study was to investigate the effects of 4-weeks of high- versus low-load resistance training to failure on rate of torque development (RTD), electromechanical delay (EMD), and contractile twitch characteristics. Fifteen men (mean±SD; age=21.7±2.4 yrs) were randomly assigned to either a high- (80% 1RM; n=7) or low-load (30% 1RM; n=8) training group and completed elbow flexion resistance training to failure 3 times per week for 4 weeks. The participants were tested at baseline, 2-, and 4-weeks of training. Peak RTD (pRTDV) and RTD at 0-30 (RTD30V), 0-50 (RTD50V), 0-100 (RTD100V), and 0-200 (RTD200V) ms, integrated EMG amplitude …

Low Energy Availability In Exercising Men Is Associated With Reduced Leptin And Insulin But Not With Changes In Other Metabolic Hormones, Karsten Koehler, Neele R. Hoerner, Jenna C. Gibbs, Christoph Zinner, Hans Braun, Mary Jane De Souza, Wilhelm Schaenzer

Department of Nutrition and Health Sciences: Faculty Publications

Low energy availability, defined as low caloric intake relative to exercise energy expenditure, has been linked to endocrine alterations frequently observed in chronically energy-deficient exercising women. Our goal was to determine the endocrine effects of low energy availability in exercising men. Six exercising men (V_O2peak : 49.3 ± 2.4 ml · kg⁻¹ · min⁻¹) underwent two conditions of low energy availability (15 kcal · kg⁻¹ fat-free mass [FFM] · day⁻¹) and two energy-balanced conditions (40 kcal · kg⁻¹ FFM · day⁻¹) in randomized order. During one low energy availability and …

Carbohydrate Intake In Form Of Gel Is Associated With Increased Gastrointestinal Distress But Not With Performance Differences Compared With Liquid Carbohydrate Ingestion During Simulated Long-Distance Triathlon, Mahdi Sareban, David Zügel, Karsten Koehler, Paul Hartveg, Martina Zügel, Uwe Schumann, Jürgen Michael Steinacker, Gunnar Treff

Department of Nutrition and Health Sciences: Faculty Publications

The ingestion of exogenous carbohydrates (CHO) during prolonged endurance exercise, such as long-distance triathlon, is considered beneficial with regard to performance. However, little is known about whether this performance benefit differs among different forms of CHO administration. To this end, the purpose of our study was to determine the impact of CHO ingestion from a semisolid source (GEL) on measures of performance and gastrointestinal (GI) comfort compared with CHO ingestion from a liquid source (LIQ). Nine well-trained triathletes participated in this randomized crossover study. Each participant completed a 60-min swim, 180-min bike exercise, and a 60-min all-out run in a …

Suppression Of Nlrp3 Inflammasome By Γ-Tocotrienol Ameliorates Type 2 Diabetes, Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung

Department of Nutrition and Health Sciences: Faculty Publications

The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals. We previously reported that γ-tocotrienol (γT3) attenuated adipose tissue inflammation and insulin resistance in diet-induced obesity, but the underlying mechanism remained elusive. Here, we investigated the effects of γT3 on NLRP3 inflammasome activation and attendant consequences on type 2 diabetes. γT3 repressed inflammasome activation, caspase-1 cleavage, and interleukin (IL) 1β secretion in murine macrophages, implicating the inhibition of NLRP3 inflammasome in the anti-inflammatory and antipyroptotic properties of γT3. Furthermore, supplementation of leptin-receptor KO mice …

Disparities In Access To Preventive Health Care Services Among Insured Children In A Cross Sectional Study, Christian King

Department of Nutrition and Health Sciences: Faculty Publications

Children with insurance have better access to care and health outcomes if their parents also have insurance. However, little is known about whether the type of parental insurance matters. This study attempts to determine whether the type of parental insurance affects the access to health care services of children. I used data from the 2009–2013 Medical Expenditure Panel Survey and estimated multivariate logistic regressions (N=26,152). I estimated how family insurance coverage affects the probability that children have a usual source of care, well-child visits in the past year, unmet medical and prescription needs, less than 1 dental visit per year, …

Food Insecurity And Housing Instability In Vulnerable Families, Christian King

Department of Nutrition and Health Sciences: Faculty Publications

Reducing the prevalence of household food insecurity has been a long-standing objective of the federal government. Previous research has found many negative consequences of food insecurity for families and households but has not examined its relationship with housing instability. Using longitudinal data from the Fragile Families and Child Wellbeing Study, difference-in-difference models show that food insecurity is associated with housing instability. The association remains statistically significant after accounting for potential selection and unobserved heterogeneity using propensity score matching and excluding households that experienced prior housing instability from the sample. Examining potential mediating factors, I find that material hardship explains about …

Soft Drinks Consumption And Child Behaviour Problems: The Role Of Food Insecurity And Sleep Patterns, Christian King

Department of Nutrition and Health Sciences: Faculty Publications

Objective: To examine whether the association between soft drinks consumption and child behaviour problems differs by food security status and sleep patterns in young children.

Design: Cross-sectional observational data from the Fragile Families and Child Wellbeing Study (FFCWS), which collected information on food insecurity, soft drinks consumption, sleep patterns and child behaviour problems. Bivariate and multivariate ordinary least-squares regression analyses predicting child behaviour problems and accounting for socio-economic factors and household characteristics were performed.

Setting: Twenty urban cities in the USA with a population of 200 000 or more.

Subjects: Parental interviews of 2829 children who were about 5 years …

Combined Iron Deficiency And Low Aerobic Fitness Doubly Burden Academic Performance Among Women Attending University, Samuel P. Scott, Mary Jane Desouza, Karsten Koehler, Laura E. Murray-Kolb

Department of Nutrition and Health Sciences: Faculty Publications

Background: Academic success is a key determinant of future prospects for students. Cognitive functioning has been related to nutritional and physical factors. Here, we focus on iron status and aerobic fitness in young-adult female students given the high rate of iron deficiency and declines in fitness reported in this population. Objectives: We sought to explore the combined effects of iron status and fitness on academic success and to determine whether these associations are mediated by cognitive performance.

Methods: Women (n = 105) aged 18–35 y were recruited for this cross-sectional study. Data were obtained for iron biomarkers, peak oxygen …

Pharmacological And Genetic Modulation Of Rev-Erb Activity And Expression Affects Orexigenic Gene Expression, Ariadna Amador, Yongjun Wang, Subhashis Banerjee, Theodore M. Kameneka, Laura A. Solt, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes. The circadian rhythm is an endogenous mechanism, which generates entrainable biological changes that follow a 24-hour period. It regulates a number of physiological processes, including sleep/wakeful cycles and feeding behaviors. We recently demonstrated that REV-ERB-specific small molecules affect sleep and anxiety. The orexinergic system also plays a significant role in mammalian physiology and behavior, including the regulation of sleep and food intake. Importantly, orexin genes are expressed in a circadian manner. Given these overlaps in function …

Oral Nutritional Supplement Use In Relation To Length Of Stay In Heart Failure Patients At A Regional Medical Center, Ellen Burkhardt Babb

Walden Dissertations and Doctoral Studies

Improving the nutritional status of hospitalized patients has been shown to reduce length of stay (LOS), hospital costs, readmission rates, complication rates, and mortality. Provision of nutrient-rich, liquid, oral nutrition supplements (ONS) is one approach to improving nutritional status. ONS use has been associated with improved outcomes among patients with diagnoses of orthopedic injuries and pressure ulcers, mainly using prospective designs among elderly and/or malnourished patients. Less information is available for other diagnoses, and no analysis of the effects of ONS could be found that considered the epidemiological triad of person, place, and time. This study used a quantitative, retrospective …

Public Health Leaders' Perceptions Of And Attitudes Concerning Eating Disorders, Karin L. Lightfoot

Walden Dissertations and Doctoral Studies

Eating disorders are associated with high mortality rates. Most eating disorder prevention research is conducted within the fields of psychology and psychiatry, not in public health. This gap in public health research can lead to insufficient attention to the root causes of eating disorders and minimal upstream prevention efforts. The purpose of this phenomenological study was to identify public health leaders' perceptions of and attitudes concerning eating disorders as a public health issue. Objectification theory was used to describe how societal expectations have created an environment in which people's self-worth is based on their outward physical appearance. Ecological theory was …

The Effect Of Body Mass Index On Graft Function And Kidney Transplant Outcomes, Morgan Galle

Theses & Dissertations

Background: When determining eligibility for kidney transplantation, body mass index (BMI) is often a debatable criterion for transplant due to the clinical indication, an elevated BMI has adverse effects on kidney transplant outcomes. There is a current gap in research on the effect BMI has on kidney transplant outcomes.

Purpose: The purpose of this study was to determine the role BMI plays in post-kidney transplant clinical outcomes including delayed graft function, new onset diabetes after transplant, wound complications, hospital length of stay, albumin, and readmissions to the hospital from initial hospitalization and at six months following kidney transplantation. The primary …

Efficiency Of Energy Utilization And Fecal Mineral Excretion In Holstein And Jersey Dairy Cows, Gabriel Garcia Gomez

Department of Animal Science: Dissertations, Theses, and Student Research

Eight multiparous Holstein and 8 Jersey dairy cows were used to complete energy balance trials designed to determine the effect of breed on the production and energy efficiency of milk, and energy partitioning. A repeated switchback design was used to compare the effect of cow breed. Diets consisted of 24.5% corn silage, 18.4% alfalfa hay, 6.9% grass hay, with either 22.9% rolled corn and 14.8% soybean meal (CON) or 8.95% rolled corn and 28.8% reduced fat distillers grains (RFDDGS) DM-basis. Diets were offered ad libitum for a 28 d adaptation period and 95% ad libitum for a 4 d collection …

Digestibility Of Two Complete Pelleted Diets By The Horse (Equus Caballus) As A Model Animal For Nondomestic Hindgut Fermenters, Emily M. Schwartz

Master's Theses

Estimating nutrient and energy requirements of exotic animals is a necessary component of nutrition management in zoos and other wildlife facilities. In the absence of species-specific data, domestic animal models are often referenced. Herbivorous hindgut fermenters, such as horses, zebra, and rhinoceros, rely on microbial fermentation in the cecum and colon to utilize dietary structural carbohydrates. The study objective was to measure the digestible energy of two (LOW, HIGH) complete pelleted diets by the horse as a model for nondomestic hindgut fermenters. Seven, individually housed, adult Quarter Horse (Equus caballus) geldings were assigned to one of two diets as 100% …

Folate Stability In Fortified Corn Masa Flour, Tortillas, And Tortilla Chips, Renee Phillips

Theses and Dissertations

Neural tube defects (NTDs) occur at higher rates in Hispanic populations in the USA. Such populations would benefit from folic acid fortification of corn masa flour (CMF). This study evaluated folate stability in fortified CMFs and products made from the flours, tortillas and tortilla chips. There was no significant loss of folate during the six-month shelf-life of fortified tortilla CMF and tortilla chip CMF. There was a 13% loss (P < 0.05) of folate during tortilla baking and no loss during tortilla chip frying. Both tortillas and tortilla chips showed significant folate losses over the two-month shelf-life for these products, with a 17% loss in fortified tortillas and 9% loss in tortilla chips. Folate in fortified CMFs, tortillas and tortilla chips is relatively stable and comparable to the stability of folate in wheat flour and breads.

‘Tis The Season, Winston J. Craig

Lake Union Herald

No abstract provided.

The Validity Of Urine Color Self-Assessment As An Index Of Hydration In Males, Daniel Layne Nixon

Graduate Theses and Dissertations

While water intake is so important, there are few practical hydration assessment techniques for the general population to use on a daily basis. The present study examined the accuracy of self-assessed urine color (Ucol) as a potential hydration assessment tool. Male college aged subjects provided a urine sample into a custom built urinal (n=76; 1.79±0.76 m, 83.9±16.0 kg). The urinal contained a picture of the 1-8 color scale and a light and dark urine color scale. Subjects were asked to give their urine color estimation as a whole number integer and to estimate if their urine was light or dark. …