Other Neuroscience and Neurobiology Commons^™

Is Concussion-Related Sleep Disturbance Present After Return To Play In College Athletes?, Alexander Gallaer

Honors Scholar Theses

As one of the most commonly experienced symptoms, the ramifications of sleep disruption as a result of concussion are potentially great, yet widely unexplored. Particularly troublesome is murky data regarding the length of sleep disruption following a concussion. By analyzing self-reported sleep data via the Pittsburgh Sleep Quality Index, this study seeks to investigate potential differences in sleep quality between injured college athletes 40 days after they have been cleared to play and matched controls. Data was analyzed using ANOVA analysis as well as Pearson correlation. No significant differences were found in sleep quality between groups, nor was there a …

Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin

Senior Honors Theses

The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …

Genetic Testing Practices Of Genetic Counselors, Geneticists, And Pediatric Neurologists With Regard To Childhood-Onset Neurogenetic Conditions, Sara Wofford

Dissertations and Theses (Open Access)

Identifying genetic diagnoses for neurological conditions with a considerable hereditary component, such as autism spectrum disorder (ASD), intellectual disability, and epilepsy, is critical to providing proper medical management for these patients and their families. However, many patients with these conditions are not tested appropriately or receive no genetic testing at all. The current study was designed to characterize the genetic testing practices of the providers most likely to evaluate or order genetic testing for these patients: pediatric neurologists, geneticists, and genetic counselors. The study noted significant variance between the testing strategies selected by pediatric neurologists compared to those of geneticists …

Arsenic Toxicity And Mitochondrial Metabolism In Astrocytes, Reilly Grealish

Honors Program: Senior Projects (Public)

The various cells that support neurons in both the central and peripheral nervous systems are known collectively as neuroglia, or glia. Astrocytes, a type of glial cell found exclusively in the central nervous system (i.e. the brain and spinal cord), are particularly abundant and serve many functions. One of the most important is the role these cells play in the brain as a defense against harmful substances, many of which can be found in the environment and make their way into the human body as xenobiotic substances. Elemental arsenic in its inorganic form occurs naturally throughout the Earth’s crust, but …

Function Of The Posterior Laryngeal Constrictor In The Túngara Frog (Engystomops Pustulosus), Ashna Rahman Haque, Marcos Gridi-Papp

Pacific Research & Scholarship Day

No abstract provided.

Arts Based Brain Research, Alicia Arendt

Lesley University Community of Scholars Day

Art is believed to be “the expression or application of the human creative skill and imagination, producing works to be appreciated primarily for their aesthetic value or emotional power” (Buk, 2009, p. 61). While there are a myriad of ways to define and categorize art, such a definition as the one above is useful as it touches upon three key areas of arts based brain research; artistic cognition, artistic production and aesthetic experience. The study of arts based brain science, or the neuroscience of art, demands an understanding of the interplay between these three facets of the artistic experience. Most …

Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol

All NMU Master's Theses

Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor …

Concussion Competencies: A Framework For School-Based Concussion Management (Flyer), Arthur C. Maerlender, Jonathan Lichtenstein, Jennifer Parent-Nichols

Center for Brain, Biology, and Behavior: Faculty Publications

This volume grew out of many years of clinical practice, research, and program projects. It is the culmination of more than 50 years of work with kids, brains, and schools. While there is research behind the Competencies and the underlying content, the intent was to create a user-friendly manual that cut across levels of responsibility and care. Concussion Competencies was not intended to be a textbook in the traditional manner; however, the Competencies have been shown to be a useful approach to teaching this material.

This volume is organized around a set of Competencies that have been shown to be …

Mechanisms Underlying Serotonergic Excitation Of Callosal Projection Neurons In The Mouse Medial Prefrontal Cortex, Emily K. Stephens, Arielle L. Baker, Allan T. Gulledge

Dartmouth Scholarship

Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT_2A (2A) receptors coupled to G_q subtype G-protein alpha subunits. G_q-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by K_V7 potassium channels (i.e., the M-current), or activation of non-specific cation conductances that underlie calcium-dependent afterdepolarizations (ADPs). However, 2A-dependent excitation of cortical neurons has not been extensively studied, and no consensus exists regarding the underlying ionic effector(s) involved. In layer 5 of the mouse medial prefrontal cortex, we tested potential mechanisms of serotonergic excitation …

Tasseography From Jung's Perspective, Avetisian, Elizabeth

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Approaching from Jung’s perspective this paper aims to understand how the unconscious communicates through symbolism that may be the basis for synchronicity arising from mantic procedures. A particular ritual of divination called tasseography will be studied whereby the seer interprets patterns in coffee grounds intuitively and by following a standard system of symbolism to foretell the seeker’s future life events or provide answers to seeker’s pressing life questions. The paper will examine various processes involved in the experience of tasseography and its ritual that enable the reader to predict the seeker’s future or bring light to the present or past …

Sourcing Enchantment: From Elemental Appropriation To Imaginal Symbolics, Schwartz, Michael

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Critical theorists and social commentators agree that modernity and postmodernity suffer from historical pathologies of world disenchantment. What might be done? Drawing on John Sallis’ phenomenology of the elemental and Tibetan Buddhist teachings on elemental practices, this paper investigates the imagination in its doubling as imaginal in generating a symbolics of the self, world, and other that is always already enchanted; an aesthetics of existence where the world itself shows forth like a work of art replete with exorbitant logics.

Factor Structure And Gender Invariance Testing For The Sport Anxiety Scale-2 (Sas-2), Leilani Madrigal, Vincenzo Roma, Todd Caze, Arthur C. Maerlender, Debra Hope

Center for Brain, Biology, and Behavior: Faculty Publications

This study aimed to provide further psychometric validation of the Sport Anxiety Scale-2 (SAS-2) by assessing the factor structure, invariance across gender, and convergent and divergent validity of the SAS-2 by correlating both related (i.e., anxiety sensitivity, brief fear of negative evaluation, intolerance of uncertainty, and negative affect) and unrelated constructs (i.e., positive affect, self-confidence). A total of 542 current and former competitive athletes completed a questionnaire through Amazon’s Mechanical Turk system. All data were collected via online survey. Participants were randomly assigned to an exploratory factor analysis (n = 271) and confirmatory factor analysis group (n = 271). Results …

Accumulating Data To Optimally Predict Obesity Treatment (Adopt): Recommendations From The Biological Domain, Michael Rosenbaum, Tanya Agurs-Collins, Molly S. Bray, Kevin D. Hall, Mark Hopkins, Maren Laughlin, Paul S. Maclean, Padma Maruvada, Cary R. Savage, Dana M. Small, Luke Stoeckel

Center for Brain, Biology, and Behavior: Faculty Publications

Background: The responses to behavioral, pharmacological, or surgical obesity treatments are highly individualized. The Accumulating Data to Optimally Predict obesity Treatment (ADOPT) project provides a framework for how obesity researchers, working collectively, can generate the evidence base needed to guide the development of tailored, and potentially more effective, strategies for obesity treatment. Objectives: The objective of the ADOPT biological domain subgroup is to create a list of high-priority biological measures for weight-loss studies that will advance the understanding of individual variability in response to adult obesity treatments. This list includes measures of body composition, energy homeostasis (energy intake and output), …

Left Lateralized Cerebral Glucose Metabolism Declines In Amyloid-Β Positive Persons With Mild Cognitive Impairment, Christopher M. Weise, Kewei Chen, Yinghua Chen, Xiaoying Kuang, Cary R. Savage, Eric M. Reiman

Center for Brain, Biology, and Behavior: Faculty Publications

Background: Previous publications indicate that Alzheimer's Disease (AD) related cortical atrophy may develop in asymmetric patterns, with accentuation of the left hemisphere. Since fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the regional cerebral metabolic rate of glucose (rCMRgl) provide a sensitive and specific marker of neurodegenerative disease progression, we sought to investigate the longitudinal pattern of rCMRgl in amyloid-positive persons with mild cognitive impairment (MCI) and dementia, hypothesizing asymmetric declines of cerebral glucose metabolism. Methods: Using florbetapir PET and cerebrospinal fluid (CSF) measures to define amyloid-β (Aβ) positivity, 40 Aβ negative (Aβ-) cognitively unimpaired controls (CU; 76 ± 5y), …

Novel Biomarkers Of Physical Activity Maintenance In Midlife Women: Preliminary Investigation, Kelly A. Bosak, Vlad B. Papa, Morgan G. Brucks, Cary R. Savage, Joseph E. Donnelly, Laura E. Martin

Center for Brain, Biology, and Behavior: Faculty Publications

The precision health initiative is leading the discovery of novel biomarkers as important indicators of biological processes or responses to behavior, such as physical activity. Neural biomarkers identified by magnetic resonance imaging (MRI) hold promise to inform future research, and ultimately, for transfer to the clinical setting to optimize health outcomes. This study investigated resting-state and functional brain biomarkers between midlife women who were maintaining physical activity in accordance with the current national guidelines and previously acquired age-matched sedentary controls. Approval was obtained from the Human Subjects Committee. Participants included nondiabetic, healthy weight to overweight (body mass index 19–29.9 kg/m …

Mesotocin Influences Pinyon Jay Prosociality, J. F. Duque, W. Leichner, H. Ahmann, Jeffrey R. Stevens

Center for Brain, Biology, and Behavior: Faculty Publications

Many species exhibit prosocial behavior , in which one individual’s actions benefit another individual, often without an immediate benefit to itself. The neuropeptide oxytocin is an important hormonal mechanism influencing prosociality in mammals, but it is unclear whether the avian homologue mesotocin plays a similar functional role in birds. Here, we experimentally tested prosociality in pinyon jays (Gymnorhinus cyanocephalus), a highly social corvid species that spontaneously shares food with others. First, we measured prosocial preferences in a prosocial choice task with two different pay-off distributions: Prosocial trials delivered food to both the subject and either an empty cage …

Investigating The Role Of The Caspase-6 Cleavage Fragment Of Mutant Huntingtin In Huntington Disease Pathogenesis, Jourdan A. Mckinnis

Honors Undergraduate Theses

Huntington disease (HD) is a devastating and fatal neurodegenerative disease. At the moment, no disease modifying therapies are available, with only symptomatic treatment offered to alleviate psychiatric and some types of motor deficits. As a result, many people will continue to suffer and die from this disease. Small molecule therapies have failed to provide benefit in HD, necessitating more complex gene therapy approaches and the identification of less traditional therapeutic targets. A previous study demonstrated that preventing cleavage of the huntingtin (HTT) protein, the protein that when mutated causes HD, by caspase 6 (C6) at amino acid 586 prevents the …

Investigating The Relationship Between Sulcogyral Patterns And Structural And Functional Connectivity Metrics In The Orbitofrontal Cortex, Bethany M. Blass

Honors Theses

Located within the frontal lobe, the human orbitofrontal cortex (OFC) is widely known for its roles in sensory integration, emotion processing, decision-making, and goal-directed behaviors. Atypical structural organization of the OFC may explain atypical social or motivational behaviors displayed by individuals with brain disorders, such as bipolar disorder patients (BP).

The human brain can be imaged using magnetic resonance imaging (MRI) to reveal interesting aspects of the underlying brain architecture. This brain is composed of different tissue types, including gray and white matter, as well as various morphological features, including sulci & gyri. Within the OFC, the sulci can be …

Human-Like Behavior And Cognition: Not A Good Starting Point, Magnus Helgheim Blystad

Animal Sentience

Chapman & Huffman make use of observations and studies that show how humans may not be as unique in our behaviour and cognition as previously thought. I wholeheartedly agree that our uniqueness might be small and that if it exists, it should not give our species any right to act cruelly towards other animals. However, this kind of logic can be problematic. I present a few of the issues in this commentary.

A Behavioral Mechanistic Investigation Of The Role Of 5-Ht1a Receptors In The Mediation Of Rat Maternal Behavior, Xiaonan Li, Xiaojing Ding, Ruiyong Wu, Leilei Chen, Jun Gao, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Previous work suggests that 5-HT_1A receptors play a special role in rodent maternal aggression, but not in other aspects of maternal care (e.g. pup retrieval and nest building). The present study re-assessed the basic effects of 5-HT_1A activation or blockade on various maternal responses in postpartum female rats. We also examined the possible behavioral mechanisms underlying the maternal effects of 5-HT_1A. Sprague–Dawley mother rats were injected with a 5-HT_1A agonist 8-OH-DPAT (0.1, 0.5 or 1.0 mg/kg, sc), a 5-HT_1A antagonist WAY-101405 (0.1, 0.5 or 1.0 mg/kg, sc) or 0.9% saline solution on postpartum days …