Carotenoids Identified From Slipper-Shaped Oyster Magallana Bilineata Powder Residue Exhibit Potent Biological Activities,
2025
Institute of Fish Processing Technology, College of Fisheries and Ocean Sciences, University of the Philippines Miagao 5023 Iloilo, Philippines
Carotenoids Identified From Slipper-Shaped Oyster Magallana Bilineata Powder Residue Exhibit Potent Biological Activities, Rhoda Mae C. Simora, Raymund B. Parcon, Andrea Roxanne J. Anas, Tatsufumi Okino
Journal of Food and Drug Analysis
Carotenoids are a diverse class of biologically active compounds that contribute significantly to human health, serving vital functions in nutrition and overall well-being. Magallana bilineata, a commercially important oyster species, yields a shelf-stable powder residue possessing bioactivities with unknown specific compounds. Carotenoids are key marine bioactive compounds, but their presence in oysters remains underexplored. The present study aimed to identify the bioactive compounds from oyster powder residue through mass spectrometry for optimum utilization and value creation as a biomedical resource. The study employed solvent extraction of oyster powder residue, followed by fractionation using octadecylsilyl (ODS) column chromatography, liquid chromatography-mass …
Selective Sodium-Glucose Cotransporter Two Inhibitor Empagliflozin Ameliorates Diabetic Cardiomyopathy By Activating The Ampk/Tfeb Signaling Pathway.,
2025
Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Selective Sodium-Glucose Cotransporter Two Inhibitor Empagliflozin Ameliorates Diabetic Cardiomyopathy By Activating The Ampk/Tfeb Signaling Pathway., Man-Chen Hsu, Ru-Wen Chang, Mu-Chun Wang, Chia-Hui Chen, Wen-Hua Chen, Tzong-Shyuan Lee, Chih-Hsien Wang
Journal of Food and Drug Analysis
The highly selective SGLT2 inhibitor (SGLT2i) is reported to have beneficial effects on diabetic cardiac hypertrophy; however, the molecular mechanisms underlying the cardioprotection of SGLT2i are not fully understood. In this study, we investigated the impact of the SGLT2 Inhibitor empagliflozin (EMPA) on diabetic hearts and its regulatory mechanisms in high-fat-diet (HFD)- and streptozotocin (STZ)-treated rats. Male rats orally administered HFD/STZ treatment for eight weeks, with or without EMPA (10 mg/kg), were used as our in vivo model. Hematoxylin and eosin (H&E) staining was used for histological examination. Western blot analysis and immunohistochemistry were used to analyze the expression of …
Targeting Chemical Carcinogenesis: Α-Pinene And D-Limonene As Chemopreventive Agents Against Nnk/ Tcdd- And Urethane-Induced Lung Tumorigenesis,
2025
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan
Targeting Chemical Carcinogenesis: Α-Pinene And D-Limonene As Chemopreventive Agents Against Nnk/ Tcdd- And Urethane-Induced Lung Tumorigenesis, Kuo-Ching Huang, Vui-Hyen Chew, Yu-Ying Chen, Huey-Jen Su, Hao-Ting Chang, Rong‑Jane Chen, Ying‑Jan Wang
Journal of Food and Drug Analysis
Lung cancer is the leading cause of cancer-related deaths worldwide, driven by carcinogens such as tobacco-derived nitrosamines, dioxins, and urethane. This study evaluated the chemopreventive effects of two monoterpenes, α-pinene and D-limonene, using NNK/TCDD- and urethane-induced lung tumor models and A549 lung cancer cells. Both compounds significantly reduce tumor number and size, with enhanced effects when combined. Mechanistic studies revealed suppression of PRC1, β-catenin, and c-Myc, alongside activation of p53, Bax, and caspase-3, indicating inhibition of the PRC1—Wnt/β-catenin pathway and induction of apoptosis. These findings suggest α-pinene and D-limonene as safe, promising agents for lung cancer chemoprevention.
Fish Oil Rich In Ω-3 Fatty Acid Alleviates Long-Term High Fructose Consumption-Induced Fatty Liver And Kidney Dysfunction In Rats,
2025
Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
Fish Oil Rich In Ω-3 Fatty Acid Alleviates Long-Term High Fructose Consumption-Induced Fatty Liver And Kidney Dysfunction In Rats, Shing-Hwa Liu, Ruoh-Wenn Hung, Ting-Yu Chang, Meng-Tsan Chiang
Journal of Food and Drug Analysis
Excessive fructose intake leads to fatty liver and kidney dysfunction, with associated inflammation and metabolic disturbances. This study evaluated the effects of fish oil rich in ω-3 fatty acid on these conditions in rats fed a high- fructose diet. Male Sprague Dawley rats were divided into three groups: normal diet, high-fructose (HF) diet, and high- fructose diet with 5% fish oil supplementation. The experiment lasted for 21 weeks. Fish oil supplementation significantly reduced blood levels of total cholesterol, triglycerides, and advanced glycation end products (AGEs) in HF-fed rat. It also improved liver function markers and kidney function indicators. Mechanistically, fish …
Effects Of Chamomile And L-Theanine Beverage On Menstrual Pain, Menstrual Symptoms, Mood, And Sleep Quality In Young Women Experiencing Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled Study,
2025
Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti Bandar Barat, Kampar 31900, Perak, Malaysia.
Effects Of Chamomile And L-Theanine Beverage On Menstrual Pain, Menstrual Symptoms, Mood, And Sleep Quality In Young Women Experiencing Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled Study, Ziqing Soh, Soo Cing Tan, Tak Hiong Wong, Seok Tyug Tan, Seok Shin Tan, Chin Xuan Tan
Journal of Food and Drug Analysis
Primary dysmenorrhea is one of the most common complaints among young women. This study aimed to evaluate the effects of chamomile and L-theanine beverage intake on menstrual symptoms, pain intensity, mood, and sleep quality in young adult females with primary dysmenorrhea, using a two-phase continuous study design. In the first phase, a cross-sectional study was conducted to assess the prevalence of primary dysmenorrhea. In the second phase, participants were randomly assigned to either the intervention group (n =15), which consumed chamomile and L- theanine beverage (CTT), or the control group (n =15), which consumed chamomile-flavored beverage (non-CTT). Beverages …
Cordycepin In Cancer Therapy: A Bibliometric Analysis And Review Of Mechanisms,
2025
Jiangxi Key Laboratory of Natural Microbial Medicine Research, College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China
Cordycepin In Cancer Therapy: A Bibliometric Analysis And Review Of Mechanisms, Zhiwei Ouyang, Yufei Zhang, Jianghan Ning, Yayi Tu, Bin He
Journal of Food and Drug Analysis
Cordycepin (3’-deoxyadenosine), a major bioactive component derived from fungi of the genus Cordyceps, has garnered significant attention in recent years for its potent antitumor properties. Drawing on literature indexed in the Web of Science Core Collection from 2004 to 2025, this study employs bibliometric tools―specifically CiteSpace and VOSviewer―to systematically examine developmental trends, research hotspots, and emerging frontiers in the field of cordycepin-related cancer research. The analysis maps a shift in focus from early-stage pharmacological validation to more advanced investigations into molecular mechanisms, with particular emphasis on cell cycle regulation. Keyword burst analysis highlights bursts in terms such as “apoptosis,” “cell …
Distinguishing Avocado Oil Quality Based On Fatty Acid Profile Using Pca: A Review Of Influencing Factors And Research Gaps,
2025
Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta 55281, Indonesia
Distinguishing Avocado Oil Quality Based On Fatty Acid Profile Using Pca: A Review Of Influencing Factors And Research Gaps, David Fernando, Ali Ridho Arif Madja, Nur Azizah, Agustina Ari Murti Budi Hastuti, Abdul Rohman
Journal of Food and Drug Analysis
The quality of avocado oil is influenced by multiple factors, including cultivar, growing region, drying method, harvest season, fruit maturity, extraction technique, and storage conditions. This review aims to show how fatty acid profiles (FAP), combined with principal component analysis (PCA), can be used to characterize avocado oil based on various established factors. A total of 23 peer-reviewed articles were included, encompassing 143 data points. PCA was applied as an exploratory tool to reduce dimensionality and visualize patterns in the data. Among the evaluated variables, the fruit part emerged as the most influential determinant, allowing clear categorization of avocado oils …
Effects Of Compound Protease Fermentation On The Industrial-Scale Production Of Very High Gravity Brewing Beer,
2025
Tsingtao Brewery Co . Ltd., Qingdao 266237 , China
Effects Of Compound Protease Fermentation On The Industrial-Scale Production Of Very High Gravity Brewing Beer, Zongming Chang, Guangfeng Liu, Li Fang, Jiajie Zhang, Hua Yin
Journal of Food Science and Biotechnology
[Objective ] This study aims to address the technical problems of insufficient nitrogen content and an imbalanced amino acid composition in very high gravity wort produced with high-level syrup adjuncts.[Method ] This study investigated the effect of protease-assisted saccharification on wort protein composition.Then,a comprehensive evaluation was conducted on the brewing performance during 22 ° P very high gravity beer production.[Result ] During the proteolysis stage of saccharification,a synergistic addition of neutral protease and flavourzyme protease at a mass ratio of 6∶4 enabled efficient directed hydrolysis of malt proteins.In the wort,the α-amino nitrogen mass concentration was increased by 30%,while the mass …
Rapid Detection Of Aflatoxin B 1 Contamination Levels In Peanuts Based On Dual-Band Hyperspectral Imaging And Machine Learning,
2025
The College of Medical Technology , Shanghai University of Medicine & Health Sciences , Shanghai 201318 , China
Rapid Detection Of Aflatoxin B 1 Contamination Levels In Peanuts Based On Dual-Band Hyperspectral Imaging And Machine Learning, Lu Ren, Shuyue Shen, Wanrong Shi, Chuang Rui, Maofeng Dong, Tingting Li
Journal of Food Science and Biotechnology
[Objective ] This study aims to achieve rapid detection of AFB 1 contamination levels in peanuts through dual-band hyperspectral imaging and machine learning.[Method ] A peanut AFB 1 contamination level warning model was constructed via a dual-band hyperspectral imaging system consisting of visible near-infrared spectroscopy at 400~1 000 nm and short-wave near-infrared spectroscopy at 900~1 700 nm,combined with machine learning.Peanut samples with four contamination levels were collected,in which the mass fraction of AFB 1 was determined by ultra-high performance liquid chromatography-tandem mass spectrometry.The effects of four pretreatment methods [first derivative,second derivative,multiplicative scatter correction,and standard normal variate (SNV )],two characteristic wavelength …
Effects Of Aerated Storage On The Microbial Community And Functional Genes Of Pickles,
2025
Institute of Eastern Himalaya Research , Dali University , Dali 671003 , China
Effects Of Aerated Storage On The Microbial Community And Functional Genes Of Pickles, Hengye Jing, Wei Deng, Fuliang Qi, Kun Tan, Rong She, Xiaoyan Yang
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects of aeration on the microbial community structure and metabolic functional genes in pickles.[Method ] Amplicon sequencing was carried out for the 16S rRNA and ITS rRNA gene fragments from three groups (aerated group,sealed group,and the initial group ) within the same pickle system.The EasyAmplicon pipeline and PICRUSt 2 were employed to assess bacterial and fungal community diversity,composition,and functional gene variations.[Result ] Compared with the initial group,the sealed group showed only minor changes in microbial diversity,whereas the aerated group exhibited significant microbial divergence from the initial group.After aeration,the number of rare taxa …
Protective Effects Of Ovalbumin-Sodium Carboxymethylcellulose Colloidal Particles On Fish Oil Emulsions,
2025
School of Food Science and Biotechnology , Zhejiang Gongshang University , Hangzhou 310018 , China
Protective Effects Of Ovalbumin-Sodium Carboxymethylcellulose Colloidal Particles On Fish Oil Emulsions, Weichun Pan, Ya Wen, Huabin Liao, Feina Gu, Qiuping Zhang, Fuge Niu
Journal of Food Science and Biotechnology
[Objective ] This study aimed to investigate the impact of curcumin-loaded ovalbumin (OVA )-carboxymethylcellulose (CMC ) (OVA -CMC-Cur ) colloidal particles on the stability of fish oil emulsions.[Method ] The OVA -CMC-Cur colloidal particles were prepared with OVA and CMC at varying mass ratios and pH.The colloidal particles were then used as the stabilizer to prepare fish oil emulsions.The structural characteristics,stability,and digestive behaviors of the emulsions were investigated.[Result ] At the OVA -CMC mass ratio of 2∶1,the OVA -CMC-Cur particle-stabilized fish oil emulsions exhibited smaller particle sizes.These particles formed a dense,compact interfacial film at the oil-water interface,resulting in more uniform …
Research Progress In The Regulation Of Intestinal Stem Cell Homeostasis By Dietary Patterns,
2025
School of Food Science and Biotechnology , Zhejiang Gongshang University , Hangzhou 310018 , China
Research Progress In The Regulation Of Intestinal Stem Cell Homeostasis By Dietary Patterns, Haichao Zhang, Qi Sun, Yumei Qin, Yanpei Gu, Jianzhong Han
Journal of Food Science and Biotechnology
Intestinal stem cells (ISCs ) located at the bottom of intestinal crypts are the key factors driving the repair and rapid renewal of the intestinal epithelium.Their proliferation and differentiation are finely regulated by the microenvironment of the niche.ISCs,as dietary nutrient sensors,can respond to different dietary signals to regulate intestinal homeostasis.The author systematically summarizes the main signaling pathways involved in the regulation of ISCs and reviews the effects and functioning mechanisms of dietary patterns such as high-fat diets,intermittent fasting,calorie restriction,and ketogenic diets on the homeostasis of ISCs,aiming to provide a theoretical basis for the development and application of dietary intervention strategies …
Therapeutic Mechanisms Of A Lilium Brownii -Plantago Asiatica L.Compound Solid Beverage Against Hyperuricemia,
2025
Food Laboratory of Zhongyuan , Luohe 462300 , China
Therapeutic Mechanisms Of A Lilium Brownii -Plantago Asiatica L.Compound Solid Beverage Against Hyperuricemia, Feng Li, Jiawei Huang, Xiaowen Guo, Lulu Jiang, Hongyan Zhao, Qiang Li, Chenxiang Sun, Shuying Feng, Qianqian Wang
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the ameliorative effects of a Lilium brownii -Plantago asiatica L.compound solid beverage on hyperuricemia and to elucidate its potential mechanisms.[Method ] Network pharmacology was employed to screen the active constituents,potential targets,and related pathways.Key targets were identified based on a protein-protein interaction (PPI) network.Molecular docking was conducted between the key proteins and active constituents.An animal experiment was performed to validate the effects of the compound solid beverage on serum uric acid levels,renal function indices,activities of uric acid-producing enzymes,and the levels of renal urate transporters.[Result ] Network pharmacology analysis indicated that Lilium brownii and Plantago …
First_Page Settings Order Article Reprints Open Accessarticle Quantitative Detection Of Salmonella Typhimurium In Ground Chicken Using A Surface Plasmon Resonance (Spr) Biosensor,
2025
Tennessee State University
First_Page Settings Order Article Reprints Open Accessarticle Quantitative Detection Of Salmonella Typhimurium In Ground Chicken Using A Surface Plasmon Resonance (Spr) Biosensor, Sandhya Thapa, Fur-Chi Chen
Food and Animal Sciences Faculty Research
Regulatory agencies worldwide have implemented stringent measures to monitor and reduce Salmonella contamination in poultry products. Rapid quantitative detection methods enable producers to identify contamination early, implement corrective actions, and enhance food safety. This study aimed to develop and optimize a surface plasmon resonance (SPR) biosensor for the quantitative detection of Salmonella Typhimurium in ground chicken. The sensor surface was functionalized with a well-characterized monoclonal antibody specific to Salmonella flagellin, and an SPR workflow was established for quantitative analysis. Ground chicken samples were inoculated with four S. Typhimurium strains at contamination levels ranging from −0.5 to 3.5 Log CFU/g and …
Research Progress In Enrichment Of Trace Elements Zinc And Selenium In Pleurotus Spp.,
2025
Jiangsu Zhongnongke Food Engineering Co ., Ltd ., Suqian 223800 , China
Research Progress In Enrichment Of Trace Elements Zinc And Selenium In Pleurotus Spp., Jing Zhang, Mengmeng Xu, Liting Zhao, Cui Li, Lei Chen, Song Ming, Zhongyang Ding
Journal of Food Science and Biotechnology
Zinc and selenium are essential trace elements for maintaining human normal physiological function.Deficiency of zinc or selenium can result in immune dysfunction,chronic diseases such as cardiovascular diseases and hyperlipidemia,and even increase the risk of cancer.The human body cannot independently synthesize these trace elements,which can only be obtained from the daily diet.However,natural food sources have low content of zinc and selenium,which is insufficient to meet the bod y’s needs.Therefore,developing fortified foods with trace nutrients is an important approach to meeting residents ’ requirements.Edible fungi serve as natural carriers for enriching trace elements and ideal dietary supplements.Pleurotus spp.,as a typical example,not only …
Construction And Optimization Of An Efficient Tyrosol Biosynthesis System In Escherichia Coli,
2025
School of Biotechnology , Jiangnan University , Wuxi 214122 , China ;Key Laboratory of Industrial Biotechnology of Ministry of Education , Jiangnan University , Wuxi 214122 , China
Construction And Optimization Of An Efficient Tyrosol Biosynthesis System In Escherichia Coli, Yizhe Xiong, Shougang Wang, Zhiming Rao, Meijuan Xu
Journal of Food Science and Biotechnology
[Objective ] An efficient biosynthetic system was constructed in Escherichia coli to achieve high-yield production of tyramine and its key derivative tyrosol.[Method ] Through the analysis of protein expression,enzymatic properties,and whole-cell catalysis results,tyrosine decarboxylase (TDC ) derived from Enterococcus faecalis was selected as the key enzyme for tyramine synthesis.Subsequently,tyramine oxidase (TYO ) was introduced to construct the TDC-TYO pathway for tyrosol production.Meanwhile,the LAAD-PDC pathway for tyrosol synthesis was established.A dual-enzyme co-expression system was established,and the effects of tandem enzyme order,production pathways,and key enzyme sources on tyrosol yield were analyzed.The recombinant strain B 1,carrying the plasmid pET 28a-EfTDC-TYO,was obtained through whole-cell …
Promoting The Synthesis Of Salicylic Acid In Escherichia Coli Based On Metabolic Engineering And Multi-Enzyme Cascade Strategy,
2025
Key Laboratory of Industrial Biotechnology of the Ministry of Education , Jiangnan University , Wuxi 214122 , China;Yixing Institute of Food and Biotechnology Co ., Ltd., Wuxi 214200 , China
Promoting The Synthesis Of Salicylic Acid In Escherichia Coli Based On Metabolic Engineering And Multi-Enzyme Cascade Strategy, Kai Wang, Xuewei Pan, Taowei Yang, Zhiming Rao
Journal of Food Science and Biotechnology
[Objective ] The production of the aromatic compound salicylic acid (SA) is limited by its inhibitory effects on enzymes related to cellular energy metabolism.This study aims to develop a strategy for avoiding the impact of SA on enzymes related to cellular energy metabolism and increase the yield of SA.[Method ] A highly efficient Escherichia coli strain was designed to improve SA production by optimizing metabolic pathways and enzyme systems.[Result ] The genome-scale metabolic model GEMS 1515 was employed to predict the key bottle necks in the phosphoenolpyruvic acid (PEP) pathway and SA biosynthesis pathways.The SA yield was successfully increased from …
Fermentation Technology Of L-Lysine Production By Immobilized Corynebacterium Glutamicum,
2025
College of Biotechnology and Pharmaceutical Engineering , Nanjing Tech University , Nanjing 211816 , China ;Nanjing Hi-Tech Biological Technology Research Institute Co ., Ltd., Nanjing 210032 , China
Fermentation Technology Of L-Lysine Production By Immobilized Corynebacterium Glutamicum, Qingguo Liu, Hanjie Ying, Wenjun Sun
Journal of Food Science and Biotechnology
[Objective ] This study aimed to investigate the feasibility of the fermentation process for L-lysine production by immobilized Corynebacterium glutamicum.[Method ] Firstly,the effects of different volume fractions of seed medium on the fermentation stability of immobilized Corynebacterium glutamicum were examined.Subsequently,the impacts of immobilization carriers with different specifications on the fermentation performance were analyzed.Finally,a comparative analysis was conducted on the differences between the fermentation processes with free and immobilized Corynebacterium glutamicum.[Result ] The addition of 5% volume fraction of seed medium adequately sustained the growth and metabolic activities of Corynebacterium glutamicum.Higher volume fractions diverted carbon sources towards bacterial growth,thereby limiting product …
Reduction Of Methanol Content By Protoplast Fusion In Fruit Wine Yeast,
2025
College of Chemistry and Bioengineering , Guilin University of Technology , Guilin 541004 , China
Reduction Of Methanol Content By Protoplast Fusion In Fruit Wine Yeast, Huixiang Zhang, Nan Lin, Jiaru Wu, Xin Cheng, Weiwu Liang, Shijun Yang
Journal of Food Science and Biotechnology
[Objective ] This study aims to breed a fruit wine yeast strain with low methanol production by protoplast fusion.[Method ] With yeast strains LAB and XR as parents,protoplast fusion was employed to breed the yeast strains for fruit wine fermentation with a low mass concentration methanol and a high volume fraction ethanol.The process of yeast protoplast preparation was optimized by single factor and orthogonal experiments with the formation rate,regeneration rate,and preparation rate of protoplasts as indicators.The parental protoplasts were inactivated by ultraviolet radiation and heating,and 35 g/dL PEG- 6000 was used for chemical fusion after inactivation.[Result ] The optimum conditions …
Effects Of Metschnikowia Pulcherrima And 24-Epibrassinolide On Postharvest Preservation Of Grapes,
2025
College of Enology , Northwest A&F University , Yangling 712100 , China
Effects Of Metschnikowia Pulcherrima And 24-Epibrassinolide On Postharvest Preservation Of Grapes, Jiayan Qu, Huiping Niu, Bowen Li, Xiao Wang, Lujun Wang, Zhumei Xi, Xuefei Wang
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects of different treatments on the postharvest preservation of grapes.[Method ] The impacts of 0.4 mg/L 24-epibrassinolide (EBR ),1×109 CFU/mL Metschnikowia pulcherrima,and their combination (YBR ) on postharvest storage of ‘Shine Muscat ’ grapes were evaluated.[Result ] Compared with the control (CK) group,EBR,Metschnikowia pulcherrima,and YBR treatments effectively reduced the water loss rate,maintained the firmness,and delayed the declines in protopectin and stem chlorophyll content of grape.In the later storage stage,YBR treatment delayed the decrease in flavonoid mass fraction,which was 12.95% higher than that of CK group.At the same time,YBR treatment reduced the mass …
