Physical Sciences and Mathematics Commons^™

Characterization Of The Interaction Between Grx4-Bol2 And The Iron-Responsive Transcription Factor Aft1 In Candida Glabrata, Evan A. Talib

Theses and Dissertations

Iron is an indispensable protein cofactor that plays a critical role in biological functions such as cellular respiration. However, excess iron causes cellular damage via the generation of reactive oxygen species. To obtain optimal intracellular iron levels, eukaryotic cells have developed mechanisms to tightly regulate iron levels. The molecular mechanism for iron regulation in the pathogenic yeast Candida glabrata has not yet been explored, although this yeast bears iron regulation pathways that are very similar to the model yeast Saccharomyces cerevisiae. Understanding how C. glabrata regulates iron levels is critical for the treatment of infections caused by this opportunistic …

Topics In Multilevel Mediation Analysis, Chung Li Wu

Theses and Dissertations

A proper study design assures adequate power to detect statistically significant differences. Existing power calculations for multilevel mediation analysis make a strong distributional assumption of normality. However, binary outcomes are commonly seen in real-world study. Motivated by this fact, we conduct a simulation-based power study for a multilevel mediation analysis with binary outcomes. The numbers of participants needed to achieve 80% power are summarized in tables for future reference.

Mixed-effect regression is commonly used in multilevel analysis for panel data. Yet, the estimated coefficients from the random-intercept model could represent either purely between-cluster, purely within-cluster, or weighted-average effects. Therefore, we …

The Optimization Of Anion Exchange Membrane Fuel Cells And Water Electrolyzers By Varying Catalyst Design And Changing Gas Inlet Composition, Jasmine D. Bohannon

Theses and Dissertations

Researchers around the globe are looking to avoid the consequences of climate change by shifting away from the burning of fossil fuels as a source of energy. While using fossil fuels have negatively affected the earth’s climate for at least the last hundred and fifty years, the introduction of renewables looks to use abundant and naturally occurring resources. Sources of renewable energy include solar power, wind power, hydropower, geothermal energy, and biomass2 . These sources work by converting the abundant source into mechanical, electrical, or chemical energy that can be used to power industrial plants or residential areas and they …

Memristive Ising Circuits, Vincent James Dowling

Theses and Dissertations

Resistance random access memory (ReRAM) cells are emerging passive components showing great promise for applications in non-volatile storage, in-memory computing, and neuromorphic circuits, to name a few. Various experimental ReRAM cells have demonstrated excellent characteristics. This includes nanoscale size, short read and write times, and small energy requirements needed to manipulate the information. The main obstacles preventing the widespread adoption of ReRAM technology are significant device-to-device and cycle-to-cycle variability.

In essence, ReRAM cells are resistors with memory whose state (resistance) can be changed by an applied signal such as voltage. Many models were developed for describing their response. These range …

Human Activity Recognition (Har) Using Wearable Sensors And Machine Learning, Chrisogonas Odero Odhiambo

Theses and Dissertations

Humans engage in a wide range of simple and complex activities. Human Activity Recognition (HAR) is typically a classification problem in computer vision and pattern recognition, to recognize various human activities. Recent technological advancements, the miniaturization of electronic devices, and the deployment of cheaper and faster data networks have propelled environments augmented with contextual and real-time information, such as smart homes and smart cities. These context-aware environments, alongside smart wearable sensors, have opened the door to numerous opportunities for adding value and personalized services to citizens. Vision-based and sensory-based HAR find diverse applications in healthcare, surveillance, sports, event analysis, Human-Computer …

Sources And Cycling Of Neodymium And Rare Earth Elements In The Arctic Amerasian Basin And Bering Sea, Brian D. Duggan

Theses and Dissertations

The isotopic composition of dissolved neodymium (¹⁴³Nd/¹⁴⁴Nd, expressed as εNd) behaves quasi-conservatively in the ocean and has been used as a palaeoceanographic tracer of ocean circulation. The εNd value of water masses is acquired—and often altered—during interaction with sediments along the margins; however, the processes involved in seawater εNd acquisition remains poorly characterized and quantified. Here we report the results of 349 Nd isotope and 354 rare earth element (REE) concentration measurements from 27 water column profiles across the Bering shelf and through the Arctic Amerasian Basin collected during U.S. Arctic GEOTRACES cruise HLY1502 (GEOTRACES section …

Applications Of Machine Learning For Improved Patient Selection And Therapy Recommendations, Brendan Elochukwu Odigwe

Theses and Dissertations

The public health domain continues to battle with illness and the growing need for continuous advancement in our approach to clinical care. Individuals experiencing certain conditions undergo tried and tested therapies and medications, practices that have become the mainstay and standard of care in clinical medicine. As with all therapies and medications, they don't always work the same way and do not work for everyone. Some Treatment regimens, like Hydroxyurea medication, which is commonly administered to Sickle cell anemia patients, come with some adverse side effects due to the chemotherapeutic nature of the drug. This would be particularly disappointing if …

Arctic Ocean And Subarctic Seas Dynamics In A Changing Climate, Sarah B. Hall

Theses and Dissertations

Salinity is the primary determinant of the Arctic Ocean’s vertical density stratification in the upper ocean, which has major implications on the ocean’s physical dynamics alongside a period of rapidly declining sea ice. In recent decades, the Arctic’s freshwater content (FWC) has increased as a result of the accumulation of freshwater source inputs. Additional freshwater exported to the North Atlantic may hinder overturning processes that are vital to the regulation of global climate. This dissertation employs in situ measurements, satellite observations, and ocean model simulations to better understand salinity and freshwater changes in the Arctic Ocean during this changing climate. …

Self-Assembling Porous Supramolecular Networks Capable Of Post-Synthetic Modification With A New Approach To Reticular Design With Semiconductor Potential, Steven A. Sloope

Theses and Dissertations

In past decades, research in self-assembling supramolecular frameworks have been produced with vast surface area, inherent from their porous nature. Predesigning monomers in a reticular manner allows a framework’s structure to be known before self-assembly occurs. This is very helpful since high porosity is sought after for many purposes such as hosting guests within the framework, post-synthetic modifications, sensing and detection, selective catalysis, semiconduction, etc. Methods of design usually focus on forming intrinsic porosity and unfortunately, sometimes the network formed is not as expected and porosity is lost.

In Chapter 1, we discuss novel ways of network formation, their potential …

Tropical Cyclone And Ocean-Atmosphere Interactions In The Gulf Of Mexico, Emily Nichole Eley

Theses and Dissertations

The Gulf of Mexico (GoM) is historically a favorable region for the formation, maintenance and intensification of tropical cyclones that frequently evolve into powerful hurricanes. These natural disasters threaten the basin’s innate habitat and wildlife diversity, and the expansive coastal economies and communities. The dominant ocean circulation feature in the GoM is the Loop Current System (LCS) which includes the Loop Current (LC) and its associated mesoscale eddy field. The LC originates at the Yucatán Channel, loops anticyclonically into the basin, and ends at the Florida Straits; further it produces both anticyclonic and cyclonic eddies. The existence of the LCS …

Cnn-Based Dendrite Core Detection From Microscopic Images Of Directionally Solidified Ni-Base Alloys, Xiaoguang Li

Theses and Dissertations

Dendrite core is the center point of the dendrite. The information of dendrite core is very helpful for material scientists to analyze the properties of materials. Therefore, detecting the dendrite core is a very important task in the material science field. Meanwhile, because of some special properties of the dendrites, this task is also very challenging. Different from the typical detection problems in the computer vision field, detecting the dendrite core aims to detect a single point location instead of the bounding-box. As a result, the existing regressing bounding-box based detection methods can not work well on this task because …

Empirical Studies On Automated Software Testing Practices, Alireza Salahirad

Theses and Dissertations

Software testing is notoriously difficult and expensive, and improper testing carries economic, legal, and even environmental or medical risks. Research in software testing is critical to enabling the development of the robust software that our society relies upon. This dissertation aims to lower the cost of software testing without decreasing the quality by focusing on the use of automation. The dissertation consists of three empirical studies on aspects of software testing. Specifically, these three projects focus on (1) mapping the connections between research topics and the evolution of research topics in the field of software testing, (2) an assessment of …

Deciphering The Molecular Circuitry That Controls Iron Regulation In Non-Pathogenic Yeast, Debolina Hati

Theses and Dissertations

The trace metal iron is essential for the survival of almost all living organisms. It is a co-factor for many proteins involved in a variety of vital functions such as respiration, nitrogen fixation, and DNA biosynthesis, to name a few. Iron homeostasis in non-pathogenic fungi such as Schizosaccharomyces pombe has been extensively studied over the past few decades to better understand how intracellular iron is regulated under different environmental conditions. Iron regulation in S. pombe is controlled by two Fe-responsive transcriptional repressors known as Php4 and Fep1. Both rely on iron-sulfur (Fe-S) clusters as signals to balance iron acquisition, storage, …

Magnetic Field Directed Self-Assembly Of Colloidal Nanoparticles Via Extreme Field Gradients Of Magnetic Recording Media, Abdul Rahman Mohtasebzadeh

Theses and Dissertations

Magnetic nanoparticles have been extensively studied over the last half century and continue to sustain interest due to their potential use in different fields. This research explores Magnetic Field Directed Self-Assembly of magnetic nanoparticles using a magnetic disk drive. The magnetic fields generated by the bits in a magnetic disk drive have rapidly changing field gradients that can self-assemble magnetic nanoparticles into various shapes. We demonstrate the ability to record and read field gradients on a commercial disk drive medium and to use monodisperse iron oxide nanoparticles to achieve self-assembly. We use image analysis techniques to quantify parameters related to …

Learning To Automate Follow-Up Question Generation Using Process Knowledge For Depression Triage On Reddit Posts, Shrey Gupta, Anmol Agarwal, Manas Gaur, Kaushik Roy, Vignesh Narayanan, Ponnurangam Kumaraguru, Amit Sheth

Publications

Conversational Agents (CAs) powered with deep language models (DLMs) have shown tremendous promise in the domain of mental health. Prominently, the CAs have been used to provide informational or therapeutic services (e.g., cognitive behavioral therapy) to patients. However, the utility of CAs to assist in mental health triaging has not been explored in the existing work as it requires a controlled generation of follow-up questions (FQs), which are often initiated and guided by the mental health professionals (MHPs) in clinical settings. In the context of `depression', our experiments show that DLMs coupled with process knowledge in a mental health questionnaire …

Overview Of The Clpsych 2022 Shared Task: Capturing Moments Of Change In Longitudinal User Posts, Adam Tsakalidis, Jenny Chim, Iman Munire Bilal, Ayah Zirikly, Dana Atzil-Slonim, Federico Nanni, Philip Resnik, Manas Gaur, Kaushik Roy, Becky Inkster, Jeff Leintz, Maria Liakata

Publications

We provide an overview of the CLPsych 2022 Shared Task, which focusses on the automatic identification of Moments of Change in longitudinal posts by individuals on social media and its connection with information regarding mental health . This year's task introduced the notion of longitudinal modelling of the text generated by an individual online over time, along with appropriate temporally sensitive evaluation metrics. The Shared Task consisted of two subtasks: (a) the main task of capturing changes in an individual's mood (drastic changes-`Switches'- and gradual changes -`Escalations'- on the basis of textual content shared online; and subsequently (b) the sub-task …

Dietary Inflammatory Index And Mortality From All Causes, Cardiovascular Disease, And Cancer: A Prospective Study, Zhen Lin, Yanfei Feng, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Xin Xu

Faculty Publications

The Energy-adjusted Dietary Inflammatory Index (E-DIITM) is a comprehensive, literature-derived index for assessing the effect of dietary constituents on inflammatory biomarkers and inflammation-related chronic diseases. Several studies have examined the association between E-DII scores and mortality, with results that vary across populations. Therefore, in the present study, we aimed to investigate the potential association between E-DII scores and all-cause, cardiovascular disease (CVD), and cancer mortality using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial. E-DII scores, calculated based on a food-frequency questionnaire, were analyzed both as a continuous variable and after categorization into quintiles. A multivariate Cox …

Using Whole-Brain Diffusion Tensor Analysis To Evaluate White Matter Structural Correlates Of Delayed Visuospatial Memory And One-Week Motor Skill Retention In Nondemented Older Adults: A Preliminary Study, Jennapher Lingo Vangilder, Maurizio Bergamino, Andrew Hooyman, Megan C. Fitzhugh, Corianne Rogalsky, Jill C. Stewart, Scott C. Beeman, Sydney Y. Schaefer

Faculty Publications

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory …

Availability Of Hospital-Based Cancer Services Before And After Rural Hospital Closure, 2008-2017, Whitney Zahnd Ph.D., Peiyin Hung Ph.D., Sylvia Kewei Shi, Anja Zgodic, Melinda A. Merrell Ph.D., Elizabeth L. Crouch, Janice C. Probst, Jan Eberth Ph.D.

Faculty Publications

Introduction

Rural populations have less access to cancer care services and experience higher cancer mortality rates than their urban counterparts, which may be exacerbated by hospital closures. Our objective was to examine the impact of hospital closures on access to cancer-relevant hospital services across hospital service areas (HSAs).

Methods

We used American Hospital Association survey data from 2008 to 2017 to examine the change in access to cancer-related screening and treatment services across rural HSAs that sustained hospitals over time, experienced any closures, or had all hospitals close. We performed a longitudinal analysis to assess the association between hospital closure …

Neighborhood Characteristics And Dementia Symptomology Among Community-Dwelling Older Adults With Alzheimer’S Disease, Dana M. Alhasan, Matthew C. Lohman Ph.D., Jana A. Hirsch, Margaret Chandlee Miller Ms, Ph.D., Bo Cai Ph.D., Chandra L. Jackson

Faculty Publications

Background: Neuropsychiatric symptoms (NPSs) lead to myriad poor health outcomes among individuals with Alzheimer’s disease (AD). Prior studies have observed associations between the various aspects of the home environment and NPSs, but macro-level environmental stressors (e.g., neighborhood income) may also disrupt the neuronal microenvironment and exacerbate NPSs. Yet, to our knowledge, no studies have investigated the relationship between the neighborhood environment and NPSs.

Methods: Using 2010 data among older adults with AD collected from a sample of the South Carolina Alzheimer’s Disease Registry, we estimated cross-sectional associations between neighborhood characteristics and NPSs in the overall population and by race/ethnicity. Neighborhood …

Yin And Yang Of Cannabinoid Cb1 Receptor: Cb1 Deletion In Immune Cells Causes Exacerbation While Deletion In Non-Immune Cells Attenuates Obesity, Kathryn Miranda, William Becker, Philip B. Busbee, Nicholas Dopkins, Osama A. Abdulla, Yin Zhong, Jiajia Zhang Ph.D., Mitzi Nagarkatti, Prakash S. Nagarkatti

Faculty Publications

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional CB1 in all cells except the immune cells or expressed CB1 only in immune cells. CB1^-/- recipient hosts were resistant to DIO, indicating that CB1 in non-immune cells is necessary for induction of DIO. Interestingly, chimeras with CB1^-/- in immune cells showed exacerbation in DIO combined with …

Applications Of The Harary-Sachs Theorem For Hypergraphs, Gregory J. Clark, Joshua N. Cooper

Faculty Publications

The Harary-Sachs theorem for k-uniform hypergraphs equates the codegree-d coefficient of the adjacency characteristic polynomial of a uniform hypergraph with a weighted sum of subgraph counts over certain multi-hypergraphs with d edges. We begin by showing that the classical Harary-Sachs theorem for graphs is indeed a special case of this general theorem. To this end we apply the generalized Harary-Sachs theorem to the leading coefficients of the characteristic polynomial of various hypergraphs. In particular, we provide explicit and asymptotic formulas for the contribution of the k-uniform simplex to the codegree-d coefficient. Moreover, we provide an explicit formula for the leading …

Geographic Proximity To Primary Care Providers As A Risk-Assessment Criterion For Quality Performance Measures, Nathaniel Bell, Ana Lopez-De Fede Ph.D., Bo Cai Ph.D., John Brooks Ph.D.

Publications

Importance Previous studies have found a mixed association between Patient-Centered Medical Home (PCMH) designation and improvements in primary care quality indicators, including avoidable pediatric emergency department (ED) encounters. Whether these associations persist after accounting for the geographic locations of providers relative to where patients reside is unknown. Objective To examine the association between geographic proximity to primary care providers versus hospitals and risk of avoidable and potentially avoidable ED visits among children with pre-existing diagnosis of attention-deficit/hyperactivity disorder or asthma. Methods Retrospective cohort study of a panel of pediatric Medicaid claims data from the South Carolina from 2016–2018 for 2,959 …

Cardiorespiratory Fitness And The Risk Of All-Cause, Cardiovascular And Cancer Mortality In Men With Hypercholesterolemia, Xuemei Sui M.D., M.P.H., Ph.D., Mark A. Sarzynski Facsm, Nicole Gribben, Jiajia Zhang Ph.D., Carl J. Lavie

Faculty Publications

Background: Whether higher cardiorespiratory fitness (CRF) confers protection against cardiovascular disease (CVD) in individuals with manifest hypercholesterolemia is poorly understood. Methods: Participants were 8920 men aged 20–82 years with hypercholesterolemia but no history of CVD and/or cancer and who received a preventive examination at the Cooper Clinic in Dallas, TX, USA, during 1974–2001. CRF was quantified as maximal treadmill test duration and was grouped for analysis as low, moderate, or high based on the traditional Aerobics Center Longitudinal Study cutpoints. Using Cox regression analyses, we computed hazard ratios and 95% confidence intervals for risk of mortality based on CRF. Results: …

Processed Food As A Risk Factor For The Development And Perpetuation Of Crohn's Disease-The Enigma Study, Gina L. Trakman, Winnie Y.Y. Lin, Amy L. Hamilton, Amy L. Wilson-O'Brien, Annalise Stanley, Jessica Y. Ching, Jun Yu, Joyce W.Y. Mak, Yang Sun, Junkin Niu, Yinglei Miao, Xiaoqing Lin, Rui Feng, Minhu Chen, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Mark Morrison, Siew C, Ng, Michael A. Kamm

Faculty Publications

(1) Background: Developing countries have experienced a rapid recent rise in Inflammatory Bowel Disease (IBD) incidence and emerging evidence suggests processed foods and food additives may predispose one to the development and perpetuation of Crohn’s disease (CD). The aim of this study was to evaluate processed food and food additive intake in CD patients and controls, in Australia (high CD incidence), Hong Kong (intermediate incidence) and mainland China (emerging incidence). (2) Methods: In 274 CD patients (CD), 82 first-degree relatives (FDR), 83 household members (HM) and 92 healthy unrelated controls (HC) from Australia (n = 180), Hong Kong (HK) (n …

Evidence Of Likely Autochthonous Chagas Disease In The Southwestern United States: A Case Series Of Trypanosoma Cruzi Seropositive Blood Donors, Mary K. Lynn, Kyndall C. Dye-Braumuller, Norman L. Beatty, Patricia L. Dorn, Stephen A. Klotz, Susan L. Stramer, Rebecca L. Townsend, Hany Kamel, Jacquelyn M. Vannoy, Patrick Sadler, Susan P. Montgomery, Hilda N. Rivera, Melissa Nolan Ph.D., Mph

Faculty Publications

Background Chagas disease is a parasitic infection that can insidiously cause non-ischemic cardiomyopathy. Given the largely silent nature of this progressive disease, asymptomatic blood donors pose potential blood transfusion risk. Blood donation screening has become an unintentional form of Chagas disease surveillance, with thousands of new cases identified since national surveillance was initiated in 2007.

Study Design and Methods We recruited T. cruzi-positive blood donors identified from California and Arizona blood centers for confirmatory blood screening and assessment of lifetime infection risk.

Results Among eight suspected cases, we identified four confirmed US autochthonous infections. The current manuscript details the …

Multi-Stage Evolution Of The Lost City Hydrothermal Vent Fluids, Karmina A. Aquino, Gretchen L. Fruh-Green, Joerg Rickli, Stefano M. Bernasconi, Susan Q. Lang Ph.D., M.S., B.S., Marvin D. Lilley, David A. Butterfield

Faculty Publications

Serpentinization-influenced hydrothermal systems, such as the Lost City Hydrothermal Field (LCHF), are considered as potential sites for the origin of life. Despite an abundance of reducing power in this system (H₂ and CH₄), microbial habitability may be limited by high pH, elevated temperatures, and/or low concentrations of bioavailable carbon. At the LCHF, the relative contribution of biotic and abiotic processes to the vent fluid composition, especially in the lower temperature vents, remain poorly constrained. We present fluid chemistry and isotope data that suggest that all LCHF fluids are derived from a single endmember produced in the hotter, …

Compositionally And Density Stratified Igneous Terrain In Jezero Crater, Mars, Roger C. Wiens, Arya Udry, Olivier Beyssac, Cathy Quantin-Nataf, Nicolas Mangold, Agnès Cousin, Lucia Mandon, Tanja Bosak, Olivier Forni, Scott M. Mclennan, Violaine Sautter, Adrian Cousin, Karim Benzerara, Jeffrey R. Johnson, Lisa Mayhew, Sylvestre Maurice, Ryan B. Maurice, Ryan B. Anderson, Samuel M. Clegg, Larry Crumpler, Stanley M. Angel

Faculty Publications

Before Perseverance, Jezero crater's floor was variably hypothesized to have a lacustrine, lava, volcanic airfall, or aeolian origin. SuperCam observations in the first 286 Mars days on Mars revealed a volcanic and intrusive terrain with compositional and density stratification.The dominant lithology along the traverse is basaltic, with plagioclase enrichment in stratigraphically higher locations. Stratigraphically lower, layered rocks are richer in normative pyroxene. The lowest observed unit has the highest inferred density and is olivine-rich with coarse (1.5 millimeters) euhedral, relatively unweathered grains, suggesting a cumulate origin. This is the first martian cumulate and shows similarities to martian meteorites, which also …

Effects Of Caffeine, Methylliberine, And Theacrine On Vigilance, Marksmanship, And Hemodynamic Responses In Tactical Personnel: A Double-Blind, Randomized, Placebo-Controlled Trial, Harry P. Cintineo, Marissa L. Bello, Alexa J. Chandler, Thomas D. Cardaci, Bridget A. Mcfadden, Shawn M. Arent

Faculty Publications

Background

Tactical athletes require fast reaction times (RT) along with high levels of vigilance and marksmanship performance. Caffeine has been shown to improve these measures but also results in increased blood pressure and jitteriness. Research on other purine alkaloids, such as methylliberine and theacrine, has suggested they do not increase blood pressure or jitteriness to the same extent, but their impact on tactical performance is unknown.

Methods

A between-subjects, randomized, placebo-controlled design was used to test the effects of placebo (PLA), 300 mg caffeine (CAF), and a combination of 150 mg caffeine, 100 mg methylliberine, and 50 mg theacrine (CMT) …

Measurement Of The Branching Fractions Of The B+ → Η′ℓ+Νℓ And B+ → Η′ℓ+Νℓ Decays With Signal-Side Only Reconstruction In The Full Q2 Range, U. Gebauer, C. Beleño, A. Frey, I. Adachi, K. Adamczyk, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, Milind Purohit, Et. Al.

Faculty Publications

The branching fractions of the decays B⁺ → ηl⁺νl and B⁺ → ηl⁺νl are measured, where l is either an electron or a muon, using a data sample of 711 fb⁻¹ containing 772 × 10⁶ BB̅ pairs collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. To reduce the dependence of the result on the form factor model, the measurement is performed over the entire q² range. The resulting branching fractions are B(B⁺ → η ℓ + ν ℓ)=(2.83 …