Physical Sciences and Mathematics Commons^™

Abiotic- And Biotic-Formation Of Manganese Oxides And Their Fate In Environmental Systems, Haesung Jung

McKelvey School of Engineering Theses & Dissertations

Manganese (hydr)oxide (Mn (hydr)oxide) minerals are ubiquitous in aquatic and terrestrial environments. These minerals have high surface areas and are highly sorptive and redox active. From decades of accumulated knowledge about natural redox cycling, we have found that Mn (hydr)oxides play critical roles as electron donors and acceptors in elemental geochemical cycling and biological metabolisms in nature. Thus, Mn (hydr)oxides have garnered increasing interest to understand natural systems. Considering the variety of redox reactions with Mn (hydr)oxides in nature, it is also expected that there should be diverse pathways to form Mn (hydr)oxides through abiotic and biotic processes. Previous studies …

Two-Component Hydrogel As Biomimetic Vitreous Substitutes, Sruthi Santhanam

McKelvey School of Engineering Theses & Dissertations

The vitreous humor of the eye is a biological hydrogel principally composed of fibrillary collagen interspersed with semi-flexible polyelectrolyte, hyaluronic acid (HA). Certain pathological conditions necessitate its removal and replacement. Current vitreous substitutes, such as silicone oils and perfluorocarbons, are hydrophobic, do not resemble the properties of the vitreous, and have known complications. An ideal vitreous substitute should have properties of the natural vitreous, perform its functions, and be biocompatible in the eye. Inspired by the structure and composition of the natural vitreous, we used bio-mimicry to develop an injectable two-component hydrogel. The hydrogel is composed of a fibrillary gellan, …

Synthesis, Characterization, And Biological Activity Of Spherical Nucleic Acid (Sna) Constructs For Cancer Therapy And Imaging, Colin Calabrese

Arts & Sciences Electronic Theses and Dissertations

This dissertation focuses on the development of biocompatible oligonucleotide-based nanomaterials, known as spherical nucleic acids (SNAs), as therapeutic and diagnostic agents for intracellular gene regulation and in vivo cancer imaging by positron emission tomography (PET). SNAs consist of a nanoparticle core functionalized with a dense shell of oligonucleotides such as deoxyribonucleic acid (DNA). Detailed synthetic procedures and characterization of novel SNAs with purpose-built biocompatible core materials are described. The SNAs exhibit comparable chemical, physical and biological properties regardless of core composition. The functionalities of the SNAs were further tailored by deliberate design and chemical modification of their oligonucleotide sequences.

The …

Aluminosilicate Dissolution And Silicate Carbonation During Geologic Co2 Sequestration, Yujia Min

McKelvey School of Engineering Theses & Dissertations

Geologic CO2 sequestration (GCS) is considered a promising method to reduce anthropogenic CO2 emission. Assessing the supercritical CO2 (scCO2)¬–gas or liquid phase water (g, l)–mineral interactions is critical to evaluating the viability of GCS processes. This work contributes to our understanding of geochemical reactions at CO2¬–water (g, l)–mineral interfaces, by investigating the dissolution of aluminosilicates in CO2-acidified water (l). Plagioclase and biotite were chosen as model minerals in reservoir rock and caprock, respectively. To elucidate the effects of brine chemistry, first, the influences of cations in brine including Na, Ca, and K, have been investigated. In addition to the cations, …

Numerical Methods For Nonlinear Optimal Control Problems And Their Applications In Indoor Climate Control, Runxin He

McKelvey School of Engineering Theses & Dissertations

Efficiency, comfort, and convenience are three major aspects in the design of control systems for residential Heating, Ventilation, and Air Conditioning (HVAC) units. In this dissertation, we study optimization-based algorithms for HVAC control that minimizes energy consumption while maintaining a desired temperature, or even human comfort in a room. Our algorithm uses a Computer Fluid Dynamics (CFD) model, mathematically formulated using Partial Differential Equations (PDEs), to describe the interactions between temperature, pressure, and air flow. Our model allows us to naturally formulate problems such as controlling the temperature of a small region of interest within a room, or to control …

Improving Pure-Tone Audiometry Using Probabilistic Machine Learning Classification, Xinyu Song

McKelvey School of Engineering Theses & Dissertations

Hearing loss is a critical public health concern, affecting hundreds millions of people worldwide and dramatically impacting quality of life for affected individuals. While treatment techniques have evolved in recent years, methods for assessing hearing ability have remained relatively unchanged for decades. The standard clinical procedure is the modified Hughson-Westlake procedure, an adaptive pure-tone detection task that is typically performed manually by audiologists, costing millions of collective hours annually among healthcare professionals. In addition to the high burden of labor, the technique provides limited detail about an individual’s hearing ability, estimating only detection thresholds at a handful of pre-defined pure-tone …

Studies In Pressurized Oxy-Combustion: Process Development And Control Of Radiative Heat Transfer, Akshay Gopan

McKelvey School of Engineering Theses & Dissertations

Fossil fuels supply over 80% of the world’s primary energy and more than two-thirds of the world’s electricity. Of this, coal alone accounts for over 41% of the electricity supplied globally. Though coal is globally well-distributed and can provide stable and reliable energy on demand, it emits a large amount of carbon dioxide—a greenhouse gas responsible for global warming. Serious concerns over the implication of the increased global temperature have prompted the investigation into low carbon energy alternatives. The idea of capturing the carbon dioxide emitted from the combustion sources is considered as one of the viable alternatives. This would …

Decoupling Information And Connectivity In Information-Centric Networking, Hila Ben Abraham, Jyoti Parwatikar, John Dehart, Adam Drescher, Patrick Crowley

All Computer Science and Engineering Research

This paper introduces and demonstrates the concept of Information-Centric Transport as a mechanism for cleanly decoupling the information plane from the connectivity plane in Information-Centric Networking (ICN) architectures, such as NDN and CICN. These are coupled in today's incarnations of NDN and CICN through the use of forwarding strategy, which is the architectural component for deciding how to forward packets in the presence of either multiple next-hop options or dynamic feedback. As presently designed, forwarding strategy is not sustainable: application developers can only confidently specify strategy if they understand connectivity details, while network node operators can only confidently assign strategies …

An Improved Algorithm For Learning To Perform Exception-Tolerant Abduction, Mengxue Zhang

McKelvey School of Engineering Theses & Dissertations

Abstract

Inference from an observed or hypothesized condition to a plausible cause or explanation for this condition is known as abduction. For many tasks, the acquisition of the necessary knowledge by machine learning has been widely found to be highly effective. However, the semantics of learned knowledge are weaker than the usual classical semantics, and this necessitates new formulations of many tasks. We focus on a recently introduced formulation of the abductive inference task that is thus adapted to the semantics of machine learning. A key problem is that we cannot expect that our causes or explanations will be perfect, …

Sub 2 Nm Particle Characterization In Systems With Aerosol Formation And Growth, Yang Wang

McKelvey School of Engineering Theses & Dissertations

Aerosol science and technology enable continual advances in material synthesis and atmospheric pollutant control. Among these advances, one important frontier is characterizing the initial stages of particle formation by real time measurement of particles below 2 nm in size. Sub 2 nm particles play important roles by acting as seeds for particle growth, ultimately determining the final properties of the generated particles. Tailoring nanoparticle properties requires a thorough understanding and precise control of the particle formation processes, which in turn requires characterizing nanoparticle formation from the initial stages. The knowledge on particle formation in early stages can also be applied …

The Effect Of Diffusive Transport On Mineral Carbonation In Geologic Carbon Sequestration, Wei Xiong

McKelvey School of Engineering Theses & Dissertations

Geologic carbon sequestration (GCS) is an effective method to mitigate environmental problems due to excessive anthropogenic CO2 emissions. It involves injecting supercritical CO2 into deep geologic formations in which CO2 will ultimately be converted to solid carbonate minerals. Basalt is a promising host rock that is rich in the divalent cations Ca, Mg and Fe that are important for mineral trapping of CO2. Fractures and pores in basalt reservoirs provide substantial surface area for geochemical reactions during carbon sequestration. The transport in fractures and pores is controlled by diffusion. The coupling of diffusive transport and geochemical reactions leads to carbonate …

Measuring Molecular Orientation And Rotational Mobility Using A Tri-Spot Point Spread Function, Oumeng Zhang

McKelvey School of Engineering Theses & Dissertations

Single molecules have become a powerful tool for biophysicists since they were first optically detected 28 years ago. Understanding molecular orientation can not only improve the accuracy of single-molecule localization, but it can also provide insight into biochemical behaviors at the nanoscale. In this thesis, I present a method to measure the molecular orientation and rotational mobility of single-molecule emitters by designing and implementing a tri-spot point spread function. The point spread function is designed so that it is capable of measuring all degrees of freedom related to molecular orientation and rotational mobility. Its design is optimized by maximizing the …

Multipath And Rate Stability, Junjie Liu, Roch A. Guérin

All Computer Science and Engineering Research

Originally Published In Proc. IEEE Globecom Conference - CQRM: Communication QoS, Reliability & Modeling Symposium

A Traders Guide To The Predictive Universe- A Model For Predicting Oil Price Targets And Trading On Them, Jimmie Harold Lenz

Doctor of Business Administration Dissertations

At heart every trader loves volatility; this is where return on investment comes from, this is what drives the proverbial “positive alpha.” As a trader, understanding the probabilities related to the volatility of prices is key, however if you could also predict future prices with reliability the world would be your oyster. To this end, I have achieved three goals with this dissertation, to develop a model to predict future short term prices (direction and magnitude), to effectively test this by generating consistent profits utilizing a trading model developed for this purpose, and to write a paper that anyone with …

Indoor Scene Localization To Fight Sex Trafficking In Hotels, Abigail Stylianou

McKelvey School of Engineering Theses & Dissertations

Images are key to fighting sex trafficking. They are: (a) used to advertise for sex services,(b) shared among criminal networks, and (c) connect a person in an image to the place where the image was taken. This work explores the ability to link images to indoor places in order to support the investigation and prosecution of sex trafficking. We propose and develop a framework that includes a database of open-source information available on the Internet, a crowd-sourcing approach to gathering additional images, and explore a variety of matching approaches based both on hand-tuned features such as SIFT and learned features …

Calcium Carbonate Formation In Energy-Related Subsurface Environments And Engineered Systems, Qingyun Li

McKelvey School of Engineering Theses & Dissertations

Geologic CO2 sequestration (GCS) in subsurface saline aquifers is a promising strategy to mitigate climate change caused by increasing anthropogenic CO2 emissions from energy production. At GCS sites, interactions between fluids and geomedia are important because they can affect CO2 trapping efficiency and the safety of CO2 storage. These interactions include the dissolution and precipitation of minerals. One of the most important minerals is calcium carbonate, because it can permanently trap CO2.

In this work, Portland cement was used as a model geomedium to investigate the chemical reactions, mechanical alterations, transport of reactive fluids, and the interplay of all these …

Nanostructured Thin Film Synthesis By Aerosol Chemical Vapor Deposition For Energy Storage Applications, Tandeep Singh Chadha

McKelvey School of Engineering Theses & Dissertations

Renewable energy sources offer a viable solution to the growing energy demand while mitigating concerns for greenhouse gas emissions and climate change. This has led to a tremendous momentum towards solar and wind-based energy harvesting technologies driving efficiencies higher and costs lower. However, the intermittent nature of these energy sources necessitates energy storage technologies, which remain the Achilles heel in meeting the renewable energy goals. This dissertation focusses on two approaches for addressing the needs of energy storage: first, targeting direct solar to fuel conversion via photoelectrochemical water-splitting and second, improving the performance of current rechargeable batteries by developing new …

Bayesian Networks To Assess The Newborn Stool Microbiome, William E. Bennett Jr.

McKelvey School of Engineering Theses & Dissertations

In human stool, a large population of bacterial genes and transcripts from hundreds of genera coexist with host genes and transcripts. Assessments of the metagenome and transcriptome are particularly challenging, since there is a great deal of sequence overlap among related species and related genes. We sequenced the total RNA content from stool samples in a neonate using previously-described methods. We then performed stepwise alignment of different populations of RNA sequence reads to different indices, including ribosomal databases, the human genome, and all sequenced bacterial genomes. Each pool of RNA at each alignment step was subjected to compression to assess …

In-Network Retransmissions In Named Data Networking, Hila Ben Abraham, Patrick Crowley

All Computer Science and Engineering Research

The strategy layer is an important architectural component in both Content-Centric Networking (CCN) and Named Data Networking (NDN). This component introduces a new forwarding model that allows an application to configure its namespace with a forwarding strategy. A core mechanism in every forwarding strategy is the decision of whether to retransmit an unsatisfied Interest or to wait for an application retransmission. While some applications request control of all retransmissions, others rely on the assumption that the strategy will retransmit an Interest when it is not satisfied. Although an application can select the forwarding strategy used in the local host, it …

Mercator (Mapping Enumerator For Cuda) User's Manual, Stephen V. Cole, Jeremy Buhler

All Computer Science and Engineering Research

Welcome to the MERCATOR user's manual! MERCATOR is a CUDA/C++ system designed to assist you in writing efficient CUDA applications by automatically generating significant portions of the GPU-side application code. We hope you find it helpful; please feel free to contact the authors with any questions or feedback.

Modeling, Simulation, And Analysis Of Lithium-Ion Batteries For Grid-Scale Applications, Matthew Thomas Lawder

McKelvey School of Engineering Theses & Dissertations

Lithium-ion batteries have become universally present in daily life, being used across a wide range of portable consumer electronics. These batteries are advantageous compared to other forms of energy storage due to their high energy density and long cycle life. These characteristics make lithium-ion batteries advantageous for many new and developing applications that require large scale energy storage such as electric vehicles and the utility grid. Typical uses for lithium-ion batteries require consistent cycling patterns that are predictable and easy to approximate across all uses, but new large scale applications will have much more dynamic demands. The cycling patterns for …

Cyclotron Production And Biomedical Imaging Applications Of The Pet Isotope Manganese-52, Andrew Lake Wooten

McKelvey School of Engineering Theses & Dissertations

Manganese is an important element for biomedical research because of its roles as an essential micronutrient and as a neurotoxin from chronic elevated exposure, as well as the role of manganese(II) as a paramagnetic core for contrast agents in T1-weighted magnetic resonance imaging (MRI). Using a radiotracer of manganese provides excellent sensitivity for studying these phenomena, but only 52Mn met the criteria for our experiments: (1) a half-life (t1/2=5.6 days) that was long enough to examine timepoints over several days, (2) a half-life that was short enough to emit sufficient counts for a realistic scan time, and (3) emitted radiation …

Distributed Target Tracking And Synchronization In Wireless Sensor Networks, Jichuan Li

McKelvey School of Engineering Theses & Dissertations

Wireless sensor networks provide useful information for various applications but pose challenges in scalable information processing and network maintenance. This dissertation focuses on statistical methods for distributed information fusion and sensor synchronization for target tracking in wireless sensor networks.

We perform target tracking using particle filtering. For scalability, we extend centralized particle filtering to distributed particle filtering via distributed fusion of local estimates provided by individual sensors. We derive a distributed fusion rule from Bayes' theorem and implement it via average consensus. We approximate each local estimate as a Gaussian mixture and develop a sampling-based approach to the nonlinear fusion …

Visualization Of Deep Convolutional Neural Networks, Dingwen Li

McKelvey School of Engineering Theses & Dissertations

Deep learning has achieved great accuracy in large scale image classification and scene recognition tasks, especially after the Convolutional Neural Network (CNN) model was introduced. Although a CNN often demonstrates very good classification results, it is usually unclear how or why a classification result is achieved. The objective of this thesis is to explore several existing visualization approaches which offer intuitive visual results. The thesis focuses on three visualization approaches: (1) image masking which highlights the region of image with high influence on the classification, (2) Taylor decomposition back-propagation which generates a per pixel heat map that describes each pixel's …

A General Framework Of Large-Scale Convex Optimization Using Jensen Surrogates And Acceleration Techniques, Soysal Degirmenci

McKelvey School of Engineering Theses & Dissertations

In a world where data rates are growing faster than computing power, algorithmic acceleration based on developments in mathematical optimization plays a crucial role in narrowing the gap between the two. As the scale of optimization problems in many fields is getting larger, we need faster optimization methods that not only work well in theory, but also work well in practice by exploiting underlying state-of-the-art computing technology.

In this document, we introduce a unified framework of large-scale convex optimization using Jensen surrogates, an iterative optimization method that has been used in different fields since the 1970s. After this general treatment, …

Goggle Augmented Imaging And Navigation System For Fluorescence-Guided Surgery, Suman Bikash Mondal

McKelvey School of Engineering Theses & Dissertations

Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and …

Revelation Of Yin-Yang Balance In Microbial Cell Factories By Data Mining, Flux Modeling, And Metabolic Engineering, Gang Wu

McKelvey School of Engineering Theses & Dissertations

The long-held assumption of never-ending rapid growth in biotechnology and especially in synthetic biology has been recently questioned, due to lack of substantial return of investment. One of the main reasons for failures in synthetic biology and metabolic engineering is the metabolic burdens that result in resource losses. Metabolic burden is defined as the portion of a host cells resources either energy molecules (e.g., NADH, NADPH and ATP) or carbon building blocks (e.g., amino acids) that is used to maintain the engineered components (e.g., pathways). As a result, the effectiveness of synthetic biology tools heavily dependents on cell capability to …

Environmental Fullerene Chemistry: Elucidating Critical Reaction Pathways And Resulting Products In The Aqueous Phase, Jiewei Wu

McKelvey School of Engineering Theses & Dissertations

As the production of fullerenes and fullerene-based materials approaches industrial scale, there are increasing interests/concerns regarding their (potential) environmental impact(s) upon release. To date, a number of critical, aqueous-based fullerene transformation pathways under environmentally relevant conditions remain poorly understood. Comprehensive, fundamental, and quantitative understanding of the potential (major) reaction pathways and resulting products of fullerene materials, particularly in aquatic systems, is now crucial for their accurate fate, transport, life cycle, risk assessment(s), and thus ultimate material sustainability.

Herein, this dissertation is focused on identifying and elucidating aqueous transformation pathways of fullerene materials, focused on C60 as a model fullerene, under …

Theory Of Carrier Transport From First Principles: Applications In Photovoltaic And Thermoelectric Materials, Alireza Faghaninia

McKelvey School of Engineering Theses & Dissertations

New sources of energy that are environmentally friendly, cost-effective, and renewable are essential if we are to combat the effects of global climate change. Two of these sources are solar photovoltaic (PV) cells to convert sunlight into electricity and thermoelectric (TE) devices to convert heat to electricity. To be practical on a large scale, the properties (e.g. electrical conductivity, band gap, Seebeck coefficient, etc) of the the underlying materials must be improved significantly through judicious control of structure and composition. Significant understanding of materials properties is required to design and engineer new high-performing materials. First principles calculations using density functional …

Dynamic Pricing And Inventory Management: Theory And Applications, Renyu Zhang

Arts & Sciences Electronic Theses and Dissertations

We develop the models and methods to study the impact of some emerging trends in technology, marketplace, and society upon the pricing and inventory policy of a firm. We focus on the situation where the firm is in a dynamic, uncertain, and (possibly) competitive market environment. The market trends of particular interest to us are: (a) social networks, (b) sustainability concerns, and (c) customer behaviors. The two main running questions this dissertation aims to address are: (a) How these emerging market trends would influence the operations decisions and profitability of a firm; and (b) What pricing and inventory strategies a …