Public Health Commons^™

Continuous Vital Sign Monitoring On Surgical Wards: The Cosmos Pilot, Shuyi Li, Amber Clemens, Christine Perez, John W Beard, Daniel I Sessler

Faculty, Staff and Student Publications

Study objectives: Alerts for vital sign abnormalities seek to identify meaningful patient instability while limiting alarm fatigue. Optimal vital sign alarm settings for postoperative patients remain unknown, as is whether alerts lead to effective clinical responses reducing vital sign disturbances. We conducted a 2-phase pilot study to identify thresholds and delays and test the hypothesis that alerts from continuous monitoring reduce the duration of vital sign abnormalities.

Design: Two-phase pilot.

Patients: 250 adults having major non-cardiac surgery.

Setting: Surgical wards.

Intervention: All patients had routine vital sign monitoring by nurses at 4-h intervals. We initially continuously recorded clinician-blinded saturation, heart …

Bivariate Genome-Wide Association Study Of Circulating Fibrinogen And C-Reactive Protein Levels, Abbas Dehghan, Maria Sabater-Lleal, Alanna C Morrison, Paul S De Vries

Faculty, Staff and Student Publications

Background: Fibrinogen and C-reactive protein (CRP) play an important role in inflammatory pathways and share multiple genetic loci reported in previously published genome-wide association studies (GWAS), highlighting their common genetic background. Leveraging the shared biology may identify further loci pleiotropically associated with both fibrinogen and CRP.

Objectives: To identify novel genetic variants that are pleiotropic and associated with both fibrinogen and CRP, by integrating both phenotypes in a bivariate GWAS by using a multitrait GWAS.

Methods: We performed a bivariate GWAS to identify further pleiotropic genetic loci, using summary statistics of previously published GWAS on fibrinogen (n = 120 246) …

Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Beth A Dombroski, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project;, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso

Faculty, Staff and Student Publications

INTRODUCTION: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

METHODS: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.

RESULTS: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10

DISCUSSION: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.

HIGHLIGHTS: We determine the association of genetic variants with Alzheimer's disease (AD) using …

Economic Disadvantage During Childhood, Obesity, And Diabetes Across Three Birth Cohorts Of Older Mexicans

Faculty, Staff and Student Publications

OBJECTIVES: Diabetes prevalence has increased markedly in Mexico. We examined the individual and joint contributions of economic disadvantage during childhood (EDDC) and elevated body weight on diabetes prevalence in 3 cohorts of Mexican adults.

METHODS: Data on those 60-69 years old from the 1930-1939, 1940-1949, and 1950-1959 birth cohorts in Waves 1 (2001), 3 (2012), and 5 (2018) of the Mexican Health and Aging Study were used. EDDC was defined as the absence of a toilet in the household before age 10. Body mass status was defined using self-reported perceived body image at age 50. Diabetes was based on respondent …

Hpv Vaccine-Related Articles Shared On Facebook From 2019 To 2021: Did Covid Make A Difference?, Ross Shegog

Faculty, Staff and Student Publications

OBJECTIVE: HPV vaccination is recommended for children beginning at age 9 to prevent several types of cancer. Many parents turn to Facebook for health information. This study describes changes in HPV vaccine-related articles shared on Facebook amidst the COVID-19 pandemic.

METHODS: HPV-related articles shared on Facebook (2019-2021) were collected using Buzzsumo, a social media analytics tool and analyzed using content analysis. Articles were categorized by valence, misinformation, evidence types, persuasive tactics, and framing. We quantified these data and tested for difference by article year.

RESULTS: Of the 138 included articles, 51% had positive valence towards the vaccine and 36% had …

Understanding The Association Between Neighborhoods And Adolescent Sleep: Evidence From Add Health, Qian Xiao

Faculty, Staff and Student Publications

INTRODUCTION: Research suggests that perceived neighborhood social environments (PNSE) may contribute to gender and race/ethnicity-based sleep disparities. Our study aimed to examine associations between PNSE factors and adolescents' sleep patterns. As a secondary aim, we examined how gender and race/ethnic groups might moderate these associations.

METHOD: Data came from the National Longitudinal Study of Adolescent to Adult Health (n=5158; mean age=15.34 years). Four self-reported sleep outcomes were created: 1) sleep duration (hours/night), 2) short sleep (≥8 hours [reference] vs <8 >hours), 3) parental set bedtime (10:00 PM/earlier [reference] among girls vs by 11:00PM vs by/after 12:00AM), and 4) sleep satisfaction (enough …

Genetic Architecture Of Cerebrospinal Fluid And Brain Metabolite Levels And The Genetic Colocalization Of Metabolites With Human Traits, Yueyao Wang, Lihua Wang, Priyanka Gorijala, Jigyasha Timsina, Agustin Ruiz, Pau Pastor, Maria Victoria Fernandez, Dominantly Inherited Alzheimer Network (Dian), Alzheimer’S Disease Neuroimaging Initiative (Adni), Daniel J Panyard, Corinne D Engelman, Yuetiva Deming, Merce Boada, Amanda Cano, Pablo Garcia-Gonzalez, Neill R Graff-Radford, Hiroshi Mori, Jae-Hong Lee, Laura Ibanez, Yun Ju Sung, Carlos Cruchaga

Faculty, Staff and Student Publications

Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals, containing 11 new loci) for 139 CSF metabolites, and 32 independent associations (43.8% new signals, containing 4 new loci) for 31 brain metabolites. Of these, 96.9% (CSF) and 71.4% (brain) of the new signals belonged to previously analyzed metabolites in blood or urine. We integrated the metabolite quantitative trait loci (MQTLs) with 23 neurological, psychiatric and common human traits and diseases through colocalization to identify metabolites and biological processes implicated …

Whole-Of-School Physical Activity Promotion: Findings From Elementary Schools In The United States, Kempson Onadeko, Laura F Defina, Timothy J Walker

Faculty, Staff and Student Publications

INTRODUCTION: Schools can support students' participation in physical activity by offering opportunities consistent with a Whole-of-School (WOS) approach; however, the extent to which physical activity opportunities are provided and how school-level characteristics associate with their use remains unclear. This study examined how elementary schools' use a WOS approach to promote physical activity, as well as associations between school-level characteristics and physical activity opportunities provided.

METHODS: Survey data was collected from 162 elementary schools participating in the NFL PLAY 60 FitnessGram Project during the 2022-2023 school year. A WOS index (ranging from 0 to 12) was created from responses by school …

Designing A Blockchain Technology Platform For Enhancing The Pre-Exposure Prophylaxis Care Continuum, Ladd Hanson, Armand Brown, Marlene Mcneese, Kayo Fujimoto

Faculty, Staff and Student Publications

OBJECTIVES: Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in the United States, but its uptake is impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, a blockchain-based, client-centered platform to enhance care to address these challenges by improving care coordination and enabling clients to securely manage their identity and PrEP-related data.

MATERIALS AND METHODS: Using Houston, Texas, as a use case, we conducted a needs assessment with PrEP collaborators to evaluate existing workflows and identify barriers in the PrEP care continuum. Based on these findings, we …

Biological Validation Of Peak-Width Of Skeletonized Mean Diffusivity As A Vcid Biomarker: The Markvcid Consortium, Rebecca Bernal, Elyas Fadaee, Haykel Snoussi, Angel Gabriel Velarde Dediós, Hector A Trevino, Monica Goss, Laura J Hillmer, Christopher E Bauer, Adam M Staffaroni, Lara Stables, Marilyn Albert, Jayandra J Himali, Thomas H Mosley, Lars Forsberg, Vilmundur Guðnason, Baljeet Singh, Herpreet Singh, Kristin Schwab, Gary A Rosenberg, Karl G Helmer, Steven M Greenberg, Mohamad Habes, Danny J J Wang, Brian T Gold, Hanzhang Lu, Arvind Caprihan, Myriam Fornage, Lenore J Launer, Konstantinos Arfanakis, Sudha Seshadri, Charles Decarli, Pauline Maillard, Claudia L Satizabal

Faculty, Staff and Student Publications

BACKGROUND: Peak-width of skeletonized mean diffusivity (PSMD), a neuroimaging marker of cerebral small vessel disease (SVD), has shown excellent instrumental properties. Here, we extend our work to perform a biological validation of PSMD.

METHODS: We included 396 participants from the Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID-1) Consortium and three replication samples (Cohorts for Heart and Aging Research in Genomic Epidemiology = 6172, Rush University Medical Center = 287, University of California Davis Alzheimer's Disease Research Center = 567). PSMD was derived from diffusion tensor imaging using an automated algorithm. We related PSMD to a composite measure …

Us Or Them: How Covid-19 Vaccine Priority Influences Perceptions Of Local-Migrant Worker Relations, Tengjiao Huang, Haochen Zhou, Liz Jones, Chin Wen Cong

Research Collection School of Social Sciences

The COVID-19 pandemic laid bare pre-existing societal fault lines, placing immense strain on intergroup relations and giving rise to xenophobic sentiments. Drawing on Realistic Conflict Theory (RCT) and Social Identity Approach (SIA), our study examined how the public allocation of COVID-19 variant vaccines could influence the dynamics between local citizens and migrant workers, and under what conditions. One key idea is that valued resource distribution that favour migrant workers may produce increased perceptions of realistic threats among local citizens which could lead to exacerbated negative attitudes and behaviours of high-status local citizens towards low-status migrants, whereas higher fairness perceptions of …

A003: Autonomy And Integration: A Qualitative Study Of Professional Practice Of Chinese Physical Education Teachers, Peipei Jiang, Huiying Chen

International Journal of Physical Activity and Health

Background/Purpose: This study aimed to explore the professional practice of Chinese physical education teachers to promote their professional development. In the context of physical education curriculum reform, by delving into the "real events" and "complete stories" of Chinese high school physical education teachers, a professional practice landscape of Chinese high school physical education teachers was constructed to deepen understanding of their patterns and future action strategies. This paper defined professional practice of Chinese physical education teachers as the process of promoting professional development through interactions in the school context.

Method: This study is based on the constructivist research paradigm, with …

A068: A Case Study Of Hippy Family Intervention On Motor Ability In Children With Developmental Delays, Jiayu Zhou, Xiaozan Wang, Qinping Xu

International Journal of Physical Activity and Health

Background: The phenomenon of motor retardation caused by serious insufficient physical activity of children is increasing. Improving the family's parenting knowledge and skills can promote the family's healthy lifestyle and have a positive impact on the healthy development of children.

Method: The children with developmental delays were followed in their natural state for three months, combined with the "HIPPY family intervention model" to improve their family's parenting knowledge and skills, and to intervene in the behavioral performance and physical activity of children with motor development delays.

Results: After 3 months of HIPPY family intervention, TGMD showed an overall upward trend, …

A083: Effects Of Muscle Energy Technique On Neuromuscular Function In Patients With Non-Specific Lower Back Pain, Zhipeng Zhou, Jianbin Zhao

International Journal of Physical Activity and Health

Background/Purpose: Non-specific lower back pain (NLBP) is one of the most common causes of disability worldwide. In patients with NLBP, reduced lumbar flexion-relaxation and reduced variability of muscle activity distribution are reported as abnormal muscle activity. Muscle energy technique (MET) is used to be a conservative, non-pharmacological treatment method for somatic dysfunctions of the musculoskeletal system. However, the effect of MET approach on the flexion-relaxation phenomena (FRP) is unclear. Therefore, the purpose of this study was to investigate the effects of MET on pain, lumbar function, and FRP in patients with NLBP.

Methods/Design: Thirty patients with NLBP were randomized into …

A111: A Study On Effect Of Learning Martial Arts By Different People Influenced By Chinese Culture, Beiqi Kang, Shengyuan Zhao, Jinpeng Li

International Journal of Physical Activity and Health

Background/Purpose: To better develop multi-racial education of practicing and learning martial arts, this essay was written by using case analysis and information analysis.

Methods: According to the recently HYX 16th World Wushu Championships, 76.9% athletes who learned about Chinese culture got the points higher than average. In addition, in the 9th World Kungfu Championships, 87% athletes had learned about Chinese culture won a prize in the contest. Meanwhile, we prepared 20 overseas students who started learning martial arts to identify whether learning Chinese culture was beneficial to martial arts learning. Every member in this program never studied Chinese culture and …

A112: Physical Exercise's Effect On Chinese Students' Negative Emotions Via Sleep And Self-Rated Health, Fanhzheng Mu, Pengyu Huo, Weidong Zhu, Xuehao Cheng

International Journal of Physical Activity and Health

Background: Negative emotions in college students are a significant factor affecting mental health, with suicide behaviors caused by negative emotions showing an annual increasing trend. Existing studies suggest that physical exercise is an important means to alleviate negative emotions, yet the intrinsic mechanisms by which it affects negative emotions have not been fully revealed.

Objective: Negative emotions in college students represent a significant issue affecting mental health. This study investigated the relationship between physical exercise and negative emotions among college students, incorporating sleep quality and self-rated health (SRH) as mediators to analyze the pathway mechanism of how physical …

A113: The Impact Of Motivational Climate On Class Engagement: Situational Interest And Self-Efficacy As Mediators, Chunli Zhong, Bo Shen

International Journal of Physical Activity and Health

Background/Purpose: An accomplishment within physical education classes involves actively involving students. Research underscores the importance of nurturing situational interest and self-efficacy to foster this engagement. Both self-determination theory and achievement goal theory propose that teachers can cultivate a supportive classroom environment, thereby boosting students' interest and confidence in their capabilities. Nevertheless, the transformable mechanism from motivational climate to actual class engagement needs further investigation. The purpose of this study was to examine the extent to which motivational climate variables (e.g., autonomy supportive climate, task-involving climate, and socially supportive climate) impacted student engagement via the mediative roles of situational interest and …

A142: A Study On The Neglective Status And Influencing Factors Of Preschool Children In Xiangxi Prefecture, Jinyin Peng, Yang Liu, Junwei Dong

International Journal of Physical Activity and Health

Objective: To understand the neglect of preschool children of ethnic minorities in Xiangxi Prefecture, to explore its influencing factors, and to provide a scientific and theoretical basis for the development of intervention measures for preschool children's neglect in ethnic minority areas.

Methods: A total of 1050 children from 4 rural kindergartens and 4 urban kindergartens were randomly selected from Xiangxi Tujia and Miao Autonomous Prefecture in March–May 2023 by stratified random cluster sampling. A questionnaire survey was conducted on 1050 parents of children using the scales and evaluation methods developed by "Norms for the Evaluation of Neglect in 3~6-year-old Children …

A156: The Effects Of School-Based Concurrent Training On Body Composition And Cardiorespiratory Fitness In Obese Children, Yuhang Gao, Meng Cao, Minhua Wu

International Journal of Physical Activity and Health

Objective: High-intensity interval training (HIIT) is a highly effective form of exercise for the obese population. Concurrent training (CT) is also an effective intervention. Simultaneous training is often in the form of strength combined with aerobic training. Considering the high efficiency of HIIT, this study considered combining HIIT with aerobic training and HIIT with resistance training respectively to form two simultaneous training programs to observe its effects on body composition and cardiorespiratory fitness in children with obesity.

Methods: Thirty children with obesity [age: (10.1 ± 0.7) years, BMI: (55.0 ± 6.1) kg/m²] were recruited from a primary school …

A178: Effect Of Aerobic Exercise Intervention On Anxiety In College Students: A Systematic Review, Yiming Chen, Shengting Dai, Xinming Ye

International Journal of Physical Activity and Health

Background/Purpose: The role of exercise interventions in the treatment of psychiatric disorders is receiving increased attention, and the positive protective effect of aerobic exercise on anxiety symptoms has now been extensively demonstrated. This study aimed to investigate the systematic evaluation of the effects of different aerobic exercise interventions on anxiety symptoms in college students.

Method: Using keywords such as “physical activity,” “anxiety,” and “college students” screened Randomized controlled trials (RCT) published until February 2024 in three databases: PubMed, Web of Science, and Scopus. A total of 5073 studies were retrieved after systematically searching individual databases. After removing duplicate literature, 4112 …

A005: Progress In Sports Rehabilitation For Adolescent Idiopathic Scoliosis, Wei Cao, Wei Qi, Dandan Liu, Zhenyu Qian, Mingyun Sun

International Journal of Physical Activity and Health

Background: Adolescent idiopathic scoliosis has become the third leading "killer" of the health of Chinese adolescents, following obesity and myopia. Scoliosis is a three-dimensional deformity of the spine, usually characterized by a lateral curvature of the spine accompanied by rotation. The diagnostic criterion is a Cobb angle greater than 10 degrees on X-ray. With the promotion of the concept of "exercise is good medicine" and the Healthy China strategy, exercise therapy has received attention and development.

Purpose: To summarize different sports rehabilitation methods for adolescents with idiopathic scoliosis worldwide with the hope to raise awareness of adolescent idiopathic scoliosis and …

A006: Liver Function And Risk Of Non-Alcoholic Fatty Liver Disease In Patients With Sarcopenia: A Meta-Analysis, Keyang Chen

International Journal of Physical Activity and Health

Background/Aim: Nonalcoholic fatty liver disease (NAFLD) has become increasingly prevalent as one of the most common chronic liver diseases worldwide. Sarcopenia, defined by the decline in muscle mass, power, strength, and performance, has been linked to NAFLD in recent epidemiological research, although findings have been inconclusive. This meta-analysis aimed to consolidate and determine the impact of sarcopenia on liver function, as well as the occurrence and severity of NAFLD in individuals with sarcopenia.

Methods: A comprehensive search was conducted in databases including PubMed, Medline, Embase, Scopus, the Cochrane Library, and the Web of Science were searched up to November 20, …

A007: Neuromuscular Factors Affecting Lower Extremity Explosive Strength Of Male Track And Field Athletes, Yanjin Li, Yue Zhou

International Journal of Physical Activity and Health

Objective: To investigate the neural and muscular factors affecting the explosive power of the lower limbs in college athletes by testing the neuromuscular function (H reflex) and explosive performance of male sprinting and long jump athletes.

Methods: H-reflex, countermovement jump (CMJ), squat jump (SJ) and one repetition maximum(1RM) tests were performed on male track and field college athletes using electromyography evoked potential and three-dimensional dynamometer. Test data of Hmax/Mmax, H-index, peak countermovement jump force and vertical stiffness of male college athletes were obtained. The Pearson's correlation coefficient was used to analyze the relationship between neuromuscular function and explosive performance in …

A011: Effects Of Aerobic Exercise On Microbiota: Gut-Brain Axis And Hippocampal Neurotransmitters In Aging Mice, Yuqian Liu, Wenqian Yang, Haitao Wang

International Journal of Physical Activity and Health

Background/Objective: Gut flora plays an important role in host stress response, anxiety, depression and cognitive function through the gut-brain axis. Microbial diversity decreases with age, which in turn affects the function of the nervous system. The role of exercise in the prevention and treatment of age-related diseases and neurodegenerative diseases has received increasing attention. The purpose of this study was to elucidate the regulatory role of intestinal flora, gut-brain axis and nervous system function in the prevention of nervous system function decline in the elderly.

Methods: The sample consisted of 16, 52-week-old SPF C57BL/6 male mice that were randomly divided …

A014: Research On Physical Education Teaching Mode In The Context Of Education Digitalization, Xiaoliang Tian

International Journal of Physical Activity and Health

Background: The 2022 National Education Work Conference clearly stated that the implementation of the strategic action of education digitalization is not only a high degree of integration of modern education and the digital information age, but also an important strategy to accelerate the digital transformation of education during the 14th Five-Year Plan period. To implement the power of sports, culture and education, physical education teaching in colleges and universities should actively explore innovative development paths for physical education.

Research methods: In this paper, "education digitalization and physical education" were the key words. Starting from 2022, when the concept of education …

A016: Effects Of Hiit Combined With Iet On Cardiac Structure And Function In Women With Now, Lumeng Yang, Peizhen Zhang

International Journal of Physical Activity and Health

Purpose: The development of a society with increasing unhealthy lifestyles and dietary habits leads to a rise in the population suffering from obesity and cardiovascular disease (CVD). NWO individuals, who are hidden obese individuals, are also at a similar risk. This study aimed to compare the effects of high-intensity interval training (HIIT) and HIIT combined with intermittent energy restriction (IET) on cardiac structure and function and to explore more effective exercise intensities and methods to provide scientific exercise guidance to enhance vascular health and reduce CVD risk factors in NWO women.

Method: Forty-five NWO women were randomly divided into a …

A018: Dual-Process Advantages Of Ball Players In Sport-Related Domains, Xuechen Mao

International Journal of Physical Activity and Health

Background: Based on a dual-process framework, two qualitatively different modes of processing guide human behaviour. Type 1 processes refer to automatic, unconscious processing that can be responsible for Task 1, while Type 2 processes refer to controlled, conscious processing required by Task 2. Although many existing sport psychology studies emphasize that the dual-process model can be applied to the sports domain, this application has shortcomings. The first debate of this application is whether dual-process advantages in athletes are limited to sport-specific realms. Furthermore, although the dual-process framework pays more attention to automatic processes (Type 1 processes), it loses sight of …

A019: Value Co-Creation Of Sports Museums In China: Lessons From International Sports Museums, Jiexin Chen

International Journal of Physical Activity and Health

Purpose: This study aimed to conclude the value achievement experience of International Olympic Museums and to provide practical advice for the development of Chinese sports museums.

Method: A critical review of existing literature was performed on sport management and theoretical considerations based on service-dominant logic. Following the value co-creation framework, this study analyzed the basics, procedures and targets of value co-creation of 27 international Olympic museums, which are members of International Group of Olympic Museums.

Results: The results showed that not all the international Olympic museums were developed successfully, but successful museums shared some common characters as follows. First, an …

A021: Hypoxic Complex Exercise Promotes Hif-1Α Expression To Improve Drosophila Cardiac Pumping Function, Xu Ping, Lan Zheng, Qiufang Li

International Journal of Physical Activity and Health

Background: Some studies have shown that the stability and transcription of HIF-1α significantly increases under hypoxic conditions, and HIF and its downstream targets are becoming a new choice for the treatment of various organ injuries to improve physical function. Combined with the team's pre-screening of suitable hypoxic compound exercise protocols, this study aimed to explore the link between the expression of exercise HIF-1α under hypoxic conditions and cardiac function, in order to provide a realistic and theoretical basis for the improvement of cardiac function by hypoxic compound exercise.

Methods: 300 Drosophila flies of wild-type W¹¹¹⁸ strain feathered within 12 …

A031: Design And Practice Of Ai-Powered Precision Teaching Model For Public Physical Education Courses In Universities, Dongxiao Liu, Xuankun Sun, Aowei Zhang

International Journal of Physical Activity and Health

Background/Purpose: Five major teaching pain points often occur in the teaching of public physical education courses in universities: (1) First pain point is easy to have deviations in movement cognition and self-practice. (2) It is difficult to accurately grasp the intensity and density of exercise. (3) Lack of process and phased teaching evaluations can inhibit the cultivation of autonomous exercise drive. (4) Unhealthy aesthetics have a negative impact, leading to a deviation in aesthetic perception among students. (5) Students lack autonomous learning ability and have difficulty cultivating post-class exercise habits. How to resolve these "pain points" are now the key …