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Articles 1 - 18 of 18
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Polyamine-Polyamine And Polyamine-Protein Transport Inhibitor Conjugates And Their Use As Pharmaceuticals And In Research Relating To Polyamine Transport, Shewan M. Aziz, Mark N. Gillespie
Polyamine-Polyamine And Polyamine-Protein Transport Inhibitor Conjugates And Their Use As Pharmaceuticals And In Research Relating To Polyamine Transport, Shewan M. Aziz, Mark N. Gillespie
Pharmaceutical Sciences Faculty Patents
Novel classes of inhibitors which selectively inhibit the cellular transport of normally transported substances, specifically polyamines are taught which comprise (i) polymers of the transported substance or (ii) protein or polypeptide conjugates of the transported substance. These inhibitors may be used in vitro to assess the effect of the transported substance on cellular functions and in vivo for treating disease conditions involving transport of the particular substance, e.g., a polyamine.
Apparatus And Method For Multiple Wavelength Of Tissue, Robert A. Lodder, Lisa A. Cassis
Apparatus And Method For Multiple Wavelength Of Tissue, Robert A. Lodder, Lisa A. Cassis
Pharmaceutical Sciences Faculty Patents
An apparatus for analyzing the chemical composition of tissue includes a near infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source onto the tissue and detectors for detecting light reflected by the tissue. The light source transmits an incident beam having a wavelength ranging from 1000 to 2500 nm. A compound parabolic concentrator (CPC) is connected to a distal end of the fiber optic probe to focus or concentrate the wavelengths of light simultaneously and in parallel on a particular spot of tissue. Alternatively, an inverted, substantially conical reflector is positioned to scatter …
The Sea Anemone Purine, Caissarone: Adenosine Receptor Antagonism, Roland A. Cooper, Josecarlos De Freitas, Frank Porreca, Cynthia M. Eisenhour, Ronald Lukas, Ryan J. Huxtable
The Sea Anemone Purine, Caissarone: Adenosine Receptor Antagonism, Roland A. Cooper, Josecarlos De Freitas, Frank Porreca, Cynthia M. Eisenhour, Ronald Lukas, Ryan J. Huxtable
Roland A. Cooper
The Comparative Metabolism Of The Four Pyrrolizidine Alkaloids, Seneciphylline, Retrorsine, Monocrotaline, And Trichodesmine In The Isolated, Perfused Rat Liver., C. C. Yan, R. A. Cooper, R. J. Huxtable
The Comparative Metabolism Of The Four Pyrrolizidine Alkaloids, Seneciphylline, Retrorsine, Monocrotaline, And Trichodesmine In The Isolated, Perfused Rat Liver., C. C. Yan, R. A. Cooper, R. J. Huxtable
Roland A. Cooper
Prospects For The Control Of Bolivian Hemorrhagic Fever, Paul E. Kilgore, Clarence J. Peters, James N. Mills, Pierre E. Rollin, Lori Armstrong, Ali S. Khan, Thomas G. Ksiazek
Prospects For The Control Of Bolivian Hemorrhagic Fever, Paul E. Kilgore, Clarence J. Peters, James N. Mills, Pierre E. Rollin, Lori Armstrong, Ali S. Khan, Thomas G. Ksiazek
Department of Pharmacy Practice
No abstract provided.
Non-Destructive Method For Radiolabelling Biomolecules By Halogenation, Anwar A. Hussain, Lewis W. Dittert
Non-Destructive Method For Radiolabelling Biomolecules By Halogenation, Anwar A. Hussain, Lewis W. Dittert
Pharmaceutical Sciences Faculty Patents
A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled.
Apparatus And Method For Noninvasive Chemical Analysis, Robert A. Lodder
Apparatus And Method For Noninvasive Chemical Analysis, Robert A. Lodder
Pharmaceutical Sciences Faculty Patents
A method and apparatus are provided for magnetohydrodynamic acoustic-resonance, near-IR spectroscopy. The method includes a step of applying to a subject under study a magnetic field having a strength between 2,00-10,000 gauss, near-IR radiation having a wavelength between 800-3,000 nm and an acoustic wave having a frequency between 10 khz-1 Mhz. The method also includes the steps of inducing vibration of ions in the magnetic field and detecting an electric wave generated magnetohydrodynamically by the acoustic wave induced vibration of the ions. Next is the collecting of the electrical, acoustical and near-IR spectra and the analyzing of the collected spectra. …
A Comparison Of The Utilization Of Health Services In The Presence Or Absence Of Prescriptive Drug Insurance In A Managed Care Environment, Martha Groblewski
A Comparison Of The Utilization Of Health Services In The Presence Or Absence Of Prescriptive Drug Insurance In A Managed Care Environment, Martha Groblewski
Health Services Research Dissertations
This study tested if the availability of third party payment for prescriptive drugs as part of employer sponsored health insurance was associated with a change in the utilization of four types of health services in an independent practice association (IPA). The study employed the individual determinants component of the Andersen-Newman theoretical framework for health services utilization. Groups of employees in companies that offered health insurance identical in all ways except for the presence or absence of the prescriptive rider were included in the study which resulted in a population of 122 companies (89 with prescriptive rider insurance and 33 without …
Spring 1995, Southwestern Oklahoma State University
Spring 1995, Southwestern Oklahoma State University
The Sig
The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1995
High Energy Coprecipitate Of Nonoxynol Oligomer, Pvp And Iodine Having Contraceptive And Potent Anti-Hiv Properties, George Digenis, Alexander G. Digenis
High Energy Coprecipitate Of Nonoxynol Oligomer, Pvp And Iodine Having Contraceptive And Potent Anti-Hiv Properties, George Digenis, Alexander G. Digenis
Pharmaceutical Sciences Faculty Patents
A composition which is a contraceptive with potent anti-HIV activity. The composition is a high energy coprecipitate of nonoxynol-9 oligomers, polyvinylpyrrolidone (PVP) and iodine or PVP-I and shows a pronounced synergistic, anti-HIV effect between the compounds of the composition. A method of obtaining a contraceptive and anti-HIV environment in a female comprising administering to said female an effective amount of a high energy coprecipitate.
The Effects Of Medication On The Attributional Styles Of Boys With Adhd, Scott Patrick Ardoin
The Effects Of Medication On The Attributional Styles Of Boys With Adhd, Scott Patrick Ardoin
Honors Theses
No abstract provided.
1995 Apothecary, Southwestern Oklahoma State University
1995 Apothecary, Southwestern Oklahoma State University
Apothecary
The 1995 Apothecary staff would like to congratulate the graduating seniors on their successful completion of the professional coursework here at Southwestern Oklahoma State University School of Pharmacy. We trust that their gained knowledge and education will allow them to obtain professional success and, through all their future endeavors, further advance the pharmacy profession.
Constitutive Ion Fluxes And Substrate Binding Domains Of Human Glutamate Transporters, Robert J. Vandenberg, Jeffrey L. Arriza, Susan G. Amara, Michael Kavanaugh
Constitutive Ion Fluxes And Substrate Binding Domains Of Human Glutamate Transporters, Robert J. Vandenberg, Jeffrey L. Arriza, Susan G. Amara, Michael Kavanaugh
Biomedical and Pharmaceutical Sciences Faculty Publications
Application of L-glutamate activates ionic currents in voltage-clamped Xenopus oocytes expressing cloned human excitatory amino acid transporters (EAATs). However, even in the absence of L-glutamate, the membrane conductance of oocytes expressing EAAT1 was significantly increased relative to oocytes expressing EAAT2 or control oocytes. Whereas transport mediated by EAAT2 is blocked by the non-transported competitive glutamate analog kainate (K = 14 μM), EAAT1 is relatively insensitive (K > 3 mM). Substitution of a block of 76 residues from EAAT2 into EAAT1, in which 18 residues varied from EAAT1, conferred high affinity kainate binding to EAAT1, and application of kainate to …
Differential Modulation Of Human Glutamate Transporter Subtypes By Arachidonic Acid, Noa Zerangue, Jeffrey L. Arriza, Susan G. Amara, Michael Kavanaugh
Differential Modulation Of Human Glutamate Transporter Subtypes By Arachidonic Acid, Noa Zerangue, Jeffrey L. Arriza, Susan G. Amara, Michael Kavanaugh
Biomedical and Pharmaceutical Sciences Faculty Publications
Arachidonic acid has been proposed to be a messenger molecule released following synaptic activation of glutamate receptors and during ischemia. Here we demonstrate that micromolar levels of arachidonic acid inhibit glutamate uptake mediated by EAAT1, a human excitatory amino acid transporter widely expressed in brain and cerebellum, by reducing the maximal transport rate approximately 30%. In contrast, arachidonic acid increased transport mediated by EAAT2, a subtype abundantly expressed in forebrain and midbrain, by causing the apparent affinity for glutamate to increase more than 2-fold. The results demonstrate that the response of different glutamate transporter subtypes to arachidonic acid could influence …
A Family Of Putative Receptor-Adenylate Cyclases From Leishmania Donovani, Marco A. Sanchez, David Zeoli, Elizabeth M. Klamo, Michael Kavanaugh, Scott M. Landfear
A Family Of Putative Receptor-Adenylate Cyclases From Leishmania Donovani, Marco A. Sanchez, David Zeoli, Elizabeth M. Klamo, Michael Kavanaugh, Scott M. Landfear
Biomedical and Pharmaceutical Sciences Faculty Publications
Leishmania parasites are exposed to pronounced changes in their environment during their life cycle as they migrate from the sandfly midgut to the insect proboscis and then into the phagolysosomes of the vertebrate macrophages. The developmental transformations that produce each life cycle stage of the parasite may be signaled in part by binding of environmental ligands to receptors which mediate transduction of extracellular signals. We have identified a family of five clustered genes in Leishmania donovani which may encode signal transduction receptors. The coding regions of two of these genes, designated rac-A and rac-B, have been sequenced and shown …
Health Professions Division Catalog 1995-1996, Nova Southeastern University
Health Professions Division Catalog 1995-1996, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Fda Reform And The European Medicines Evaluation Agency, Theodore Ruger
Fda Reform And The European Medicines Evaluation Agency, Theodore Ruger
All Faculty Scholarship
No abstract provided.
Effect Of Ibogaine On Morphine: Induced Modifications Of Palatability, Hardy Joseph Rideout
Effect Of Ibogaine On Morphine: Induced Modifications Of Palatability, Hardy Joseph Rideout
Theses and Dissertations (Comprehensive)
The ability of the potential anti-addictive agent ibogaine to module the morphine-induced modification of quinine and sucrose palatability was assessed utilizing the taste reactivity test. Ibogaine (40mg/kg) was administered 24 hr prior to an injection of morphine (2 mg/kg), followed 30 min later by a 5 min intraoral infusion of 0.05% quinine solution (Experiment 1) or 10% sucrose solution (Experiment 2). Treatment with morphine enhanced the palatability of both quinine and sucrose solution. Morphine reduced the aversiveness of quinine solution during the 5 min of testing and enhanced ingestive responding to sucrose solution, however, only during min 1 of the …