Psychiatry Commons^™

Cortical Abnormalities In Youth At Clinical High-Risk For Psychosis: Findings From The Napls2 Cohort, Y. Chung, D. Alswede, J. Addington, C. E. Bearden, K. Cadenhead, B. Cornblatt, D. H. Mathalon, T. Mcglashan, D. Perkins, T. D. Cannon, +6 Additional Authors

Journal Articles

No abstract provided.

Structural Brain Characteristics In Treatment-Resistant Depression: Review Of Magnetic Resonance Imaging Studies, M. P. Klok, P. F. Van Eijndhoven, M. Argyelan, A. H. Schene, I. Tendolkar

Journal Articles

No abstract provided.

Association Between Decreased Serum Tbil Concentration And Immediate Memory Impairment In Schizophrenia Patients, X. L. Yin, Q. F. Jia, G. Y. Zhang, J. P. Zhang, T. Shirao, C. X. Jiang, X. Y. Yin, Y. S. Liu, P. Chen, L. Hui, +4 Additional Authors

Journal Articles

© 2019, The Author(s). Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of serum total BIL (TBIL) concentration with cognitive impairment in SCH patients. We recruited 34 SCH patients and 119 healthy controls (HCs) in this case-control design. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum TBIL concentration was measured using the immunoturbidimetric method. Serum TBIL concentration …

Erratum: Best Practices For Evaluation And Treatment Of Agitated Children And Adolescents (Beta) In The Emergency Department: Consensus Statement Of The American Association For Emergency Psychiatry (Western Journal Of Emergency Medicine (2019) 20:2 (409-419) Doi: 10.5811/Westjem.2019.1.41344), R. Gerson, N. Malas, V. Feuer, G. H. Silver, R. Prasad, M. M. Mroczkowski

Journal Articles

No abstract provided.

The Impact Of Pharmacological And Non-Pharmacological Interventions To Improve Physical Health Outcomes In People With Schizophrenia: A Meta-Review Of Meta-Analyses Of Randomized Controlled Trials, D. Vancampfort, J. Firth, C. U. Correll, M. Solmi, D. Siskind, M. De Hert, R. Carney, A. Koyanagi, A. F. Carvalho, F. Gaughran, B. Stubbs

Journal Articles

No abstract provided.

Low Incidence Of Neuroleptic Malignant Syndrome Associated With Paliperidone Palmitate Long-Acting Injectable A Database Report And Case Study, J. M. Kane, C. U. Correll, N. Delva, S. Gopal, A. Savitz, M. Mathews

Journal Articles

No abstract provided.

Acute Psychosis Following 1,1-Difluoroethane Inhalation, Clara B. Novotny, Sarah Irvin, Eduardo D. Espiridion

Faculty & Staff Scholarship

Inhalants are often abused due to their ability to acutely induce feelings of euphoria. Difluoroethane is a toxic lipophilic hydrocarbon that crosses the blood-brain barrier and inhibits the central nervous system. Studies have shown the cardiac, renal, and respiratory effects it has when abused; however, our literature review yielded no previous report of acute psychosis after difluoroethane inhalation. In order to prevent poor outcomes by missed diagnosis, we present a case of difluoroethane-induced acute psychosis.

Breadth And Depth Of Working Memory And Executive Function Compromises In Mild Cognitive Impairment And Their Relationships To Frontal Lobe Morphometry And Functional Competence, L. Garcia-Alvarez, J. J. Gomar, A. Sousa, M. P. Garcia-Portilla, T. E. Goldberg

Journal Articles

© 2019 Introduction: The extent of working memory (WM) and executive function (EF) impairment in mild cognitive impairment (MCI) is not well-characterized. Methods: We compared 48 patients with MCI, 124 noncognitively impaired elderly healthy controls, and 57 patients with Alzheimer's disease (AD) on multiple WM/EF measures, frontal lobe integrity indexes, and functioning. Results: Patients with MCI demonstrated worse performance on nearly all WM/EF tests. This profile of impairment was refined in a factor analysis that identified three primary WM/EF constructs: WM storage; speed and controlled visual search; and manipulation of information and problem solving. EF impairments were associated with reductions …

Internet Searches For Medical Symptoms Before Seeking Information On 12-Step Addiction Treatment Programs: A Web-Search Log Analysis, G. Nitzburg, I. Weber, E. Yom-Tov

Journal Articles

© 2019 George Nitzburg, Ingmar Weber, Elad Yom-Tov. Background: Brief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. However, despite considerable evidence of delay discounting in patients with substance use disorders, most brief advice by physicians focuses on the long-term negative medical consequences, which may not be the best way to motivate patients to seek treatment information. Objective: Identification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used …

Objective User Engagement With Mental Health Apps: Systematic Search And Panel-Based Usage Analysis., A. Baumel, F. Muench, S. Edan, J. Kane

Journal Articles

BACKGROUND: Understanding patterns of real-world usage of mental health apps is key to maximizing their potential to increase public self-management of care. Although developer-led studies have published results on the use of mental health apps in real-world settings, no study yet has systematically examined usage patterns of a large sample of mental health apps relying on independently collected data.

OBJECTIVE: Our aim is to present real-world objective data on user engagement with popular mental health apps.

METHODS: A systematic engine search was conducted using Google Play to identify Android apps with 10,000 installs or more targeting anxiety, depression, or emotional …

Pleiotropic Meta-Analysis Of Cognition, Education, And Schizophrenia Differentiates Roles Of Early Neurodevelopmental And Adult Synaptic Pathways, M. Lam, W. D. Hill, J. W. Trampush, J. Yu, E. Knowles, G. Davies, E. Stahl, P. Derosse, A. K. Malhotra, T. Lencz, +58 Additional Authors

Journal Articles

No abstract provided.

Abnormal Involuntary Movement Scale In Tardive Dyskinesia: Minimal Clinically Important Difference, M. Stacy, M. Sajatovic, J. M. Kane, A. J. Cutler, G. S. Liang, C. F. O'Brien, C. U. Correll

Journal Articles

No abstract provided.

Lithium For The Maintenance Treatment Of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study, R. L. Findling, N. K. Mcnamara, M. Pavuluri, J. A. Frazier, M. Rynn, R. Scheffer, V. Kafantaris, A. Robb, M. Delbello, P. Taylor-Zapata, +7 Additional Authors

Journal Articles

No abstract provided.

Interrogating The Genetic Determinants Of Tourette's Syndrome And Other Tic Disorders Through Genome-Wide Association Studies, D. Yu, J. H. Sul, F. Tsetsos, M. S. Nawaz, A. Y. Huang, I. Zelaya, C. Illmann, C. L. Budman, C. Budman, M. Woods, +119 Additional Authors

Journal Articles

No abstract provided.

Gene Expression Imputation Across Multiple Brain Regions Provides Insights Into Schizophrenia Risk, L. M. Huckins, A. Dobbyn, D. M. Ruderfer, G. Hoffman, W. Wang, A. F. Pardinas, V. M. Rajagopal, T. D. Als, A. K. Malhotra, P. F. Sullivan, +343 Additional Authors

Journal Articles

No abstract provided.

Clinical Relevance Of Paliperidone Palmitate 3-Monthly In Treating Schizophrenia, M. Mathews, S. Gopal, I. Nuamah, L. Hargarter, A. J. Savitz, E. Kim, W. Tan, B. Soares, C. U. Correll

Journal Articles

No abstract provided.

The Early Psychosis Screener For Internet (Epsi)-Sr: Predicting 12 Month Psychotic Conversion Using Machine Learning, B. B. Brodey, R. R. Girgis, O. V. Favorov, C. E. Bearden, S. W. Woods, J. Addington, D. O. Perkins, E. F. Walker, B. A. Cornblatt, K. S. Cadenhead, +3 Additional Authors

Journal Articles

No abstract provided.

Long-Term Effectiveness Of Oral Second-Generation Antipsychotics In Patients With Schizophrenia And Related Disorders: A Systematic Review And Meta-Analysis Of Direct Head-To-Head Comparisons, T. Kishimoto, K. Hagi, M. Nitta, J. M. Kane, C. U. Correll

Journal Articles

No abstract provided.

Association Of Antipsychotic Polypharmacy Vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia, J. Tiihonen, H. Taipale, J. Mehtala, P. Vattulainen, C. U. Correll, A. Tanskanen

Journal Articles

No abstract provided.

Erratum: This Article Corrects: Best Practices For Evaluation And Treatment Of Agitated Children And Adolescents (Beta) In The Emergency Department: Consensus Statement Of The American Association For Emergency Psychiatry (Western Journal Of Emergency Medicine (2019) 20: 2 (409-419) Doi: 10.5811/Westjem.2019.1.41344), R. Gerson, N. Malas, V. Feuer, G. H. Silver, R. Prasad, M. M. Mroczkowski

Journal Articles

No abstract provided.

Neural Computations Of Threat In The Aftermath Of Combat Trauma, P. Homan, I. Levy, E. Feltham, C. Gordon, J. Hu, J. Li, R. H. Pietrzak, S. Southwick, J. H. Krystal, D. Schiller, +1 Additional Author

Journal Articles

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues that did not predict what they had expected, indicating greater sensitivity to prediction errors for negative outcomes. This exaggerated weighting of prediction errors shapes the dynamic learning rate (associability) and value of threat predictive cues. The degree to which the striatum tracked the associability partially mediated the positive …

Cholinergic Control Of Inflammation, Metabolic Dysfunction, And Cognitive Impairment In Obesity-Associated Disorders: Mechanisms And Novel Therapeutic Opportunities, E. H. Chang, S. S. Chavan, V. A. Pavlovh

Journal Articles

No abstract provided.

Electroconvulsive Therapy Modulates Resting-State Eeg Oscillatory Pattern And Phase Synchronization In Nodes Of The Default Mode Network In Patients With Depressive Disorder, A. Takamiya, J. Hirano, B. Yamagata, S. Takei, T. Kishimoto, M. Mimura

Journal Articles

© 2019 Takamiya, Hirano, Yamagata, Takei, Kishimoto and Mimura. Introduction: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements remain elusive. Methods: Individuals with unipolar depressive disorder receiving bilateral ECT were recruited. Five minutes of resting, eyes-closed, 19-lead EEG recordings were obtained before and after a course of ECT. Non-overlapping 60 artifact-free epocs of 2-s duration were used for the analyses. We used exact low resolution electromagnetic tomography (eLORETA) to compute …

Improvement Of Psychiatrists’ Clinical Knowledge Of The Treatment Guidelines For Schizophrenia And Major Depressive Disorders Using The ‘Effectiveness Of Guidelines For Dissemination And Education In Psychiatric Treatment (Eguide)’ Project: A Nationwide Dissemination, Education, And Evaluation Study, Y. Takaesu, K. Watanabe, S. Numata, M. Iwata, N. Kudo, S. Oishi, T. Takizawa, K. Nemoto, T. Kishimoto, R. Hashimoto, +38 Additional Authors

Journal Articles

© 2019 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs. …

Best Practices For Evaluation And Treatment Of Agitated Children And Adolescents (Beta) In The Emergency Department: Consensus Statement Of The American Association For Emergency Psychiatry, R. Gerson, N. Malas, V. Feuer, G. H. Silver, R. Prasad, M. M. Mroczkowski

Journal Articles

No abstract provided.

Antibodies In The Diagnosis, Prognosis, And Prediction Of Psychotic Disorders., Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip Mcguire

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the …

Eukaryotic Initiation Factor 3, Subunit C Silencing Inhibits Cell Proliferation And Promotes Apoptosis In Human Ovarian Cancer Cells, Fang Wen, Zhang-Ying Wu, Lei Nie, Qi-Zhu Zhang, Yuan-Kun Qin, Zun-Lun Zhou, Jin-Jian Wu, Xing Zhao, Jun Tan, Darrell Sawmiller, Dan Zi

Psychiatry & Behavioral Neurosciences Faculty Publications

Ovarian cancer remains the leading cause of death among all gynaecological cancers, illustrating the urgent need to understand the molecular mechanisms involved in this disease. Eukaryotic initiation factor 3c (EIF3c) plays an important role in protein translation and cancer cell growth and proliferation, but its role in human ovarian cancer is unclear. Our results showed that EIF3c silencing significantly up-regulated 217 and down-regulated 340 genes. Ingenuity Pathway Analysis (IPA) indicated that the top differentially expressed genes are involved in ‘Classical Pathways’, ‘Diseases and Functions’ and ‘Networks’, especially those involved in signalling and cellular growth and proliferation. In addition, eIF3c silencing …

Associations Of Hemoglobin A1c With Cognition Reduced For Long Diabetes Duration, Jeremy M. Silverman, James Schmeidler, Pearl G. Lee, Neil B. Alexander, Michal Schnaider Beeri, Elizabeth Guerrero-Berroa, Rebecca K. West, Mary Sano, Martina Nabozny, Carolina Rodriguez Alvarez

Publications and Research

Introduction: Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration.

Methods: The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young-old” veterans …

Depressive Symptoms In Older Versus Younger People With Epilepsy: Findings From An Integrated Epilepsy Self-Management Clinical Research Dataset, Zaira Khalid, Hasina Momotaz, Farren Briggs, Kristin A. Cassidy, Betsy K. Wilson, Martha Sajatovic

Faculty Scholarship

Aim: There are limited data on psychological outcomes in older people with epilepsy (PWE). This analysis, from a large pooled dataset of clinical studies from the Managing Epilepsy Well (MEW) Network, examined clinical variables including depressive symptom severity, quality of life and epilepsy self-management competency among older (age 55+) vs younger (

The Effects Of Compassion Fatigue On Burnout Among Inpatient Psychiatric And Intensive Care Unit Nurses, Amita Madan Neidlinger

DNP Projects

PURPOSE: This DNP project is relevant to nurses of the psychiatric and Intensive Care Unit (ICU) setting, as high stress environments may produce higher rates of compassion fatigue and burnout. Investigation of these areas may help illuminate unnecessary healthcare costs that are associated with these phenomena. This DNP project is important to the University of Kentucky’s healthcare system, its patients, and nurses. Increased absenteeism and increased medication errors are positively associated with the prevalence of compassion fatigue and burnout in nurses. Outcomes from this project will allow identification of unnecessary healthcare costs and encourage administrators to focus on reducing nurse …