Medical Sciences Commons^™

Different Local Anesthetic Volumes In Pericapsular Nerve Group Block For Hip Fracture Patients, Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jüli̇de Ergi̇l, Erbi̇l Aydin

Turkish Journal of Medical Sciences

Background/aim: The pericapsular nerve group (PENG) block is an effective method for pain management in patients with hip fractures. In our study, we compared three different local anesthetic volumes of the PENG block in patients who underwent surgery for hip fracture.Materials and methodsː Patients who underwent surgery with spinal anesthesia for intertrochanteric femur fractures (60 patients) were divided into three groups based on the volume of local anesthetic administered: Group 1 (20 mL), Group 2 (30 mL), and Group 3 (40 mL). Postoperative patient-controlled analgesia was initiated. Postoperative tramadol consumption, rest and movement pain scores, and the duration of motor …

Diagnostic Accuracy And Potential Triage Utility Of The Shetty Test In Foot And Ankle Trauma: A Cross-Sectional Study, Burcu Doğan, Seval Komut, Erdal Komut, Nezi̇h Kavak, Osmancan Güneş, Anilcan Tahsi̇n Karahan

Turkish Journal of Medical Sciences

Background/aim: Foot and ankle trauma represents a common reason for emergency department visits. While the majority of cases involve soft tissue injuries, radiographic imaging is frequently overutilized due to concerns about missed fractures, leading to increased costs and emergency department crowding. The Shetty test, a recently introduced clinical decision rule, may serve as a simpler alternative to established tools such as the Ottawa ankle rules. This study aimed to assess the diagnostic accuracy of the Shetty test and its potential role as a supportive tool within existing triage systems for patients presenting with foot and ankle trauma.

Materials and methods: …

Ultrasonographic And Elastographic Evaluation Of Plantar Fascia And Achilles Tendon Alterations In Type 2 Diabetes Mellitus, Rifat Bozkuş, İhsani̇ye Süer Doğan, Berna Turhan, Sümeyya Duran Kaymak, Mustafa Hulusi̇ Kurt, Rasi̇me Peli̇n Kavak

Turkish Journal of Medical Sciences

Background/aim: The primary aim of this study is to compare the thickness and stiffness of the PF and AT between healthy volunteers and patients with type 2 diabetes mellitus (T2DM). A secondary objective is to explore the correlations between the thickness and stiffness of the PF and AT with diabetes duration (in months) and hemoglobin A1c (HbA1c) levels in T2DM patients without peripheral neuropathy or foot ulcers, with peripheral neuropathy or with foot ulcers.Material and Methods: A total of 289 participants, including 117 healthy volunteers (Group A) and 172 T2DM patients (59.5%), matched for age, sex, and body mass index, …

Detection And Quantification Of Microplastics In Cerumen, Bengi̇ Arslan, Yüce İslamoğlu, Ali̇ Sami̇ Berçi̇n, Selen Akbulut, Mehmet Meli̇koğlu

Turkish Journal of Medical Sciences

Background/aim: Microplastics (MPs) are a growing concern due to their pervasive environmental presence and potential environmental and human exposure impacts. Given evidence of systemic MP presence in human tissues and fluids, and the ear canal's environmental exposure, this novel study aimed to identify these particles in human cerumen. Cerumen was collected from the proximal ear canal to minimize potential airborne contamination.

Materials and methods: Cerumen samples were prospectively collected from 12 adult patients (23 patient-derived specimens) and 3 control water samples, following ethical approval and consent. Samples were extracted using sterile instruments, stored in glass, diluted, and filtered through 0.22 …

Addition Of Antimicrobials To Oral Sprays Containing Non-Steroidal Anti-Inflammatory Drugs Does Not Reduce The Severity Of Postoperative Sore Throat: A Prospective, Randomized, Placebo-Controlled Trial, Peli̇n Yildiz, Mobi̇n Hemmati̇, Leyla Kutlucan, Tankut Uzun, Togay Müderri̇s

Turkish Journal of Medical Sciences

Background/aim: Postoperative sore throat (POST) is a common complication following general anesthesia that significantly affects patient satisfaction, prolongs recovery, and increases treatment costs. This study aimed to evaluate whether the addition of antimicrobial agents to NSAID-based oral sprays could enhance the preventive efficacy against POST.

Materials and methods: In this prospective, randomized, placebo-controlled trial, 105 patients (ASA I–II; age 18–65 years) scheduled for elective ear surgery under general orotracheal anesthesia were enrolled. Patients were randomly allocated into three groups: a placebo group; a flurbiprofen oral spray group; and a group receiving an oral spray containing benzydamine hydrochloride, chlorhexidine digluconate, and …

Are Paraplegic Wheelchair Users Vulnerable To Overuse Syndromes?, Kutay Tezel, Esra Ülgen Kiratlioğlu, Hüseyi̇n Kayadi̇bi̇, İlkay Karabay, Mi̇tat Cebeci̇, Eda Gürçay

Turkish Journal of Medical Sciences

Background and Aims: The purposes of this study are to determine the frequency of upper extremity overuse syndromes in patients with spinal cord injury (SCI) using manual wheelchairs, to evaluate them clinically and sonographically, and to reveal possible factors that predispose to overuse syndromes.

Materials and methods: A total of 38 traumatic SCI patients who were over 18 years of age and manual wheelchair users were enrolled in this cross-sectional study. The patients were evaluated with clinical and sonographic findings of the wrist, elbow and shoulder joints. Functional capacity, physical ability and symptoms of upper extremity, and quality of …

Treadmill-Based Submaximal Vo₂ Estimation In Patients With Coronary Artery Disease: Can A Model Derived From Healthy Individuals Be Valid?, Levent Karataş, Esra Sena Orbak Yeni̇dünya, Nesri̇n Demi̇rsoy

Turkish Journal of Medical Sciences

Background/aim: Existing treadmill-based VO₂ prediction models may not accurately estimate submaximal VO₂ in patients with coronary artery disease (CAD), as they are often derived from healthy populations. This study aimed to develop and validate a submaximal VO₂ prediction model derived from healthy individuals and tested for generalizability in CAD patients by incorporating clinically relevant parameters.

Materials and methods: A retrospective analysis was conducted with 101 participants (54 healthy, 47 CAD patients) undergoing cardiopulmonary exercise testing using the modified Bruce protocol. To better represent the submaximal VO₂ reached during exercise, the average VO₂ in the last minute of each stage was …

Incidence Of And Risk Factors For Hyperoxemia Among Potentially Critically Ill Patients Treated In The Wards: A Retrospective Study, Mehmet Nuri̇ Yakar, Doğukan Şenberber, Ozan Balkabak, Nurgazy Shermatov, Kaan Köşker, Seli̇n Elden, Emel İbi̇şoğlu, Begüm Ergan, Volkan Hanci, Necati̇ Gökmen

Turkish Journal of Medical Sciences

Background/aim: The literature shows a link between hyperoxemia and poor outcomes, whereas this association remains unclear in hospital wards. This study aims to determine the incidence of hyperoxemia in hospital wards and its risk factors.

Materials and methods: Patients aged ≥ 18 years who underwent an evaluation by an intensivist between 1 January 2020 and 31 December 2020, while receiving treatment in hospital wards, were included in the study following ethics committee approval. Patients with hypoxemia (partial pressure of oxygen [PaO2] < 60 mmHg), a condition related to Coronavirus disease 2019, a hospital stay < 1 day, or missing data were excluded. Patients were divided into two groups: normoxemia (60 mmHg ≤ PaO2 < 120 mmHg) and hyperoxemia.

Results: The incidence of hyperoxemia was 42.2%. Patients with hyperoxemia had longer hospital stays and higher intensive care unit …

Blood Group Profile Of Türkiye With Regional And Demographic Differences: A 23-Year Retrospective Study, Levent Sağdur, Azi̇z Karaca, Mustafa Nuri̇ Günçikan, Mustafa Yilmaz, Kerem Kinik

Turkish Journal of Medical Sciences

Background/aim: This study aims to comprehensively analyze the distribution of ABO and Rh blood groups, as well as demographic characteristics and regional variations, using data from 9.5 million blood donors across Türkiye.

Materials and methods: In this multicenter, retrospective, cross-sectional study, data were collected from 9,587,592 healthy, voluntary donors who donated to the Turkish Red Crescent between 1998 and 2021. Donors met the criteria of being 18–70 years old, weighing over 50 kg, with hemoglobin levels above 13.5 g/dL for male and 12.5 g/dL for female. The data were evaluated based on age, gender, education level, and geographic region.

Results: …

Prognostic Role Of Systemic Immune-Inflammation Index And Pan-Immune-Inflammation Value In Acute Methanol Poisoning, Hati̇ce Şahi̇n, Gülay Ulusal Okyay, Fatma Ayerden Ebi̇nç, Fevzi̇ Coşkun Sökmen, Emre Yaşar, Gülşen Akçay, Mehmet Deni̇z Ayli

Turkish Journal of Medical Sciences

Background/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the Systemic Immune-Inflammation Index (SII) and the Pan-Immune-Inflammation Value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye [University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (January 1, 2015–October 1, …

Comparison Of Novel Diard-Hbv Dna Qpcr Kit With The Artus Hbv Qs-Rgq Kit For Quantification Of Hbv Dna In Clinical Samples, Ülker Çuhaci, Hande Toptan, Bengül Durmaz, Mehmet Köroğlu, Riza Durmaz

Turkish Journal of Medical Sciences

Background/aim: Hepatitis B virus (HBV) leads to widespread chronic infections that may result in long-term complications such as cirrhosis and hepatocellular carcinoma. The use of sensitive molecular methods for HBV DNA quantitation has provided significant contributions for diagnosis and monitoring of disease. The current study aimed to evaluate the diagnostic performances of a novel DiaRD HBV qPCR kit (novel kit) in comparison with the artus HBV QS-RGQ kit (comparator kit).

Materials and methods: A total of 288 plasma samples—105 HBV DNA-positive and 183 HBV DNA-negative—were tested using both kits. The diagnostic and quantitative results of the novel kit were compared …

Mirna-Target Gene Network Analysis In Siblings With Cystic Fibrosis And Phenotypic Variability, Ayberk Mustafaoğlu, Senem Noyan, Yeli̇z Z. Akkaya Ulum, Bala Gür Dedeoğlu, Nagehan Emi̇rali̇oğlu, Uğur Özçeli̇k, Ebru Yalçin, Deni̇z Doğru, Nural Ki̇per, Di̇dem Dayangaç Erden

Turkish Journal of Medical Sciences

Background/aim: Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF is characterized by respiratory tract infections, pancreatic insufficiency, meconium ileus, intestinal obstruction, and male infertility. A genotype to phenotype correlation is difficult to establish because of the heterogeneity of disease severity. Even patients with the same CFTR mutation can have varying clinical severities. In recent years, studies have explored the role of microRNA (miRNA) expression in the regulation of respiratory diseases. However, no research has been conducted to date on miRNAs in siblings with the same CFTR mutation. …

Metabolic And Genotypic Characterization Of Meropenem Susceptible And Resistant Serratia Marcescens Isolates, Şeyma Ni̇gi̇z, Gülşen Hazirolan, Gülşen Altinkanat Gelmez, Ceren Özkul Koçak, Engi̇n Koçak, Sevi̇lay Erdoğan Kablan, Emi̇rhan Nemutlu, Aycan Gündoğdu, Fatma Bayrakdar, Ufuk Hasdemi̇r, Deni̇z Gür

Turkish Journal of Medical Sciences

Background/aim: Serratia marcescens which is a nosocomial pathogen, is naturally resistant to a wide spectrum of antibiotics, which makes the management of infections difficult. The aim of this study was to determine the in vitro susceptibilities of S. marcescens to ceftriaxone, ceftazidime, meropenem, amikacin, gentamicin, ciprofloxacin, and to compare the metabolic profiles of meropenemresistant isolates under basal conditions and after exposure to sublethal concentrations of meropenem.

Materials and methods: A total of 84 S. marcescens isolates were included from various samples. Genes for meropenem resistance were determined by polymerase chain reaction (PCR). Genetic similarities among isolates of S. marcescens were …

Letter To The Editor Regarding “Kılıçarslan A, Kurt Çevik G, Doğan M, Aksoy Altınboğa A, Ceran F, Et Al. Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma? Turkish Journal Of Medical Sciences: 2025; 55 (1): 22”, Burcu Baba, Ayşegül Akbay

Turkish Journal of Medical Sciences

No abstract provided.

Erratum To " The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model " [ Turkish Journal Of Medical Sciences 49 6 1789 1799], İnayet Güntürk, Cevat Yazici, Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Yay

Turkish Journal of Medical Sciences

Due to an inadvertent error during the labeling of images in the figure included in the article, the authors have provided a revised version of the figure. In this updated version, the image corresponding to the NAC-250 group has been replaced with a new photograph, and all labels have been corrected accordingly.

This correction does not affect the conceptual content, results, statistical analysis, or conclusions of the article.The authors apologize for any confusion this may have caused.

The original article can be accessed at: https://doi.org/10.3906/sag-1903-225

Erratum To " Vitamin D Deficiency And Surgical Cellulose Mimicking Parathyroid Adenomaafter Initial Parathyroidectomy " [ Turkish Journal Of Medical Sciences 55 3 696 701], Mustafa Şahi̇n, Volkan Genç, Koray Ceyhan, Demet Çorapçioğlu

Turkish Journal of Medical Sciences

We have identified that the article type of our publication entitled “Vitamin D deficiency and surgical cellulose mimicking parathyroid adenomaafter initial parathyroidectomy" was mistakenly entered incorrectly during the submission process. This error occurred due to an oversight at the time of submission.The correct article type should be Case Report instead of the previously indicated type. This correction does not affect the scientific content, results, or conclusions of the article.We apologize for any inconvenience this may have caused to our readers and the indexing services.

The original article can be accessed at: https://doi.org/10.55730/1300-0144.6017

Consensus Paper On Candida Auris By Türkiye Ekmud, Thsk Of Ministry Of Health Of The Republic Of Türkiye, Klimud, Tmc, Tard, Tybd And Id-Iri, Canan Ağalar, Hakan Erdem, Yasemi̇n Çağ, Bi̇lgi̇n Arda, Recep Balik, Ali̇ye Baştuğ, Burcu Dalyan-Ci̇lo, Nuretti̇n Erben, Esma Eryilmaz-Eren, Gülşen İskender, Ayşe Kalkanci, Ni̇lgün Karabiçak, Zeli̇ha Koçak-Tufan, Emi̇ne Parlak, Nagehan Di̇dem Sari, Murat Sayin, Seni̇ha Şenbayrak, Recep Teki̇n, Ayşegül Ulu-Kiliç, Tuğhan Utku, Ömrüm Uzun, Göknur Yapar Toros, Sevtap Arikan-Akdağli

Turkish Journal of Medical Sciences

Candida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report, developed with the collaboration of several Turkish medical specialty societies, including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology …

Transcriptomic And Epigenomic Profiling Of Immune Cells Responses To Simian Immunodeficiency Virus Infection In The Brain, Xiaoke Xu

Theses & Dissertations

Human immunodeficiency virus type 1 (HIV-1) is an enveloped retrovirus that significantly impairs the human immune system. A common complication of HIV-1 infection is HIV-associated neurocognitive disorder (HAND), which, prior to the introduction of antiretroviral therapy (ART), led to considerable morbidity and mortality due to untreated neuropsychiatric manifestations. Although ART has substantially reduced the incidence of HIV-associated dementia (HAD), approximately 50% of people living with HIV (PLWH) continue to experience milder forms of HAND. The CNS is seeded by HIV during the acute phase of infection. Once in the brain, HIV targets and activates resident immune cells, primarily microglia and …

Sox2 Regulates Foregut Squamous Epithelial Homeostasis And Is Lost During Barrett’S Esophagus Development, Ramon U Jin, Yuanwei Xu, T Mamie Lih, Yang-Zhe Huang, Toni M Nittolo, Blake E Sells, Olivia M Dres, Jean S Wang, Qing K Li, Hui Zhang, Jason C Mills

Faculty, Staff and Students Publications

Esophageal adenocarcinoma is increasingly prevalent and is thought to arise from Barrett's esophagus (BE), a metaplastic condition in which chronic acid and bile reflux transforms the esophageal squamous epithelium into a gastric-intestinal glandular mucosa. The molecular determinants driving this metaplasia are poorly understood. We developed a human BE organoid biobank that recapitulates BE's molecular heterogeneity. Bulk and single-cell transcriptomics, supported by patient tissue analysis, revealed that BE differentiation reflects a balance between SOX2 (foregut/esophageal) and CDX2 (hindgut/intestinal) transcription factors. Using squamous-specific inducible Sox2-KO (Krt5CreER/+ Sox2Δ/Δ ROSA26tdTomato/+) mice, we observed increased basal proliferation, reduced squamous differentiation, and expanded metaplastic glands at …

The Speech-To-Song Illusion Across Development And The Effects Of High-Level Expectations, Rodica R. Constantine

UNLV Theses, Dissertations, Professional Papers, and Capstones

The typical listener can readily categorize auditory stimuli as either speech or song even though these structures share many acoustic similarities. These musical and linguistic categories may nevertheless take time to develop as children acquire language- and music-specific knowledge. In the Speech-to-Song (STS) illusion, multiple repetitions of a natural spoken utterance can give rise to a perceptual switch wherein the stimulus begins to sound song-like to the listener. While the STS illusion has been well-researched in adult listeners, it had yet to be investigated in children. In our study, we examined whether children experience the STS illusion by presenting participants …

An Analysis Of The Influence Of Human Disease Pathogens On Core Behaviors Of The Black-Legged Tick, Emily F. Marinko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Ixodes scapularis, the black-legged or deer tick, is a vector for several different disease-causing microbes, including the causative agent of Lyme disease. As such, it is a major health concern for people living within its range in the eastern half of the United States, a habitation area that is increasing due to climate change. Despite its medical relevance as a disease vector, there is still much to learn about the basic behavior of these arachnids in the wild. Thus, the major hypothesis of this thesis is that ticks that are infected with specific human disease-causing microbes behave differently than those …

Comparison Of Scoring Systems For Bleeding In Open Cardiac Surgery Patients, İpek Yakin, Çağri Düzyol, İlke Dolğun, Ahmet Yüksek, Kemal Tolga Saraçoğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to determine which preoperative bleeding risk scoring system is more sensitive in predicting perioperative transfusion requirement in patients undergoing open-heart surgery.

Materials and methods: This is a retrospective single-center cohort study. Seven scoring systems (TRACK, PAPWORTH, WILL-BLEED, CRUSADE, ACTION, TRUST, ACTA-PORT) were used to predict the likelihood of perioperative erythrocyte suspension (ES) transfusion requirement.

Results: Four hundred patients were enrolled in the study. Age, creatinine level, and diagnoses of diabetes mellitus and hypertension were significantly higher in patients who required ES (p ˂ 0.05). In addition, ejection fraction percentages and hemoglobin and hematocrit …

The Role Of Carbon Dioxide Angiography In Reducing Contrast-Induced Nephropathy In Diabetic Foot Patients Undergoing Endovascular Treatment, Sadik Ahmet Uyanik, Erdem Bi̇rgi̇, Saffet Öztürk, Umut Asfuroğlu, Erdi̇ Tangobay, Hi̇kmet Erhan Güven

Turkish Journal of Medical Sciences

Background/aim: This study investigates the role of carbon dioxide (CO2) angiography, delivered with an automated CO2 delivery system, in decreasing the amount of iodinated contrast and preventing contrast-induced nephropathy (CIN) in diabetic foot patients who underwent endovascular revascularization.

Materials and methods: A total of 272 diabetic foot patients who underwent endovascular treatment for infrainguinal chronic peripheral arterial disease (PAD) were included in the study. Of these, 64 patients underwent endovascular intervention using CO2 angiography (study group), while 208 patients underwent endovascular intervention using only contrast media (control group). The rates of CIN and the amount of contrast used during interventions …

Factors Affecting Extremity Fracture Risk In Children With Attention Deficit Hyperactivity Disorder, Yüksel Sümeyra Naralan, Esra Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized not only for its behavioural and cognitive challenges but also for its potential implications in physical health, particularly injury risk. This study aimed to investigate the incidence of extremity fractures among children and adolescents diagnosed with ADHD and to evaluate the influence of demographic, clinical, and pharmacological variables—including ADHD subtypes and medication types—on fracture risk

Materials and Methods: This retrospective cross-sectional study included 754 children and adolescents aged 6–18 years who were diagnosed with ADHD according to DSM-5 criteria. Data were collected from electronic health records at a tertiary referral hospital. Variables …

Evaluation Of Teachers' Knowledge And Awareness About Autism Spectrum Disorder, Hami̇t Harun Bağci, Abi̇de Aksungur, Gülsüm Öztürk Emi̇ral, Erhan Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Teachers play an essential role in the early identification of autism spectrum disorder (ASD) and associated difficulties in children. Increasing teachers’ knowledge of ASD can be helpful in identifying these children and making the necessary referrals. This study aimed to assess teachers’ knowledge and awareness of ASD and the factors affecting them.

Materials and methods: This is a cross-sectional study conducted among school counsellors. A total of 171 school counsellors were contacted; school visits were arranged by prior appointment, and the purpose of the study was explained. Data were collected using a questionnaire prepared by the researchers and the …

Sinapic Acid Alleviates Renal Ischemia-Reperfusion Injury By Regulating Oxidative Stress, Apoptosis, And Inflammation, Mustafa Can Güler, Fazi̇le Nur Eki̇nci̇ Akdemi̇r, Ersen Eraslan, Ayhan Tanyeli̇, Derya Güzel Erdoğan, Behzat Tebri̇zi̇

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury (AKI) is a major clinical issue, frequently resulting from ischemia-reperfusion (I/R) injury. Sinapic acid (SA), a natural phenolic molecule included in numerous plant-based foods, exhibits antiapoptotic, antioxidant, and antiinflammatory properties. This study aimed to investigate the renoprotective effects of SA in an I/R-induced acute kidney injury (AKI) model.

Materials and methods: Sprague–Dawley male rats (n = 32) were randomly assigned to four groups: sham, I/R, SA 20 mg/kg, and SA 40 mg/kg. SA was administered intraperitoneally before reperfusion. Renal tissues were examined using biochemical, histopathological, and immunohistochemical methods, focusing on oxidative stress, cytokine expression, and apoptosis …

Clinical, Tumor, And Product Features Associated With Outcomes After Axicabtagene Ciloleucel Therapy In Follicular Lymphoma, Soumya Poddar, Jiali Yan, Gayatri Tiwari, Darawan Rinchai, Justin Budka, Wangshu Zhang, Weixin Peng, Shruti Salunkhe, Madison Davis, Qinghua Song, Sara Beygi, Harry Miao, Mike Mattie, Rhine S Shen, Caron A Jacobson, Davide Bedognetti, Simone Filosto, Sattva S Neelapu

Faculty, Staff and Student Publications

Background: Axicabtagene ciloleucel (axi-cel), anti-CD19 chimeric antigen receptor (CAR) T cell therapy, demonstrated remarkable efficacy with manageable toxicity in relapsed/refractory indolent B cell lymphomas in the ZUMA-5 trial.

Methods:Here, we report associations of product attributes, serum biomarkers, clinical features, and tumor characteristics with outcome in 124 patients with follicular lymphoma (FL).

Results: In univariate and multivariate analyses, pretreatment inflammatory markers, including TNF-α and IL-12p40, as well as total metabolic tumor volume (TMTV), associated with disease progression. Conversely, T-naive–like product phenotype associated with improved outcome, particularly in patients with high TMTV. These covariates improved risk stratification when combined with the …

Mathematical Modeling And Association Analysis Decipher The Impact Of The Gut Microbiome On Cancer Immunotherapy, Andreas G Hadjigeorgiou, Constantinos Harkos, Aditya K Mishra, Golnaz Morad, Sarah B Johnson, Nadim J Ajami, Jennifer A Wargo, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Faculty, Staff and Student Publications

The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimize outcomes. To this end, we developed a mathematical model to obtain insights into the effect of the microbiome on the immune system and immunotherapy response. This model was based on (i) gut microbiome data derived from preclinical studies, (ii) mathematical modeling of the antitumor immune response, (iii) association analysis of microbiome profiles with model-predicted immune profiles, and (iv) statistical models that correlate model parameters with …

Outcomes Of Patients With Newly Diagnosed Acute Myeloid Leukemia With Flt3-Tyrosine Kinase Domain Mutations: Prognostic Implications Of Npm1 Co-Mutation, Sankalp Arora, Wei-Ying Jen, Musa Yilmaz, Indraneel Deshmukh, Jayastu Senapati, Sanam Loghavi, Ghayas C Issa, Nicholas J Short, Tapan M Kadia, Courtney D Dinardo, Gautam Borthakur, Joseph Jabbour, Naveen Pemmaraju, Michael Andreeff, Koichi Takahashi, Kapil Bhalla, Uday Popat, Elizabeth J Shpall, Betul Oran, Hussein A Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Background: The prognostic impact of Fms-like tyrosine kinase 3 (FLT3)-tyrosine kinase domain (TKD) mutation in patients with acute myeloid leukemia (AML) is not well defined. The authors described outcomes of one of the largest cohorts of patients with FLT3-TKD mutated (FLT3-TKDmut) AML to date.

Methods: This retrospective study included patients with newly diagnosed AML who received frontline treatment at The University of Texas MD Anderson Cancer Center from January 2012 to March 2024 divided into two cohorts: FLT3-TKDmut AML and nucleophosmin-mutated (NPM1mut)/FLT3-TKD wild-type (FLT3-TKDwt) AML. Patients with FLT3 internal tandem duplication mutations were excluded.

Results: In total, 2922 patients were …

Lipidomic And Proteomic Insights From Extracellular Vesicles In The Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes, Chioma M Okeoma, Wasifa Naushad, Bryson C Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

Faculty, Staff and Student Publications

Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chronic neuroinflammation, potentially mediated by the release of extracellular particles (EPs), such as extracellular condensates (ECs) and extracellular vesicles (EVs). These particles, which reflect the physiological, pathophysiological, and metabolic states of their cells of origin, might carry molecular signatures indicative of SUD. In particular, our study investigated neuroinflammatory signatures in SUD patients by isolating EVs from the dorsolateral prefrontal cortex (dlPFC) Brodmann's area 9 (BA9) from postmortem subjects. We isolated BA9-derived …