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Articles 1 - 30 of 206
Full-Text Articles in Medical Sciences
E6 Inhibtion-Mediated Combinatorial Therapy For Hpv+ Hnscc, Sonia Whang
E6 Inhibtion-Mediated Combinatorial Therapy For Hpv+ Hnscc, Sonia Whang
Loma Linda University Electronic Theses, Dissertations & Projects
High-risk human papillomaviruses (HPV) are the causative agents of virtually all cases of cervical cancer and up to 80% of head and neck squamous cell carcinoma (HNSCC). Current treatment options include chemo- and radiotherapy, though the effectiveness of these therapies is limited by the viral oncoprotein E6, which disrupts apoptotic pathways by binding to and accelerating the degradation of molecules such as p53 and caspase- 8. Our hypothesis was that inhibiting E6 and rescuing the apoptotic mediators would increase the effectiveness of apoptotic agents. The aims of this study were to first, develop an HPV+ HNSCC xenograft model to test …
An Investigation Of The Anti-Stemness Actions Of Two Mirnas After Their Induction By Aminoflavone In Luminal A Breast Cancer, Nicole Ursula Rumbidzai Mavingire
An Investigation Of The Anti-Stemness Actions Of Two Mirnas After Their Induction By Aminoflavone In Luminal A Breast Cancer, Nicole Ursula Rumbidzai Mavingire
Loma Linda University Electronic Theses, Dissertations & Projects
Approximately 40% of estrogen receptor positive breast cancer (BC) patients develop resistance to endocrine therapy (ET) agents like tamoxifen (Tam). Resistance promotes metastasis, recurrence, and death since metastatic BC is often incurable. Breast cancer stem cells (CSCs) greatly contribute to disease progression and drug resistance. We previously showed that aryl hydrocarbon receptor (AhR) agonist aminoflavone (AF) inhibits the expression of CSC biomarker α6-integrin (ITGA6) to disrupt the formation of endocrine-sensitive and -resistant luminal A mammospheres. In this study, we performed miRNAsequencing analysis of luminal A MCF-7 and MCF-7TamR mammospheres before and after AF treatment to further develop the mechanism of …
Phytochemical And Synthetic Ahr Ligands As Novel Therapy For Refractory Breast Cancer, Jonathan V. Wooten
Phytochemical And Synthetic Ahr Ligands As Novel Therapy For Refractory Breast Cancer, Jonathan V. Wooten
Loma Linda University Electronic Theses, Dissertations & Projects
Patients with triple-negative breast cancer (TNBC) possess tumors that lack estrogen receptor, progesterone receptor, and human growth factor receptor 2 expression. Such patients have lower survival rates than those diagnosed with other breast cancer subtypes in part, due to the scarcity of targeted therapy for TNBC. In addition to chemotherapy, patients with TNBC often consume natural remedies, which has led us and others to evaluate the ability of plant isolates to confer anticancer and chemopreventive actions. Poly-ADP ribose polymerase (PARP) is an enzyme that promotes DNA single-strand break repair. PARP inhibitor olaparib exploits DNA repair enzyme deficiency in tumors to …
The Role Of The Filifactor Alocis Hypothetical Protein Fa519 In Oxidative Stress Resistance, Ezinne Rebecca Aja
The Role Of The Filifactor Alocis Hypothetical Protein Fa519 In Oxidative Stress Resistance, Ezinne Rebecca Aja
Loma Linda University Electronic Theses, Dissertations & Projects
Filifactor alocis, a fastidious, Gram-positive, obligate anaerobic bacterium, is a newly appreciated member of the periodontal community, which is now proposed to be a diagnostic indicator of periodontal disease. Its pathogenic characteristics are highlighted by its ability to survive in the oxidative-stress rich environment of the periodontal pocket and to significantly alter the microbial community dynamics by forming biofilms and interacting with several oral bacteria. Currently, there is incomplete information on the pathogenic mechanism(s) and a possible dynamic functional role of F. alocis in the dysbiotic microbial community. Because the stress response of this bacterium to the oxidative environment …
Contribution Of The Ledgf/P75 Protein Interactome To Prostate Cancer Chemoresistance, Greisha Lee Ortiz Hernández
Contribution Of The Ledgf/P75 Protein Interactome To Prostate Cancer Chemoresistance, Greisha Lee Ortiz Hernández
Loma Linda University Electronic Theses, Dissertations & Projects
Prostate Cancer (PCa) progression leads to an advanced stage called metastatic castration resistant PCa (mCRPC), for which currently there is no cure in spite of advances in treatment with new generation anti-androgen drugs and chemotherapy with taxanes such as docetaxel (DTX). Our laboratory demonstrated previously that the stress oncoprotein Lens Epithelium Derived Growth Factor of 75 kD (LEDGF/p75) is upregulated in clinical prostate tumors and contributes to DTX-resistance in mCRPC cells. However, little is known about the molecular mechanisms by which LEDGF/p75 promotes taxane resistance. The C-terminus of LEDGF/p75 contains a domain called the Integrase Binding Domain (IBD), which in …
The Hippo/Yap Signaling Pathway In Cardiovascular Repair, Victor Camberos
The Hippo/Yap Signaling Pathway In Cardiovascular Repair, Victor Camberos
Loma Linda University Electronic Theses, Dissertations & Projects
Following cardiovascular injury, neonatal mammalian hearts are capable of restoring damaged tissue while adult hearts cannot. Adults are hindered by their inability to replenish lost cardiomyocytes resulting in increased scar tissue formation and reduced cardiovascular function. The Hippo pathway and its downstream effector Yap1 have recently been identified as key modulators of cardiac development and regeneration in neonates. We investigated the role of Yap1 in a sheep model of cell-based cardiovascular repair in which regenerative neonatal cardiovascular progenitor cells (CPCs) were introduced following LAD ligation. Yap1 was induced in the infarcted regions of the heart following cell treatment, as shown …
The Role Of The Snail/Let-7 Axis In Stemness Induction In Distinct Subtypes Of Ovarian Cancer: The Search For Cancer Stem Cell Targeting Strategies, Hanmin Wang
Loma Linda University Electronic Theses, Dissertations & Projects
Epithelial ovarian cancer (EOC) has the one of the lowest survival rates, partly due to modern therapy’s failure to consider the heterogeneity of EOC and the failure to effectively target cancer stem cells (CSC). CSCs lead to cancer relapse and metastasis. Studies of stem cell reprogramming have linked let-7 repression and acquisition of stemness with the EMT factor, SNAI1. The mechanisms for the loss of let-7 in cancer cells are incompletely understood. We aimed to determine the mechanism of epithelialmesenchymal transition (EMT)-induced stemness in cancer cells. The central hypothesis for this study is that SNAI1 directly represses let-7, leading to …
The Role Of Survivin Splice Variants In Pancreatic Ductal Adenocarcinoma Chemoresistance, Janviere Kabagwira
The Role Of Survivin Splice Variants In Pancreatic Ductal Adenocarcinoma Chemoresistance, Janviere Kabagwira
Loma Linda University Electronic Theses, Dissertations & Projects
Pancreatic cancer is currently one of the most difficult diseases to treat due to difficulty of detection and its aggressive nature. In addition, pancreatic cancer has the highest mortality rates compared to other cancer types. These mortality rates are attributable in part to increasing resistance to cancer therapy. Cancer therapy resistance is caused by adaptations that favor cancer cell survival. Some of these adaptations occur intrinsically before chemotherapy exposure (innate resistance) while others are a result of chemotherapy through selective and cellular adaptations (acquired chemoresistance). Important to pancreatic cancer diagnosis and management is to determine an optimal combination of clinical …
Oxidative Stress And Dna Damage As Promoting Factors Of Hpv Integration, Meghri Katerji
Oxidative Stress And Dna Damage As Promoting Factors Of Hpv Integration, Meghri Katerji
Loma Linda University Electronic Theses, Dissertations & Projects
Human papillomaviruses (HPVs) cause virtually all cervical cancer cases and are also associated with other types of anogenital and oropharyngeal cancers. HPV-mediated carcinogenesis typically begins with the HPV episome integrating into the human genome. Unfortunately, the factors that promote this key process are not well defined. Since viral integration requires breaks in both viral and human genomes, DNA damage is likely a key determinant. The latter is primarily caused by an overproduction of reactive oxygen species (ROS). Therefore, high levels of background ROS in host cells, which may result from genetic/epigenetic factors together with exogenous influences, in principle, have the …
Development And Maturation Of The Brain Following Pediatric Mtbi, Jeong Bin Lee
Development And Maturation Of The Brain Following Pediatric Mtbi, Jeong Bin Lee
Loma Linda University Electronic Theses, Dissertations & Projects
Pediatric mild traumatic brain injury (mTBI) is a major public health concern with the potential to produce long-lasting cognitive, adaptive, and socio-behavioral outcomes. However, our understanding of how TBI pathophysiology evolves in the developing brain is lacking. Our central hypothesis was that pediatric mTBI results in evolving microstructural dysregulation that leads to functional and structural deficits late in life. To test this hypothesis, we first sought to assess the influence of pediatric mTBI on white matter (WM) dysregulation in early adulthood. To accomplish this, we investigated the effects of single and repeated pediatric mTBI on white matter, focusing on the …
Neuroprotective Functions Of Docosahexaenoic Acid And Epidermal Fatty Acid Binding Protein, Manuel Luis Montero
Neuroprotective Functions Of Docosahexaenoic Acid And Epidermal Fatty Acid Binding Protein, Manuel Luis Montero
Loma Linda University Electronic Theses, Dissertations & Projects
Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition of necroptosis and promotion of autophagy do. DHA decreases the expression of HIF-1α and BNIP3 and rescues PA-induced cell death by inhibiting apoptosis and necroptosis. Besides DHA stimulates the mRNA expression, phosphorylation and conjugation of autophagy controlling proteins. Inhibiting autophagy during DHA treatment decreases its capacity …
A Novel Exo-Proteomic Approach To The Study Of Traumatic Brain Injury, Ron B. Moyron
A Novel Exo-Proteomic Approach To The Study Of Traumatic Brain Injury, Ron B. Moyron
Loma Linda University Electronic Theses, Dissertations & Projects
Concussions and Traumatic Brain Injuries (TBI) are significant health concerns and affect a wide cross section of society. Current diagnostic criteria and modalities, such as brain imaging and subjective measures of consciousness such as the Glasgow Coma Scale (GCS) score, are insufficient to properly diagnose the full spectrum of head injuries. Assessment of injury severity and outcome are further complicated by the vast array of symptoms, many of which mimic those displayed by other disorders. It is important to possess a better diagnostic tool for head injury triage and outcome prediction. One current line of inquiry seeks to discover a …
Aminoflavone Inhibits Α6-Integrin And Growth Of Tamoxifen Resistant Breast Cancer, Petreena S. Campbell
Aminoflavone Inhibits Α6-Integrin And Growth Of Tamoxifen Resistant Breast Cancer, Petreena S. Campbell
Loma Linda University Electronic Theses, Dissertations & Projects
Approximately 40% of estrogen receptor positive (ER+) breast cancer patients develop resistance to standard of care agent tamoxifen, while ER negative (ER-) breast cancer patients are intrinsically resistant to tamoxifen. Resistance often promotes metastasis, recurrence and death. Tumor-initiating cells (TICs) represent key contributors to resistance and adhesion protein α6-integrin is a putative TIC biomarker. Investigational agent Aminoflavone (AF) demonstrates efficacy against breast cancer cells irrespective of ER status. Interestingly, we found tamoxifen resistant (TamR) cells and tumors exhibited elevated α6-integrin expression in comparison to their tamoxifen sensitive counterparts. AF effectively disrupted mammospheres enriched for TICs and reduced α6-integrin levels in …
Rna-Seq Reveals Transcriptomic Program Associated With Stemness In Taxane Resistant Prostate Cancer, Christina K. Cajigas-Du Ross
Rna-Seq Reveals Transcriptomic Program Associated With Stemness In Taxane Resistant Prostate Cancer, Christina K. Cajigas-Du Ross
Loma Linda University Electronic Theses, Dissertations & Projects
There is no cure for advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the benchside, but clinical trials have not resulted in newly approved drugs due in part to redundant survival pathways utilized by prostate tumor cells to maintain therapy-resistance. Using RNAsequencing—an innovative approach for quantifying gene expression changes—this dissertation sought to elucidate chemoresistance-associated molecular pathways as a catalyst to develop new therapeutic targets. Results revealed a differential upregulation of stemness-associated genes …
Microgravity Exerts An Age-Dependent Effect On Cardiovascular Progenitor Cell Development, Jonathan Baio
Microgravity Exerts An Age-Dependent Effect On Cardiovascular Progenitor Cell Development, Jonathan Baio
Loma Linda University Electronic Theses, Dissertations & Projects
The heart and its cellular components are profoundly altered by missions to space and injury on Earth. Increasing evidence has identified that one such alteration induced by spaceflight is the promotion of the efficacious use of stem cells in therapies on Earth. For this reason, neonatal and adult human cardiovascular progenitor cells (CPCs) were cultured aboard the International Space Station (ISS). Subsequently, we assessed the effects of mechanical unloading on developmental properties and signaling. Spaceflight induced the expression of genes that are typically associated with an earlier state of cardiovascular development. In particular, in neonatal CPCs, we measured increased expression …
Gene Delivery Of Adenoviral-Tmbim6 Vector Protects The Neonatal Brain After Hypoxic-Ischemic Injury, Desislava Doycheva
Gene Delivery Of Adenoviral-Tmbim6 Vector Protects The Neonatal Brain After Hypoxic-Ischemic Injury, Desislava Doycheva
Loma Linda University Electronic Theses, Dissertations & Projects
Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive oxygen species (ROS), from cytochrome P450 members (CYP) and NADPH-P450 reductases (NPR), in combination with activation of the unfolded protein response (UPR) are two major consequences of ER stress that cause oxidative damage and cell death. Herein we identified the role of Bax Inhibitor-1 (BI-1), an evolutionary conserved protein encoded by the Transmembrane Bax inhibitor Motif Containing …
Changes In The Morphology Of Hypoglossal Motor Neurons In The Brainstem Of Developing Rats, Paul Allen Williams
Changes In The Morphology Of Hypoglossal Motor Neurons In The Brainstem Of Developing Rats, Paul Allen Williams
Loma Linda University Electronic Theses, Dissertations & Projects
The autonomic brainstem generates and modifies breathing rhythm by integrating inputs from chemo- and mechanosensors in the viscera while coordinating descending outputs from higher CNS structures. Hypoglossal motoneurons (XII MNs) receive inputs from respiratory premotor neurons in the medulla. Previous studies in rodents have demonstrated significant changes in breathing control during the first three weeks of life, with a sensitive period at 10 to 13 days post-birth (P10–P13) characterized by pronounced changes in neurotransmitters, receptors, excitation-inhibition balance, and breathing. However, age-dependent morphological changes of XII MNs during the first three weeks post-birth and especially during this sensitive period, have not …
The Role Of Glucocorticoid Signaling In Prostate Cancer Health Disparities, Leanne W. Burnham
The Role Of Glucocorticoid Signaling In Prostate Cancer Health Disparities, Leanne W. Burnham
Loma Linda University Electronic Theses, Dissertations & Projects
African-American men are more likely to develop aggressive prostate cancer (PCa) and die from the disease than other ethnic groups. Glucocorticoid signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. The mechanism involves glucocorticoids binding to glucocorticoid receptor (GR) and bypassing the androgen receptor (AR) signaling pathway to activate AR-target genes that promote tumor aggressiveness and therapy-resistance. This is problematic as African-American men have hypersensitive GR signaling and chronically-elevated levels of glucocorticoids linked to cumulative stressful life events. To explore the role of glucocorticoid …
Epidemiological, Environmental, And Biological Risk Factors For Gastroschisis, Arti Ketan Desai
Epidemiological, Environmental, And Biological Risk Factors For Gastroschisis, Arti Ketan Desai
Loma Linda University Electronic Theses, Dissertations & Projects
Gastroschisis, a congenital defect of the abdominal wall, manifests as external herniation of viscera, most commonly the fetal bowel. The worldwide prevalence of gastroschisis continues to rise, and this increase can also be seen in California with an overall birth prevalence of 2-3 per 10,000 births. While the etiology and pathogenesis of gastroschisis remains unknown, previous studies indicate several risk factors including young maternal age, nulliparity, and low maternal body mass index, in addition to environmental factors and exposure, given the increase in global prevalence with a predisposition of cases to occur in clusters, and absence of a genetic link. …
Effects Of Omega-3s And Vitamin E Prophylactic Diets And The Implications Of Lipid Transport In Spinal Cord Injury, Kathia Cordero-Caban
Effects Of Omega-3s And Vitamin E Prophylactic Diets And The Implications Of Lipid Transport In Spinal Cord Injury, Kathia Cordero-Caban
Loma Linda University Electronic Theses, Dissertations & Projects
Traumatic injury to the central nervous system (CNS) presents a devastating problem to our society. Although current interventions are promising, no effective treatments are available. The neural membrane fatty acid composition is markedly altered during the first few days after spinal cord injury (SCI). SCI results in autonomic dysfunction, paralysis, spasticity, and significant chronic neuropathic pain. The trauma leads to significantly increased levels of free radical and oxidative stress that contribute to obstructing tissue healing and recovery. A growing body of evidence shows that administration of hydrophobic molecules such as Vitamin E and long-chain omega-3 polyunsaturated fatty acids (ω3PUFAs) are …
The Role Of Wnt3a In Ischemic Stroke, Nathanael Matei
The Role Of Wnt3a In Ischemic Stroke, Nathanael Matei
Loma Linda University Electronic Theses, Dissertations & Projects
After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a is a naturally occurring protein that has been shown to have protective effects in the brain for traumatic brain injury. Although wnt3a has been investigated in the phenomena of neurogenesis, anti-apoptosis, and anti-inflammation, it has never been investigated as a therapy for stroke. We hypothesized that the potential neuroprotective agent wnt3a would reduce infarction and improve behavior following ischemic stroke by attenuating neuronal apoptosis and promoting cell survival through the Frizzled-1/PIWI1a/FOXM1 pathway in MCAO rats. 229 Sprague-Dawley rats were assigned to male, female, and aged 9-month …
Endothelin-1 And Hypoxic Vascular Remodeling In Ovine Fetal Cerebral Arteries, Jinjutha Silpanisong
Endothelin-1 And Hypoxic Vascular Remodeling In Ovine Fetal Cerebral Arteries, Jinjutha Silpanisong
Loma Linda University Electronic Theses, Dissertations & Projects
Intrauterine hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that can affect transcription. This temporary rise in HIF-1 can promote gene transcription of ligands such as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is …
Effect Of Extracellular Survivin And Lymphoma Exosomes On Natural Killer Cells, Heather R. Ferguson Bennit
Effect Of Extracellular Survivin And Lymphoma Exosomes On Natural Killer Cells, Heather R. Ferguson Bennit
Loma Linda University Electronic Theses, Dissertations & Projects
Tumors alter their microenvironment to promote survival using methods such as angiogenesis promotion, growth signals, and immune suppression. The immune system becomes unresponsive to transformed neoplastic cells through a variety of methods including T cell suppression, increased myeloid-derived suppressor cells (MDSCs), and reduced natural killer (NK) cell activity. NK cells have inherent killing capabilities and thus are among the first responders in recognizing and destroying abnormal cells. However, many types of cancers inhibit the surveillance and cytotoxic abilities of NK cells by releasing exosomes, vesicles that can modulate the tumor microenvironment (TME) and intercellular communication for the purpose of enhancing …
The Role Of Vegf And Smooth Muscle Phenotype In Hypoxic Remodeling Of Ovine Carotid And Cerebral Arteries, Margaret C. Hubbell
The Role Of Vegf And Smooth Muscle Phenotype In Hypoxic Remodeling Of Ovine Carotid And Cerebral Arteries, Margaret C. Hubbell
Loma Linda University Electronic Theses, Dissertations & Projects
Arteries are a dynamic tissue with multiple cell types that incorporate systemic and local factors to maintain homeostasis. Hypoxia stimulates capillary angiogenesis to effectively match metabolic demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic brain injury, myocardial ischemia, diabetes, and developmental anomalies. With this remodeling comes changes in vessel structure including medial thickness and organization of contractile proteins as well as changes in myogenic tone. All of these factors culminate in changes in status or behavior of the vascular smooth muscle within the vessel …
The Role Of Tgf-Β In Ctb-Insulin Regulated Human Dendritic Cell Tolerance, Grace Edosewe Esebanmen
The Role Of Tgf-Β In Ctb-Insulin Regulated Human Dendritic Cell Tolerance, Grace Edosewe Esebanmen
Loma Linda University Electronic Theses, Dissertations & Projects
Cholera toxin B subunit fusion to autoantigen vaccines such as proinsulin (CTB-INS) down regulates dendritic cell (DC) activation and induces the synthesis of DC immunosuppressive cytokines. Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased IDO1 biosynthesis may play an important role in CTB-INS vaccine inhibition of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological tolerance in murine DCs. To elucidate the mechanisms by which CTB-INS may stimulate IDO1 biosynthesis and mediate tolerance in human DCs, we investigated the …
Pas Signaling Mechanisms In Aer And Aer2, Darysbel Garcia
Pas Signaling Mechanisms In Aer And Aer2, Darysbel Garcia
Loma Linda University Electronic Theses, Dissertations & Projects
PAS domains are widespread signal sensors that share a conserved three-dimensional αβ fold that consists of a central β-sheet flanked by several α- helices. The aerotaxis receptor Aer from Escherichia coli and the Aer2 chemoreceptor from Pseudomonas aeruginosa both contain PAS domains. Aer senses oxygen (O2) indirectly via an FAD cofactor bound to its PAS domain, while Aer2 directly binds O2 to its PAS b-type heme cofactor. The Aer and Aer2 PAS domains both interact with a signal transduction domain known as a HAMP domain. The PAS-HAMP arrangement differs between Aer and Aer2, with Aer- PAS residing adjacent to its …
Targeting Ledgf/P75 To Sensitize Chemoresistant Prostate Cancer Cells To Taxanes, Leslimar Rios-Colón
Targeting Ledgf/P75 To Sensitize Chemoresistant Prostate Cancer Cells To Taxanes, Leslimar Rios-Colón
Loma Linda University Electronic Theses, Dissertations & Projects
Prostate cancer (PCa) is the second most diagnosed cancer in males. This disease disproportionately affects African American men, with a higher incidence and mortality compared to other ethnic/racial groups. An aging male population and the complexity of addressing the health disparities associated with this disease puts PCa into the spotlight due to its serious public health implications and the imminent fiscal challenge over the next decades. Chronic prostate inflammation resulting in activation of stress and prosurvival pathways contribute to disease progression and the development of chemoresistance. Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival …
A Novel Population Of Cardiovascular Progenitors Persist In Neonates As Mesendodermal Cells, Julia Kim
A Novel Population Of Cardiovascular Progenitors Persist In Neonates As Mesendodermal Cells, Julia Kim
Loma Linda University Electronic Theses, Dissertations & Projects
The rise in mortality due to cardiovascular disease has increased the need to develop an efficient regenerative therapeutic for heart failure. Numerous cell-based therapies have been investigated for myocardial regeneration; however, an optimal progenitor has yet to be discovered. Identifying a resident cell population with enhanced ability to differentiate into multiple lineages would greatly contribute to the field of stem cell-based regenerative therapy. Evidence suggests that endogenous cardiovascular progenitor cells (CPCs) that have been isolated from the heart itself express ISL1, KDR, and MESP1, and are capable of differentiating into all major cardiac lineages. The earlier developmental stage at which …
Prenatal Undernutrition, Metyrapone, And The Cerebrovasculature, Lara Durrant
Prenatal Undernutrition, Metyrapone, And The Cerebrovasculature, Lara Durrant
Loma Linda University Electronic Theses, Dissertations & Projects
The link between intrauterine environmental conditions and adult cardiovascular system is well established. Independent of lifestyle factors such as poor diet and exercise habits, individuals who have been exposed to stressful conditions in utero show an increased risk of health problems such as hypertension, stroke, and type II diabetes. In support of the Fetal Origin of Adult Disease hypothesis, many labs have reported permanent anatomical and physiological changes associated with fetal stress and nutrient deficiency, with a focus on organ systems such as the kidney and heart. One key idea proposed by many of these studies is the glucocorticoid hypothesis, …
Anti-Tumor Mechanisms Of Hpv16 E6*, Whitney S. Evans
Anti-Tumor Mechanisms Of Hpv16 E6*, Whitney S. Evans
Loma Linda University Electronic Theses, Dissertations & Projects
High-risk types of the human papillomavirus (HR-HPV) are the causative agents of nearly all cases of cervical cancer, as well as a significant number of head, neck, penile, vulvar and anal cancers. Like many other viruses with small genomes, HPV (~8 kb) utilizes numerous mechanisms to increase the capacity of its genome to encode the proteins necessary for successful completion of its infectious life cycle, including alternative splicing. Studies over the past few decades have focused intensively on the activities and roles of E6 proteins from HR-HPVs during the process of cellular transformation, clearly implicating E6 as a major transforming …