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Articles 1891 - 1920 of 2762

Full-Text Articles in Alternative and Complementary Medicine

The Herbal Cabinet, David J. Mokler, Amber Rigdon, Samantha Schildroth Jan 2016

The Herbal Cabinet, David J. Mokler, Amber Rigdon, Samantha Schildroth

Biomedical Sciences Faculty Projects

Description of a historical Eli Lilly herb identification collection belonging to University of New England professor David Mokler, including herb scientific names, common names, ranges, and uses. Each herb bottle is pictured, its label information is reproduced, and each herb’s historical and current uses are briefly described.


Dogs: A Prescription For Health Issues?, Denise Magallon Jan 2016

Dogs: A Prescription For Health Issues?, Denise Magallon

Nebraska College Preparatory Academy: Senior Capstone Projects

The human-­‐animal bond has been seen throughout many generations. Pet owners, especially those who own dogs, are known to live a different lifestyle than non-­‐pet owners. However, the individuals who can receive the most benefits from dogs are those with certain psychological and physical health issues. Humans who suffer from diseases find that owning a dog is very helpful and can even improve and/or treat their illness.

Although dogs are not one-­‐hundred percent effective in curing all health conditions, they are still very useful and can improve health even by the slightest result. There is much medical evidence that proves …


Music Therapy As Procedural Support For Young Children Undergoing Immunizations: A Randomized Controlled Study, Olivia S. Yinger Jan 2016

Music Therapy As Procedural Support For Young Children Undergoing Immunizations: A Randomized Controlled Study, Olivia S. Yinger

Music Faculty Publications

Background: Children undergoing routine immunizations frequently experience severe distress, which may be improved through music therapy as procedural support.

Objective: The purpose of this study was to examine effects of live, cognitive-behavioral music therapy during immunizations on (a) the behaviors of children, their parents, and their nurses; and (b) parental perceptions.

Methods: Participants were children between the ages of 4 and 6 years (N = 58) who underwent immunizations, their parents (N = 62), and the nurses who administered the procedure (N = 19). Parent/child dyads were randomly assigned to receive music therapy (n = 29) …


Phytopharmaceuticals In Mongolia: Past, Present, And Future, Disan Gunbilig, Ulziinyam Rentsendorj Jan 2016

Phytopharmaceuticals In Mongolia: Past, Present, And Future, Disan Gunbilig, Ulziinyam Rentsendorj

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

Over the last two decades, the consumption of medicinal plants has increased in Mongolia. Once banned by the post-revolutionary government, it is now valued by the practitioners of orthodox medicine, government as well as by the society. Yet the scientific community has to give this major and crucial component of traditional Mongolian medicine the attention it deserves, scientific knowledge about biologically active principles within medicinal plants remain poorly unknown. At the same time, due to over exploitation of plants many species are becoming extinct together with invaluable traditional knowledge being lost. For these reasons, there is a certain urgency to …


Therapy Options For Winged Scapula Patients: A Literature Review, Samantha L. Normand Jan 2016

Therapy Options For Winged Scapula Patients: A Literature Review, Samantha L. Normand

Honors Undergraduate Theses

Winged scapula is a condition characterized by lateral or medial protrusion of the scapula caused by nerve damage leading to muscular paralysis. The purpose of this systematic review of literature is to evaluate the current research literature related to the effectiveness of therapy options for winged scapula. Eleven peer reviewed English language research articles published from 1998 to present were included for evaluation. Study results revealed positive therapeutic outcomes for physical therapy and scapular bracing. Results also showed positive outcomes for the use of transcutaneous electrical nerve stimulation and acupuncture for the treatment of nerve related conditions similar to winged …


The Effect Of Therapeutic Horseback Riding On Balance And Self-Efficacy In Children With Developmental Disabilities, Alexandra Smola, Lauren Hurley Jan 2016

The Effect Of Therapeutic Horseback Riding On Balance And Self-Efficacy In Children With Developmental Disabilities, Alexandra Smola, Lauren Hurley

Williams Honors College, Honors Research Projects

Therapeutic horseback riding (THR) has positive health related outcomes in children with developmental disabilities. The purpose of this study was to determine the effect of a 10-week THR intervention on balance and task-specific self-efficacy in children with developmental disabilities. Bandura’s social cognitive theory and the physical stress theory guided the quasi-experimental study. A pre-test post-test design (N=20) was implemented with a 10-week THR class at a riding center in Midwest United States. The first research question was: In children with developmental disabilities ages 5 to 18, does one 10-week session of THR affect balance? With time 1 balance mean at …


Piloting An Intervention To Improve Continuity In Lung Cancer Patients, Stacy L. Richey Jan 2016

Piloting An Intervention To Improve Continuity In Lung Cancer Patients, Stacy L. Richey

DNP Projects

Purpose: Kentuckians facing a lung cancer diagnosis are at greater risk for care fragmentation due to the complexities associated with the diagnosis, staging and treatment of the disease combined with multiple health disparities such as advanced age, multiple comorbid conditions, low socioeconomic status, geographic isolation, and low literacy levels. Transitioning from primary to specialist care can be especially difficult for these patients. The main purpose of this paper was to determine the feasibility and effect of a nurse-led, multidimensional intervention designed to improve relational (RC), informational (IC), and management continuity (MC) across the primary to secondary care interface, as well …


Dualism, Physicalism, And Professional Or Alternative Health Seeking: A Gendered Perspective, Taylor M. Caldwell Jan 2016

Dualism, Physicalism, And Professional Or Alternative Health Seeking: A Gendered Perspective, Taylor M. Caldwell

Pitzer Senior Theses

Evidence supporting a range of 6-14 years between mental illness symptom recognition and psychological help seeking has spurred a substantial interest in help seeking barriers. The present study suggests that mind and body dualism, the perceiving of the mind as an entity distinct from the body, is one such barrier to help seeking. Despite the fact that beliefs in mind-body dualism or its opposite, that of physicalism, are evident in virtually all human cultures and religions, surprisingly little is known about the psychological and behavioral implications of holding such beliefs. An exception to this disparity is a study that demonstrated …


Yoga As Complementary Alternative Medicine, Let’S Not Forget What Works!, James M. Mckivigan Jan 2016

Yoga As Complementary Alternative Medicine, Let’S Not Forget What Works!, James M. Mckivigan

College of Health & Human Services (TUN) Publications and Research

Practitioners today have to contend with a stream of new treatment options that are increasing in number almost daily. The patients undeniably win when we incorporate the latest technology with traditional treatment methods but too often the old gets completely pushed out to make room for the new. While many Complementary Alternative Medicine (CAM) therapies may be considered “old” by some practitioners, there is still a steady flow of articles being published showing that they remain effective. What if instead of abandoning the traditional therapies we used them in true compliment to the newest options? Here we will explore some …


Histological Evidence Of The Effect Of Oil Palm Phenolics In Atherogenic Diet Induced Rat Model Of Alzheimer’S Disease, Kenechukwu Monplaisir Monplaisir Jan 2016

Histological Evidence Of The Effect Of Oil Palm Phenolics In Atherogenic Diet Induced Rat Model Of Alzheimer’S Disease, Kenechukwu Monplaisir Monplaisir

Wayne State University Theses

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disease with the clinical presentation of memory loss and cognitive impairment. Alzheimer's disease pathology is the accumulation of beta amyloid plaques and neurofibrillary tangles.

METHOD: In this study atherogenic diet was used to induce AD in aged Brown Norway rats. The rats were assigned to the following four groups fed isocaloric diets; control group (C ),high cholesterol diet (H), high cholesterol + oil palm phenolics group (HP), high cholesterol + curcumin group (HC). The impact of oil palm phenolics (OPP) on neuronal health and its effect on amyloid deposition was evaluated using histology …


Is Acupuncture Effective In Reducing The Pain Intensity Due To Primary Dysmenorrhea?, Allison Eichenlaub Jan 2016

Is Acupuncture Effective In Reducing The Pain Intensity Due To Primary Dysmenorrhea?, Allison Eichenlaub

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: the objective of this selective EBM review is to determine whether or not acupuncture is effective in reducing the pain intensity due to primary dysmenorrhea in women ages 15 to 35.

STUDY DESIGN: Review of three randomized control trials (RCTs) written in English, one of which was published in 2011 and two in 2013.

DATA SOURCES: Three non-blind randomized control trials published in peer reviewed journals found via PubMed.

OUTCOME MEASURED: Pain intensity due to primary dysmenorrhea was measured using visual analog scale (VAS), Cox Menstrual Symptom Scale (CMSS), and Cox Retrospective Symptom Scale (RSS COX2 – average …


Wo’Kikso’Ye!: Live And Remember. Reflections On Akicita Cik’Ila, Little Soldier, Alex Lunderman (1929-2000), Richard William Voss, Joel R. Ambelang Jan 2016

Wo’Kikso’Ye!: Live And Remember. Reflections On Akicita Cik’Ila, Little Soldier, Alex Lunderman (1929-2000), Richard William Voss, Joel R. Ambelang

Social Work (Undergraduate) Faculty Publications

It isn’t often that one gets to meet someone like Alex J. Lunderman, Sr. His Lakota name was Akicita Cik’ala (Little Soldier). The co-authors of this reflection worked closely with Alex over the years in different ways. Richard Voss, who is the speaker in this narrative, met Alex (Little Soldier) in his personal spiritual journey that eventually linked to his research interests in a number of collaborations with Alex (Little Soldier) and other Lakota Elders (Voss, R. W., Douville, V., Little Soldier, A., & White Hat, Sr., 1999a; Voss, Douville, Little Soldier, & Twiss, 1999b). Joel Ambelang followed this research …


A Study On Stress And Aromatherapy Intervention Efficacy, Mckinley J. Sangwin Jan 2016

A Study On Stress And Aromatherapy Intervention Efficacy, Mckinley J. Sangwin

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Stress is one of the most common psychological conditions college students suffer. Stress is associated with anxiety, depression, high blood pressure, heart disease, disordered eating, irritability, decreased academic performance, and decreased life satisfaction. Intervention is needed. Essential oils are non-invasive and simple to use and were chosen for this study based on their potential ability to reduce stress. The aim of this study was to investigate the effectiveness of aromatherapy as a stress reduction tool for college students. This study took place in Aber Hall and involved residents of floors 6 and 7, as assigned by the residence life director. …


The Effect Of Curcumin On Cardiovascular Health In Obese Men, Marilyn S. Campbell Jan 2016

The Effect Of Curcumin On Cardiovascular Health In Obese Men, Marilyn S. Campbell

Theses and Dissertations--Kinesiology and Health Promotion

Cardiovascular disease is the leading cause of death in the United States, and conventional treatment often emphasizes pharmaceutical approaches. Research has recently started exploring non-pharmaceutical approaches, including nutritional interventions. This research study was conducted to test the effectiveness of a novel nutritional approach, curcumin, on the improvement of cardiovascular health in young, obese males (BMI≥30 kg/m2). This study included 22 men, matched based on BMI and randomly assigned to the intervention (n=11) or placebo group (n=11). The intervention consisted of 12 weeks of curcumin supplementation (1.0 g/day) with fenugreek added to enhance the curcumin bioavailability; the placebo consisted …


Cytotoxicity And Chemical Investigation Of The Aerial Parts Of Markhamia Zanzibarica (Bojer Ex Dc.) K. Schum. (Bignoniaceae), Dina M. El-Kersh, Riham S. El Dine, Dina R. Abou-Hussein, Fatma S. El-Sakhawy, Mohamed M. Elmazar Jan 2016

Cytotoxicity And Chemical Investigation Of The Aerial Parts Of Markhamia Zanzibarica (Bojer Ex Dc.) K. Schum. (Bignoniaceae), Dina M. El-Kersh, Riham S. El Dine, Dina R. Abou-Hussein, Fatma S. El-Sakhawy, Mohamed M. Elmazar

Pharmacy

The ethanolic extract of the aerial parts of Markhamia zanzibarica (Bignoniaceae) was tested for its cytotoxic activity against human cervical adenocarcinoma cell line (HeLa). It showed a potent effect with an IC50 of 9.68 μg/ml compared to Doxorubicin (7.28 μg/ml). The fractions obtained from the successive partitioning of the total extract, were tested against the same cell line; the results revealed that n-hexane extract was the most potent 9.23 μg/ml, followed by ethyl acetate, butanol and chloroform fractions with IC50 of 21.2, 22.4 and 49.6 μg/ml, respectively. Column chromatography led to the isolation of oleanolic acid (1), ursolic acid (2) …


A Review Of Factors Contributing To The Shortage Of Palliative Care Service For Adolescent And Young Adult Oncology Patients, Erin K. Harper Jan 2016

A Review Of Factors Contributing To The Shortage Of Palliative Care Service For Adolescent And Young Adult Oncology Patients, Erin K. Harper

Antioch University Dissertations & Theses

Adolescent and young adult oncology (patients aged 15–39 years old) is an emerging group of patients that are recognized to have distinctive qualities concerning their cancer treatment, including intensified psychosocial needs compared to their adult and child counterparts (Bleyer, 2012). The quality of life for adolescent and young adults during and after cancer treatment is disproportionally worse than what is reported by adults and children and the incidence of cancer in this population is steadily growing (Bleyer, 2011, 2012; Pritchard, Cuvelier, Harlos, & Barr, 2011; Rosenberg & Wolfe, 2013; Siegel, Naishadham, & Jemal, 2013; Wein, Pery, & Zer, 2011). Palliative …


Comparing Textbooks From Entry-Level Courses In Music Therapy And Related Health Professions, Alexandria Langella Jan 2016

Comparing Textbooks From Entry-Level Courses In Music Therapy And Related Health Professions, Alexandria Langella

Theses and Dissertations--Music

Music therapists often co-treat with other therapists from related professions, including physical therapy, occupational therapy, and speech-language pathology. In order to co-treat effectively and obtain referrals for music therapy services, it is important that other professionals have an awareness of the profession of music therapy. University-level professional training program courses are one place where health care professionals may learn about music therapy. The purpose of this study was to see if required textbooks used in physical therapy, occupational therapy, and speech-language pathology entry-level courses in Kentucky contain references to music therapy, and if the required textbooks used in music therapy …


Is Acupuncture, Including Electroacupuncture, Effective In Treating Pain In Plantar Fasciitis?, Alicia Campiglia Jan 2016

Is Acupuncture, Including Electroacupuncture, Effective In Treating Pain In Plantar Fasciitis?, Alicia Campiglia

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether the use of acupuncture, including electroacupuncture, is effective in treating pain in patients with plantar fasciitis.

STUDY DESIGN: Review of 3 RCTs published between 2011-current, all in the English language.

DATA SOURCES: Three RCTs analyzed the effectiveness of acupuncture therapy compared to a control group using alternate analgesic therapies. All studies were found using EBSCOhost and PubMed and were selected based on relevance to the proposed clinical question.

OUTCOMES MEASURED: Each of the 3 articles analyzed the effectiveness of treating pain with acupuncture treatment in patients diagnosed with …


How Effective Is Acupuncture In Treating Cancer-Related Fatigue In Adult Cancer Patients?, Anita Elizabeth Kurian Jan 2016

How Effective Is Acupuncture In Treating Cancer-Related Fatigue In Adult Cancer Patients?, Anita Elizabeth Kurian

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not acupuncture is an effective course of treatment for improving cancer-related fatigue in adult cancer patients.

DESIGN: Review of three English language primary randomized controlled studies published from 2006-2012.

DATA SOURCES: Three randomized controlled trials studying the effects of acupuncture therapy on cancer-related fatigue were found using PubMed and Cochrane databases.

OUTCOMES MEASURED: Each of the three trials assessed the efficacy and clinical improvement of cancer-related fatigue after acupuncture therapy. Results were measured on the Functional Assessment of Chronic-Illness Therapy-Fatigue Subscale (FACIT-F) or the Multidimensional Fatigue Inventory …


Is Yoga An Effective Treatment For Post-Traumatic Stress Disorder (Ptsd)?, Marissa Ionna Jan 2016

Is Yoga An Effective Treatment For Post-Traumatic Stress Disorder (Ptsd)?, Marissa Ionna

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is Yoga An Effective Treatment For Post-Traumatic Stress Disorder (PTSD)?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published in peer reviewed journals between 2010-2014, all English language.

Data Sources: Three randomized controlled trials were found using PubMed.

Outcomes Measured: All three studies measured improvement in PTSD symptoms through yoga therapy using self-reported patient questionnaires, visual analog scales, and vital signs.

Results: Studies by Telles et al. and van der Kolk et al. found that yoga therapy significantly improved symptoms in patients with Post-Traumatic …


Is Acupuncture An Effective Treatment For Women With Chronic Migraine?, Elham Oumer Jan 2016

Is Acupuncture An Effective Treatment For Women With Chronic Migraine?, Elham Oumer

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not acupuncture is effective in treating chronic migraine in women between the ages of 18-65.

STUDY DESIGN: Review of two randomized controlled trials and one prospective controlled trial published in English language between 2009 and 2014.

DATA SOURCES: Two PCTs and one prospective CT published in peer reviewed journals, searched through PubMed, EBSCOhost.

OUTCOMES MEASURED: The outcome measured included improvement in quality of life, reduction in intensity and number of headache days. This were measured using 50% responders analysis, self reporting by participants, short form 36 (SF-36) …


Does Yoga Decrease Self-Report Of Antenatal Depression Among Healthy Pregnant Women Aged 18-40 Years Old In The 2nd And 3rd Trimesters?, Emily J. Moore Jan 2016

Does Yoga Decrease Self-Report Of Antenatal Depression Among Healthy Pregnant Women Aged 18-40 Years Old In The 2nd And 3rd Trimesters?, Emily J. Moore

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not yoga decreases self-report of antenatal depression among healthy pregnant women aged 18-40 years old in the 2nd and 3rd trimesters.

Study Design: Review of three randomized controlled trials (RCTs) published in peer reviewed journals in 2013 and one RCT published in a peer reviewed journal in 2012 were used.

Data Source: Data sources included articles published in English in peer reviewed journals found using PubMed. Articles were selected based on their relevance to my clinical question.

Outcomes Measured: All four studies measured self-report of symptoms of …


Equine Assisted Activities And Therapies: The Measuring Of Equine Temperament, Thecla M. Helmbrecht Howard Jan 2016

Equine Assisted Activities And Therapies: The Measuring Of Equine Temperament, Thecla M. Helmbrecht Howard

Walden Dissertations and Doctoral Studies

The field of equine assisted activities and therapies (EAAT) is growing in popularity as an alternative healing approach. However, there is a paucity of peer-reviewed research on the horses who serve as equal partners in EAAT. The purpose of this quantitative study was to discover the impact of equine-facilitated therapeutic activities on the temperament of horses, and to determine how to select a better human-to-horse therapeutic match when providing EAAT services. The theoretical framework for this research drew from Romanes' theory of animal intelligence, which predicts that temperament would change as a result of prolonged participation in specific work (EAAT …


Self-Efficacy And Coping In Transition Of Care After Remission Of Cancer In Adolescents, Leah M. Mcdonnell Jan 2016

Self-Efficacy And Coping In Transition Of Care After Remission Of Cancer In Adolescents, Leah M. Mcdonnell

Honors Undergraduate Theses

The improvement in cancer remission rates in children and adolescents due to advances in cancer treatment and therapy has led to the development of guidelines that address long-term follow up for survivors of childhood cancers. Adolescents often experience negative emotions related to the fear of uncertainty about long-term survival after cancer remission, yet often report feelings of hope and optimism for the future more than adult cancer survivors. The purpose of this study was to understand the role of self-efficacy and coping in adolescents after remission of cancer. A secondary purpose was to analyze which coping strategies supported long-term survival …


The Efficacy Of Non-Pharmacological Pain Management Methods Amongst Premature Neonates In The Neonatal Intensive Care Unit (Nicu), Hannah R. Martinez Jan 2016

The Efficacy Of Non-Pharmacological Pain Management Methods Amongst Premature Neonates In The Neonatal Intensive Care Unit (Nicu), Hannah R. Martinez

Honors Undergraduate Theses

The purpose of this study was to conduct an integrated review of the literature examining the use of non-pharmacologic pain management strategies in premature neonates and to explore the relationship between health outcomes and time to discharge from the neonatal intensive care unit (NICU). Non-pharmacologic pain management strategies include human touch, facilitated tucking, non-nutritive sucking, and kangaroo care. A systematic review of the literature was conducted from multiple online databases. Peer reviewed, English-language articles containing the keywords ‘pain management’, ‘neonatal intensive care unit’, and ‘non-pharmacologic’ were included for synthesis. Exclusion criteria included articles with a focus on infants not admitted …


Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon Jan 2016

Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon

PCOM Psychology Dissertations

Background: Psoriasis is a multifactorial disease that effect approximately 7.5 million Americans. There are a variety of traditional treatments for psoriasis (e.g. topical medications, biologics) that for many, are effective in combating the disease. However, traditional treatments often have aversive side effects and may not be appropriate for every patient (e.g. pregnant women). Additionally, the efficacy of these medications are variable leaving some looking for adjunctive treatment options. There is increasing evidence to support the use of adjunctive treatments for psoriatic patients (e.g. psychotherapy, mindfulness). However, research is variable in regards to medical professionals’ attitudes towards integrative medicine (IM) as …


The Effect Of An 8-Minute Yoga Breathing Program On Fitness, Weight Loss And Breathing Capacity, Jerrold S. Petrofsky, Michael S. Laymon, Iman Akef Khowailed, Haneul Lee, Allie Petrofsky Jan 2016

The Effect Of An 8-Minute Yoga Breathing Program On Fitness, Weight Loss And Breathing Capacity, Jerrold S. Petrofsky, Michael S. Laymon, Iman Akef Khowailed, Haneul Lee, Allie Petrofsky

College of Health & Human Services (TUN) Publications and Research

This was a single blinded randomized study with an intervention group and a control group to examine a modification in lifestyle and an 8-minute exercise session each day to lose weight. Fifty-seven female subjects participated. Subjects underwent girth measurements at the umbilicus, hips, thigh and upper arm; weight, height (for BMI), body fat, heart rate, blood pressure, abdominal strength, leg strength, arm strength, sedentary O2 saturation, treadmill challenged O2 saturation, resting metabolism (which includes fat metabolism), and lung capacity. Measures were repeated at baseline and the end of the 6-week period. During the 6-week period, they followed a healthy recommended …


Book Review Of Cure, David Yells Jan 2016

Book Review Of Cure, David Yells

Journal of Social, Behavioral, and Health Sciences

In Cure: A Journey Into The Science of Mind Over Body, Dr. Jo Marchant explores the world of complementary and alternative medicine. The context for her exploration is the limitations of standard, Western medicine. In some cases, traditional Western medicine has been unable to provide reliably effective treatment for medical conditions. In other cases, the treatment may result in intolerable side effects. Marchant addresses approaches such as hypnotherapy, virtual reality, and even the power of belief (as reflected in the placebo effect) in the treatment of such disparate conditions as Parkinson’s disease, Irritable Bowel Syndrome, and Fibromyalgia. She combines …


Prevalence And Predictors Of Complementary And Alternative Medicine Use Among Lebanese College Students, Lama Jizi Jan 2016

Prevalence And Predictors Of Complementary And Alternative Medicine Use Among Lebanese College Students, Lama Jizi

Walden Dissertations and Doctoral Studies

In Lebanon, estimates of Complementary and Alternative Medicine (CAM) use among college students are not available. CAM practices are not well regulated and some products contain unsafe substances. The purpose of this study was to estimate the prevalence and predictors of CAM use among Lebanese college students using the health belief model. A quantitative cross sectional research design was used. An online survey was administered to 126 Lebanese college students with the aim of determining the most important predictors of CAM use. A majority (89%) of surveyed students reported the use of CAM in the last 12 months. Based on …


Contribution Of New Thiol Antioxidant In The Treatment Of Acetaminophen Toxicity, Ahdab Naeem Khayyat Jan 2016

Contribution Of New Thiol Antioxidant In The Treatment Of Acetaminophen Toxicity, Ahdab Naeem Khayyat

Doctoral Dissertations

"Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. It is safe at therapeutic doses, but an overdose can result in severe hepato-nephrotoxicity, a leading cause of drug-induced acute liver failure in the U.S. Although a few different mechanisms have been proposed for APAP-induced toxicity, a significant amount of evidence has pointed to the potential involvement of oxidative stress in acetaminophen toxicity. Depletion of glutathione (GSH) is one of the initiating steps in APAP-induced toxicity; therefore, one strategy for restricting organ damage is to restore GSH levels by using GSH prodrugs like N-acetylcysteine (NAC). Although …