Medicine and Health Sciences Commons^™

An Exploratory Analysis Of Gait Biomechanics And Muscle Activation In Pregnant Females With High And Low Scores For Low Back Or Pelvic Girdle Pain During And After Pregnancy, Jennifer J. Bagwell, Nicholas Reynolds, Jo Armour Smith, Michelle Walaszek, Hannah Runez, Kristina Lam, Julie Peterson, Dimitrios Katsavelis

Physical Therapy Faculty Articles and Research

Background

The purpose of this study was to compare gait kinematics, kinetics, and muscle activation between pregnant females with high and low scores for low back and/or pelvic girdle pain during and after pregnancy.

Methods

Twenty participants tested during second trimester, third trimester, and again post-partum. At each session, motion capture, force plates, and surface electromyography data were captured during self-selected velocity over-ground walking. Participants completed the Quebec Back Pain Disability Scale (QBPDS) and were assigned to high (QBPDS ≥15) or low pain groups (QBPDS

Findings

Nine participants met the high pain group criteria and 11 were low pain. During …

Stroke Recovery Phenotyping Through Network Trajectory Approaches And Graph Neural Networks, Sanjukta Krishnagopal, Keith Lohse, Robynne Braun

2020-Current year OA Pubs

Stroke is a leading cause of neurological injury characterized by impairments in multiple neurological domains including cognition, language, sensory and motor functions. Clinical recovery in these domains is tracked using a wide range of measures that may be continuous, ordinal, interval or categorical in nature, which can present challenges for multivariate regression approaches. This has hindered stroke researchers' ability to achieve an integrated picture of the complex time-evolving interactions among symptoms. Here, we use tools from network science and machine learning that are particularly well-suited to extracting underlying patterns in such data, and may assist in prediction of recovery patterns. …

Outcome Predictors In Catheter Interventions For Severe Right Ventricular Outflow Tract Obstructions, Sonia A. El-Saiedi, Wael A. Attia, Ashraf Abdelrahim, Baher M. Hanna

Journal of the Saudi Heart Association

Introduction & Aim of Work: Transcatheter treatment for critical pulmonary stenosis and membranous pulmonary atresia has become the gold standard of care in many centers. We aimed at evaluating the predictors of outcome in interventions for treatment of duct-dependent right ventricular outflow tract obstruction with intact interventricular septum. Subjects & Methods: 68 cases with pulmonary atresia with intact interventricular septum (PA/IVS) and 50 cases with critical pulmonary stenosis (CPS), all younger than 3 months of age, were operated during the period of 10 years; excluding patients with tricuspid valve annulus Z-score smaller than -4, evidence of right ventricular-dependent coronary circulation …

Improving Chronic Illness Self-Management With The Apsáalooke Nation: The Báa Nnilah Project, A Cluster Randomized Trial Protocol, John Hallett, Du Feng, Alma Knows His Gun Mccormick, Sarah Allen, Jillian Inouye, Mark Schure, Shannon Holder, Lucille Other Medicine, Suzanne Held

Nursing Faculty Research

Chronic illness (CI) is a major cause of morbidity and mortality for Indigenous people. In Montana, Indigenous communities disproportionately experience CI, a legacy of settler colonialism. For over two decades, Messengers for Health, an Apsáalooke (Crow Indian) non-profit, and Montana State University have partnered to improve community health using a community-based participatory research (CBPR) approach. We developed Báa nnilah, an intervention utilizing community strengths, to improve CI self-management. This manuscript describes the protocol for a cluster randomized trial with two arms: an intervention group and a wait list control group, who both participated in the Báa nnilah program. Enrollment occurred …

Hoxa9 Overexpression Contributes To Stem Cell Overpopulation That Drives Development And Growth Of Colorectal Cancer, Brian Osmond, Caroline O.B. Facey, Chi Zhang, Bruce M. Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

HOX proteins are transcription factors that regulate stem cell (SC) function, but their role in the SC origin of cancer is under-studied. Aberrant expression of HOX genes occurs in many cancer types. Our goal is to ascertain how retinoic acid (RA) signaling and the regulation of HOXA9 expression might play a role in the SC origin of human colorectal cancer (CRC). Previously, we reported that aldehyde dehydrogenase (ALDH) and other RA pathway components are co-expressed in colonic cancer SCs (CSCs) and that overpopulation of ALDH-positive CSCs occurs during colon tumorigenesis. Our hypothesis is RA signaling regulates HOXA9 expression, and dysregulated …

Aspartyl Protease Inhibitors As Anti-Filarial Drugs, Liana Beld, Hyeim Jung, Christina A Bulman, Bruce A Rosa, Peter U Fischer, James W Janetka, Sara Lustigman, Judy A Sakanari, Makedonka Mitreva

2020-Current year OA Pubs

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode,

Time-To-Event Modeling For Hospital Length Of Stay Prediction For Covid-19 Patients, Yuxin Wen, Md. Fashiar Rahman, Yan Zhuang, Michael Pokojovy, Honglun Xu, Peter Mccaffrey, Alexander Vo, Eric Walser, Scott Moen, Tzu-Liang Bill Tseng

Engineering Faculty Articles and Research

Providing timely patient care while maintaining optimal resource utilization is one of the central operational challenges hospitals have been facing throughout the pandemic. Hospital length of stay (LOS) is an important indicator of hospital efficiency, quality of patient care, and operational resilience. Numerous researchers have developed regression or classification models to predict LOS. However, conventional models suffer from the lack of capability to make use of typically censored clinical data. We propose to use time-to-event modeling techniques, also known as survival analysis, to predict the LOS for patients based on individualized information collected from multiple sources. The performance of six …

Lilrb2-Mediated Trem2 Signaling Inhibition Suppresses Microglia Functions, Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An

Faculty, Staff and Student Publications

Background: Microglia plays crucial roles in Alzheimer's disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here we study the negative regulation of TREM2 functions by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2), an inhibitory receptor bearing ITIM motifs.

Methods: To specifically interrogate LILRB2-ligand (oAβ and PS) interactions and microglia functions, we generated potent antagonistic LILRB2 antibodies with sub-nanomolar level activities. The biological effects of LILRB2 antagonist antibody (Ab29) were studied in human induced pluripotent stem cell (iPSC)-derived microglia (hMGLs) for migration, oAβ phagocytosis, and upregulation of inflammatory …

Pneumococcal Carriage In Infants Post-Pcv10 Introduction In Pakistan: Results From Serial Cross-Sectional Surveys, Shahira Shahid, Amala Khan, Muhammad Imran Nisar, Farah Khalid, Muhammad Farrukh Qazi, Sheraz Ahmed, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Syed Asad Ali, Anita K. M. Zaidi, Fyezah Jehan

Department of Paediatrics and Child Health

The 10-valent pneumococcal vaccine was introduced in Pakistan's Expanded Program on Immunization (EPI) in 2013 as a 3 + 0 schedule without catchup. We conducted three annual cross-sectional surveys from 2014-2016 to measure vaccine-type (VT) carriage in infants from a rural part of Pakistan. Nasopharyngeal specimens were collected by random sampling of infants from two union councils of Matiari. Samples were then transported to the Infectious Disease Research Laboratory (IDRL) at the Aga Khan University within 6-8 h of collection. Serotypes were established using sequential multiplex PCR. Of the 665 children enrolled across three surveys, 547 were culture-positive for pneumococcus. …

Does Individualized Guided Selection Of Antiplatelet Therapy Improve Outcomes After Percutaneous Coronary Intervention? A Systematic Review And Meta-Analysis, Naser Yamani, Samuel Unzek, Muhammad Hasnain Mankani, Talal Almas, Adeena Musheer, Humera Qamar, Shausha Farooq, Waqas Shahnawaz, Kaneez Fatima, Vincent Figueredo

Department of Medicine

Background: The potential benefits of individualized guided selection of antiplatelet therapy over standard antiplatelet therapy in improving outcomes in patients undergoing percutaneous coronary intervention (PCI) have not been established. Therefore, we pooled evidence from available clinical trials to assess the effectiveness by comparing the two regimens in patients undergoing PCI.
Methods: We queried two electronic databases, MEDLINE and Cochrane CENTRAL, from their inception to April 20, 2021 for published randomized controlled trials in any language that compared guided antiplatelet therapy, using either genetic testing or platelet function testing, versus standard antiplatelet therapy in patients undergoing PCI. The results from trials …

Fondaparinux As An Alternative Anticoagulant Treatment In Patients With Left Ventricular Assist Devices And Recurrent Gastrointestinal Bleeding: Case Series, Daniela Piani, Andrea Lechiancole, Massimo Maiani, Igor Vendramin, Sandro Sponga, Elisabetta Auci, Ugolino Livi

The VAD Journal

Gastrointestinal bleeding (GIB) can occur in patients after left ventricular assist device (LVAD) implantation. In cases of recurrent GIB, the management of anticoagulation treatment represents a challenging situation in which the risk of bleeding recurrence and the need for long-term anticoagulation must be balanced. This case series describes the successful management of anticoagulation in three patients with recurrent GIB using fondaparinux.

To our knowledge, these are the first reported cases of recurrent GIB in which a single dose of subcutaneous fondaparinux was used instead of oral anticoagulation. None of the patients presented with signs of pump thrombosis or arterial embolism. …

Anxiety Symptoms Among Extension Professionals' During The Covid-19 Pandemic With The Gad-2, Glenn D. Israel, Colleen E. Gariton, Harsha E. James

Journal of Rural Social Sciences

According to the National Institute of Mental Health, anxiety disorders are a common mental health disorder but often remain undetected and undertreated. During the COVID-19 pandemic, Extension professionals have worked hard to address emerging issues that communities face, possibly impacting the amount of anxiety they experience. This study determined the prevalence of anxiety symptoms among Extension professionals in the United States. Participants from 24 states completed a survey containing the Generalized Anxiety Disorder 2-item (GAD-2) screener. Almost one-quarter of Extension professionals had a GAD-2 score greater than three, an indicator of anxiety with a possibility of generalized anxiety disorder, which …

Implications Of Covid-19 Mitigation Policies On Recreational Trail Users: Exploring Antecedents To Physical Distancing On Trails Across The Rural-Urban Continuum, Christopher J. Wynveen, Ingrid Schneider, Deonne Vanderwoude, Taylor Stein, Heather Gibson, Kim Shinew, William Hendricks, Megha Budruk

Journal of Rural Social Sciences

The COVID-19 pandemic and subsequent travel restrictions led to a worldwide increase in greenspace use. The U.S. Centers for Disease Control and Prevention encouraged policies including physical distancing and COVID-related signage. However, the extent to which these policies influenced behavior is unknown. To fill this gap, we report on a 2020 observational study at 14 trails across six U.S. states framed within a social-ecological model. Behavioral observations of 8,093 groups assessed compliance rates with infection-mitigation behaviors. Additionally, we noted the presence of COVID-related signs, the days between the observation and stay-at-home order start date, the setting (i.e., urban, suburban, and …

Rural-Urban And Within-Rural Differences In Covid-19 Mortality Rates, Yue Sun, Kent Jason G. Cheng, Shannon M. Monnat

Journal of Rural Social Sciences

Since late-2020, COVID-19 mortality rates have been higher in rural than in urban America, but there has also been substantial within-rural heterogeneity. Using CDC data, we compare COVID-19 mortality rates across the rural-urban continuum as well as within rural counties across different types of labor markets and by metropolitan adjacency. As of October 1, 2021, the cumulative COVID-19 mortality rate was 247.0 per 100,000 population in rural counties compared to 200.7 in urban counties. Higher COVID-19 mortality rates in rural counties are explained by lower average educational attainment and lower median household income. Within rural counties, mortality rates have been …

Orthodontic Correction Of A Completely Transposed Impacted Maxillary Canine, Yi-Jen Tsai, Chung-Li Wang, Chun-Liang Kuo, Yi-Hua Liu, Chun-Hsiu Yang, Yu-Ling Tsai, Chien-Hung Lin

Taiwanese Journal of Orthodontics

In complete dental transposition, aligning the transposed teeth to its normal anatomic position is always a complicated and difficult challenge, which needs multiple clinical considerations. This case report illustrates an orthodontic treatment of a 20-year-old female patient who had a concave profile, skeletal and dental Class III malocclusion with anterior crossbite and complete transposed maxillary left lateral incisor and impacted canine. The correction of transposition was performed by moving the canine by maintaining its high position in the vestibular fold and use lever arm and temporary anchorage device (TAD) to facilitate traction of the maxillary canine. Vestibular incision subperiosteal tunnel …

Severe Obstructive Sleep Apnea With Skeletal Class Ii Malocclusion Treated With Marpe And Maxillomandibular Advancement Surgery, Chao-Yu Jeremy Lu, Yu-Feng Chen, Yu-Chuan Tseng, Shih-Hsuan Lin

Taiwanese Journal of Orthodontics

A 27-year-old male patient was diagnosed as severe obstructive sleep apnea (OSA), having problems of skeletal Class II jaw related with mandibular retrognathism, orthodivergent facial pattern, dental Class II malocclusion, and occlusal plane canting. By intervention of miniscrew assisted rapid palatal expansion (MARPE) and maxillomandibular advancement (MMA), the clinical result presented significant improvement in functional and esthetic aspects after 18 months of treatment.

Strategies Of Non-Extraction Treatment For Class Lll Malocclusion, Tao-Wei Chang, Hoi-Shing Luk, Wen-Ken Tai, Chih-Chen Chou, Chia-Tze Kao

Taiwanese Journal of Orthodontics

The decision of whether to have an extraction or non-extraction treatment plan is a controversial issue for an orthodontist. Many orthodontic techniques can help to resolve the crowding dentition by using the non-extraction treatment plan. This case report describes the correction of Class III molar malocclusion with the application of two mini-screws. The line of action of the force from the temporary anchorage devices pass through the center of resistance in the mandible, therefore the movement of the lower arch can be controlled without lingual tipping or intrusion of the mandibular incisors. At the end of the treatment, Class I …

Evaluation Of Pain-Relieving Effect Of Menthol And Benzocaine Patches In Orthodontic Patients: A Triple-Blind Randomized Controlled Trial, Sanaz Soheilifar, Mehdi Zandian, Maryam Farhadian, Sara Soheilifar, Fatemeh Dehghani, Sepideh Soheilifar, Navid Naghdi

Taiwanese Journal of Orthodontics

Purpose: This study aimed to compare the effect of benzocaine and menthol patches on pain alleviation following elastomeric separator placement.
Patients and Methods: This triple-blind split-mouth trial was conducted on healthy 14-25 years old patients of orthodontic department. Eligibility criteria included presence of second premolar, first and second molars in both sides of the mandible, no chronic pain in oral cavity, or chronic consumption of analgesic drugs. Elastomeric separators were placed mesial and distal of first mandibular molars and patients were randomized into two groups: 1) menthol/ placebo patches, 2) benzocaine/ placebo patches. The mucosal patches were placed …

Important Orthodontic Considerations In Preparation Of Orthognathic Surgical Cases, Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Nowadays some adult patients seeking for orthodontic treatment may present severe malocclusion associated with pronounced skeletal discrepancies. Accordingly, thorough consideration and planning would be beneficial for the patient by the combined efforts of orthodontic and orthognathic approaches. This review reiterated the genetic impact on the growth velocity of the jaw with age in Class III malocclusion, and outlined the treatment protocol for the steps including the initial evaluation, the diagnosis, and the alignment of the teeth and dental arches before and after surgical correction. Specifically, emphasis is addressed on how to obtain records of jaw relationship in centric relation (CR) …

Peer Review, Robert Ferguson

CHED Talks

No abstract provided.

2022-06-17 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Cardiac Rehabilitation Adherence Rates In Elderly Patients Using A Mobile Application, Amanda Wilson

Yale School of Medicine Physician Associate Program Theses

Adherence to cardiac rehabilitation reduces cardiovascular disease mortality. Despite this, adherence rates remain suboptimal especially among older patients. Mobile applications are increasingly utilized to deliver virtual healthcare with similar health outcomes. However, no studies have determined whether cardiac rehabilitation delivered via mobile applications can increase adherence rates in elderly patients who may be limited by logistical barriers, such as difficulties with transportation. The aim of this study is to examine whether cardiac rehabilitation conducted via mobile application can increase adherence rates to cardiac rehabilitation in patients over 65 years old compared with traditional cardiac rehabilitation. We will conduct a randomized, …

Medical School Watercooler Newsletter - June 17, 2022, Lindsey Lyle

Watercooler Newsletter

This is the June 17, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• White Coat Ceremony marks transition for Class of 2024
• Medical students and residents win at regional emergency medicine conference
• USA Medical Alumni Association hosts reunion weekend

Effects Of Paternal High-Fat Diet And Maternal Rearing Environment On The Gut Microbiota And Behavior., Austin C Korgan, Christine L Foxx, Heraa Hashmi, Saydie A Sago, Christopher E Stamper, Jared D Heinze, Elizabeth O'Leary, Jillian L King, Tara S Perrot, Christopher A Lowry, Ian C G Weaver

Faculty Research 2022

Exposing a male rat to an obesogenic high-fat diet (HFD) influences attractiveness to potential female mates, the subsequent interaction of female mates with infant offspring, and the development of stress-related behavioral and neural responses in offspring. To examine the stomach and fecal microbiome's potential roles, fecal samples from 44 offspring and stomach samples from offspring and their fathers were collected and bacterial community composition was studied by 16 small subunit ribosomal RNA (16S rRNA) gene sequencing. Paternal diet (control, high-fat), maternal housing conditions (standard or semi-naturalistic housing), and maternal care (quality of nursing and other maternal behaviors) affected the within-subjects …

17Β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation Of Mesenteric Arteries In Ovariectomized Uc Davis Type 2 Diabetes Mellitus Rats In Prediabetic State, Md Rahatullah Razan, Farjana Akther, Rifat Ara Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel, Roshanak Rahimian

School of Pharmacy Faculty Articles

We recently reported sex differences in mesenteric arterial function of the UC Davis type-2 diabetes mellitus (UCD-T2DM) rats as early as the prediabetic state. We reported that mesenteric arteries (MA) from prediabetic male rats exhibited a greater impairment compared to that in prediabetic females. However, when females became diabetic, they exhibited a greater vascular dysfunction than males. Thus, the aim of this study was to investigate whether the female sex hormone, estrogen preserves mesenteric arterial vasorelaxation in UCD-T2DM female rats at an early prediabetic state. Age-matched female Sprague Dawley and prediabetic (PD) UCD-T2DM rats were ovariectomized (OVX) and subcutaneously implanted …

Intolerance Of Uncertainty, Sensory Processing, And Related Correlates In Autistic Children During The Covid-19 Pandemic, Mollie Bradley

Theses and Dissertations

The COVID-19 pandemic increased uncertainty and anxiety for most and was especially disruptive to autistic people and their families. Autistic children were particularly vulnerable due to their intolerance for increased uncertainty and disruption to their school and therapy support. This study aimed to investigate the effect that increased uncertainty had on autistic children, specifically their sensory behaviors and stress levels and on the stress levels of their primary caregivers. Parents and guardians of 47 autistic children completed an online survey consisting of questions investigating background and demographic information, their experiences during the first six months of the pandemic, information about …

A Comparative Study On The Expository Writing Abilities Of Kindergarten Students With And Without Developmental Language Disorder, Kristine Michelle Dayley Andrus

Theses and Dissertations

State standards require kindergarten students to produce expository writing, but little research has been done regarding their abilities in this area. This study describes expository writing samples of 47 typically developing (TD) kindergarteners and 43 kindergarteners with developmental language disorder (DLD). The Expository Language Measures (ELM) Flow Chart and the Systematic Analysis of Language Transcripts (SALT) software were used to detail the language complexity and text structure features the children in the sample produced. When comparing TD and DLD children's expository written samples, no significant differences in the language and text structure measures were found. It is important to continue …

Channelopathy Of Small- And Intermediate-Conductance Ca2+-Activated K+ Channels, Young-Woo Nam, Myles Downey, Mohammad Asikur Rahman, Meng Cui, Miao Zhang

Pharmacy Faculty Articles and Research

Small- and intermediate-conductance Ca²⁺-activated K⁺ (K_Ca2.x/K_Ca3.1 also called SK/IK) channels are gated exclusively by intracellular Ca²⁺. The Ca²⁺ binding protein calmodulin confers sub-micromolar Ca²⁺ sensitivity to the channel-calmodulin complex. The calmodulin C-lobe is constitutively associated with the proximal C-terminus of the channel. Interactions between calmodulin N-lobe and the channel S4-S5 linker are Ca²⁺-dependent, which subsequently trigger conformational changes in the channel pore and open the gate. KCNN genes encode four subtypes, including KCNN1 for K_Ca2.1 (SK1), KCNN2 for K_Ca2.2 (SK2), KCNN3 for K …

Ems To Trauma Care Transitions: An Investigation Of Patient And Handoff Outcomes, Richard Simonson

Doctoral Dissertations and Master's Theses

The helicopter as a method of emergency medical service transportation of trauma patients has a long history of effective use-cases dating back to its inception during the Vietnam war. Compared to ground-based emergency medical transit, helicopters have been able to reach severely injured patients in environments with challenging terrain features that ground-based medical services cannot traverse. Additionally, the helicopter offers quicker and more direct-route transit options that result in both quicker response and shorter transportation times compared to their ground-based alternative. Further, research has indicated that helicopter ambulance teams utilize paramedics with more experience than ground ambulance paramedics. Prior research …

Channelopathy Of Small- And Intermediate-Conductance Ca2+-Activated K+ Channels, Young-Woo Nam, Miles Downey, Mohammad Asikur Rahman, Meng Cui, Miao Zhang

Pharmacy Faculty Articles and Research

Small- and intermediate-conductance Ca²⁺-activated K⁺ (K_Ca2.x/K_Ca3.1 also called SK/IK) channels are gated exclusively by intracellular Ca²⁺. The Ca²⁺ binding protein calmodulin confers sub-micromolar Ca²⁺ sensitivity to the channel-calmodulin complex. The calmodulin C-lobe is constitutively associated with the proximal C-terminus of the channel. Interactions between calmodulin N-lobe and the channel S4-S5 linker are Ca²⁺-dependent, which subsequently trigger conformational changes in the channel pore and open the gate. KCNN genes encode four subtypes, including KCNN1 for K_Ca2.1 (SK1), KCNN2 for K_Ca2.2 (SK2), KCNN3 for K …