Medicine and Health Sciences Commons^™

Pediatric Open Long-Bone Fracture And Subsequent Deep Infection Risk: The Importance Of Early Hospital Care, Andrew W Kuhn, Stockton C Troyer, Jeffrey E Martus

2020-Current year OA Pubs

The purpose of the current study was to identify risk factors for deep infection after an open long-bone fracture in pediatric patients. Systematic billing queries were utilized to identify pediatric patients who presented to a level I trauma center from 1998 to 2019 with open long-bone fractures. There were 303 open long-bone fractures, and 24 (7.9%) of these became infected. Fractures of the tibia/fibula (

A Nanoengineered Topical Transmucosal Cisplatin Delivery System Induces Anti-Tumor Response In Animal Models And Patients With Oral Cancer, Manijeh Goldberg, Aaron Manzi, Amritpreet Birdi, Brandon Laporte, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T Pearson, Eric R Goldberg, Sam Goldberger, Benjamin Flaum, Rifat Hasina, Nyall R London, Gary L Gallia, Chetan Bettegowda, Simon Young, Vlad Sandulache, James Melville, Jonathan Shum, Sonya E O'Neill, Erkin Aydin, Alex Zhavoronkov, Anxo Vidal, Atenea Soto, Maria Jose Alonso, Ari J Rosenberg, Mark W Lingen, Anil D'Cruz, Nishant Agrawal, Evgeny Izumchenko

Faculty, Staff and Students Publications

Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often leads to dose-limiting toxicity (DLT), affecting quality of life. PRV111 is a nanotechnology-based system for local delivery of cisplatin loaded chitosan particles, that penetrate tumor tissue and lymphatic channels while avoiding systemic circulation and toxicity. Here we evaluate PRV111 using animal models of oral cancer, followed by a clinical trial in patients with OCSCC. In vivo, PRV111 results in elevated cisplatin retention in tumors and negligible systemic levels, compared to the intravenous, intraperitoneal or intratumoral delivery. Furthermore, PRV111 produces robust anti-tumor …

The Laws Of The Dead, Gillian Naro, Md, Med, Marie-Laure Flamer, Md

The Medicine Forum

George Washington suddenly fell ill with a sore throat and labored breathing at his estate in 1799. Initial management consisted of a "mixture of molasses, vinegar and butter," that was followed by “sage, tea and vinegar.” With no signs of clinical improvement, his doctors were called to his bedside. As was standard medical care at the time and thought to be beneficial in various afflictions, he was “bleed” more than 2L of blood in an attempt to restore his good health. The three doctors overseeing the bleeding process noticed the General become weaker despite their best efforts. His breathing became …

Internal Medicine Residents’ Experience With Using Handheld Ultrasound Machines In Point-Of-Care Ultrasonography, Michael Dong, Md, Tudor Sturzoiu, Md, Fred Karaisz, Max Ruge, Md

The Medicine Forum

Point-of-care ultrasonography (POCUS) is defined as the acquisition and interpretation of ultrasonographic images generated by the clinician at the bedside. The advent of handheld machines has increased access and practical application of ultrasound technology in internal medicine training and medical education. The most common system involves a single portable ultrasound probe that connects to a smartphone or tablet, and storage of images are stored via cloud-based technology. We discuss our experience with POCUS using handheld ultrasound machines in the Thomas Jefferson University Hospital academic setting.

Pulmonary Metastases Of Basal Cell Adenocarcinoma Presenting As Hemoptysis, Matthew Dimeglio, Do, Mba, Mark Mallozzi, Md, Prarthna Kulandaisamy, Md, Julie Barta, Md, Jennifer Johnson, Md

The Medicine Forum

Basal Cell Adenocarcinoma (BCAC) is a rare malignancy, only accounting for approximately 2% of all salivary neoplasms. Considered the malignant counterpart of basal cell adenoma, it most commonly presents at 60 years of age without gender predilection. Sites of involvement frequently includes the parotid gland, but sites in the minor salivary glands, nasopharynx, buccal mucosa, and tongue have also been reported. Often regarded as an indolent malignancy, BCAC can occasionally cause invasive disease and infrequently, metastatic disease. Among all solid tumors, endobronchial metastases is quite a rare occurrence, contributing to approximately 4% of endobronchial biopsies4. Most common sites of metastases …

Spontaneous Tumor Lysis Syndrome In Undifferentiated Pelvic Solid Tumor With Associated New Onset Atrial Flutter: A Case Report, Sameep Thapa, Md, Max Ruge, Md, Tamar Wolinsky Md

The Medicine Forum

Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by electrolyte derangements from the lysis of malignant tumor cells. The syndrome consists of several laboratory abnormalities including hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia1,2. When these lab findings are associated with end-organ damage such as acute renal failure, seizures, or cardiac dysrhythmias amongst others, it is known as clinical TLS3. TLS is more commonly associated with hematological malignancies given their tendency of rapid cellular turnover. The most common culprits include acute lymphocytic leukemia and Burkitt’s lymphoma. It is, however, quite rare for TLS to occur secondary to a solid malignancy4. …

A Case Report Of Methemoglobinemia And Hemolytic Anemia In The Setting Of Covid-19 Pneumonia And G6pd Deficiency, Grant W. Jirka, Md, Travis Hunt, Md, Sushil Ghimire, Md, Rakhshanda Akram, Md, Urvashi Vaid, Md, Ms

The Medicine Forum

It is well known that hereditary or acquired methemoglobinemia can cause hypoxia due to the oxidation of heme, which impairs its ability to offload oxygen (Figures 1 & 2), and that acquired methemoglobinemia is most often caused by exposure to drugs and toxins that oxidize hemoglobin to methemoglobin, directly or indirectly1. Recently, a few case reports have highlighted methemoglobinemia in patients with COVID-19 pneumonia. Some of these reports were due to treatment with hydroxychloroquine and others from unidentifiable causes2-4. We present a case in which a patient with COVID-19 pneumonia was diagnosed with methemoglobinemia and acute hemolysis from G6PD deficiency …

A Case Of Acute Pancreatitis Associated With Empagliflozin, Tudor Sturzoiu, Md, Sameep Thapa, Md, Ellen Solomon, Suchit Bhutani, Md

The Medicine Forum

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are being prescribed increasingly more often for type 2 diabetes mellitus as well as heart failure. They have not typically been associated with acute pancreatitis, but there has been a steady flow of case reports implicating them in acute pancreatitis over the years since they were initially approved. Here, we present the case of an 82-year-old woman with a past medical history of T2DM, COPD, hyperlipidemia, a remote stroke, peripheral arterial disease, and remote breast cancer now with recurrent localized breast cancer on treatment with ademaciclib and letrozole who presented to the emergency department with …

A Confounding Case Of Acute Hepatitis A, Andrea Molin, Md, Michael Cheung, Md, Timothy Kuchera, Md

The Medicine Forum

Hepatitis A (HAV) is a picornavirus transmitted via fecal-oral route that disproportionately affects homeless persons, men who have sex with men, and individuals who use intravenous drugs. Acute HAV typically presents with nausea, vomiting, abdominal pain, and fever. It is most commonly self-limited but can progress to fulminant hepatic failure in less than 1% of cases. The following case is a unique presentation of acute HAV infection requiring diagnostic dexterity and critical thinking.

Shocked But Not Surprised: The Philly Cardioversion, Gillian Naro, Md, Med, Naman Upadhyay, Md, Emilie Thompson, Md, Tudor Sturzoiu, Md

The Medicine Forum

Neuromuscular incapacitating devices, colloquially known as ‘tasers’, are typically used by police and security personnel as a non-lethal way to subdue combative assailants. Unfortunately, there are times in the hospital when patients can become assailants, thus potentially necessitating the use of tasers to ensure the safety of staff and other patients. Tasers come in several varieties. However, those typically used by law enforcement have a 50,000-V capacity and deliver 0.36 - 1.76 Joules of energy per pulse, at a rate of ~20 pulses per second, via two barbed projections. This leads to incapacitation of the assailant via the induction of …

A Case Of Patent Foramen Ovale As A Cause Of Persistent Hypoxia, Jaya Janadhyala, Md, Jonathan Foster, Md

The Medicine Forum

Patent foramen ovale (PFO) is a congenital cardiac variant caused by failure of the closure of a passage in the atrial septum. It is quite common, occurring in as much as 27% of the population based on autopsy studies. Most cases of PFOs are incidentally discovered or found during work-up of cryptogenic strokes as a potential cause of the stroke.1 New research is being conducted on the role PFOs play in hypoxia from intracardiac right-to-left shunting, including in patients with co-existent cardiovascular and pulmonary disease

Cardiac Amyloidosis: A Known Disease With An Unknown Presentation, Svenja Schneider, Md, Tudor Sturzoiu, Md, Tanuka Datta, Md, Yevgeniy Brailovsky, Do, Facc, Sung-Hae Cho, Md, Facc, Paulina Gorodin-Kiliddar, Md

The Medicine Forum

Cardiac amyloidosis is an increasingly recognized entity that causes significant morbidity and mortality. Transthyretin amyloidosis (ATTR) is present in about 16% of patients with severe aortic stenosis and up to 17% of patients with heart failure with preserved ejection fraction9,10. Though the screening test of choice, echocardiography is not highly sensitive or specific, and it should not be relied upon to rule out cardiac amyloidosis, especially if clinical suspicion is high.

We present a case of a 58-year-old woman with a history of bilateral carpal tunnel syndrome who presented with paresthesia and syncope. Extensive workup for neurologic, infectious, and malignant …

Another Case Of Takotsubo Syndrome: Excluded By The Presence Of Significant Coronary Artery Disease, Or Caused By Significant Coronary Artery Disease?, Bharaniabirami Rajaram, Md, Neveda Murugesan, Md, Gregary D. Marhefka, Md

The Medicine Forum

Takotsubo syndrome (TTS) is a reversible condition of abnormal myocardial contraction that was first given this name in Japan by Dr. Sato in 1991. The name comes from the Japanese word for “octopus trap,” which has a similar shape to that of the left ventricle on ventriculography during Takotsubo syndrome. It is also known as broken heart syndrome, stress-induced cardiomyopathy, or apical ballooning syndrome. The first descriptions of this phenomenon date as far back as the 1960s.

TTS typically presents with symptoms and clinical signs suggestive of acute coronary syndrome (ACS). It may include ST segment elevations on electrocardiogram (ECG) …

Challenges Of Managing Giant Cell Myocarditis: A Case Report On The Mechanical Support Perspective, Abdul W. Kazi, Md, Mba, Harsh Doshi, Md

The Medicine Forum

Giant cell myocarditis is a rare and fatal disease which may result in heart failure, complete heart block, or ventricular arrhythmias. We describe a patient who previously had been discharged from our institution with a left ventricular assist device and immunosuppressive therapy for management of his giant cell myocarditis. His subsequent course was complicated by further deterioration of heart function which required multiple mechanical circulatory support devices. He successfully received a heart transplant which later had recurrence of giant cell myocarditis. This case highlights the challenges of left and right sided mechanical assist devices in managing giant cell myocarditis.

AG …

From The Chief Residents, Cristina Angelo, Md, Katherine Duffey, Md, Evan Nardone, Md, Michelle Perkons, Md

The Medicine Forum

The four of us have had the unique opportunity to work alongside you and watch you grow throughout the last three years. During an extremely turbulent time at Jefferson, in the city of Philadelphia, and the larger healthcare landscape you all have been the constant presence that has kept the Jefferson IM residency culture alive. Jefferson residents are: Compassionate, intelligent, dedicated, fun, and resilient. But most of all, Jefferson residents look out for each other and have each other’s backs. This is the culture that brings people to our program and the culture that makes residency training which would otherwise …

From The Editors, Shuji Mitsuhashi, Md, Abdul W. Kazi, Md, Matthew Dimeglio, Do, Mba

The Medicine Forum

It is our honor to present the 23rd Annual edition of The Medicine Forum to the Jefferson community. With all the uncertainties and stressors that exist both inside and outside of the hospital walls, it is truly remarkable to see the quality of contributions by our authors. From the multitude of case reports to the collection of artworks, our residents have generated an array of unique and interesting work. We hope that this edition will continue to honor the tradition of The Medicine Forum, which is the celebration of scholarly activity among physicians in training at our institution.

Editorial …

From The Desk Of The Residency Program Director, Emily Stewart, Md, Facp

The Medicine Forum

Our program continues to train the best and brightest residents in the country. As we complete another challenging academic year marred by the ongoing fight against gun violence in Philadelphia and across the United States, the opioid pandemic and the ever present threat of another COVID-19 surge our residents have continued to rise to every challenge and thrive as physicians. During the three years we are fortunate to have them at our program, it is my distinct pleasure to watch them grow into confident, dedicated, compassionate clinicians. The residents are not just outstanding clinicians but excel in all aspects of …

Table Of Contents: The Medicine Forum Volume 23, 2021-2022

The Medicine Forum

Table of Contents: The Medicine Forum Volume 23, 2021-2022

2022-08-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

2022 August 16 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

2022-08-16_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2022-08-16_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

2022-08-16_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Development And Validation Of A Simple Model To Predict The Risk Of Nonmelanoma Skin Cancer On Screening Total Body Skin Examination, Rebecca Hartman, Yun Xue, Ryan Karmouta, Elizabeth Tkachenko, Sara J. Li, David G. Li, Cara Joyce, Arash Mostaghimi

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective. There is insufficient evidence to generate skin cancer screening guidelines at the population level, resulting in arbitrary variation in patient selection for screening skin examinations. This study was aimed at developing an easy-to-use predictive model of nonmelanoma skin cancer (NMSC) risk on screening total body skin examination (TBSE).

Methods. This epidemiologic assessment utilized data from a prospective, multicenter international study from primarily academic outpatient dermatology clinics. Potential predictors of NMSC on screening TBSE were identified and used to generate a multivariable model that was converted into a point-based scoring system. The performance characteristics of the model were validated in …

Covid-19 Newsletter (Vol. 132), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

A Manualized Occupational Therapy Mindfulness Module For Clients With Ptsd, Michael Ramirez

Student Capstone Papers

Posttraumatic stress disorder (PTSD) adversely impacts an individual’s functioning across areas of daily occupation. There is a paucity of literature addressing occupational therapy (OT) for people with PTSD. The literature has advocated for the development of a manualized OT intervention with the inclusion of mindfulness as one of its components. To date, a mindfulness-based OT treatment guide or manualized program specifically for clients with PTSD has not yet been developed. The aim of this paper is to bridge a gap in the literature and to develop a resource for occupational therapists to employ mindfulness as a clinical intervention with clients …

Critical Access Hospital Nurses' Qualitative Reports Of Major Obstacles In End-Of-Life Care, Con K. Newman

Theses and Dissertations

Background: Critical Care Nurses have previously noted obstacles in caring for dying patients. Obstacles noted by nurses working in more urban settings have been reported. What is not known is the obstacles to providing end-of-life (EOL) care as perceived by nurses working in Critical Access Hospitals (CAHs). Objective: To determine the stories/experiences related to obstacles in providing EOL care as reported by nurses working in CAHs. Methods: This was an exploratory, cross-sectional study. Previous quantitative data has been reported. Documentation of the qualitative stories/experiences of nurses working in CAHs related to obstacles to providing EOL care for dying patients and …

Synthesis And Characterization Of D5-Barbarin For Use In Barbarin-Related Research, Sucheta Kudrimoti, Jacob Machin, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F. Lehner, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Based on structural similarities and equine administration experiments, Barbarin, 5-phenyl-2-oxazolidinethione from Brassicaceae plants, is a possible source of equine urinary identifications of aminorex, (R,S)-5-phenyl-4,5-dihydro-1,3-oxazol-2-amine, an amphetamine-related US Drug Enforcement Administration (DEA) controlled substance considered illegal in sport horses. We now report the synthesis and certification of d₅-barbarin to facilitate research on the relationship between plant barbarin and such aminorex identifications. D₅-barbarin synthesis commenced with production of d₅-2-oxo-2-phenylacetaldehyde oxime (d₅-oxime) from d₅-acetophenone via butylnitrite in an ethoxide/ethanol solution. This d₅-oxime was then reduced with lithium aluminum …

When Comparing Hyperarc And Gammaknife Treatment Techniques For Brain Metastasis, Which Technique Offers Optimal Treatment To Achieve The Highest Biological Effective Dose (Bed)?, Carrie Merfert

Masters Projects

Introduction

HyperArc-VMAT and GammaKnife treatment techniques are both considered to be the best types of SRS treatment methods regarding conformity, homogeneity, gradient, and mean brain dose. The BED calculation is used to calculate the treatment regimens that are effective biologically and used for extrapolation to normal tissue limits.

Methods

This is a retrospective study that analyzes 15 lesions from 10 randomly selected patients with brain metastasis within the cerebrum. Each of the lesions had a single fraction treatment plan created using the same PTV for the HyperArc-VMAT and GammaKnife techniques. Each treatment technique was dose escalated until the healthy brain …

Interobserver Variability Among Expert Readers Quantifying Plaque Volume And Plaque Characteristics On Coronary Ct Angiography: A Clarify Trial Sub-Study, Rebecca Jonas, Shaneke Weerakoon, Rebecca Fisher, William F Griffin, Vishak Kumar, Habib Rahban, Hugo Marques, Ronald P Karlsberg, Robert S Jennings, Tami R Crabtree, Andrew D Choi, James P Earls

Division of Internal Medicine Faculty Papers & Presentations

Background: The difference between expert level (L3) reader and artificial intelligence (AI) performance for quantifying coronary plaque and plaque components is unknown.

Objective: This study evaluates the interobserver variability among expert readers for quantifying the volume of coronary plaque and plaque components on coronary computed tomographic angiography (CCTA) using an artificial intelligence enabled quantitative CCTA analysis software as a reference (AI-QCT).

Methods: This study uses CCTA imaging obtained from 232 patients enrolled in the CLARIFY (CT EvaLuation by ARtificial Intelligence For Atherosclerosis, Stenosis and Vascular MorphologY) study. Readers quantified overall plaque volume and the % breakdown of noncalcified plaque (NCP) …