Medicine and Health Sciences Commons^™

Hiv-1 Tat Upregulates The Receptor For Advanced Glycation End Products And Superoxide Dismutase-2 In The Heart Of Transgenic Mice, Alaa N. Qrareya, Nason S. Wise, Emmanuel R. Hodges, Fakhri Mahdi

Faculty and Student Publications

Cardiovascular disorder (CVD) is a common comorbidity in people living with HIV (PLWH). Although the underlying mechanisms are unknown, virotoxic HIV proteins, such as the trans-activator of transcription (Tat), likely contribute to CVD pathogenesis. Tat expression in mouse myocardium has been found to induce cardiac dysfunction and increase markers of endothelial toxicity. However, the role that Tat may play in the development of CVD pathogenesis is unclear. The capacity for Tat to impact cardiac function was assessed using AC16 human cardiomyocyte cells and adult male and female transgenic mice that conditionally expressed Tat [Tat(+)], or did not [Tat(−)]. In AC16 …

Immunomodulatory Effects Of Plant Extracts From Salvia Deserta Schang. And Salvia Sclarea L., Aizhan Zhussupova, Gaziza Zhumaliyeva, Vyacheslav Ogay, Assel Issabekova

Faculty and Student Publications

Medicines, their safety, effectiveness and quality are indispensable factors of national security, important on a global scale. The COVID-19 pandemic has once again emphasized the importance of improving the immune response of the body in the face of severe viral infections. Plants from the Salvia L. genus have long been used in traditional medicine for treatment of inflammatory processes, parasitic diseases, bacterial and viral infections. The aim of the current study was to evaluate the immunomodulatory effects of plant extracts LS-1, LS-2 from Salvia deserta Schang. and LS-3, LS-4 from Salvia sclarea L. plants growing in southern Kazakhstan by conventional …

Quality Of Life In Older And Younger People With Hiv And Diabetes, Lauren F. O’Connor, La’Marcus Wingate, Sam Simmens, Amanda D. Castel, Anne K. Monroe

Epidemiology Faculty Posters and Presentations

No abstract provided.

Dean's Report- Fall 2022, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.

Phytochemical Investigation Of Egyptian Spinach Leaves, A Potential Source For Antileukemic Metabolites: In Vitro And In Silico Study, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

Spinacia oleracea L., Amaranthaceae, leaves cultivated in Egypt demonstrated a potential antileukemic activity against the chronic myeloid leukemia, K562 cell line. Thus, the aim of this study is to carry out a phytochemical investigation of S. oleracea leaves as well as the isolation of its antileukemic phytoconstituents. Phytochemical investigation of S. oleracea leaves resulted in the isolation of seventeen known compounds. The biological study revealed that compounds hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a remarkable antiproliferative activity against K562 cells in vitro. A mechanistic in silico study showed that hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a strong binding …

Effects Of Covid-19 On Pregnant Women And Newborns: A Review, Bhavesh M. Patel, Deepesh Khanna, Siya Khanna, Vera Hapshy, Pragya Khanna, Payal Kahar, Mayur S. Parmar

HPD Articles

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus originated in Wuhan, China, and spread all over the world, causing the worst pandemic of the century. The disease has a broad continuum of clinical presentations, from mild to life-threatening. The virus is highly contagious and transmittable to humans. Emerging evidence of its effects on pregnant women and newborns is inconsistent and ever-evolving. Therefore, the objective of this review is to compile the scientific literature on the effects of SARS-CoV-2 coronavirus on pregnancy, pregnant women, and newborns. Data were obtained by several authors using PubMed, MEDLINE, Google Scholar, and Web …

Mechanistic Research Approaches In Music Therapy For Pain: Humanizing And Contextualized Options For Clinician-Researchers, Andrea M. Hunt

College of Performing Arts Departmental Research

No abstract provided.

The Impact Of Adverse Childhood Experiences On Type 2 Diabetes Mellitus And The Role Of Early Intervention, Alexus S. Yang, Jay Jamieson, Justin Gambini

Doctor of Medical Science (DMSc)

ABSTRACT

Purpose: The purpose of this article is to provide an understanding of negative health effects of adverse childhood experiences (ACEs) on Type II Diabetes Mellitus and the role of primary healthcare providers in decreasing morbidity and mortality through screening and intervention. Method: A literature search was conducted through PubMed, EBSCO, ProQuest Education and PLOS ONE using keywords such as: adverse childhood experiences (ACEs), type 2 diabetes mellitus, primary care intervention. The most relevant articles were selected with additional selectivity based on the publication year as the basis for this piece.

Results: Currently, minimal information exists on the …

Care Of The Heart, Loma Linda University Health

Scope

Table of Contents

Features
14 | Campus of cardiac care
18 | The hearts of women
22 | Cardiopulmonary rehab
24 | Robotic surgery at LLUH
26 | Interventional procedures
28 | St. Paisley Day
30 | Heart health through nutrition

Departments
4 | From the President: Health care
8 | News: Clinical and campus news
38 | Alumni: Serving our world
44 | Annual Report: The year's people and stats

Santa Clara Magazine, Volume 63 Number 2, Fall 2022 [Print Issue 62:2], Santa Clara University

Santa Clara Magazine

14 - AFTER THE CANNONBALL What does it mean to wrestle with your own human limitations and vulnerability as you follow the footsteps of a saint? Hung Pham, S.J.

18 - GROWING When I was little, there seemed to be this nondescript era of life, a foggy “someday,” when becoming an adult just happened. Nikhita Panjnani ’24.

20 - HOW IT STARTED, HOW IT'S GOING For decades, the internet has shaped the way we communicate, but two years of being extremely online hit fast forward on its real-world impact. Matt Morgan.

26 - NURTURING NATURE A story in two stories: …

College Of Health Sciences Newsletter, College Of Health Sciences, Old Dominion University

Ellmer College of Health Sciences Newsletters

October 2022 issue of Old Dominion University's College of Health Sciences Newsletter.

Diabetic Ketoacidosis Intravenous Fluids, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Acute Otitis Media: Low Dose Versus High Dose Amoxicillin, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

The Crucial Role Of Nurses In Promoting Quality Of Life Of Cancer Patients Through Therapeutic Communication, Yvonne Tan

Honors Program Contracts

No abstract provided.

Croup: Observation Time Post Racemic Epinephrine Dosing In Children With Croup, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Genetic Quality: A Complex Issue For Experimental Study Reproducibility., Atsushi Yoshiki, Gregory Ballard, Ana V Perez

Faculty Research 2022

Laboratory animal research involving mice, requires consideration of many factors to be controlled. Genetic quality is one factor that is often overlooked but is essential for the generation of reproducible experimental results. Whether experimental research involves inbred mice, spontaneous mutant, or genetically modified strains, exercising genetic quality through careful breeding, good recordkeeping, and prudent quality control steps such as validation of the presence of mutations and verification of the genetic background, will help ensure that experimental results are accurate and that reference controls are representative for the particular experiment. In this review paper, we will discuss various techniques used for …

Animals, Quality And The Pursuit Of Relevance., Karen L. Svenson, Stephen D Krasinski, Michael Ellis, Nadia Rosenthal, Edison Liu, Kenneth H Fasman

Faculty Research 2022

In 2021, the National Institutes of Health Advisory Committee to the Director (ACD) announced recommendations to improve the reproducibility of biomedical research using animals. In response, The Jackson Laboratory faculty and institutional leaders identified key strategies to further address this important issue. Taking inspiration from the evolution of clinical trials over recent decades in response to similar challenges, we identified opportunities for improvement, including establishment of common standards, use of genetically diverse populations, requirement for robust study design with appropriate statistical methods, and improvement in public databases to facilitate meta-analyses. In this Perspective, we share our response to ACD recommendations, …

A Standardized Nomenclature For Mammalian Histone Genes., Ruth L Seal, Paul Denny, Elspeth A Bruford, Anna K Gribkova, David Landsman, William F Marzluff, Monica Mcandrews, Anna R Panchenko, Alexey K Shaytan, Paul B Talbert

Faculty Research 2022

Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resulted in agreement amongst experts on a revised systematic protein nomenclature for histones, which is based on a combination of phylogenetic classification and historical symbol usage. Human and mouse histone gene symbols previously followed a genome-centric system that was not applicable across all vertebrate species and did not reflect the systematic histone protein nomenclature. This prompted a collaboration between histone experts, the Human Genome Organization (HUGO) Gene …

Autosomal Recessive Lrp1-Related Syndrome Featuring Cardiopulmonary Dysfunction, Bone Dysmorphology, And Corneal Clouding., Paul R Mark, Stephen A Murray, Tao Yang, Alexandra Eby, Angela Lai, Di Lu, Jacob Zieba, Surender Rajasekaran, Elizabeth A Vansickle, Linda Z Rossetti, Lucia Guidugli, Kelly Watkins, Meredith S Wright, Caleb P Bupp, Jeremy W Prokop

Faculty Research 2022

We provide the first study of two siblings with a novel autosomal recessive LRP1-related syndrome identified by rapid genome sequencing and overlapping multiple genetic models. The patients presented with respiratory distress, congenital heart defects, hypotonia, dysmorphology, and unique findings, including corneal clouding and ascites. Both siblings had compound heterozygous damaging variants, c.11420G > C (p.Cys3807Ser) and c.12407T > G (p.Val4136Gly) in

Acute Otitis Media, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Neuromuscular Patients Undergoing Major Orthopedic Surgery Eras, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Mainegeneral Hrsa Rcorp Grant Summary, Mary Lindsey Smith Phd, Evelyn Ali Bs, Katharine Knight, Tyler Egeland Ba

Substance Use Research & Evaluation

MaineGeneral received a Rural Communities Opioid Response Program (RCORP) Implementation grant to further the work of the Substance Use Prevention Expanded Recovery (SUPER) Consortium. Over the course of the three-year grant, the SUPER Consortium: (1) expanded harm reduction work, including naloxone distribution, and (2) increased organizational capacity to treat and prevent SUD through education efforts in healthcare organizations, first responder organizations, community organizations, and schools. The Substance Use Research and Evaluation team at the University of Southern Maine’s Catherine Cutler Institute was contracted to evaluate MaineGeneral’s RCORP grant. This grant summary presentation includes data from community outreach and training grant …

Highlighting The Mechanistic Relationship Between Perinatal Depression And Preeclampsia: A Scoping Review, Mei Yuan, Samantha Bedell, Barbra De Vrijer, Genevieve Eastabrook, Jefferson C. Frisbee, Stephanie J. Frisbee

Obstetrics & Gynaecology Publications

Background: Although there is scientific literature supporting an association between depression and preeclampsia (PE), little is known about the underlying mechanistic pathways that may explain these observed associations. Thus, this study aimed to outline the relationship between depression and PE, and to highlight the underlying cardiovascular and metabolic risk factors that are common to both. Methods: A scoping review of the literature was conducted in Medline, Scopus, and Web of Science. Results: From 706 articles initially identified, 23 articles met the inclusion criteria and were included in this review. Although some studies reported a positive association between PE and postpartum …

Cancer Incidence And Stage At Diagnosis Among People With Psychotic Disorders: Systematic Review And Meta-Analysis., Jared C Wootten, Joshua C Wiener, Phillip S Blanchette, Kelly K. Anderson

Epidemiology and Biostatistics Publications

Research regarding the incidence of cancer among people with psychotic disorders relative to the general population is equivocal, although the evidence suggests that they have more advanced stage cancer at diagnosis. We conducted a systematic review and meta-analysis to examine the incidence and stage at diagnosis of cancer among people with, relative to those without, psychotic disorders. We searched the MEDLINE, EMBASE, PsycINFO, and CINAHL databases. Articles were included if they reported the incidence and/or stage at diagnosis of cancer in people with psychotic disorders. Random effects meta-analyses were used to determine risk of cancer and odds of advanced stage …

Examining Bourdieu’S Concepts Of Capital, Habitus, And Field In Women’S Health Research In Nigeria: A Feminist Perspective, Mary Ndu

Health Studies Publications

Global health’s persistent focus on women’s health-seeking behaviour necessitates a philosophical understanding of the meaning behind women’s health decision-making. In studying health-seeking behaviour, researchers use philosophical paradigms to explicate and understand complex social concepts that continue to maintain health inequities and injustices. A commonly used theory is Bourdieu’s Theory of Practice. This paper examines the scholastic application of Bourdieu’s theory of practice to theorize women’s health-seeking behaviour in qualitative research to understand the rationale behind using health services. The theory of practice consists of four concepts: practice, habitus, field, and capital. Each concept conceptualizes the theory to find a logical …

Objective Structured Clinical Evaluation For Volume Control And Pressure Control Ventilator Modes, Brian Bailey, Anthony Newsom

Doctoral Projects

The purpose of this doctoral project was to create a tool to teach student registered nurse anesthetists (SRNAs) in The University of Sothern Mississippi’s (USM’s) anesthesia program about pressure control and volume control ventilator modes, and how to use them. To accomplish this goal an Objective Structured Clinical Examination (OSCE) was developed. The framework used for creating this OSCE was Kolb's Theory. Kolb's Theory uses a four-stage learning cycle in which the learner encounters a new experience, reflects on the observations of said new experience, conceptualizes or modifies a concept based on this experience, and then applies their idea to …

Quality Improvement For Patients With Alcohol Withdrawal Syndrome Starts With An Evaluation Tool, Jessica Bass

Doctoral Projects

Patients with alcohol withdrawal syndrome (AWS) have adverse outcomes to the traditional methods of assessing for and treating withdrawal within the intensive care unit (ICU), which includes a standardized treatment plan. Some negative outcomes include acquiring costly and dangerous hospital-acquired infections, safety concerns, and traumatic experiences that deter further treatment. More individualized assessments and treatments are needed to prevent or decrease the severity of AWS from occurring in critical care settings, which will facilitate more positive outcomes and experiences for the staff and patients. The Minnesota detoxification scale has been shown to be a more appropriate tool for the critical …

Alumni Journal - Volume 93, Number 3, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
6 | From the Dean

News
8 | Alumni News + This and That
10 | APC 2023 Preview
12 | School of Medicine News
14 | Students
16 | Department Reports: Family Medicine

Bioethics
18 | What Does the Lord Require of Us?

Features
26 | Alumni Mission Stories
28 | Malawi
30 | Kenya
34 | Nigeria
36 | Ukraine
41 | Alumni Trips 2022
46 | Life After Medicine
48 | Historical Snapshot

In Memoriam
51 | Alumni Remembered

Exploring The Occupational Transition Of Leaving A Cult, Justine Thompson, Baylee R. Chelossi, Emily Osborn, Christian Jan Quitoriano

Occupational Therapy | Graduate Student Research Posters

No abstract provided.

The Innovator - Fall 2022, Matthew Hamel

Faculty Affairs & Research Newsletters - The Innovator

Newsletter published by the Offices of Faculty Affairs & Research