Medicine and Health Sciences Commons^™

In Vivo Metabolic Analysis Of The Anticancer Effects Of Plasma-Activated Saline In Three Tumor Animal Models, Miao Qi, Dehui Xu, Shuai Wang, Bing Li, Sansan Peng, Qiaosong Li, Hao Zhang, Runze Fan, Hai-Lan Chen, Michael G. Kong

Bioelectrics Publications

In recent years, the emerging technology of cold atmospheric pressure plasma (CAP) has grown rapidly along with the many medical applications of cold plasma (e.g., cancer, skin disease, tissue repair, etc.). Plasma-activated liquids (e.g., culture media, water, or normal saline, previously exposed to plasma) are being studied as cancer treatments, and due to their advantages, many researchers prefer plasma-activated liquids as an alternative to CAP in the treatment of cancer. In this study, we showed that plasma-activated-saline (PAS) treatment significantly inhibited tumor growth, as compared with saline, in melanoma, and a low-pH environment had little effect on tumor growth in …

Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression And Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1–Induced Acute Lung Injury In K18-Hace2 Transgenic Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, John D. Catravas

Bioelectrics Publications

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, alcohol consumption increased markedly. Nearly one in four adults reported drinking more alcohol to cope with stress. Chronic alcohol abuse is now recognized as a factor complicating the course of acute respiratory distress syndrome. and increasing mortality. To investigate the mechanisms behind this interaction, we developed a combined acute respiratory distress syndrome and chronic alcohol abuse mouse model by intratracheally instilling the S1 subunit of SARS-CoV-2 spike protein (S1SP) in K18-human angiotensin-converting enzyme 2 (ACE2) transgenic mice that express the human ACE2 receptor for SARS-CoV-2 and are kept on an …

The Heat Shock Protein 90 Inhibitor, At13387, Protects The Alveolo-Capillary Barrier And Prevents Hci-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, Betsy Gregory, Tierney Day, John D. Catravas

Bioelectrics Publications

Hydrochloric acid (HCl) exposure causes asthma-like conditions, reactive airways dysfunction syndrome, and pulmonary fibrosis. Heat Shock Protein 90 (HSP90) is a molecular chaperone that regulates multiple cellular processes. HSP90 inhibitors are undergoing clinical trials for cancer and are also being studied in various pre-clinical settings for their anti-inflammatory and anti-fibrotic effects. Here we investigated the ability of the heat shock protein 90 (HSP90) inhibitor AT13387 to prevent chronic lung injury induced by exposure to HCl in vivo and its protective role in the endothelial barrier in vitro. We instilled C57Bl/6J mice with 0.1N HCl (2 µL/g body weight, intratracheally) and …

The Paradox Of Pulmonary Vascular Resistance: Restoration Of Pulmonary Capillary Recruitment As A Sine Qua Non For True Therapeutic Success In Pulmonary Arterial Hypertension, David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Nathan Messas, Michele Giovinazzo, John D. Catravas

Bioelectrics Publications

Exercise-induced increases in pulmonary blood flow normally increase pulmonary arterial pressure only minimally, largely due to a reserve of pulmonary capillaries that are available for recruitment to carry the flow. In pulmonary arterial hypertension, due to precapillary arteriolar obstruction, such recruitment is greatly reduced. In exercising pulmonary arterial hypertension patients, pulmonary arterial pressure remains high and may even increase further. Current pulmonary arterial hypertension therapies, acting principally as vasodilators, decrease calculated pulmonary vascular resistance by increasing pulmonary blood flow but have a minimal effect in lowering pulmonary arterial pressure and do not restore significant capillary recruitment. Novel pulmonary arterial hypertension …

Endothelial Cell-Derived Extracellular Vesicles Impair The Angiogenic Response Of Coronary Artery Endothelial Cells, Nigeste Carter, Allison H. Mathiesen, Noel Miller, Michael Brown, Ruben M.L. Colunga Biancatelli, John D. Catravas, Anca D. Dobrian

Bioelectrics Publications

Cardiovascular disease (CVD) is the most prominent cause of death of adults in the United States with coronary artery disease being the most common type of CVD. Following a myocardial event, the coronary endothelium plays an important role in the recovery of the ischemic myocardium. Specifically, endothelial cells (EC) must be able to elicit a robust angiogenic response necessary for tissue revascularization and repair. However, local or distant cues may prevent effective revascularization. Extracellular vesicles (EV) are produced by all cells and endothelium is a rich source of EVs that have access to the main circulation thereby potentially impacting local …

Activation Of Cannabinoid-2 Receptor Protects Against Pseudomonas Aeruginosa Induced Acute Lung Injury And Inflammation, Nagaraja Nagre, Gregory Nicholson, Xiaofei Cong, Janette Lockett, Andrew C. Pearson, Vincent Chan, Woong-Ki Kim, K. Yaragudri Vinod, John D. Catravas

Bioelectrics Publications

Background

Bacterial pneumonia is a major risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Pseudomonas aeruginosa (PA), an opportunistic pathogen with an increasing resistance acquired against multiple drugs, is one of the main causative agents of ALI and ARDS in diverse clinical settings. Given the anti-inflammatory role of the cannabinoid-2 receptor (CB2R), the effect of CB2R activation in the regulation of PA-induced ALI and inflammation was tested in a mouse model as an alternative to conventional antibiotic therapy.

Methods

In order to activate CB2R, a selective synthetic agonist, JWH133, was administered intraperitoneally (i.p.) to C57BL/6J …

How To Alleviate Cardiac Injury From Electric Shocks At The Cellular Level, Pamela W. Sowa, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova

Bioelectrics Publications

Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome. Copolymers such as Poloxamer 188 (P188) are known to preserve the membrane integrity and viability of electroporated cells, but their utility against cardiac injury from cardiopulmonary resuscitation (CPR) remains to be established. We studied the time course of cell killing, mechanisms of cell death, and protection with P188 in AC16 human cardiomyocytes exposed to micro- or nanosecond pulsed electric field (μsPEF and nsPEF) shocks. A 3D printer was customized with an electrode holder to precisely position electrodes orthogonal to …

In Vitro And In Vivo Correlation Of Skin And Cellular Responses To Nucleic Acid Delivery, M. Bosnjak, K. Znidar, A. Sales Conniff, T. Jesenko, B. Markelc, Nina Semenova, J. Tur, K. Kohena, S. Kranjc Brezar, L. Heller, M. Cemazar

Bioelectrics Publications

Skin, the largest organ in the body, provides a passive physical barrier against infection and contains elements of the innate and adaptive immune systems. Skin consists of various cells, including keratinocytes, fibroblasts, endothelial cells and immune cells. This diversity of cell types could be important to gene therapies because DNA transfection could elicit different responses in different cell types. Previously, we observed the upregulation and activation of cytosolic DNA sensing pathways in several non-tumor and tumor cell types as well in tumors after the electroporation (electrotransfer) of plasmid DNA (pDNA). Based on this research and the innate immunogenicity of …

Mechanisms Of Memory Updating: State Dependency Vs. Reconsolidation, Christopher Kiley, Colleen M. Parks

Psychology Faculty Research

Reactivating a memory trace has been argued to put it in a fragile state where it must undergo a stabilization process known as reconsolidation. During this process, memories are thought to be susceptible to interference and can be updated with new information. In the spatial context paradigm, memory updating has been shown to occur when new information is presented in the same spatial context as old information, an effect attributed to a reconsolidation process. However, the integration concept holds that memory change can only occur when reactivation and test states are the same, similar to a state-dependent effect. Thus, in …

Prevalence And Determinants Of Home Delivery In Urban And Rural Philippines: Evidence From The 2017 National Demographic And Health Survey, Arianna Maever L. Amit, Veincent Christian F. Pepito, Sarah J. De Los Reyes, Clinton S. Tang, Neil Andrew K. Aliazas, Lourdes S. Tanchanco

Ateneo School of Medicine and Public Health Publications

Background: Women’s choice of place of delivery has implications on maternal and child mortality. This study aims to provide an updated and detailed comparison of prevalence and determinants of home delivery in the Philippines, and in urban and rural communities.

Methods: Based on data from the 2017 Philippine National Demographic and Health Survey (NDHS), we estimated the prevalence of home delivery and determined factors influencing women’s decision to deliver at home. Analyses were restricted to data from 7229 women who were cohabiting or married, and their last-born child using logistic regression methods for survey data.

Results: There remain a considerable …

Determinants Of Consistent Condom Use Among Filipino Women: Results From The 2017 Philippine National Demographic And Health Survey, Veincent Christian F. Pepito, Arianna Maever L. Amit, Clinton S. Tang, Ryan Gabriel C. Molen, Luis Miguel B. Co, Neil Andrew K. Aliazas, Sarah J. De Los Reyes, Lourdes S. Tanchanco

Ateneo School of Medicine and Public Health Publications

Background: Consistent condom use in women, defined as the self-reported usage of male condom in every sexual encounter of the respondent with her most recent partner in the last 12 months, had been perennially low in the Philippines. This is despite consistent condom use being a tested and proven public health intervention to prevent unwanted pregnancy and sexually transmitted infections. Considering the high fertility rate, teenage pregnancy rate, and the rapidly increasing incidence of HIV in the country, we identified the determinants of consistent condom use in the Philippines.

Methods: We used data from the individual recode of the 2017 …

Covid-19 Vaccine Brand Hesitancy And Other Challenges To Vaccination In The Philippines, Arianna Maever L. Amit, Veincent Christian F. Pepito, Lourdes S. Tanchanco, Manuel Dayrit

Ateneo School of Medicine and Public Health Publications

Effective and safe COVID-19 vaccines have been developed at a rapid and unprecedented pace to control the spread of the virus, and prevent hospitalisations and deaths. However, COVID-19 vaccine uptake is challenged by vaccine hesitancy and anti-vaccination sentiments, a global shortage of vaccine supply, and inequitable vaccine distribution especially among low- and middle-income countries including the Philippines. In this paper, we explored vaccination narratives and challenges experienced and observed by Filipinos during the early vaccination period. We interviewed 35 individuals from a subsample of 1,599 survey respondents 18 years and older in the Philippines. The interviews were conducted in Filipino, …

Detection Of Progression Or Regression Of Gynecologic Cancers By Circulating Tumor Dna (Ctdna), Bipin Ghimire, Ujjwal Karki, Emma Herrman, Mohammad Muhsin Chisti

Conference Presentation Abstracts

Objectives The use of post-operative circulating tumor DNA (ctDNA) to detect cancer recurrence has been reported in various studies but the literature describing variable changes in ctDNA is limited. The objective of this study is to describe the utility of single and serial ctDNA values in detecting the progression or regression of gynecological cancers.

Methods This is a retrospective observational study including nineteen patients, aged >=18 years who had the ctDNA test completed at hematology/oncology clinic of William Beaumont – Royal Oak and Troy Hospitals, Michigan, USA.

Results Among the nineteen patients, fifteen had breast, three had ovarian, and one …

Mindfulness And The Veteran: Increasing Veteran Participation In Mindfulness Programs At A Va Medical Center, Cynthia Lang-Groening

West Chester University Doctoral Projects

The U.S. Department of Veterans Affairs (VA) supports the use of mindfulness-based therapies for the medical and mental health treatment of veterans. The Wilmington, Delaware VA Medical Center (VAMC) offers mindfulness-based programs in guided imagery, tai chi and mindful meditation; however, the veterans who receive primary care services do not participate in these programs to their full potential. The purpose of this quality improvement (QI) project was to increase veteran participation in the mindfulness-based programs at the Wilmington VAMC. Based on a retrospective chart review of veterans’ electronic medical records (EMR), mindfulness-based program referral and enrollment patterns were analyzed, and …

Predicting Cancer Immunotherapy Response From Gut Microbiomes Using Machine Learning Models, Hai Liang, Jay-Hyun Jo, Zhiwei Zhang, Margaret A Macgibeny, Jungmin Han, Diana M Proctor, Monica E Taylor, You Che, Paul Juneau, Andrea B Apolo, John A Mcculloch, Diwakar Davar, Hassane M Zarour, Amiran K Dzutsev, Isaac Brownell, Giorgio Trinchieri, James L Gulley, Heidi H Kong

Faculty, Staff and Student Publications

Cancer immunotherapy has significantly improved patient survival. Yet, half of patients do not respond to immunotherapy. Gut microbiomes have been linked to clinical responsiveness of melanoma patients on immunotherapies; however, different taxa have been associated with response status with implicated taxa inconsistent between studies. We used a tumor-agnostic approach to find common gut microbiome features of response among immunotherapy patients with different advanced stage cancers. A combined meta-analysis of 16S rRNA gene sequencing data from our mixed tumor cohort and three published immunotherapy gut microbiome datasets from different melanoma patient cohorts found certain gut bacterial taxa correlated with immunotherapy response …

The Role Of Socioeconomic Status In Cognition And Brain Health Across The Lifespan, Erica Chung

Honors Theses

Disparities in cognition are inevitable throughout the lifespan due to socioeconomic gaps. Individuals of lower socioeconomic status (SES) may have fewer access to environmental resources, especially with regard to education, than individuals of higher socioeconomic status. Differences in available resources from a young age may affect brain development, leading to detriments in cognition and behavior, further impacting socioeconomic success in adulthood. In the present study, we modeled the development of the dorsolateral prefrontal cortex (DLPFC) and changes in cognitive function throughout the life trajectory in the Nathan Kline Institute for Psychiatric Research Rockland Sample. The DLPFC volume was predicted to …

Understanding The Role Of Race In American Medicine, Fariel C. A. Lamountain

Honors Theses

Long running inequity in health care and outcomes in the United States stem from failure to acknowledge the underlying role of the Transatlantic slave trade as it manifests in all facets of American society and commerce. This paper focuses specifically on the American medical system and its foundations to understand the precursors to generational trends in lack of access to healthcare and poor health for Black communities. This paper uses a three-pronged approach to understand the racist cycle of inequity, highlighting the history and origins of racism in American medicine, personal accounts and statistical evidence of inequity, and community and …

Pfas Environmental Contamination In Central Maine, Megan H. Andersen

Honors Theses

PFAS (per- and polyfluoroalkyl substances) are toxic, persistent, and bioaccumulative chemicals that are used in a variety of consumer products and industrial applications. Paper mills across the state of Maine have used PFAS in their industrial paper making processes, and their wastes often flow for treatment into municipal sewage treatment facilities. PFAS contaminated municipal wastewater from the general use of PFAS consumer products are also processed by these plants. Liquid waste is condensed into solid waste septage and sludge, and in what was thought to be an environmentally friendly repurposing practice, municipal sludge and septage has been spread on plots …

Science And Sadness: Critiques On How We Handle Alzheimer’S Disease And Dementia, Katherine Martinez

Honors Theses

In our society, an individual’s worth is tied to the state of their cognitive function which affects the discourse about neurodegenerative illnesses, causing it to mostly fall under two branches: “The Dread” and “Science as the Holy Grail”. “The Dread” addresses how Alzheimer’s Disease (AD) and other dementias are typically perceived as devastating illnesses to be feared. “Science as the Holy Grail” represents the hope and faith that is invested into potential technoscientific developments without the guarantee of any consequential results. Limiting the narrative to these two categories negatively impacts the quality of life (QOL) of AD patients, caregivers, and …

Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman

Honors Theses

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that affects over 5 million individuals in the United States alone. While AD is primarily thought of as a disease that destroys neural networks required for memory recall and formation, AD also cause impairment in emotional regulation, cognitive flexibility, and executive function pathways. The cause of AD is unknown; however, the allele ApoE4 has been identified as a risk factor for the onset of AD. ApoE4 provides a valuable opportunity to study AD through animal models. This thesis utilized a human ApoE4 transgenic rat model (hApoE4) to investigate the biological and behavioral …

The New Mainers: An Exploratory Analysis Of Healthcare Experiences In The Somali Bantu Community, Jordan R. Mcclintock

Honors Theses

Healthcare inequities within the United States’ Western model of medicine have existed for hundreds of years. The purpose of this year-long project was to analyze the existing qualitative and quantitative studies of healthcare barriers for the Southern Maine Somali Bantu population, as well as compiling narrative pieces from Maine non-governmental organizations that provide community resources. In doing so, the idea of healthcare access and literacy was analyzed through means of understanding systemic barriers. Overall, the findings of this exploratory project point to a lack of cultural humility within medicine, the importance of recognizing intersectional identities in quality of healthcare, and …

"It’S Just Another Thing”: Perceptions Of Well Water Quality And Barriers In An Arsenic Hot Spot, Linzy Rosen

Honors Theses

Privately owned water is the primary source of drinking water for 43 million Americans. Although residential or private wells are susceptible to a variety of contaminants, the Safe Drinking Water Act of 1974 positions individuals as responsible for the testing, remediation, and management of this water. Despite the elevated presence of arsenic in Maine, which is linked to various cancers, cardiovascular disease, and neurological damage, little is known about how private well owners perceive the safety and quality of their own water.

This study takes a qualitative approach to understanding concerns and opinions by conducting semi - structured interviews with …

The Multifront Battle Waged Against Female Autonomy: A Comparative Study Of Ancient Medical And Literary Texts, Leah K. Montello

Honors Theses

Male authors have long waged a multifront campaign against female independence. In this thesis, I focus on two specific fronts: literary and medical texts of the Classical Greek period. This thesis intends to explore the varying strategies in a selection of works, employed to reinforce prescribed gender norms. I approach this with a feminist lens to critique attempts made by elite educated Greek men to define what a woman ought to be like. I do not, however, explore every single tactic a medical and literary writer has applied to uphold patriarchal norms. My two body chapters revolve respectively around two …

Don’T Go Shocking My Heart, Christinia Patel, Md, Shelley Schoepflin Sanders

Articles, Abstracts, and Reports

2022-2023 PGY1

No Need To Schedule That Colonoscopy!, Banu Ramachandran, Md, Laura Loertscher, Md

Articles, Abstracts, and Reports

2022-2023 PGY3

Effects Of Thai Traditional Formularies Medicine Treatment In The Breast Cancer Mouse Model, Ariya Khamwut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Breast cancer (BC) is an important global health problem impacting women globally. Standard treatments are also limited, so developing novel alternative therapies is needed. Thai traditional formulary medicines (TTFMs) comprise various herbs, which have been reported to contain anti-cancer properties to treat several types of cancer. The TTFM recipes utilized in the current investigation were taken from the traditional Thai medicine scripture, Atisaravak scripture. These TTFMs have been used to treat cancer and digestive systems disorders. Nevertheless, the impact of TTFMs' anti-cancer activities on breast cancer is poorly understood. Moreover, the underlying molecular mechanism of TTFM still needs to be …

ความแตกต่างระหว่างระดับเมตาเนฟรินในพลาสมาที่ได้จากการเจาะเลือดจากหลอดเลือดดำโดยตรงและการดูดเลือดจากสายสวนหลอดเลือดหลังเจาะคาไว้ในผู้ป่วยความดันโลหิตสูง, วรรณิดา พิศุทธิ์สวัสดิ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มา: ปัจจัยก่อนการตรวจวิเคราะห์มีผลต่อระดับเมตาเนฟรินในพลาสมา ความเจ็บปวดระหว่างการเจาะเลือดอาจส่งผลต่อระบบประสาทซิมพาเทติก และระดับเมตาเนฟรินในพลาสมา การศึกษานี้มีวัตถุประสงค์เพื่อศึกษาความแตกต่างของระดับเมตาเนฟรินในพลาสมาที่ได้จากการเจาะเลือดจากหลอดเลือดดำเทียบกับการดูดเลือดจากสายสวนหลอดเลือดในผู้ป่วยความดันโลหิตสูง วิธีการศึกษา: ผู้ป่วยความดันโลหิตสูงทั้งหมด 68 คน ได้รับการใส่สายสวนหลอดเลือดที่ข้อพับแขน และเก็บเลือดจากสายสวนหลอดเลือดหลังเจาะคาไว้และนอนหงายเป็นเวลา 30 นาที หลังจากนั้นเก็บเลือดจากการเจาะเลือดบริเวณเส้นเลือดดำที่ข้อพับแขนอีกข้างหนึ่งในเวลาใกล้เคียงกัน ส่งตรวจวัดระดับเมตาเนฟรินในพลาสมาที่ได้จากการเก็บเลือดทั้ง 2 วิธี ผลการศึกษา: ค่าเฉลี่ยของระดับนอร์เมตาเนฟรินในพลาสมาที่ได้จากการเจาะเลือดจากหลอดเลือดดำโดยตรงมีค่าสูงกว่าการดูดเลือดจากสายสวนหลอดเลือดหลังเจาะคาไว้ อย่างมีนัยสำคัญทางสถิติ โดยมีความแตกต่างเฉลี่ย 4.14 พิโคกรัมต่อมิลลิลิตร, 95% CI 0.22 ถึง 8.06, p-value 0.039 และร้อยละของความแตกต่างเฉลี่ย ร้อยละ 8.06, 95% CI 2.44 ถึง 13.69, p-value 0.006 แต่ค่าเฉลี่ยของระดับเมตาเนฟริน และระดับเมทอกซีไทรามีนในพลาสมาจากการเก็บเลือดทั้ง 2 วิธี ไม่มีความแตกต่างกันอย่างมีนัยสำคัญทางสถิติ นอกจากนี้คะแนนความเจ็บปวดไม่มีความสัมพันธ์กับการเปลี่ยนแปลงของระดับเมตาเนฟรินในพลาสมา สรุปผล: การเก็บเลือดจากการเจาะเลือดจากหลอดเลือดดำโดยตรงเพื่อตรวจระดับนอร์เมตาเนฟรินในพลาสมาในผู้ป่วยความดันโลหิตสูง พบว่ามีค่าสูงกว่าการดูดเลือดจากสายสวนหลอดเลือด ดังนั้นต้องพิจารณาถึงวิธีการเก็บเลือดซึ่งอาจส่งผลต่อการแปลผลการตรวจระดับเมตาเนฟริน นอร์เมตาเนฟริน และเมทอกซีไทรามีนในพลาสมา

The Observation Of Relative Occlusal Forces Of Posterior Implant-Supported Fixed Prostheses In Tooth-Borne And Distal End Circumstance By Using T-Scan System : A Prospective Study, Jinjudhapak Thongdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: to assess the relative occlusal forces (ROF) of posterior implants in two different occlusion designs in tooth-borne and distal end circumstances over time using the T-scan system and to compare the marginal bone loss in those situations and designs over time. Material and methods: Twenty patients requiring single posterior or distal end implants were randomly assigned to two groups: Implant-protected occlusion (IPO) or load (LOAD). The ROFs were measured using a T-scan on five occasions. Custom-made jigs were used to collect periapical parallel x-rays. The implant platforms were used as a reference to assess marginal bone loss. Results: In …

A Comparison Of Shear Bond Strength On Human Dentin Using Acrylic Resin Cement And Self-Adhesive Resin Cements With The Use Of Universal Adhesives, Phatcha Maiwatana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To evaluate the shear bond strength of human dentin with two different phosphate-monomer containing self-adhesive resin cements, an acrylic resin cement, and the effect of universal adhesive pretreatment on human dentin. Materials and Methods: Fifty extracted human third molars with the superficial dentin exposure at the buccal side were prepared. Resin composite cylinders with 2.38 mm diameter were cemented with 5 groups of resin cements and universal adhesives: Rely X U200, Single Bond Universal Adhesive with Rely X U200, Panavia SA Luting Multi, Clearfil Tri-S Bond Universal Quick with Panavia SA Luting Multi, and Super Bond C&B. Then, the …

Translation And Validation Of A Thai Version Of The Xerostomia Inventory, Chotima Lapnimitanun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: This study aimed to translate and validate the Xerostomia Inventory (XI) and Summated Xerostomia Inventory (SXI) -Thai version in Thai middle-aged and older adults Methods: This study was a cross-sectional study which consisted of translation and validation phases. The XI and SXI were cross-culturally forward and backward translated and validated in 200 middle-aged and older Thai adults. The validity relied on the content, construct, and criterion validity. The reliability was determined by internal consistency. Results: The translation was done with good content validity. Both discriminant validity, which can distinguish between xerostomia and non-xerostomia groups, and the convergent validity, which …