Medicine and Health Sciences Commons^™

Rationalization Of The Laboratory Diagnosis For Good Management Of Malaria: Lessons From Transitional Methods, Neguemadji N. Ngaba, Imteyaz A. Khan, Namrata Hange, Maria Kezia Lourdes Ligsay Pormento, Manoj Kumar Reddy Somagutta, Ajay Kumar, Youssouf Abdelkerim, Alarangue Djindimadje, Samia Jahan

Ateneo School of Medicine and Public Health Publications

Introduction. Malaria is an endemic disease in sub-Saharan Africa. In clinical practice, the main concern is the overdiagnosis of malaria leading to inappropriate drug prescription without laboratory confirmation. Objective. This study aimed to evaluate clinical examination reliability compared with translational laboratory methods of malaria diagnosis. Methods. The study was conducted in Goundi Hospital among hospitalized patients over a seven-month period. Patients were interviewed, and malaria tests done included the Giemsa-stained thick and thin blood smears. Diagnostic accuracy was analysed by calculating sensitivity, specificity, and predictive values. Results. Among 1,874 participants, 674 (35.96%) patients had positive Giemsa-stained …

The Challenges Of Combatting Antimicrobial Resistance In The Philippines, Janine Patricia G. Robredo, Michelle Ann B. Eala, Joseph A. Paguio, Maria Sonia S. Salamat, Leo Anthony G. Celi

Ateneo School of Medicine and Public Health Publications

No abstract provided.

Prevalence, Determinants And Outcomes Of Traditional, Complementary And Alternative Medicine Use For Hypertension Among Low-Income Households In Malaysia And The Philippines, Lia M. Palileo-Villanueva, Benjamin Palafox, Arianna Maever L. Amit, Veincent Christian F. Pepito, Fadhlina Ab-Majid, Farnaza Ariffin, Dina Balabanova, Mohamad-Rodi Isa, Nafiza Mat-Nasir, Mazapuspavina My

Ateneo School of Medicine and Public Health Publications

Background

Traditional, complementary and alternative medicine (TCAM) is used to treat a broad range of conditions. In low- and middle-income countries (LMICs), TCAM use is particularly common among those with low socio-economic status. To better understand the patterns and impact of TCAM use on the management of non-communicable diseases in these populations, this study examines the prevalence and characteristics of TCAM use for hypertension, its determinants, and its association with hypertension management outcomes and wellbeing among low-income adults in two Southeast Asian countries at different levels of economic and health system development, Malaysia and the Philippines.

Methods

We analysed cross-sectional …

Consumer Health Information Services In Philippine Libraries: Navigating Obstacles And Capitalizing On Opportunities, Joenabie Encanto Arevalo

Ateneo School of Medicine and Public Health Publications

The limited role of medical libraries in providing consumer health information services in the Philippines presents a challenge. To address such a challenge, this paper suggests that information professionals, healthcare providers, and the government must collaborate to meet the information needs of healthcare consumers. Information professionals can be crucial in promoting health literacy by providing access to reliable and easy-to-understand health information. They must be equipped with the necessary skills to assess the readability of resources and identify signs of low literacy among library patrons. Librarians should develop more relevant and effective health information services tailored to the specific needs …

Exposure To Family Planning Messages And Teenage Pregnancy: Results From The 2017 Philippine National Demographic And Health Survey, Veincent Christian F. Pepito, Arianna Maever L. Amit, Clinton S. Tang, Luis Miguel B. Co, Neil Andrew K. Aliazas, Sarah J. De Los Reyes, Raymundo S. Baquiran, Lourdes Bernadette S. Tanchanco

Ateneo School of Medicine and Public Health Publications

Background

Teenage pregnancy is known to have physical, emotional, and psychosocial effects. Because of these risks, family planning and contraception messages have been disseminated in various forms of media, but their association with teenage pregnancy has not been studied previously in the Philippines. This study aims to examine the association between exposure to various family planning and contraception messages disseminated in various media channels and pregnancy among Filipino women aged 15–19. The study also intended to examine interactions between the different media channels where these family planning and contraception messages are being disseminated on their effect on teenage pregnancy.

Methods …

‘Doing’ Hypertension: Experiential Knowledge And Practice In The Self-Management Of ‘High Blood’ In The Philippines, Gideon Lasco, Alicia Renedo, Jhaki A. Mendoza, Maureen L. Seguin, Benjamin Palafox, Lia M. Palileo-Villanueva, Dina Balabanova, Martin Mckee

Development Studies Faculty Publications

Patients’ embodied experiences do not always correspond to the biomedical concepts of particular diseases. Drawing from year-long fieldwork in the Philippines that involved semi-structured interviews, focus group discussions and digital diaries, we examine how individuals ‘do’ hypertension through their embodied experiences and the knowledge and practice that emerge from them. Drawing inspiration from Annemarie Mol’s work on the notion of ‘multiplicity’ of disease, our analysis was informed by a commitment to privileging patients’ embodied experiences and the multiple ontologies of hypertension. We find that for patients diagnosed with hypertension in the Philippines, symptoms enact illness; patients rely on their …

The Politics Of Drug Rehabilitation In The Philippines, Gideon Lasco, Lee Edson Yarcia

Development Studies Faculty Publications

The international consensus to end compulsory drug treatments and close forced rehabilitation facilities needs urgent transformation to country policies. In the Philippines, as with other countries in Asia, rehabilitation can be compulsory and is seen as the humane alternative to the “war on drugs.” In this paper, we present the landscape of rehabilitation and narrate the ways in which people who use drugs are forced to undergo treatment. We unpack the politics behind rehabilitation and explain the sociocultural foundations that support compulsory treatment. We argue that a transition to a human rights-based approach, including voluntary alternatives in community settings, is …

Participant Use Of Digital Diaries In Qualitative Research: A Strong Structuration Analysis, Maureen L. Seguin, Jhaki A. Mendoza, Eunice Mallari, Gideon Lasco, Arianna Maever L. Amit, Lia M. Palileo-Villanueva, Benjamin Palafox, Alicia Renedo, Martin Mckee, Dina Balabanova

Development Studies Faculty Publications

Lived experiences of chronic conditions are marked by fluidity and change, which should be considered if care is to be truly patient-centered. Seeking to capture this fluidity, we used digital diaries via mobile phones to communicate with hypertensive patients in the Philippines over approximately 12 months. This paper draws on Strong Structuration Theory to conceptualize the complex array of factors shaping participants’ usage (and non-usage) of the diaries, thereby offering a comprehensive understanding of how the diaries were perceived and used. We draw on qualitative data from 42 participants (73 baseline/follow-up interviews and 37 digital diaries), purposively selected from a …

‘Loob’ And ‘Labas’: Spatial Constructions Of Safety And Risk Amid The Covid-19 Pandemic In The Philippines, Gideon Lasco, Michael L. Tan, Vincen Gregory Yu

Development Studies Faculty Publications

This article argues that local constructions of risky and safe spaces, as articulated by the notions ‘loob’ (inside) and ‘labas’ (outside), informed popular and political responses to the COVID-19 pandemic in the Philippines, leading to an overemphasis on staying at home and, conversely, a general avoidance or fear of outdoor spaces that was at times reinforced by public health authorities. Practices and policies related to the pandemic response rendered this binary opposition between ‘loob’ and ‘labas’ visible, from regulations concerning the use of personal protective equipment to restrictions of access to outdoor spaces. While this emergent …

Comparison Of Prescribed Physical Therapy To A Home Exercise Program For Pediatric Sports-Related Concussion Patients, August M. Price, Nicholas Arvin, Benjamin Seagraves, Scott O. Burkhart, Gregory Knell

Faculty Publications - Doctor of Psychology (PsyD) Program

The purpose of this retrospective chart review was to compare sports-related concussion (SRC) recovery time in protracted recovery (≥28 days) patients who were prescribed physical therapy (PPT) with those who were only provided a home exercise program (HEP). We hypothesized PPT would be associated with shorter recovery times relative to HEP. Associations were evaluated with multivariable zero-truncated negative binomial regressions. Among the 48 (30.2%) PPT and 111 (69.8%) HEP patients, the majority were female (57.9%), the mean age was 15.3 ± 1.4 (PPT) and 14.2 ± 2.8 (HEP), and time to clinic was a median 6.0 (IQR = 3.0–27.0; PPT) …

Correlates Of Health-Related Quality Of Life In Primary Caregivers Of Perinatally Hiv Infected And Hiv Exposed Uninfected Adolescents At The Kenyan Coast, Patrick N. Mwangala, Derrick Ssewanyana, Paul Mwangi, Esther Chongwo, Carophine Nasambu, Vincent A. Kagonya, Gaia Scerif, Charles R. Newton, Amina Abubakar

Institute for Human Development, East Africa

Background: Mothers and other primary caregivers play a crucial role in looking after perinatally HIV infected, and HIV exposed uninfected adolescents in sub-Saharan Africa. Day- to-day caregiving in the context of limited instrumen- tal support and added biomedical risk (HIV seropositivity) may expose these caregivers to adverse states of health. Unfortunately, very few studies have examined their health-related quality of life (HRQoL). Our study documents the HRQoL profile, and associated factors in primary caregivers of perinatally HIV infected, perinatally HIV exposed but uninfected and HIV unexposed/uninfected adolescents aged 12–17 years at the Kenyan Coast.

Methods: This was a …

Psychosocial And Mental Health Challenges Faced By Emerging Adults Living With Hiv And Support Systems Aiding Their Positive Coping: A Qualitative Study From The Kenyan Coast, Moses K. Nyongesa, Carophine Nasambu, Rachael Mapenzi, Hans M. Koot, Pim Cuijpers, Charles R. J. C. Newton, Amina Abubakar

Institute for Human Development, East Africa

Background: In sub-Saharan Africa, there is little data on the challenges faced by young people living with HIV tran- sitioning into adult life. Adapting the socio-ecological framework, this qualitative study investigated the challenges faced by emerging adults living with HIV from a rural Kenyan setting. Additionally, the study explored support systems that aid positive coping among these young adults.

Methods: In April 2018, in-depth interviews were conducted with a convenience sample of 22 young adults living with HIV (12 females), 18–24 years old, from rural Kilifi, coast of Kenya. Data were analyzed thematically using NVIVO 11 software.

Results …

Development Of An Hipsc-Cortical Neuron Long-Term Potentiation Model And Its Application To Alzheimer's Disease Modeling And Drug Evaluation, Kaveena Autar

Electronic Theses and Dissertations, 2020-2023

Alzheimer's disease (AD) is commonly characterized by a loss of cognitive function due to the deterioration of neuronal synapses from the presence of senile amyloid beta-42 (Aß42) plaques. Evaluating cognitive deficits caused by Aß42 using human cortical neurons poses a challenge due to sourcing difficulties, and the use of animal models to assess drug efficacy creates biological hurdles from lack of species translatability. Recent advances in induced-pluripotent stem cell technology have enabled the development of mature, human-based cortical neuron models. The development of an hiPSC-cortical neuron differentiation protocol facilitates the exploration of disease onset and functional analysis from a patient-derived …

A Critical Intersectional Analysis Of Black Doulas' Experiences In Maternal Healthcare, Emely Matos

Electronic Theses and Dissertations, 2020-2023

According to the U.S. Centers for Disease Control and Prevention (CDC), maternal death ratios are severely racially stratified as African American women face the most significant risk. Currently, Black women are four times more likely to die from pregnancy-related death in the United States than white women. Race disparities in maternal health outcomes may be exacerbated by the Covid-19 pandemic as preliminary research suggests that the pandemic's disproportionate impact on Black communities and existing concerns about Black women's medical treatment may indicate an increase in mortality within the next few years. Racial health disparities reflect the nation's flawed maternal healthcare …

Social Support And Empowerment Among Caregivers Of Children With Asthma, Lauren Lebo

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to better understand the concept of empowerment among caregivers of children with asthma. This study investigated what is already known about empowerment among caregivers and the instruments available to measure caregiver empowerment. This study then examined the relationship between social support and caregiver empowerment as well as income level and empowerment amongst caregivers of children with asthma. This study used the Federal Poverty Guidelines, Family Empowerment Scale and MOS Social Support Survey to measure these relationships. It was found that there was no relationship between income level and empowerment, but there was a significant …

Attenuation Of Excess Tnfα Release In Crohn's Disease By Silencing Of Irhoms 1/2 And The Restoration Of Tgfβ-Mediated Immunosuppression Through The Modulation Of Tace Trafficking, Taylor Louis

Electronic Theses and Dissertations, 2020-2023

Although treatment of Crohn's disease (CD) with TNFa monoclonal antibodies is beneficial, many patients stop responding over time and become at risk of acquiring infections. This study investigated an alternative approach to attenuate the release of excess TNFα by silencing iRHOMs 1/2 with the intention of restoring TGFβ-mediated Immunosuppression through Mitigation of TNFα converting enzyme (TACE) Trafficking. TACE, a transmembrane metalloprotease involved in signaling of receptors/cytokines/growth factors/adhesion proteins, is upregulated in CD, resulting in a marked increase of membranous TNFα cleavage and inflammation. Initially, we measured TGFβRII shedding in plasma from CD patients and healthy controls (N=40 per group). We …

Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker

Electronic Theses and Dissertations, 2020-2023

Cholera is an acute disease that is a global threat to the world and can kill people within a few hours if left untreated. In the last 200 years, seven pandemics occurred, and, in some countries, it remains endemic. The World Health Organization (WHO) declared a global initiative to prevent cholera by 2030. Cholera dynamics are contributed by several environmental factors such as salinity level of water, water temperature, presence of plankton especially zooplankton such as cladocerans, rotifers, copepods, etc. Vibrio cholerae (V. cholerae) bacterium is the main reason behind the cholera disease and the growth of V. cholerae depends …

Plasmonic Sensor Based Detection Of Dopamine, Sang Lee

Electronic Theses and Dissertations, 2020-2023

With a rapidly ageing population, neurological diseases are becoming increasingly relevant in the design of public health policies and strategies in western societies. In the last decades, biochemical research has consistently shown the critical role that neurotransmitters and their associated metabolites play as biomarkers in tracking and diagnosis of different brain disorders and cancers. In particular, dopamine, an organic electrochemical neurotransmitter, has been shown to be paramount for the proper functioning of the neural system. Dopamine's dysfunction, has been shown to underlie the pathogenesis in several neurological disorders such as Parkinson's disease, depression, chronic schizophrenia and psychosis. Unfortunately, currently available …

The Risk Factors For Self-Monitoring Of Blood Glucose Among Individuals Diagnosed With Type 2 Diabetes In Saudi Arabia, Mohammed Abdulrahman Alsuliman, Qi Zhang, Shelley Mishoe, Praveen K. Durgampudi

Community & Environmental Health Faculty Publications

Background: Lack of self-monitoring of blood glucose (SMBG) is a known risk factor for controlling type 2 diabetes mellitus (T2DM). Nevertheless, little research has been conducted on SMBG among Saudis with T2DM.

Aim: The study aimed to investigate personal and cognitive-perceptual factors for SMBG among Saudis with T2DM guided by Health Promotion Model.

Methods: A cross-sectional study was conducted with a sample size of 808 Saudi adults with T2DM utilizing secondary data from the Saudi Health Interview Survey for 2013.

Statistical Analysis: Bivariate and multivariate logistic regressions were applied to examine the risk factors for SMBG among Saudis with T2DM. …

Factors Associated With Hpv16 Cervical Precancerous Stage : Microbiome/Virome And Hpv16 E1, Thanayod Sasivimolrattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The human papillomavirus type 16 (HPV16) and/or high-risk (Hr-) HPV are the main causes of cervical cancer. The viral factors, such as the E6 and E7 oncogenes, have been recognized as the major factors of carcinogenesis. However, it is currently unknown how other HPV genes, particularly E1, contribute to the development of cancer. Beside HPV, another element that may contribute to the development of cervical cancer is the microbiota in the cervix. Cervical bacteriome and mycobiome have been the focus of numerous investigations; less is known about cervical virome, particularly when HPV is present. No study has investigated the entire …

Using Audio-Visual Simulation To Elicit Nursing Students’ Noticing And Interpreting Skills To Assess Pain In Culturally Diverse Patients, Michelle A. Kelly, Susan Slatyer, Helen Myers, Shelley Gower, Jaci Mason, Kathie Lasater

Nursing Papers and Journal Articles

Background: Pain is a complex and multi-dimensional phenomenon. Nurses play a vital role in assessing and managing pain and must use sound clinical reasoning to accurately make clinical judgments to notice, interpret and respond to patients’ pain.

Method: Exploratory research on the impact of a newly developed AV simulation on nursing students’ Noticing and Interpreting skills in assessing pain of culturally diverse patients. Data were collected via self-administered pre and post–intervention surveys.

Findings: The majority of participants were able to identify that the patient was in greater pain than reported, however some participants were unable to notice and interpret the …

Stakeholder Perspectives Of A Pilot Multicomponent Delirium Prevention Intervention For Adult Patients With Advanced Cancer In Palliative Care Units: A Behaviour Change Theory-Based Qualitative Study, Anna Green, Annmarie Hosie, Jane L. Phillips, Slavica Kochovska, Beverly Noble, Meg Brassil, Anne Cumming, Peter G. Lawlor, Shirley H. Bush, Jan M. Davis, Layla Edwards, Jane Hunt, Julie Wilcock, Carl Phillipson, Eugene Wesley Ely, Cynthia Parr, Melanie Lovell, Meera Agar

Nursing Papers and Journal Articles

Background: Theory-based and qualitative evaluations in pilot trials of complex clinical interventions help to understand quantitative results, as well as inform the feasibility and design of subsequent effectiveness and implementation trials.

Aim: To explore patient, family, clinician and volunteer (‘stakeholder’) perspectives of the feasibility and acceptability of a multicomponent non-pharmacological delirium prevention intervention for adult patients with advanced cancer in four Australian palliative care units that participated in a phase II trial, the ‘PRESERVE pilot study’.

Design: A trial-embedded qualitative study via semi-structured interviews and directed content analysis using Michie’s Behaviour Change Wheel and the Theoretical Domains Framework.

Setting/participants: Thirty-nine …

Cognitive Continuum Theory: Can It Contribute To The Examination Of Confidentiality And Risk-Actuated Disclosure Decisions Of Nurses Practising In Mental Health?, Darren Conlon, Toby Raeburn, Timothy Wand

Nursing Papers and Journal Articles

Nurses practising in mental health are faced with challenging decisions concerning confidentiality if a patient is deemed a potential risk to self or others, because releasing pertinent information pertaining to the patient may be necessary to circumvent harm. However, decisions to withhold or disclose confidential information that are inappropriately made may lead to adverse outcomes for stakeholders, including nurses and their patients. Nonetheless, there is a dearth of contemporary research literature to advise nurses in these circumstances. Cognitive Continuum Theory presents a single-system intuitive-analytical approach to examining and understanding nurse cognition, analogous to the recommended single-system approach to decision-making in …

Neurological Patient And Informal Caregiver Quality Of Life, And Caregiver Burden: A Cross-Sectional Study Of Postdischarge Community Neurological Nursing Recipients, Judith Dianne Pugh, Kathleen Mccoy, Anne M. Williams, Catherine A. Pienaar, Brenda Bentley, Leanne Monterosso

Nursing Papers and Journal Articles

Background: Neurological conditions produce considerable disease burden.

Aims: To describe quality of life in patients with neurological conditions and informal caregivers receiving postdischarge generic community neurological nursing services, and caregiver burden.

Method: A descriptive cross-sectional design was used with researchers administering the WHOQOL-BREF Australian Version questionnaire and Zarit Burden Interview.

Results: Most patients and caregivers rated quality of life as 'Good'. The patients’ physical, psychological and environment domain scores, and caregivers’ physical domain scores, were below norms. Half of the caregivers experienced burden and 42% had risk for depression.

Conclusion: A heterogeneous group of patients with neurological conditions had …

Preconception Primary Care Access And Preterm Birth: A Nested Case Control Study, Amelia Stutman Do, Elaine Banerjee Md, Mph, Melanie B. Johnson Mpa, Nicole M. Burgess, Katarzyna Jabbour Pharmd, Bcps, Katie Nesbitt Pharmd, Bcps, Kyle Shaak Bs, Roya Hamadani Mph, Beth Careyva M.D., Ashwini Kamath Mulki

Department of Family Medicine

No abstract provided.

An Autoethnographic Examination Of The Patient-Clinician Relationship During Covid-19 Pandemic, Alexandra Bersani Do, Abby S. Letcher Md, Jose Rivera, Nicole Defenbaugh Phd

Department of Family Medicine

No abstract provided.

Radical Welcome: Unexpected Healing Spaces In Community-Researcher-Clinician Partnership For Health Equity, Abby S. Letcher Md, Nyann Biery Ms, Mary Mitsdarffer Phd, Mph, Carol Moeller Phd, Ba, Ma, Autumn Kieber-Emmons Md, Mph, Alexandra Bersani Do, Melanie B. Johnson Mpa

Department of Family Medicine

No abstract provided.

Alteration In Facial Contour Associated With Aging: Case Report, Bohan Lin Ba, Dds, Louis Mandel Dds

The New York State Dental Journal

The authors examined a 73-year-old female because of a chief complaint of bilateral swellings of the parotid gland. After detailed questioning, the authors determined that the perceived facial swelling was caused by the inferior displacement of separate and identifiable facial fat compartments. Aging coupled with gravity results in both a compartmental and intracompartment inferior displacement of facial fat. Long-lasting fillers injected intra-or extra-compartmentally also partake in this inferior migration.

Optimizing Antidotal Treatment With The Oral Hsp90 Inhibitor Tas-116 Against Hydrochloric Acid-Induced Pulmonary Fibrosis In Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Christiana Dimitropolou, Tierney Day, John Catravas

Bioelectrics Publications

Exposure to high concentrations of hydrochloric acid (HCl) can lead to severe acute and chronic lung injury. In the aftermath of accidental spills, victims may be treated for the acute symptoms, but the chronic injury is often overlooked. We have developed a mouse model of acute and chronic lung injury, in which the peak of acute lung injury occurs on the day 4 after HCl exposure. We have also demonstrated that HSP90 inhibitors are effective antidotes when administered starting 24 h after HCl. In this study we examined the hypothesis that the novel oral HSP90 inhibitor TAS-116 can effectively ameliorate …

Pulmonary Capillary Recruitment And Distention In Mammalian Lungs: Species Similarities, David Langleben, Benjamin D. Fox, Stylianos E. Orfanos, Michele Giovinazzo, John D. Catravas

Bioelectrics Publications

Pulmonary arterial pressure rises minimally during exercise. The pulmonary microcirculation accommodates increasing blood flow via recruitment of pulmonary capillaries and, at higher flows, by distention of already perfused capillaries. The flow transition range between recruitment and distention has not been studied or compared across mammalian species, including humans. We hypothesised that the range would be similar. Functional pulmonary capillary surface area (FCSA) can be estimated using validated metabolic techniques. We reviewed data from previous studies in three mammalian species (perfused rabbit lungs and dog lung lobes, and exercising humans) and generated blood flow-FCSA curves over a range of flows. We …