Medicine and Health Sciences Commons^™

January 2022, New England Osteopathic Heritage Center

New England Osteopathic Heritage Center Newsletter

New England Osteopathic Heritage Center's annual newsletter for January 2022

Methamphetamine Use: A Narrative Review Of Adverse Effects And Related Toxicities., Amber N. Edinoff, Sarah E. Kaufman, Keionne M. Green, Daniel A. Provenzano, Jesse Lawson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Methamphetamine has been labeled "America's most dangerous drug" and has received significant public health attention. Stimulant addiction and tolerance are heavily documented in the literature; increasingly larger doses maintain euphoria in short time periods to withstand stimulant tolerance. Stimulant deaths are high in the United States and abroad. Between 2013 and 2019, deaths related to methamphetamine use quadrupled from 3,616 to 16,127. Methamphetamine use increased four-fold from 2015 to 2016. Due to this increase in methamphetamine use and its associated medical complications, the mortality rate associated with methamphetamine use has doubled over the past ten years. Cardiopulmonary symptoms include chest …

Managing Hypertension, Diabetes, And Cardiovascular Disease Risk Via Short-Term Medical Trips: A Retrospective Longitudinal Study In Santo Domingo, Rose Baumann, Reuben P. Retnam, Carlos M. Hernandez, Victoria Edwards, Mark Ryan

Biostatistics Publications

Background: Short-term medical trips (STMTs) from high-resource countries frequently provide care in low and middle-income countries. Little existing literature objectively tracks the long-term outcomes of these interventions on the receiving populations over time to assess potential benefits and to ensure no harm is being done.

Objectives: The purpose of this study was to objectively analyze the outcomes of a biannual STMT to Santo Domingo, Dominican Republic on hypertension (HTN), diabetes mellitus type 2 (DM2), and cardiovascular disease (CVD) risk over a five-year period (2015-2019).

Methods: Data from 1655 patients was extracted from the electronic medical record. In …

Long-Read Sequencing Of The Zebrafish Genome Reorganizes Genomic Architecture, Yelena Chernyavskaya, Xiaofei Zhang, Jinze Liu, Jessica Blackburn

Biostatistics Publications

Background

Nanopore sequencing technology has revolutionized the field of genome biology with its ability to generate extra-long reads that can resolve regions of the genome that were previously inaccessible to short-read sequencing platforms. Over 50% of the zebrafish genome consists of difficult to map, highly repetitive, low complexity elements that pose inherent problems for short-read sequencers and assemblers.

Results

We used long-read nanopore sequencing to generate a de novo assembly of the zebrafish genome and compared our assembly to the current reference genome, GRCz11. The new assembly identified 1697 novel insertions and deletions over one kilobase in length and placed …

Social Cognitive Outcomes Are Associated With Improvements In Mobility Performance Following Lifestyle Intervention In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy, Zachary L. Chaplow, Alexander R. Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M. Fairman, Victoria R. Descenza, Jessica Bowman, Steven K. Clinton, Brian C. Focht

Health Policy Publications

Objective
To compare the effects of an exercise and dietary intervention with those of standard-of-care management upon change in lift and carry performance and mobility-related self-efficacy beliefs and explore associations in prostate cancer patients undergoing androgen deprivation therapy.

Methods
32 prostate cancer patients (M age = 66.2 years; SD = 7.8) undergoing androgen deprivation therapy were randomly assigned to a 3-month exercise and dietary lifestyle intervention (n = 16) or standard-of-care management (n = 16). Outcome assessments were obtained at baseline, 2- and 3-month follow-up.

Results
The lifestyle intervention resulted in significantly greater improvements in lift and …

Early Cognitive Predictors Of Language, Reading, And Mathematics Outcomes In The Primary Grades, Theresa Pham, Marc F. Joanisse, Daniel Ansari, Janis Oram, Christine Stager, Lisa Archibald

Data and Test Instruments

Recently, cross-domain research has shown that some early predictors of language, reading, and mathematics overlap and predict one another. This study investigated how early cognitive predictors across domains could predict future academic skills across domains using data from 563 students in kindergarten to second grade (ages 5 to 8; 288 males; largely monolingual English). The roles of verbal, symbolic, and magnitude comparison skills as predictors of later academic grades for various language and math subjects were examined. Results found that Grade 1 marks were predicted by kindergarten verbal and symbolic skills, while Grade 2 marks were predicted by verbal skills …

Characterizing Mental Health Related Service Contacts In Children And Youth: A Linkage Study Of Health Survey And Administrative Data, Kelly Anderson, Jordan Edwards, Lin Wang, Laura Duncan, Jinette Comeau, Katholiki Georgiades

Data and Test Instruments

No abstract provided.

What Do Speech-Language Pathologists Want To Know When Assessing Vocal Development In Children Who Are Deaf/Hard-Of-Hearing?, Olivia Daub, Marlene P. Bagatto, Janis Oram Cardy

PRECISe Preschool Speech and Language Publications

Abstract

Purpose: Delays in vocal development are an early predictor of ongoing language difficulty for children who are deaf/hard-of-hearing (CDHH). Despite the importance of monitoring early vocal development in clinical practice, there are few suitable tools. This study aimed to identify the clinical decisions that speech-language pathologists (SLPs) most want to make when assessing vocal development and their current barriers to doing so.

Method: 58 SLPs who provide services to CDHH younger than 22 months completed a survey. The first section measured potential barriers to vocal development assessment. The second section asked SLPs to rate the importance of 15 clinical …

Current Practices, Supports, And Challenges In Speech-Language Pathology Service Provision For Autistic Preschoolers, Amanda V. Binns, Barbara Jane Cunningham, Allison Andres, Janis Oram Cardy

PRECISe Preschool Speech and Language Publications

Background: Speech-language pathology services are among the most frequently accessed services for young autistic children. Therefore, understanding the nature of these services, what challenges these clinicians face, and what supports they value is critical for developing appropriate policies and practices that can maximize positive outcomes for children and families. This study had two primary aims. The first was to examine the self-reported assessment and intervention practices of community-based Speech Language Pathologists (SLPs) and communicative disorders assistants (CDAs; who provide services under the supervision of a SLP) in supporting preschool children with suspected and diagnosed autism. The second aim was to …

Exploring Practice-Based Clinical–Research Partnerships In Speech-Language Pathology: A Scoping Review, Meghan Vollebregt, Lisa Archibald, Julie Theurer, Janis Oram Cardy

PRECISe Preschool Speech and Language Publications

Collaborative partnerships between speech-language pathologists and researchers present an opportunity for practice-based research. For practice-based research to become more widely used in speech-language pathology, a crucial step is outlining the potential purposes and outcomes of these partnership projects. The current article is two-fold. First, we describe a model for practice-based partnerships between researchers and speech-language pathologists. The practice-based research cocreation model developed for this project includes three distinct partnership outcomes: (a) creating practice, (b) capturing current practice, and (c) changing practice. Then, informed by our model, we completed a scoping review to explore the extent and type of practice-based research …

Deconstructing Stereotypes: Stature, Match-Playing Time, And Performance In Elite Women's World Cup Soccer, Ciara N. Manning, Yasuki Sekiguchi, Courteney L. Benjamin, Mckenna R. Spaulding, Erin E. Dierickx, Jayson M. Spaulding, Dayshia M. Davenport, Jillian Picard-Busky, George T. Chiampas, George P. Nassis, Douglas J. Casa

PTHMS Undergraduate Publications

Recruiting companies recommend elite female soccer players be ≥165 cm (5'5″) in stature. This study investigated if stature limits match-playing time and performance in elite World Cup soccer among players, positions, and countries. We hypothesized stature would not affect match-playing time or performance. Descriptive data were collected on 552 players from 2019 FIFA Women's World Cup. Odds ratios determined likelihood of starting for players ≥165 cm. ANOVAs compared playing time between stature groups, among positions, and between countries. Performance factors including assists, goals, attempts, corners, shots blocked, and defending blocks were reported. Independent t-tests compared differences between players (≥165 cm, …

Association Between Periodontal Disease And Oral Cancer Screening Among Us Adults: Nhanes 2011-2014, Shillpa Naavaal, Dina T. Garcia, Xiaoyan Deng, Dipankar Bandyopadhya

Dental Public Health and Policy Publications

Objectives:

To examine oral cancer screening rates and associated factors among adults with periodontal disease (PD). We hypothesized that adults with severe PD will be less likely to report receipt of any type of oral cancer screening than adults with no PD.

Materials and Methods:

We used 2011-2014 National Health and Nutrition Examination Survey (NHANES) data on adults ≥ 30 years. PD status was classified as no PD, mild/moderate PD, and severe PD. Survey-adjusted logistic regression analysis was used to examine the model adjusted risk ratio (RR) and 95% confidence intervals (CI) for the outcome of not receiving intraoral, extraoral …

The Impact Of Mindful Breathing On Stress Of Employees Working From Home, Lindsey Goldberg

Doctor of Nursing Practice Projects

This DNP project was designed to decrease stress among employees working from home (WFH) by educating them on mindful breathing practices. Through the implementation of a mindful breathing activity, the intended project outcome was to improve stress levels of employees working from their homes. Mindful breathing is an evidence-based strategy that has demonstrated decreased stress levels. Mindful breathing was implemented among two companies employing an estimate of 170 WFH employees to improve health and well-being with potential long-term positive impact on sustainability of organizations in the post-COVID, work from home environment. The participants were invited to perform 8-minutes of daily …

Faith-Based Approach: Reaching The Rural Population To Increase Diabetes Awareness, Regina Ledford

Doctor of Nursing Practice Projects

With diabetes at an epidemic level in the United States, more awareness needs to be brought surrounding prediabetes and diabetes prevention. This DNP Project consists of implementing a faith-based educational informational event at a local rural church to increase diabetes awareness. Findings within this DNP project suggest that the rural population can increase knowledge of diabetes awareness through faith-based education. With a sample size of 21 participants, positive statistical significance was found on analysis of pre-test and post-test Likert style questions regarding diabetes prevention, risk factors, and diabetic resources.

Improving Self-Care Awareness Among Undergraduate Nursing Students, D'Anna Helms

Doctor of Nursing Practice Projects

The purpose of this DNP project was to improve self-care (SC) awareness among undergraduate nursing students by educating on the use of constructive SC activities. Twenty-two senior level nursing students attended an educational seminar, completed the Mindful Self-Care Scale – Clinical (MSCS-C) pre- and post-survey, and reflective journaling. A paired-samples t test was calculated to compare the mean pretest score to the mean posttest score. The mean on the pretest was 77.68 (sd= 9.33), and the mean on the posttest was 75.27 (sd= 31.59). A significant increase from pretest to posttest was found (t (21) = .307, p < .05). Thematical analysis revealed enhanced awareness and incorporation of constructive SC activities. Educational interventions which seek to improve SC awareness will generate practical and sustainable acts of SC, thus improving students’ overall success and further empowering students in their transition from graduate to licensed nurses.

Research News, Grants, 2022, Volume 1, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January - March 2022.

Research News, Grants, 2022, Volume 4, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October - December 2022

Donut Hole Fall 2022, Medicare Donations & Design Committee

Donut Hole Newsletter

No abstract provided.

Donut Hole Summer 2022, Medicare Donations & Design Committee

Donut Hole Newsletter

No abstract provided.

Anti-Abortion Crisis Pregnancy Centers In Central Florida, Isabel Adamus

Honors Program Theses

Anti-abortion pregnancy centers, also known as crisis pregnancy centers (CPCs), are nonprofit organizations that target pregnant women and aim to dissuade them from considering abortion. In the U.S., CPCs are increasing in prevalence, accumulating government/state funding and support, and becoming more medicalized. Medicalization includes offering limited medical services, such as pregnancy testing, limited ultrasounds, and testing for sexually transmitted infections (STIs). CPCs are largely unlicensed and unregulated, frequently advertising in misleading ways and providing inaccurate health information. The goal of this research is to (1) understand how CPCs in Central Florida utilize rhetorical strategies to frame their services and health …

Seasonal Dynamics Of Parasitic Vector-Borne Pathogens In Cattle Farms And The Development Of Dna Amplification And Artificial Intelligent-Assisted Detection Methods, Apinya Arnuphapprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vector-borne pathogens in cattle have detrimental effects on animal health and the quality of animal products. These pathogens are prevalent worldwide, particularly in tropical and sub-tropical regions like Thailand. Notable vector-borne pathogens affecting cattle in Thailand include Anaplasma marginale, Babesia bovis, B. bigemina, Theileria orientalis, Trypanosoma evansi, and T. theileri. Additionally, climate change influences the behaviour of these vector-borne pathogens through its impact on their vectors. Prompt and accurate diagnosis is crucial to mitigate the adverse effects caused by these pathogens. However, conventional microscopic examination, considered the gold standard, may have limitations in terms of sensitivity and time requirements. Therefore, …

Virginia Dental Journal (Vol. 99, No. 4, 2022)

Virginia Dental Journal

No abstract provided.

Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Sarcoidosis, Sarah Shapiro, Sindhuja Koppu, Mavra Masood, Beth Rubinstein, Huzaefah Syed

Open and Affordable Course Content at VCU

No abstract provided.

The Influence Of Losing A Parent In The Development Of Anxiety, Depression, And Academic Motivation In Latino College Students, Sandra Luz Galvan

Graduate Research Theses & Dissertations

The current study focuses on understanding how the potential consequences of losing a parent before the age of eighteen influence depression, anxiety, and academic motivation in Latino college students. The study also explored how social support could interfere with these consequences. Five participants were recruited from various universities, and they were interviewed virtually, guided by a phenomenology design. The data was analyzed using a narrative approach. The results show that social support is fundamental to mitigating the consequences of losing a parent at a young age. It is recommended that future research consider the difference between losing a mother and …

The Efficacy And Acceptability Of A Virtual Versus Hybrid Wellness Program On Health Outcomes Among Faculty And Staff At A Northeastern University During Covid-19, Elizabeth Tenison

Graduate Research Theses & Dissertations

According to American Psychological Association Work and Well-being Survey of 1,501 U.S. adult workers, 79% of employees reported negative impacts of work-related stress, including lack of interest (26%) and effort (19%) at work. Workplace wellness programs offer a means to alleviate stress among employees. The research explored the perceived acceptability and efficacy of a virtual versus hybrid wellness program and some specific health outcomes, total cholesterol, BP, and BMI, perceived well-being and stress among faculty and staff at a northeastern university. Participants (n=61) included women (77%), 30-50 years of age (67.7%), and staff (30%) vs. faculty (70%) enrolled in the …

Underlying Factors Of Laboratory Safety Behaviors In College Students Using The Theory Of Planned Behavior And Risk Perceptions, Michele M. Crase

Graduate Research Theses & Dissertations

Laboratory safety in academic settings has long been a concern for colleges and universities worldwide. Education and training for lab safety is often a one size fits all process. That is, the same training given to faculty and staff is also given to students. However, students are generally younger, less educated and less experienced than faculty or staff. To better understand the students’ educational needs related to lab safety, it was important to understand their attitudes toward safety behaviors and perceived risks of hazards in a lab. To confound matters, the COVID-19 pandemic added another level of concern regarding personal …

The Lived Experiences Of Muslim Women With Infertility, Samia Abdelnabi

Wayne State University Dissertations

Background: Infertility, ranked as the 5th highest global disability, is estimated to impact 180 million couples worldwide. Muslim couples associate parenthood or the ability to have children as an accomplishment in their marriage, adulthood, social status, and security in later life. A failure to conceive in Muslim societies may lead to stigma, social isolation, grief, and despair. There is a gap in the literature on how Muslim women perceive, understand, and cope with infertility in the U.S. This knowledge gap limits the ability in to understand how social, religious, and cultural practices impact a diagnosis of infertility on Muslim American …

Role Of Aldehyde Dehydrogenase 2 (Aldh2) In The Decrease In Coronary Angiogenesis In Type 2 Diabetes Mellitus: Identifying Novel Signaling Pathways, Bipradas Roy

Wayne State University Dissertations

Coronary endothelial cell (CECs) damage and rarefaction of coronary microvasculature are implicated in diabetes-induced heart failure with preserved ejection fraction (HFpEF). 4-hydroxy-2-nonenal (4-HNE), a reactive aldehyde that is increased in diabetic hearts, contributes to CEC dysfunction and cardiotoxicity. Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme that detoxifies 4-HNE and confers cardioprotection. However, ALDH2 activity is decreased in diabetic hearts, which results in the augmentation of 4HNE-induced cardiotoxicity. Thus, we hypothesize that activation of ALDH2 in CECs reduces 4-HNE-mediated cell signaling aberrations and preserves coronary angiogenesis. We employed cell culture studies and animal models to test our hypothesis. In our cell …

Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan

Wayne State University Dissertations

The CXCR4-CXCL12 chemokine signaling axis plays a key role in migration and bone metastasis in prostate cancer (PC). Androgens regulate CXCR4 expression and its receptor activation in lipid-raft micro domains of PC cells, resulting in higher protease expression and invasion. In order to identify some novel CXCR4 co-regulators associated within the lipid-raft, a SILAC (Stable isotope labeling using amino acid in cell culture)-based proteomic analysis was performed with PC3 stable cell-lines over-expressing or knocking-down CXCR4. Phosphatidylinositol 4-kinase III alpha (PI4KIIIα or PI4KA) and SAC1 lipid phosphatase were identified as candidate proteins enriched in CXCR4 expressing cells. PI4KA is an evolutionarily …

Sorafenib, Rapamycin, And Venetoclax Attenuate Doxorubicin-Induced Senescence And Promote Apoptosis In Hct116 Cells, Homood M. As Sobeai, Munirah Alohaydib, Ali R. Alhoshani, Khalid Alhazzani, Mashal M. Almutairi, Tareq Saleh, David A. Gewirtz, Moureq R. Alotiabi

Pharmacology and Toxicology Publications

Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity. Promising new drugs named senolytics selectively target senescent cells and commit them into apoptosis. Accordingly, senolytics have been proposed as adjuvant cancer treatment to cull senescent tumor cells, and thus, screening for agents that exhibit senolytic properties is highly warranted. Our study aimed to investigate three agents, sorafenib, rapamycin, and venetoclax for their senolytic potential in doxorubicin-induced senescence in HCT116 cells. HCT116 cells were treated with one of the three agents, sorafenib …