Medicine and Health Sciences Commons^™

The Use Of Compression To Treat Phlebolymphedema Symptomology: A Systematic Review, Naomi Moran

Occupational Therapy Doctorate Capstone Projects

Background: There is a lack of clinical practice guidelines regarding treating phlebolymphedema symptomology. To facilitate client centered evidence-based practice, occupational therapists (OTs) who are Certified Lymphedema Therapists (CLTs) need disease specific evidence for treating phlebolymphedema. Finding available evidence regarding the use of complete decongestion therapy (CDT) for this population will support evidence-based practice. For this capstone compression usage is the one component of CDT that will be researched.

Purpose: A systematic review of evidence related to use of static compression for treatment of lower leg phlebolymphedema that is within the scope of a CLT who is not wound care certified. …

Emerging Biomedical Applications Of The Vesicular Stomatitis Virus Glycoprotein, Sheeba Rehman, Suman Bishnoi, Rajarshi Roy, Anshu Kumari, Harikrishnan Jayakumar, Sharad Gupta, Parimal Kar, Asit K. Pattnaik, Bebasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Nanoparticles (NPs) made of metals, polymers, micelles, and liposomes are increasingly being used in various biomedical applications. However, most of these NPs are hazardous for long- and short-term use and hence have restricted biomedical applications. Therefore, naturally derived, biocompatible, and biodegradable nanoconstructs are being explored for such applications. Inspired by the biology of viruses, researchers are exploring the viral proteins that hold considerable promise in biomedical applications. The viral proteins are highly stable and further amenable to suit specific biological applications. Among various viral proteins, vesicular stomatitis virus glycoprotein (VSV-G) has emerged as one of the most versatile platforms for …

Phip-Seq Reveals Autoantibodies For Ubiquitously Expressed Antigens In Viral Myocarditis, Mahima T. Rasquinha, Ninaad Lasrado, Erika M. Petro-Turnquist, Eric A. Weaver, Thiagarajan Venkataraman, Daniel R. Anderson, H. Benjamin Larman, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Simple Summary: Myocarditis is the inflammation of the heart muscle, and viral infections are a common cause of this disease. Myocarditis in some patients can progress to dilated cardiomyopathy (DCM). The mouse model of coxsackievirus B3 (CVB3) is commonly used to understand this disease progression in DCM patients. In this paper, we have attempted to analyze antibodies for heart antigens that could be produced as a result of heart damage in animals infected with CVB3 using a technique called Phage ImmunoPrecipitation Sequencing (PhIP-Seq). The analyses led us to identify antibodies for several proteins that were not previously reported that may …

History, Cognition And Nostromo: Conrad’S Explorations Of Torture, Trauma, And The Human Rage For Order, Richard Ruppel

English Faculty Articles and Research

Focusing on Joseph Conrad’s Nostromo, this essay historicizes the treatment of what we now call post-traumatic stress disorder, demonstrating how Conrad anticipated our current understanding and treatment of the illness. The second part of the essay addresses Nostromo’s treatment of historiography. Part three is concerned with epistemology and the relationship between neurological discoveries concerning the gap between perception and consciousness, relating those discoveries to Conrad’s use of delayed decoding.

The Applications And Challenges Of The Development Of In Vitro Tumor Microenvironment Chips, Annika Johnson, Samuel Reimer, Ryan Childres, Grace Cupp, Tia C L Kohs, Owen J T Mccarty, Youngbok (Abraham) Kang

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

The tumor microenvironment (TME) plays a critical, yet mechanistically elusive role in tumor development and progression, as well as drug resistance. To better understand the pathophysiology of the complex TME, a reductionist approach has been employed to create in vitro microfluidic models called “tumor chips”. Herein, we review the fabrication processes, applications, and limitations of the tumor chips currently under development for use in cancer research. Tumor chips afford capabilities for real-time observation, precise control of microenvironment factors (e.g. stromal and cellular components), and application of physiologically relevant fluid shear stresses and perturbations. Applications for tumor chips include drug screening …

Sexual And Reproductive Health Literacy In Rwanda Kazo Sector Murusenyi Village, Sandrine Nikuze, Mdp

Regis University Student Publications (comprehensive collection)

Unplanned pregnancies and other reproductive health issues are global health problems. Nowadays, young people are highly exposed compared to last time. Internet and other sources of misleading sexual information are available to them. Parents who are supposed to be the health information providers are not responsible because they do not want, but because they have limited knowledge, and they also face different challenges which prevent them from fulfilling their responsibilities towards their children such as education level, income level, gender, and religion. All these issues to young people have increased the number of young people who get pregnancies before and …

Comorbid Pad And Mvd: A Retrospective Nrd Analysis Of Trends, Outcomes, And Readmissions, Miguel Algara

Yale Medicine Thesis Digital Library

ABSTRACTBackground: Previous studies on select populations have shown worsened limb outcomes among patients with comorbid Peripheral artery disease (PAD) and Microvascular disease (MVD), however this connection has not been studied in larger populations. Using a national database, we aimed to analyze the frequency of Major Adverse Limb Events (MALE), as well as Major Adverse Cardiac Events (MACE), Mortality, and other comorbidities for patients with comorbid PAD/MVD, as compared to patients with PAD or MVD alone. Methods: Using 2011 to 2018 National Readmission Database (NRD) data, we identified the frequency of PAD and MVD-related admissions based on ICD-9/10 codes. The primary …

Doodling As Self-Expression: Building Self-Efficacy In Normally Functioning Adults, Journey Coward

Art Therapy | Theses and Dissertations

While previous studies identify doodling as a useful educational tool, this study sought to determine if doodling can build creative or emotional self-efficacy. Self-efficacy is an individual’s belief in their own capacity to express behaviors necessary to attain specific performance goals. The current study also sought to determine if doodling can be a form of self-care. Research collected was quantitative and qualitative using surveys to measure both creative and emotional self-efficacy along with a doodling activity. Ten participants were recruited through convenience sampling on social media and were included in the study after meeting the inclusion criteria of identifying themselves …

Bill Gatton College Of Pharmacy Viewbook - 2022, Bill Gatton College Of Pharmacy, East Tennessee State University

Bill Gatton College of Pharmacy Miscellaneous Publications

No abstract provided.

Putting The Pieces Back Together: Using A Kintsugi-Influenced Directive To Promote Self-Forgiveness And Resiliency In Young Adults With Shame And Guilt, Marieev Krista Princer

Art Therapy | Theses and Dissertations

Kintsugi is the ancient Japanese art form of repairing broken pieces with lacquer. It is highly regarded as an art form that represents the beauty of scars and life after destruction. Currently, the field of art therapy has little literature on how destruction of art can be used in the field to aid clients. This study was dedicated to researching a new art directive based on the kintsugi form of art making and its philosophies. To assess the therapeutic value of the destruction of art, the chosen population was millennials, an age group that is misunderstood. This study aims to …

Heterogeneity Of Diabetes: B-Cells, Phenotypes, And Precision Medicine: Proceedings Of An International Symposium Of The Canadian Institutes Of Health Research’S Institute Of Nutrition, Metabolism And Diabetes And The U.S. National Institutes Of Health’S National Institute Of Diabetes And Digestive And Kidney Diseases, William T. Cefalu, Dana K. Andersen, Guillermo Arreaza-Rubín, Christopher L. Pin, Sheryl Sato, C. Bruce Verchere, Minna Woo, Norman D. Rosenblum

Paediatrics Publications

One hundred years have passed since the discovery of insulin—an achievement that transformed diabetes from a fatal illness into a manageable chronic condition. The decades since that momentous achievement have brought ever more rapid innovation and advancement in diabetes research and clinical care. To celebrate the important work of the past century and help to chart a course for its continuation into the next, the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases recently held a joint international symposium, bringing together …

A Million Is More Than A Thousand: Children's Acquisition Of Very Large Number Words, Pierina Cheung, Daniel Ansari

Paediatrics Publications

Very large numbers words such as “hundred,” “thousand,” “million,” “billion,” and “trillion” pose a learning problem for children because they are sparse in everyday speech and children's experience with extremely large quantities is scarce. In this study, we examine when children acquire the relative ordering of very large number words as a first step toward understanding their acquisition. In Study 1, a hundred and twenty-five 5–8-year-olds participated in a verbal number comparison task involving very large number words. We found that children can judge which of two very large numbers is more as early as age 6, prior to entering …

Frequency Of Diabetes Team Contacts In Children And Adolescents Using Insulin Pumps, Funmbi T. Babalola, Michael R. Miller, Andrea R. Ens, Robert I. Stein, Patricia H. Gallego, Cheril L. Clarson

Paediatrics Publications

Background: The purpose of this study is to assess if a relationship exists between A1c within target (≤ 7.5%) and frequency of patient-initiated contact with diabetes team, in children with type 1 diabetes (T1DM) on an insulin pump. Additionally, to determine factors impacting frequency of contact. Methods: This was a retrospective study of children with T1DM on an insulin pump. Frequency of contact, type of contact, and A1c were collected. Study participants filled out a questionnaire at study entry. Results: One hundred and seventy-six participants were enrolled, with a mean age of 13 years. The median duration of T1DM was …

Through An Equity Lens: Illuminating The Relationships Among Social Inequities, Stigma And Discrimination, And Patient Experiences Of Emergency Health Care, Colleen Varcoe, Annette J. Browne, Vicky Bungay, Nancy Perrin, Erin Wilson, C.Nadine Wathen, David Byres, Elder Roberta Price

Nursing Publications

People who experience the greatest social inequities often have poor experiences in emergency departments (EDs) so that they are deterred from seeking care, leave without care complete, receive inadequate care, and/or return repeatedly for unre- solved problems. However, efforts to measure and monitor experiences of care rarely capture the experiences of people facing the greatest inequities, experiences of discrimination, or relationships among these variables. This analysis examined how patients’ experiences, including self-reported ratings of care, experiences of discrimination, and repeat visits vary with social and economic circumstances. Every consecutive person presenting to three diverse EDs was invited if/when they were …

"Maybe I'M Not That Approachable": Using Simulation To Elicit Team Leaders' Perceptions Of Their Role In Facilitating Speaking Up Behaviors, Rachael Pack, Lauren Columbus, Trevor Hines Duncliffe, Harrison Banner, Priyanka Singh, Natashia Seemann, Taryn Taylor

Obstetrics & Gynaecology Publications

BACKGROUND: Simulation research that seeks to solve the problem of silence among interprofessional teams has focused almost exclusively on training subordinate team members to be more courageous and to speak up to team leaders using direct challenge scripts despite the great interpersonal cost. Consequently, the existing literature overemphasizes the responsibility of subordinate team members for speaking up and fails to consider the role and responsibilities of team leaders in sustaining silence. The purpose of this study is to identify and describe the subtle behaviors and actions of team leaders that both promote and discourage speaking up.

METHODS: This study used …

Gestational Age Impacts Birth To Placental Weight Ratio And Umbilical Cord Oxygen Values With Implications For The Fetal Oxygen Margin Of Safety, Bryan S Richardson, Barbra De Vrijer, Hilary K Brown, Larry Stitt, Sheryl Choo, Timothy R H Regnault

Obstetrics & Gynaecology Publications

Background: We determined the impact of gestational age (GA) from near term to term to post-term on birth/placental weight ratio and cord oxygen values with implications for placental transport efficiency for oxygen, fetal O2 consumption relative to delivery or fractional O2 extraction, and oxygen margin of safety.

Materials and methods: A hospital database was used to obtain birth/placental weight ratios, cord PO2 and other information on patients delivering between Jan 1, 1990 and Jun 15, 2011 with GA > 34 completed weeks (N=69,852). Oxygen saturation was calculated from the cord PO2 and pH data, while fractional O2 extraction was calculated from …

Impostorism And Anxiety Contribute To Burnout Among Resident Physicians, Rachel Q. Liu, Jacob Davidson, Tamara A. Van Hooren, Julie Ann M. Van Koughnett, Sarah Jones, Michael C. Ott

Paediatrics Publications

Purpose: Physician burnout is an issue that has come to the forefront in the past decade. While many factors contribute to burnout the impact of impostorism and self-doubt has largely been ignored. We investigated the relationship of anxiety and impostorism to burnout in postgraduate medical learners. Materials and methods: Postgraduate learners in four diverse training programs: Family Medicine (FM), Paediatric Medicine (PM), Anesthesiology (AN), and General Surgery (GS) were surveyed to identify the incidence of impostorism (IP), anxiety, and burnout. IP, anxiety, and burnout were evaluated using the Clance Impostor Phenomenon Scale (CIPS), Maslach Burnout Inventory-Human Services Survey (MBI-HSS), and …

The 2021 Eurpean Alliance Of Associations For Rheumatology/American College Of Rheumatology Points To Consider For Diagnosis And Management Of Autoinflammatory Type I Interferonopathies: Candle/Praas, Savi And Ags, Kader Cetin Gedik, Lovro Lamot, Micol Romano, Erkan Demirkaya, David Piskin, Sofia Torreggiani, Laura A. Adang, Thais Armangue, Kathe Barchus, Devon R. Cordova, Yanick J. Crow, Russell C. Dale, Karen L. Durrant, Despina Eleftheriou, Elisa M. Fazzi, Marco Gattorno, Francesco Gavazzi, Eric P. Hanson, Min Ae Lee-Kirsch, Gina A. Montealegre Sanchez, Bénédicte Neven, Simona Orcesi, Seza Ozen, M. Cecilia Poli, Elliot Schumacher, Davide Tonduti, Katsiaryna Uss, Daniel Aletaha, Brian M. Feldman

Paediatrics Publications

Objective: Autoinflammatory type I interferonopathies, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature/proteasome-associated autoinflammatory syndrome (CANDLE/PRAAS), stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) and Aicardi-Goutières syndrome (AGS) are rare and clinically complex immunodysregulatory diseases. With emerging knowledge of genetic causes and targeted treatments, a Task Force was charged with the development of 'points to consider' to improve diagnosis, treatment and long-term monitoring of patients with these rare diseases. Methods: Members of a Task Force consisting of rheumatologists, neurologists, an immunologist, geneticists, patient advocates and an allied healthcare professional formulated research questions for a systematic literature …

Concordance Of Regional Hypoperfusion By Pcasl Mri And 15O-Water Pet In Frontotemporal Dementia: Is Pcasl An Efficacious Alternative?, Tracy Ssali, Lucas Narciso, Justin Hicks, Linshan Liu, Sarah Jesso, Lauryn Richardson, Matthias Günther, Simon Konstandin, Klaus Eickel, Frank Prato, Udunna C. Anazodo, Elizabeth Finger, Keith St Lawrence

Paediatrics Publications

Background: Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities. Purpose: This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water (15O-water). Methods and materials: Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and 15O-water data were acquired …

"Making Change By Shared Doing": An Examination Of Occupation In Processes Of Social Transformation In Five Case Studies., Sandra Schiller, Hanneke Van Bruggen, Sarah Kantartzis, Debbie Rudman, Ryan Lavalley, Nick Pollard

Occupational Therapy Publications

BACKGROUND: As social and health inequalities deepen around the world, scholarship in occupational therapy and occupational science has increasingly emphasised the role of occupation as a powerful tool in transformative processes.

OBJECTIVE: To explore how opportunities for everyday doing together may contribute to processes of social transformation by identifying ways occupation is being taken up in socially-transformative practice.

MATERIAL AND METHODS: A generic descriptive qualitative case study design was utilised in order to describe current practice examples and identify ways occupation was being taken up in five initiatives working towards social transformation located in Canada, Germany, South Africa and the …

Situating Occupational Injustices Experienced By Children With Disabilities In Rural India Within Sociocultural, Economic, And Systemic Conditions, Tanya Elizabeth Benjamin-Thomas, Debbie Rudman, Colleen Mcgrath, Debra Cameron, Vinod Joseph Abraham, Jeshuran Gunaseelan, Samuel Prasanna Vinothkumar

Occupational Therapy Publications

This paper contributes to diversifying and situating understandings of occupational injustices through presenting findings from the knowledge generation phase of a participatory action research (PAR) project that utilized participatory filmmaking with children with disabilities in rural South India as co-researchers. Centering on situations of occupational injustices generated through a participatory analysis conducted with the child co-researchers, a critical theoretical analysis, informed by critical occupational science and critical disability perspectives, was carried out. This theoretical analysis of data generated through the filmmaking process, as well as data generated with parents of children with disabilities, community members, and service providers, was used …

Promoting Critically Informed Learning And Knowing About Occupation Through Conference Engagements, Rebecca Aldrich, Roshan Galvaan, Alison Gerlach, Debbie Rudman, Lilian Magalhaes, Nick Pollard, Lisette Farias

Occupational Therapy Publications

As occupation-focused discussions and applications of critical theoretical perspectives increase, attention must also be paid to how different spaces of knowledge dissemination, exchange, and production support critically informed learning and knowing about occupation. This paper presents the reflections of a group of international scholars and lecturers whose shared interest in critical theoretical perspectives prompted the incremental co-development of a series of conference engagements. We describe how our group came together, what kinds of learning experiences we developed to promote and support engagement with critical theoretical perspectives, and what understandings we gained through ongoing critical reflexivity about those learning experiences. Our …

What Are The Barriers And Facilitators To Polio Vaccination And Eradication Programs? A Systematic Review., Obidimma Ezezika, Meron Mengistu, Eric Opoku, Aiman Farheen, Anuradha Chauhan, Kathryn Barrett

Health Studies Publications

Global efforts to eradicate polio by the Global Polio Eradication Initiative agency partners and country-level stakeholders have led to the implementation of global polio vaccination programs. This study presents the findings of existing studies regarding the barriers and facilitators that countries face when implementing polio interventions. A comprehensive search was conducted in OVID Medline, OVID Embase, EBSCO CINAHL Plus, and Web of Science. Eligible studies underwent quality assessment. A qualitative evidence synthesis approach was conducted and aligned to the Consolidated Framework for Implementation Research (CFIR). The search identified 4147 citations, and following the removal of duplicates and screening according to …

Development And Implementation Of A Reflective Writing Assignment For Undergraduate Students In A Large Public Health Biology Course, Obidimma Ezezika, Nancy Johnston

Health Studies Publications

Reflective writing may be undervalued as purely expressive rather than a critical or an academic tool in undergraduate public health biology courses. When grounded in course concepts and academic learning, a reflective essay can be a learning tool for students that helps them use discipline knowledge and apply it to real-world issues. Studies on teaching reflection have identified its value for training students in critical thinking and improving self-regulated learning. Considering Gibbs’ Reflective Cycle framework, in this article, we detail the design, implementation, and evaluation of a reflective writing assignment integrated into a lower-year undergraduate public health biology course. Through …

Family Physician Clinical Inertia In Managing Hypoglycemia, Caroline V.M. Rebicki, Bridget L. Ryan, Alexandria Ratzki-Leewing, Paul F. Tremblay, Stewart B. Harris

Family Medicine Publications

Aims: Clinical inertia behaviour affects family physicians managing chronic disease such as diabetes. Literature addressing clinical inertia in the management of hypoglycemia is scarce. The objectives of this study were to create a measurement for physician clinical inertia in managing hypoglycemia (ClinInert_InHypoDM), and to determine physicians’ characteristics associated with clinical inertia. Methods: The study was a secondary analysis of data provided by family physicians from the InHypo-DM Study, applying exploratory factor analysis. Principal axis factoring with an Oblimin rotation was employed to detect underlying factors associated with physician behaviors. Multiple linear regression was used to determine association between the ClinInert_InHypoDM …

Radiation Exposure Determination In A Secure, Cloudbased Online Environment, Ben C. Shirley, Eliseos J. Mucaki, Joan H.M. Knoll, Peter Rogan

Biochemistry Publications

Rapid sample processing and interpretation of estimated exposures will be critical for triaging exposed individuals after a major radiation incident. The dicentric chromosome (DC) assay assesses absorbed radiation using metaphase cells from blood. The Automated Dicentric Chromosome Identifier and Dose Estimator System (ADCI) identifies DCs and determines radiation doses. This study aimed to broaden accessibility and speed of this system, while protecting data and software integrity. ADCI Online is a secure web-streaming platform accessible worldwide from local servers. Cloud-based systems containing data and software are separated until they are linked for radiation exposure estimation. Dose estimates are identical to ADCI …

A Neural Signature Of Regularity In Sound Is Reduced In Older Adults, Björn Herrmann, Burkhard Maess, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Sensitivity to repetitions in sound amplitude and frequency is crucial for sound perception. As with other aspects of sound processing, sensitivity to such patterns may change with age, and may help explain some age-related changes in hearing such as segregating speech from background sound. We recorded magnetoencephalography to characterize differences in the processing of sound patterns between younger and older adults. We presented tone sequences that either contained a pattern (made of a repeated set of tones) or did not contain a pattern. We show that auditory cortex in older, compared to younger, adults is hyperresponsive to sound onsets, but …

Completing The Puzzle: Why Studies In Non-Human Primates Are Needed To Better Understand The Effects Of Non-Invasive Brain Stimulation, Sebastian J. Lehmann, Brian D. Corneil

Brain and Mind Institute Researchers' Publications

Brain stimulation is a core method in neuroscience. Numerous non-invasive brain stimulation (NIBS) techniques are currently in use in basic and clinical research, and recent advances promise the ability to non-invasively access deep brain structures. While encouraging, there is a surprising gap in our understanding of precisely how NIBS perturbs neural activity throughout an interconnected network, and how such perturbed neural activity ultimately links to behaviour. In this review, we will consider why non-human primate (NHP) models of NIBS are ideally situated to address this gap in knowledge, and why the oculomotor network that moves our line of sight offers …

Learning Words Without Trying: Daily Second Language Podcasts Support Word Form Learning In Adults, Elise Alexander, Stephen C. Van Hedger, Laura Batterink

Brain and Mind Institute Researchers' Publications

Spoken language contains overlapping patterns across different levels, from syllables to words to phrases. The discovery of these structures may be partially supported by statistical learning (SL), the unguided, automatic extraction of regularities from the environment through passive exposure. SL supports word learning in artificial language experiments, but few studies have examined whether it scales up to support natural language learning in adult second language learners. Here, adult English speakers (n = 70) listened to daily podcasts in either Italian or English for two weeks while going about their normal routines. To measure word knowledge, participants provided familiarity ratings of …

Differential Behaviour Of Distinct Motoneuron Pools That Innervate The Triceps Surae, Josh W. Cohen, Taian M. Vieira, Tanya D. Ivanova, Jayne Garland

Kinesiology Publications

It has been shown that when humans lean in various directions, the central nervous system (CNS) recruits different motoneuron pools for task completion; common units that are active during different leaning directions, and unique units that are active in only one leaning direction. We used high-density surface electromyography (HD-sEMG) to examine if motor unit (MU) firing behaviour was dependent on leaning direction, muscle (medial and lateral gastrocnemius; soleus), limits of stability, or whether a MU is considered common or unique. Fourteen healthy participants stood on a force platform and maintained their center of pressure in five different leaning directions. HD-sEMG …