Medicine and Health Sciences Commons^™

Evaluation Of Liver Function (Gpt, Got, Alp) And Cardiac Isoenzyme (Ldh1, Ldh2, Ldh3, Ldh4) In Covid19 Patients After Recovering, Abeer Ghazi Nazzal, Ahmmad Ghazi Sabbar

Al-Nisour Journal for Medical Sciences

The present study was carried out to evaluate liver function and estimate specific cardiac biomarker in 200 subject including 150 recovered Covid-19 Patients and 50 healthy control groups. GOT, GPT, ALP and LDH isoenzyme were estimated using CUSIBIO protocol. While LDH isoenzymes were also estimated using CUSBIO protocol. The data revealed increase levels of liver enzyme GOT, GPT and ALP in recovered patients, while the LDH isoenzyme showed increasing level of LDH2, LDH3, and LDH4 except LDH1 revealed decrease level. We conclude that the dysregulation in liver function and increase of liver enzyme is due to the present the ACE2 …

The Impact Of Gram Positive Bacteria On Semen Quality In Infertile Men And Assessment Antibiotic Susceptibility Profile, Huda Mohammed Jawed, Mohammed Sh. Jebur

Al-Nisour Journal for Medical Sciences

Despite of bacterial infections have been known as a potential condition of male infertility but clear definition and role of these conditions is not very clear. Presence of bacteria in the genital tract has been frequently discovered to be associated with reduced sperm function and as a result causes infertility. The goal of this study was to identify bacterial pathogens in infertile men's sperm culture and their antibiotic susceptibility patterns in vitro, which would aid in the formulation and monitoring of antibiotic policies and appropriate empiric therapy. A total of 50 semen specimen were collected from infertile men and 50 …

Quarantine Was Very Productive But Lonely, Anonymous

Community Reflections

Class assignment for HI-102-P. No two people’s experiences with Covid-19 are the same, and in February of 2022, it is still a very relevant issue.

Sex-Specific Associations Among Total Bone-Specific Physical Activity Score, Aortic Parameters, And Body Composition In Healthy Young Adults, Sojung Kim, Harshvardhan Singh

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

Background/Objective: Physical inactivity is one of the major cardiovascular disease risk factors; however, not much is known regarding lifetime bone-specific physical activity and arterial stiffness. The aim of this cross-sectional study was to determine whether total bone-specific physical activity score (tBPAQ) was related to arterial stiffness and body composition in healthy young adults. Methods: Healthy young women (n = 56, 20.3 ± 1.3 years) and men (n = 52, 21.0 ± 1.2 years) between 18 and 25 years were recruited for this study. The tBPAQ was used to obtain a comprehensive account of lifetime bone-loading physical activity. We …

Ua25 Covid-19 Communications, Wku Finance & Administration

WKU Administration Documents

Official emails sent to faculty & staff regarding issues involved with Covid-19 Coronavirus from 2020 through 2022.

• WKU COVID-19 Grading Policy, 3/24/2020
• Signage Requests
• Steps to Help Keep Everyone Safe
• Latest Information on Covid-19 Vaccine Distribution, 2/25/2021
• Update on Covid 19 Guidance from Centers for Disease Control, 3/12/2021
• Human Resources / Business Services
• Fraudulent Unemployment Compensation Claims, 3/1/2021
• COVID Vaccines Available on Campus, 4/2021
• COVID 19 Vaccination Update, 7/28/2021
• Fall Semester Covid Message, 8/13/2021
• WKU Covid Vaccination Reporting, 8/20/2021
• Update on Proposed OSHA Rule for Covid 19 Vaccinations in the Workplace, 11/4/2021
• COVID-19, 10/21/2021
• Fall Covid Update, 8/3/2022

Development And Validation Of A Raman Spectroscopic Classification Model For Cervical Intraepithelial Neoplasia (Cin), Damien Traynor, Shiyamala Duraipandian, Ramya Bhatia, Kate Cuschieri, Prerna Tewari, Padraig Kearney, Tom D'Arcy, John J. O'Leary, Cara M. Martin, Fiona Lyng

Articles

The mortality associated with cervical cancer can be reduced if detected at the precancer stage, but current methods are limited in terms of subjectivity, cost and time. Optical spectroscopic methods such as Raman spectroscopy can provide a rapid, label-free and nondestructive measurement of the biochemical fingerprint of a cell, tissue or biofluid. Previous studies have shown the potential of Raman spectroscopy for cervical cancer diagnosis, but most were pilot studies with small sample sizes. The aim of this study is to show the clinical utility of Raman spectroscopy for identifying cervical precancer in a large sample set with validation in …

Mirna-Mediated Fibrosis In The Out-Of-Target Heart Following Partial-Body Irradiation, Barbara Tanno, Flavia Novelli Flavia Novelli, Simona Leonardi, Caterina Merla, Gabriele Babini, Paola Giardullo, Munira Kadhim, Damian Traynor, Dinesh Medipally, Aidan Meade, Fiona Lyng, Soile Tapio, Luca Marcetti, Anna Saran, Simonetta Pazzaglia, Mariateresa Mancuso

Articles

A causal association between radiation exposure and various types of non-malignant diseases, especially cardiovascular diseases, has been extensively reported [1,2]. The risks of radiation-induced heart disease (RIHD) were described in therapeutically exposed cohorts of patients with thoracic tumors in which a high incidence of long-term complications (i.e., pericarditis, cardiomyopathy, coronary artery disease, valvular heart disease, conduction abnormalities and myocardial fibrosis) increased the risk of heart-disease-related mortality [3]. Patients who received post-mastectomy radiotherapy for left-sided breast cancer were at a 2–3-time higher risk of developing cardiovascular disease, due to the apex and anterior wall of the heart being exposed to doses …

Spectrograms For Seizure Detection In Critically Ill Children, Saptharishi Lalgudi Ganesan, Cecil Hahn

Data and Test Instruments

No abstract provided.

A Novel Chelator For Pb-212/Bi-212-Based Alpha-Particle Radiotherapy For Cancers, Eric Doorn, Mengshi Li, Brianna Cagle, Nicholas Baumhover, Zhiming Dai, Dijie Liu, Ivy Vance, Frances Johnson, Michael K. Schultz

Summer Research

Lead-212 ( 212Pb) has been identified as a promising candidate for alpha(α)- particle radiotherapies for cancers in preclinical and clinical studies. Using a low molecular weight peptide, the radiotherapy will target with high affinity selective markers highly expressed in cancer cells but found in low concentration in healthy tissue. A radiometal is coupled to a chelator moiety linked to the peptide to deliver the α-particle radiation destroying cancer cells.

To develop a novel Pb specific chelator (PSC) that will provide high affinity to Pb212 and improve the in vitro and in vivo binding pharmacokinetics and stability of progeny of the …

The Impact Of Summer Program Intervention Strategies On Girls' Knowledge And Health Behaviors, Olivia Cerny, Dzifa Agbossey-Dimado, Awayinooluwa Seriki, Adejoke Ayoola

Summer Research

The well-being of youth in the United States is being threatened by physical inactivity, poor nutrition, and a range of health risk behaviors (Pierce et al., 2017). According to the U.S. Center for Disease Control and Prevention, there are worsening trends in youth health behaviors (Pierce et al., 2017). Sepúlveda and Hutton (2019) suggest with evidence that summer programs effectively reduce drug use, decrease violent crime arrests, increase safe sex practices and dispositions, maintain physical fitness, prevent excessive weight gain, and reduce anxiety

Rehabilitation Following Unilateral Total Hip Arthoroplasty Of A Patient With A Collapsed, Necrotic Femoral Head: A Case Study, Chelsea Christina Edwards

Physical Therapy Scholarly Projects

Background and Purpose: Avascular necrosis is a disease that results from the temporary or permanent loss of blood supply to the bone. This case study evaluates the effectiveness of physical therapy following a unilateral total hip arthroplasty (THA) for management of avascular necrosis. The purpose of this case study is to provide information regarding avascular necrosis, its prognosis, and the best forms of treatment with or without surgery.

Case Description: The patient was a 70-year-old female who received post-surgical physical therapy in the outpatient setting to regain functional mobility and a return to prior level of function.

Intervention: The therapy …

How The Physical Long-Haul Symptoms Of Covid-19 Influence Occupational Performance From A Person-Environment-Occupation Perspective: A Critically Appraised Topic, Emmalee Burtsfield, Amber Matlock, Alyssia Pucel

Critically Appraised Topics

An increasing number of adults continue to experience the long-term physical effects of COVID-19. Currently, there is uncertainty regarding the best practices in occupational therapy to address long-haul COVID-19 symptomology and its effects on people as research on the topic continues to emerge (Robinson et al., 2021). The purpose of this critically appraised paper is to identify prominent areas on which occupational therapists should focus during evaluation and intervention planning while considering the person, environment, and occupation to encompass the ideals of best practice when working with adult clients who are facing disruptions as a result of long-haul COVID-19 symptoms.

Moderate To Severe Traumatic Brain Injury And Cerebral Hemorrhage And The Effects Of Physical Therapy In The Acute Care Setting: A Case Study, Rachel Marie Beaner

Physical Therapy Scholarly Projects

Background and Purpose: Traumatic brain injuries (TBI) are one of the leading causes of death and disability in the United States (CDC). Patients who experience a TBI may require hospitalization and intensive medical treatment. The purpose of this case study is to evaluate the role of physical therapy intervention in the acute care setting for a patient with a moderate to severe TBI and cerebral hemorrhage.

Case Description: The patient is a female in her early 30’s who experienced a TBI and cerebral hemorrhage. She required an emergency craniotomy and was admitted to the intensive care unit for further care. …

Quantitative Sustainable Design (Qsd) For The Prioritization Of Research, Development, And Deployment Of Technologies: A Tutorial And Review, Yalin Li, John T. Trimmer, Steven Hand, Xinyi Zhang, Katherine G. Chambers, Hannah A. C. Lohman, Rui Shi, Diana M. Byrne, Sherri M. Cook, Jeremy S. Guest

UK CARES Faculty Publications

The pursuit of sustainability has catalyzed broad investment in the research, development, and deployment (RD&D) of innovative water, sanitation, and resource recovery technologies, yet the lack of transparent and agile methodologies to navigate the expansive landscape of technology development pathways remains a critical challenge. This challenge is further complicated by the higher levels of uncertainty that are intrinsic to early-stage technologies. In this work, we review and synthesize published literature on the sustainability analyses of water and related technologies to present quantitative sustainable design (QSD) – a methodology to expedite and support technology RD&D. With a shared lexicon and a …

The Politics Of Humanitarian Aid: A Case Study Of Emdr In Cambodia, Lorien S. Jordan, Desiree M. Seponski, Amber Kelley, Nea Krpo

Rehabilitation, Human Resources and Communication Disorders Faculty Publications and Presentations

The global expansion of psychotherapy through humanitarian aid is a political act. International aid organizations assert power over resource-scarce countries, make critical decisions about who receives care, who provides care, and what modalities are delivered. Once embedded in a country, programs exert influence between international interests, local governance, and the targeted population. This study adds to the limited information on how the humanitarian aid phenomenon is experienced by the practitioners who must navigate these conflicts through a case study of eye movement desensitization and reprocessing (EMDR) in Cambodia. As a non-Western nation with a colonial and autogenocidal history, Cambodia offers …

The Effects Of A Teletherapy Follow-Up Education Program On The Quality Of Life And Self-Care Management Of Lymphedema Among Breast Cancer Patients: A Doctoral Capstone Experience, Victoria Tanyag

OT Student Capstones

Background and Purpose. The primary purpose of this doctoral capstone research project was to evaluate the effect of a teletherapy follow-up education program on the participants’ quality of life in lymphedema management. A secondary objective was to determine whether an increase occurred in compliance and independence in the following recommended lymphedema management protocols within the home setting. Methods. A 14-week prospective study design was conducted at Banner Gateway Medical Center (BGMC). Eight female subjects (mean age of 61.88 years) were recruited and randomized into two treatment groups. The control group resumed care as usual. The intervention group participated in a …

The Relationship Between Head And Neck Lymphedema And Dysphagia For Individuals With Oropharyngeal Cancer: A Retrospective Study, Madison A. Cherry

OT Student Capstones

The American Cancer Society (2022) estimates about 54,000 new cases of oropharyngeal cancer in 2022. Oropharyngeal cancer, a type of head and neck cancer (HNC), typically refers to cancer in the base of tongue, oropharynx, tonsils, or mouth. The American Cancer Society (as cited by Cohen et al., 2016) recommends that physicians assess HNC survivors for lymphedema and refer them to a lymphedema therapist if necessary. Lymphedema presents as soft-tissue swelling and localized accumulation of high-protein fluid that can cause an inflammatory response resulting in disfigurement, tissue fibrosis, functional limitation, pain, and infections (Gutiérrez et al., 2020). There are two …

Use Of Occupational Therapy To Optimize Feeding In The Transition Home From The Nicu, Morgan Oster

OT Student Capstones

Current literature demonstrates a need for occupational therapy services following fragile infants’ discharge from a neonatal intensive care unit (NICU), specifically regarding feeding. Infants receive necessary medical attention and therapy services while in the NICU but are often discharged without a plan of care for continued services. NICU follow up programs (NFUs) strive to close the gap in services by providing immediate follow up post NICU discharge for the infants and their caregivers. However, occupational therapists (OTs) remain inconsistently consulted in these programs, creating potential for missed opportunities to provide the best possible health outcomes for these fragile infants. This …

Establishing Test-Retest Reliability And Internal Consistency Of The Occupational Resilience Measure, Kara Gore

OT Student Capstones

Without a clear understanding of the dynamic relationship between resilience and occupation, occupational therapy has lacked the tools necessary to optimize resilience in research and clinical practice.

Occupational resilience is defined as “the capacity for persistence in the performance of an occupation, whereby capacity is reflected in both duration and intensity of engagement in a specified occupation” (Muriithi et al., 2022).

Occupational Resilience Measure 1.0 (ORM) and the Occupational Resilience Individual Perception Scale (ORIPS) to be used as the primary assessment tools for measuring resilience in individual occupations.

Aim: Establish the test-retest reliability and internal consistency of the ORM; establish …

Ability360 Program Evaluation And Modification, Tim Filion

OT Student Capstones

Health care in the United States has shifted over the past several decades, from an emphasis on addressing morbidity and mortality to health promotion and overall quality of life (Centers for Disease Control and Prevention [CDC], 2018a). As a result, clinicians in various fields have begun to incorporate considerations for wellness initiatives in addition to preventive strategies. The phrase health-related quality of life (HRQOL) refers to “an individual’s or group's perceived physical and mental health over time” (CDC, 2018a, p. 7). As specified in that definition, HRQOL can be viewed at an individual or community level. For individuals, this includes …

The Development Of An Exercise-Based Fall Prevention Program Tailored To Incorporate Caregivers Caring For Older Adults At Risk For Falls, Emma Heldt

OT Student Capstones

Older adults are living longer than ever. The global proportion of individuals 65 years or older was 526 million in 2010 and is estimated to reach 1.5 billion in 2050 (Duarte et al., 2020). The growing aging population comes with various challenges, such as chronic health conditions, which are the leading cause of mortality and disability worldwide. Chronic health conditions can lead to other difficulties, such as declines in physical function or mobility. Duarte et al. (2020) found that around 10 million American older adults have serious difficulty walking or climbing stairs, presenting a risk for falls.

Falling in older …

Developing A Resource For Optimizing Occupational Engagement In Adults With Dementia, Maria Del Carmen Rosas Ojeda

OT Student Capstones

Dementia is an umbrella term for cognitive impairments in memory, language, executive function, which may affect behavior and personality. Globally, about 50 million people have dementia, and that number is expected to reach 150 million by the year 2050 (Fortinsky et al., 2020). Dementia is a progressive disease that affects an individual’s ability to perform their daily occupations. The progression of dementia stages can be classified as early/mild, middle/moderate, and late/severe. Alzheimer’s disease makes up 60-80% of all dementia cases, although there are various other types of dementia, including Frontotemporal dementia, Lewy Body dementia, Vascular dementia, and Parkinson’s disease dementia …

Implementation Of Functional Cognition Screening Tool And Program Development In An Inpatient Rehabilitation Setting, Michelle Spotskey

OT Student Capstones

This project aims to develop and educate occupational therapists on functional cognition screening tools and interventions in an inpatient setting. This program development is intended to improve occupational therapist evaluation processes at Banner Baywood Facility to include cognitive components and improve the interdisciplinary approach to treating cognitive deficits amongst other professionals, especially speech pathologists. The implementation of this program development provided the therapist with tools and resources vital for determining the disposition and level of independence for medication management/bill paying upon discharge. Therapists gained skill levels to implement appropriate functional cognition interventions, goals, and family training to guide the plan …

Implementation Of A Protocol For Conservative Treatment Of Thumb Carpometacarpal Osteoarthritis, Kylie R. Eklund

OT Student Capstones

Background and Purpose. Pain and stiffness in the hands often occurs in older age because of osteoarthritis. The thumb carpometacarpal joint is the most affected site, producing more pain and disability than any other joint in the hand. Conservative treatment to stabilize the joint, including manual therapy, joint mobilization, splinting, education, activity modification, stretches, and exercises, has proven effective to slow disease progression. Inclusion of functional activity is not studied yet is warranted. Methods. Five participants were included. All participants were between 53 and 82 years old. Participants completed several weeks of hand therapy depending on their presentation. Measures included …

Occupational Therapy Scope Of Practice: Pediatric Mental Health Across The Continuum, Kacey Varnell

OT Student Capstones

This capstone project was completed in a pediatric hospital setting and is written to generalize observations, resources created, and a plan for implementing change to a larger population. Pediatric mental health conditions and the related psychosocial components are underserved client factors in the hospital setting. It typically falls second to physical limitations of the client when it comes to therapy, especially in the intensive care setting. Long term outcomes that are seen post-hospitalization include negative psychosocial consequences that decline overall quality of life. Anxiety, depression, and PTSD are the main conditions that can follow the traumatic experiences related to being …

A Comprehensive Manual Of The Shoulder Exercise Machine And An Introduction To The Potential Benefits Of The Novel Device, Angus Lochhead

OT Student Capstones

The most common standard therapy exercise equipment for upper extremity (UE) strengthening consists of elastic/resistance bands, dumbbells, and dowels. During the rehabilitation process, more effective equipment may assist patients in achieving the strength needed for optimal UE functioning. The novel shoulder exercise machine allows linear movement exercises in any direction and attaches to nonporous surfaces (horizontal to vertical surfaces) via two powerful vacuum cups. It uses resistance bands to provide tension during resistance training to target muscles of the shoulder complex. The machine enhances safety by providing controlled linear movements and increased UE support and stabilization compared to using weights …

Identifying An Association Between Sensory Processing And Food Sensitivities, Taylor Tonks

OT Student Capstones

Introduction: Feeding difficulties are quite common in children and can lead to a multitude of poor health outcomes. Children with sensory processing difficulties can present with feeding difficulties. The relationship between sensory processing and feeding difficulties in children has been previously researched. However, most of the existing research focuses on children diagnosed with autism spectrum disorder. Methods: The purpose of the present study was to identify the association between sensory processing and food sensitivities in children of varying diagnoses using retrospective data. In the study, the researcher included 47 children who presented to an outpatient pediatric clinic for a feeding …

Occupational Health And Safety For Commercial Pilots During The Coronavirus Pandemic, Autumn M. Dawley

OT Student Capstones

BACKGROUND

The aviation industry has been growing with the number of aircraft pilots jumping from 590,038 in 2015 to 664,563 in 2019. With an increasing demand for distribution of cargo, a review of the effects of work-related stressors during the coronavirus pandemic and, further, a solution to increase the health and well-being of individuals in the industry is essential. The Federal Aviation Administration (FAA) addresses fatigue and routinely revises regulations which alleviate job stress; however, the coronavirus pandemic has added new stressors to the aviation industry.

PURPOSE

The purpose of this study was to examine the impact of the pandemic …

Fostering Healthy Therapeutic Relationships: Foster Parent Education Program, Sydnie Barboza

OT Student Capstones

Background: Children who have been placed in the foster care system due to trauma often have difficulty coping with past experiences. These traumatic experiences can often affect their development, physically and mentally, and emotional regulation, relationships, and attachment. As of April 2021, more than 13,400 children were placed in the foster care system in Arizona. While removing children from their birth home to a safer environment is critical, it brings along many challenges such as emotional trauma and inconsistent caregiving. Methods: The foster parent educational program described in this paper, “Fostering Healthy Therapeutic Relationships,” is a foster and adoptive parent …

Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab

Faculty and Student Publications

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and 19.56 µM against A549 and HCT-116, respectively. Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT). Compound 12b was the most potent member showing an IC50 value of 0.016 µM. In addition, compound 12b showed noticeable …