Medicine and Health Sciences Commons^™

Care Alert Program In Chronic Recurrent Ed Utilizing Patients, Kaitlyn Phelps, Erica Gibbons, Jonathan Leggett, Jonathan Bryan

South Atlantic Division GME Research Day 2022

No abstract provided.

Envenomation By A Gaboon Viper, Mary Claire Lark, Jarratt Lark

South Atlantic Division GME Research Day 2022

No abstract provided.

Blunt Cardiac Injury Breaks The Heart: A Case Of Traumatic Ventricular Septal Defect And Literature Review Of The Same, Austin Mccrea, Allison Mccrae, Saptarshi Biswas

South Atlantic Division GME Research Day 2022

No abstract provided.

Case Report: Disseminated Mucormycosis In An Ostensibly Immunocompetent Patient, Chad Froes, Matt Gellatly, Brian Watson

South Atlantic Division GME Research Day 2022

No abstract provided.

Fever Of Unknown Origin: A Grave Diagnosis, Ryan Miller, Richard Allen

South Atlantic Division GME Research Day 2022

No abstract provided.

Intrapulmonary Teratoma: A Rare Presentation Of Bronchiectasis, Beren Chandler, Garret Duron, Jason Mcclune, Lindsey Goldberg

South Atlantic Division GME Research Day 2022

No abstract provided.

Free, Fair, And Fabulous: Five Data Tools To Support Open And Reproducible Research At Your Institution, Christine Nieman, Katie Pierce-Farrier, Sean Corning, Elizabeth Roth

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

With more publishers and funders requiring data management and sharing plans, it is important for librarians, researchers, and support staff to be aware of the tools available to help them skillfully manage research data. There are a wide variety of tools available, both free and paid, that can work with data but selecting an affordable, accessible tool can be a barrier to use.

Description

This poster seeks to promote awareness of freely available tools for data management, wrangling, and sharing for use in daily work and research projects. The poster will review five data tools (DMPTool, NIH Common Data …

Choose Environmental Health And Justice As Your Next Adventure, April Wright, Faith Steele, Tiffany Chavis, Christine Nieman

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

With health outcomes and disparities being linked to environmental degradation, libraries and librarians have an opportunity to empower their communities with information. Librarians, public health practitioners and community scientists can benefit from learning about environmental health and justice, specifically about how these topics can have an impact on heath literacy and rural health.

Description

Environmental conditions as a social determinant of health was identified by Healthy People 2030 as one of its priority areas. Our lightning talk will discuss the importance of understanding environmental health and justice issues related to medically underserved communities. Environmental justice issues are known to …

Resources For Osteopathic Medicine, Elaine Powers, Jessica Muller

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Collection development for Colleges of Osteopathic Medicine (COMs) has been a challenge since strictly osteopathic resources are somewhat specialized in regard to content and acquisition.

Description

This poster will present a list of textbooks and journals needed to develop an osteopathic library collection. Organizations and publishers with osteopathic resources will also be described.

Conclusions

A “top ten” list of osteopathic titles as well as a comprehensive list of osteopathic books and resources provide collection development guidelines for Colleges of Osteopathic Medicine as well as for librarians in other types of medical facilities. Creation of a QR code will provide …

Healthcare Utilization And Costs Among High-Need And Frail Mexican American Medicare Beneficiaries, Maricruz Rivera-Hernandez, Amit Kumar, Lin-Na Chou, Tamra Keeney, Nasim Ferdows, Amol Karmarkar, Kyriakos S. Markides, Kenneth Ottenbacher

Physical Medicine and Rehabilitation Publications

Objectives
To examine Medicare health care spending and health services utilization among high-need population segments in older Mexican Americans, and to examine the association of frailty on health care spending and utilization.

Methods
Retrospective cohort study of the innovative linkage of Medicare data with the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) were used. There were 863 participants, which contributed 1,629 person years of information. Frailty, cognition, and social risk factors were identified from the H-EPESE, and chronic conditions were identified from the Medicare file. The Cost and Use file was used to calculate four categories …

Perspectives On Primary Blast Injury Of The Brain: Translational Insights Into Non-Inertial Low-Intensity Blast Injury, Heather R. Siedhoff, Shanyan Chen, Hailong Song, Jiankun Cui, Ibolja Cernak, David X. Cifu, Ralph G. Depalma, Zezong Gu

Physical Medicine and Rehabilitation Publications

Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild” and frequently caused by non-impact blast exposures. Experimental models were developed to reproduce the biological consequences of high-intensity blasts causing moderate to severe brain injuries. However, the pathophysiological mechanisms of low-intensity blast (LIB)-induced neurological deficits have been understudied. This review provides perspectives on primary blast-induced mild TBI models and discusses translational aspects of LIB exposures as defined by standardized physical parameters including overpressure, impulse, and shock wave velocity. Our mouse LIB-exposure model, which reproduces deployment-related scenarios of open-field blast (OFB), caused neurobehavioral changes, including reduced exploratory activities, …

Age-Related Changes And Longitudinal Stability Of Individual Differences In Abcd Neurocognition Measures, Andrey P. Anokhin, Monica Luciana, Marie Banich, Deanna M. Barch, James M. Bjork, Marybel R. Gonzalez, Raul Gonzalez, Frank Haist, Joanna Jacobus, Krista Lisdahl, Erin Mcglade, Bruce Mccandliss, Bonnie Nagel, Sara J. Nixon, Susan Tapert, James T. Kennedy, Wesley K. Thompson

Psychiatry Publications

Temporal stability of individual differences is an important prerequisite for accurate tracking of prospective relationships between neurocognition and real-world behavioral outcomes such as substance abuse and psychopathology. Here we report age-related changes and longitudinal test-retest stability (TRS) for the Neurocognition battery of the Adolescent Brain and Cognitive Development (ABCD) study, which included the NIH Toolbox (TB) Cognitive Domain and additional memory and visuospatial processing tests administered at baseline (ages 9–11) and two-year follow-up. As expected, performance improved significantly with age, but the effect size varied broadly, with Pattern Comparison and the Crystallized Cognition Composite showing the largest age-related gain (Cohen’s …

An Exploration In Health Analytics: Pediatric Burns, Care Policy Assessment And Interrupted Time Series, Chao Wang

2022

Healthcare systems globally face multiple challenges in the face of population growth and changes in disease pathology. With regard to the rising demand of the healthcare and the global threats of the pandemic, the medical datasets can be trained further to develop preventive methods. Meanwhile, policy reforms of health systems could be a critical aspect to deal with the public crisis and concerns. However, two basic problems must be addressed first: identification of key factors on a priority basis and evaluation of changes.

Thus, the paper presents a series of trials on the application of data analytics to health-related problems, …

Inflammatory Response To Sleep Fragmentation In Skeletal, Cardiac, And Smooth Muscle Tissues In Female Mice, Patton Allen

Mahurin Honors College Capstone Experience/Thesis Projects

Sleep is a critical process that the body undergoes. When sleep is interrupted, so that an individual is awakened for some period before going back into sleep, the sleep can be described as fragmented. Studies in the past have shown that sleep fragmentation (SF) promotes an inflammatory environment, especially in the brain and peripheral tissue. However, studies have not been conducted to observe inflammatory responses in muscle. To examine this, C57BL/6J female mice were subjected to either a control group (no SF) or a SF group which involved using an automated SF chamber to disrupt sleep every 2 min over …

Chemical Analysis Of Amoxicillin Samples Using Ultra Performance Liquid Chromatography In Tandem With Mass Spectrometry For The Distributed Pharmaceutical Analysis Laboratory, Sophie Samiee

Pitzer Senior Theses

The global health crisis of “fake” drugs is rampant worldwide and causes 1 million deaths and $30 billion in damage annually, according to a recent report by the United States Pharmacopeia in 2021. Substandard and falsified medicines remain uncontrolled due to underreporting, poor detection methods, and a lack of cooperation between countries. To combat this, the University of Notre Dame and Chemists Without Borders established the Distributed Pharmaceutical Analysis Laboratory (DPAL) in 2014 to provide high quality, validated analysis of pharmaceutical samples from partners in the developing world. Heretofore, ultra-performance liquid chromatography in tandem with mass spectrometry (UPLC-MS) has not …

Seizure‑Related Differences In Biosignal 24‑H Modulation Patterns, William Bosl, Solveig Vieluf, Rima El Atrache, Sarah Cantley, Michele Jackson, Justice Clark, Theodore Sheehan, Bo Zhang, Tobias Loddenkemper

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

Health And Technology: Online Platform To Facilitate Access To Care And Prevention For Chronic Non-Communicable Conditions In Rwanda, Arnaud Michel Nibaruta Mdp

Regis University Student Publications (comprehensive collection)

Rwanda is confronted with a growing problem of non-communicable diseases (NCD). It is important that people in Rwanda have access to effective prevention and treatment. This paper explores a program that would use a digital platform to facilitate access to information, services, and products that would help NCD at risk populations in Rwanda to access appropriate prevention and care. The program was developed based on the author’s experience in Rwanda’s healthcare industry, the information from review of literature as well as key informant interviews (NCD patients, advocates, and caregivers) and a survey with health professionals. The research conducted highlighted that …

Effects Of Heat On Seven Endodontic Sealers, Daniel Chavarria-Bolanos, Takashi Komabayashi, Ivy Shen, Jose Vega-Baudrit, Maria G. Gandolfi, Carlo Prati, Mauricio Montero-Aguilar

Dental Medicine Faculty Publications

Purpose: To examine the microscopic surface features, chemical composition, and thermodynamic profile of seven endodontic sealers (AH Plus, Adseal, MTA-Fillapex, RoekoSeal, GuttaFlow 2, GuttaFlow BioSeal, and EndoRez) exposed to high-temperature changes using an endodontic obturation device.

Methods: The thermal properties were examined using scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Then, six disc-shaped specimens of each sealer were prepared and divided into two groups – a room temperature group and a heat exposure group – for analysis of surface and chemical changes using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS).

Results: DSC analysis showed that AH Plus had …

Coarse-Graining And The Haar Wavelet Transform For Multiscale Analysis, William Bosl, Tobias Loddenkemper, Solveig Vieluf

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

Ifn-Γ Transforms The Transcriptomic Landscape And Triggers Myeloid Cell Hyperresponsiveness To Cause Lethal Lung Injury, Atul K. Verma, Michael Mckelvey, Md Bashir Uddin, Sunil Palani, Meng Niu, Christopher Bauer, Shengjun Shao, Keer Sun

Journal Articles: Pathology and Microbiology

Acute Respiratory Distress Syndrome (ARDS) is an inflammatory disease that is associated with high mortality but no specific treatment. Our understanding of initial events that trigger ARDS pathogenesis is limited. We have developed a mouse model of inflammatory lung injury by influenza and methicillin-resistant Staphylococcus aureus (MRSA) coinfection plus daily antibiotic therapy. Using this pneumonic ARDS model, here we show that IFN-γ receptor signaling drives inflammatory cytokine storm and lung tissue damage. By single-cell RNA sequencing (scRNA-seq) analysis, we demonstrate that IFN-γ signaling induces a transcriptional shift in airway immune cells, particularly by upregulating macrophage and monocyte expression of genes …

Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth Of Staphylococcus Aureus In Defined Medium Lacking Glucose And Arginine, Itidal Reslane, Cortney R. Halsey, Amanda Stastny, Barbara J. Cabrera, Jong-Sam Ahn, Dhananjay Shinde, Madeline R. Galac, Margaret F. Sladek, Fareha Razvi, Mckenzie K. Lehman, Kenneth W. Bayles, Vinai Chittezham Thomas, Luke D. Handke, Paul D. Fey

Journal Articles: Pathology and Microbiology

Previous studies have found that arginine biosynthesis in Staphylococcus aureus is repressed via carbon catabolite repression (CcpA), and proline is used as a precursor. Unexpectedly, however, robust growth of S. aureus is not observed in complete defined medium lacking both glucose and arginine (CDM-R). Mutants able to grow on agar-containing defined medium lacking arginine (CDM-R) were selected and found to contain mutations within ahrC, encoding the canonical arginine biosynthesis pathway repressor (AhrC), or single nucleotide polymorphisms (SNPs) upstream of the native arginine deiminase (ADI) operon arcA1B1D1C1. Reverse transcription-PCR (RT-PCR) studies found that mutations within ccpA or ahrC or …

Value And Impact Of Nurse Innovators Working In Academic, Industry, And Government Settings: A Qualitative Study, Olivia A. Lemberger

Graduate Research Theses & Dissertations

This dissertation explores the value and impact of nurse innovators working in academic, industry, and government settings. A qualitative descriptive study was chosen to understand the contributions of nurse innovators and the outcomes associated with their innovative endeavors. The purpose of this study is to better understand the contributions of nurse innovators by answering the following research questions: 1) How do nurses perceive that nursing innovation adds value to and/or impacts patients or the United States health care system? 2) What metrics/outcome measures do nurse innovators identify as relevant or useful to evaluate innovation success? And 3) What methods/resources do …

Exploring Epigenetic Reprogramming During Central Nervous System Infection, Zachary Van Roy, Tammy Kielian

Journal Articles: Pathology and Microbiology

Epigenetics involves the study of various modes of adaptable transcriptional regulation, contributing to cell identity, characteristics, and function. During central nervous system (CNS) infection, epigenetic mechanisms can exert pronounced control over the maturation and antimicrobial properties of nearly every immune cell type. Epigenetics is a relatively new field, with the first mention of these marks proposed only a half-century ago and a substantial body of immunological epigenetic research emerging only in the last few decades. Here, we review the best-characterized epigenetic marks and their functions as well as illustrate how various immune cell populations responding to CNS infection utilize these …

The Staphylococcus Aureus Cida And Lrga Proteins Are Functional Holins Involved In The Transport Of By-Products Of Carbohydrate Metabolism, Jennifer L. Endres, Sujata S. Chaudhari, Xinyan Zhang, Janani Prahlad, Shu-Qi Wang, Lily A. Foley, Sorin Luca, Jeffrey L. Bose, Vinai C. Thomas, Kenneth W. Bayles

Journal Articles: Pathology and Microbiology

The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD). Based on the structural similarities that CidA and LrgA share with bacteriophage holins, we have hypothesized that these proteins function by forming pores within the cytoplasmic membrane. To test this, we utilized a "lysis cassette" system that demonstrated the abilities of the cidA and lrgA genes to support bacteriophage endolysin-induced cell lysis. Typical of holins, CidA- and LrgA-induced lysis was dependent on the coexpression of endolysin, consistent with the proposed holin-like functions of these proteins. In …

Datasets For The Reporting Of Primary Tumour In Bone: Recommendations From The International Collaboration On Cancer Reporting (Iccr), Judith V. M. G. Bovée, Fleur Webster, Fernanda Amary, Daniel Baumhoer, J. L. Hans Bloem, Julia A. Bridge, Justin M. M. Cates, Enrique De Alava, Angelo Paolo Dei Tos, Kevin B. Jones, Annabelle Mahar, G. Petur Nielsen, Alberto Righi, Andrew J. Wagner, Akihiko Yoshida, Christopher D. M. Fletcher

Journal Articles: Pathology and Microbiology

BACKGROUND AND OBJECTIVES: Bone tumours are relatively rare and, as a consequence, treatment in a centre with expertise is required. Current treatment guidelines also recommend review by a specialised pathologist. Here we report on international consensus-based datasets for the pathology reporting of biopsy and resection specimens of bone sarcomas. The datasets were produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major (inter-)national pathology and cancer organisations.

METHODS AND RESULTS: According to the ICCR's process for dataset development, an international expert panel consisting of pathologists, an oncologic orthopaedic surgeon, a medical oncologist, and …

A Quality Improvement Project To Increase Diabetic Retinopathy Screenings, Daniel Joh, Reema George, Brandi Addison

Gulf Coast Division GME Research Day 2022

No abstract provided.

Triceps Tendon Avulsion In Elderly Male, Mary Claire Lark, Garrett Root, Bryan T. Luu

South Atlantic Division GME Research Day 2022

No abstract provided.

Incidence Of Adult (≥40y) Traumatic Intracranial Bleeding And Likelihood Of Routine Discharge: Do Co-Morbidities Matter?​, Stephanie Anderson, Heather Rhodes, Antonio Pepe, Donald Courtney

South Atlantic Division GME Research Day 2022

No abstract provided.

A Newfound Breach In Repeat Vaginal Delivery: Unscarred Uterine Rupture, Merritt Mcgowan, Amethyst Wilder, Ashley Hawes

South Atlantic Division GME Research Day 2022

No abstract provided.

Locked In: The Impact Of The Pandemic On Suicide, Evelyn Coile, Tatiana Eversley-Kelso, Eric Shaw, Sara Hamilton

South Atlantic Division GME Research Day 2022

No abstract provided.