Medicine and Health Sciences Commons^™

Identification Of A Novel Microdeletion Causative Of Nance-Horan Syndrome, Mariana Lopez Martinolich, Hope Northrup, Pedro Mancias, Paul Hillman, Kavya Rao, Kate Mowrey

Faculty, Staff and Student Publications

BACKGROUND: Nance-Horan syndrome (NHS) is a rare X-linked genetic disorder characterized by ophthalmologic and dental anomalies as well as dysmorphic facies. The clinical phenotype in males includes congenital cataracts, vision loss, microcornea, nystagmus, microphthalmia, glaucoma, screwdriver blade-shaped incisors, supernumerary maxillary incisors, diastema, delays, intellectual disability, and dysmorphic facies. With the evolution of array-CGH technology, a total of five kindreds with NHS have been reported in the medical literature with microdeletions encompassing the NHS gene rather than sequencing variants.

METHODS: The patient is a 19-year-old male born to non-consanguineous parents with a past medical history of bilateral congenital cataracts, nystagmus, poor …

Predicting 31- To 60-Day Heart Failure Rehospitalization Among Older Women, Carolyn Biggs Sue-Ling Phd, Rn, Mpa, Nalini Jairath

Publications

The current study sought to identify social, hemodynamic, and comorbid risk factors associated with 31-to 60-day heart failure (HF) rehospitalization in African American and Caucasian older (aged >65 years) women. A non-equivalent, case-control, quantitative design study using secondary data analysis of medical records from a local community hospital in the Southeast region of the United States was performed over a 3-year period. Relationships between predictor variables and the outcome variable, 31- to 60-day HF rehospitalization, were explored. The full model containing all predictors was not able to distinguish between predictors (χ[21, N = 188] = 35.77, p = 0.12). However, …

Pharmacological Antagonism Of Ep2 Receptor Does Not Modify Basal Cardiovascular And Respiratory Function, Blood Cell Counts, And Bone Morphology In Animal Models., Varun Rawat, Avijit Banik, Radhika Amaradhi, Asheebo Rojas, Shashidharamurthy Taval, Tamas Nagy, Raymond Dingledine, Thota Ganesh

PCOM Scholarly Works

The EP2 receptor has emerged as a therapeutic target with exacerbating role in disease pathology for a variety of peripheral and central nervous system disorders. We and others have recently demonstrated beneficial effects of EP2 antagonists in preclinical models of neuroinflammation and peripheral inflammation. However, it was earlier reported that mice with global EP2 knockout (KO) display adverse phenotypes on fertility and blood pressure. Other studies indicated that EP2 activation with an agonist has a beneficial effect of healing fractured bone in animal models. These results impeded the development of EP2 antagonists, and EP2 antagonism as therapeutic strategy. To determine …

Natural Mycoplasma Bovis Infection Associated With Epithelioid Granulomatous Caseonecrotic Bronchiolitis At A Progressed Disease Stage In Calves, Mathurot Suwanruengsri, Ryoko Uemura, Uda Zahli Izzati, Takuya Kanda, Naoyuki Fuke, Masahiro Yasuda, Takuya Hirai, Ryoji Yamaguchi

The Thai Journal of Veterinary Medicine

Mycoplasma bovis (M. bovis) is a pathogen that especially effects the respiratory system of cattle. We focused on the histopathological changes in the lungs caused by M. bovis because the lesions in the bronchi or bronchioles and alveoli are quite different in natural infections. Thirty-five lung samples from 2-to 12-month-old Japanese Black calves with respiratory symptoms were collected and examined for bacteria presence and pathological changes using immunohistochemistry (IHC). Using the loop-mediated isothermal amplification method, 18 of the 35 samples were found to be positive for M. bovis, which was isolated and identified. In 7 of the samples, only M. …

Indications For Canine Fecal Microbiota Transplantation, Kerong Li, Xiaoxiao Zhou, Zhijun Zhong, Haifeng Liu, Min Li, Guangneng Peng, Ziyao Zhou

The Thai Journal of Veterinary Medicine

Fecal microbiota transplantation (FMT) is a novel method to treat intestinal and extraintestinal diseases by transplanting the microbiota in the feces of healthy animals into the gastrointestinal tracts of patients and reconstructing intestinal flora in the patients' intestine. In this article, we reviewed the recent studies of canine FMT focusing on its indications. FMT was proved effective to treat canine Clostridioides difficile infection (CDI), inflammatory bowel disease (IBD), canine parvovirus (CPV) diarrhea and acute diarrhea; upregulate the intestinal microbiota in dogs with acute hemorrhagic diarrhea syndrome (AHDS); and may have benefit for preventing canine post-weaning diarrhea. However, the specific FMT …

Seasonal And Antimicrobial Resistance Distributions Of Salmonella Isolated From Pork, Beef And Chicken Meat In Vientiane Capital, Lao Pdr, Sitthasone Xaymountry, Kanit Chukanhom, Seri Klangair, Jatesada Jiwakanon, Sunpetch Angkititrakul

The Thai Journal of Veterinary Medicine

The objectives in this study was to investigate the prevalence, seasonal variation and antimicrobial resistance of Salmonella isolated from pork, beef and chicken meat at retail markets in Vientiane capital, Lao PDR. During May 2018 to April 2019, 445 swab samples were randomly collected from pork (n = 258), beef (n = 81) and poultry meat (n = 106) in three seasons at three retail big markets in Vientiane capital, Lao PDR, Thongkhankham, Lao-Aussi, and Nongchan markets. All samples were isolated and identified for Salmonella spp. using the ISO 6579:2002/AMD 1:2007 procedure. The isolates were tested for antimicrobial susceptibility using …

Investigation Of Bacterial Pathogens In Milk From Mastitic Dairy Cattle By Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry, Gokben Ozbey, Baris Otlu, Yusuf Yakupogullari, Betul Celik, Elif Seren Tanriverdi, Neslihan Kelestemur, Tarik Safak, Ali Risvanli, Anil Persad, Emma Sproston

The Thai Journal of Veterinary Medicine

The scope of the present study was to assess the use of Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) Mass Spectrometry (MS) as a quick technique for the identification of bacterial species in mastitis. In this study, milk samples from each udder quarter from a total of 250 dairy cattle were aseptically collected and tested. The samples were grouped into California Mastitis Test (CMT) positive, CMT negative and clinical mastitis. The samples were streaked on blood agar and the bacterial isolates were analysed using MALDI-TOF MS. Using MALDI-TOF MS, certain species such as Staphylococcus chromogenes (44/188, 23.4%), Aerococcus viridans (40/188, 21.3%) …

Inflammatory Mediator Gene Expression Of The Kidneys Induced By Daboia Siamensis Venom And Its Components, Suchitra Khunsap, Sunutcha Suntrarachun, Orawan Khow, Jureeporn Noiphrom

The Thai Journal of Veterinary Medicine

Phospholipase A2 (PLA2) and metalloprotease (MP) from Daboia siamensis (Ds) venom are believed to contribute to renal tissue toxicity. Imbalance of the cytokine system induced by snake envenomation causes tissue injury and cell damage which leads to acute toxic kidney injury. A better understanding of the pathological mechanism involved in renal injury after venom administration is needed. In the present study, we aimed to investigate inflammatory mediator genes (IL-2, IL-10, TNFα, IFN, and COX-2) in mouse kidney tissue after venom injection. Quantitative real time PCR was performed to detect the cytokine gene profiles. Beta actin was used as a house-keeping …

Expression Of Prostaglandin F2 Alpha Receptors (Ptgfr) And C-Reactive Protein (Crp) In The Canine Uterus And Cervix With Opened- And Closed-Cervix Pyometra, Narong Tiptanavattana, Pokchon Khirilak, Theerawat Tharasanit, Natapol Duangtum, Kijsopon Jankaew, Prawit Sae-Jia, Nongnapat Kaewchana

The Thai Journal of Veterinary Medicine

Pyometra is a common reproductive disorder in female dogs. This study investigated the protein expression of prostaglandin F2 alpha receptors (PTGFR) and C-reactive protein (CRP) in responses to inflammatory events of uterine and cervical tissues in dogs. Uterus and cervix samples were collected from six dogs which had closed-cervix pyometra (n = 3) and opened- cervix pyometra (n = 3). Healthy dogs in diestrus (n = 3) and anestrus (n=3) were used as controls. Tissues were histologically prepared and stained with hematoxylin and eosin. Immunohistochemistry (IHC) and western blot analysis for the PTGFR and CRP were used to verify the …

Comparison Of An Intra-Articular Suture Technique And A Lateral Suture Technique In Toy Breed Dogs With Cranial Cruciate Ligament Rupture, Sirun Tuek-Um, Chaiyakorn Thitiyanaporn, Phitchaya Phongwirat, Naris Thengchaisri

The Thai Journal of Veterinary Medicine

Cranial cruciate ligament rupture (CCLR) can result in inflammation, pain, lameness and osteoarthritis. Because there is no isometric point for surgical stabilization for CCLR, the anatomical replacement of the ruptured cranial cruciate ligament with synthetic material may provide better outcomes. This retrospective study compared short-term post-operative outcomes between an intra-articular suture technique and a lateral suture technique for treating CCLR in toy breed dogs. Twenty dogs with unilateral CCLR were divided into two groups. The lateral suture technique was a lateral circumfabellar tibial suture with monofilament nylon and the intra-articular suture was performed by passing a suture through the femoral …

Therapeutic Potential Of Bulgarian Propolis Against Antibiotic-Resistant Salmonella Species, Manar M. Farouk, Amal El-Molla, Fayez A. Salib, Yousef A. Soliman, Mohamed Shaalan

The Thai Journal of Veterinary Medicine

The emergence of multidrug-resistant (MDR) Salmonella spp. has increased the need for investigation of antimicrobial alternatives. Ethanolic extract of propolis (EEP) has been identified to have wide-ranging medical applications related to its antimicrobial activity. The current study aimed to identify the major chemical components of EEP with antibacterial effects, evaluate the antibacterial efficacy of EEP against MDR Salmonella spp. isolates, and further examine the therapeutic efficacy of EEP against MDR S. Enteritidis infected mouse model. Bulgarian propolis EEP was prepared by using ethanol based extraction method. The chemical composition of EEP was characterized using the gas chromatography-mass spectroscopy (GC-MS). The …

Surveillance Of Zoonotic Brugia Pahangi In Monastery Cats, Samphran District, Nakhon Pathom, Thailand, Thanakorn Rawangchue, Nuttasiri Sripirom, Sivapong Sungpradit

The Thai Journal of Veterinary Medicine

The mosquito-borne filarial nematode parasites Brugia pahangi and B. malayi have been proposed as potential zoonotic pathogens, with dogs and cats being the main reservoir hosts. The monasteries where both stray and semi-domesticated animals live often serve as areas where humans are exposed to these reservoirs. In Thailand, the prevalence of B. pahangi, particularly in infected monastery cats, is underreported. In this study, we investigated B. pahangi prevalence in cats at 24 temples in the Samphran district, Nakhon Pathom province, central Thailand. In total, 196 blood samples were collected from the cats and examined using the hematocrit capillary tube technique. …

The Relationship Of Abortion, Dog Management And Neospora Caninum In Dairy Herds In Taiwan, Hsu-Hsun Lee, Chen-Chih Chen, Yi-Lun Tsai, Shyh-Shyan Liu, Po-An Yueh, Huan-Yu Hsu, Ai-Mei Chang

The Thai Journal of Veterinary Medicine

Neospora caninum (N. caninum) has caused an abortion storm in dairy herds for two decades in Taiwan. There is no effective medicine for N. caninum infection for livestock, therefore, prevention by farm management is very important. The risk factors for N. caninum infection in Taiwan is still unclear. Dogs are the common definitive hosts of N. caninum on farms. This study aims to estimate the sero-prevalence and detection of N. caninum DNA in 361 pregnant dairy cows and establish an effective strategy to prevent abortion caused by N. caninum in dairy farms in Taiwan by logistic regression. The sero-prevalence of …

Complete Genome Sequence Of A Novel Recombinant Muscovy Duck Parvovirus Isolated In The Heilongjiang Province Of China, Jing Yang, Ming Li, Tianfei Yu

The Thai Journal of Veterinary Medicine

Muscovy duck parvovirus (MDPV) is fatal for young ducklings of less than 3 weeks of age and has caused severe economic loss in duck production in many countries and regions. We report here on a complete genome sequence of a recombinant MDPV strain YL08 isolated from an ill Muscovy duck in 2008 at Qiqihar, Heilongjiang province, China. This genome, MDPV YL08, was 5061 nucleotides long and retained the two ORFs, which are typical in the Parvovirinae family. The genome of YL08 strain has a putative recombination breakpoint on its VP1 gene. This study has helped our understanding of the genetic …

The Validation Of Haemagglutinin Inhibition Test For The Detection Of Antibodies Against Canine Influenza Virus In A Guinea Pig Serum Model, Ratanaporn Tangwangvivat, Supassama Chaiyawong, Nutthawan Nonthabenjawan, Kamonpan Charoenkul, Taveesak Janethanakij, Duangduen Prakairungnamthip, Wittawat Wechtaisong, Supanat Boonyapisitsopa, Napawan Bunpapong, Alongkorn Amonsin

The Thai Journal of Veterinary Medicine

No abstract provided.

Biomechanical Analysis Of Atlantoaxial Dorsal Fixation Using Finite Element Models, Beomju Bae, Dongwook Kim, Hyejong Oh, Gonhyung Kim

The Thai Journal of Veterinary Medicine

Atlantoaxial instability can cause spinal cord compression with clinical signs ranging from cervical pain to tetraplegia and death. Although a variety of dorsal fixation techniques have been described, some of them have been related to the fracture of the dorsal arch of the atlas, leading to surgical failure. Under the hypothesis that the shape of the dorsal arch of the atlas and types of implants might affect these bone fractures, the objective of this study was to analyze bone stresses through simulations of the dorsal fixation using finite element models. Arbitrary tension forces were given to implants for simulations of …

A Dorsal Sling Technique In A Dermoid Sinus Dog With Nuchal Ligament Excision, Nithida Boonwittaya, Pakthorn Lewchalermwong, Kanokwan Keadwut

The Thai Journal of Veterinary Medicine

A dorsal sling technique for correction of nuchal ligament excision in a dermoid sinus canine case is presented in this report. At surgery, there were multiple tubes of the dermoid sinus tracts of different types. The nuchal sinus was treated using a segmental resection at the area of involvement and a dorsal sling technique was performed. The dog recovered uneventfully and regained normal daily activities within a short time after surgery. The technique was accomplished as evaluated by non-pain normal motion of the cervical region and no complications were found during the follow-up period. This is the first report on …

Clinical Characteristics, Antimicrobial Resistance And Treatment Outcomes Of Multidrug-Resistant Escherichia Coli Infection In Dogs And Cats At A Veterinary Teaching Hospital In Thailand, Jeerawat Soonthornsit, Sukanya Apiratwarrasakul, Nathita Phumthanakorn

The Thai Journal of Veterinary Medicine

This retrospective study investigated the clinical characteristics of multidrug-resistant (MDR) Escherichia coli and its antimicrobial resistance phenotypes and analyzed the treatment outcomes of MDR E. coli infection in dogs and cats. The medical data of dogs and cats diagnosed in 2020 with E. coli infection at a veterinary teaching hospital were analyzed. Of 94 cases, the frequency of MDR E. coli (66%) infection was higher than that of non-MDR E. coli (34%). MDR E. coli was significantly more frequently detected in female dogs than non-MDR E. coli (P < 0.026). The most frequent MDR E. coli isolation sites were the urinary tract in dogs and skin wounds in cats. MDR E. coli isolates from dogs were highly resistant to ampicillin (96.1%), enrofloxacin (80.4%) and tetracycline (78.4%). Resistance to ampicillin (100%), enrofloxacin (90.9%), marbofloxacin (72.7%) and tetracycline (72.7%) occurred frequently in MDR E. coli isolates from cats. Low resistance to amikacin was detected in the MDR E. coli isolates from dogs and cats. The rates of clinical cure and non-clinical cure of the MDR E. coli and non-MDR E. coli cases were not significantly different. The duration of antimicrobial treatment for MDR E. coli was significantly longer in cats (12.6 ± 5.85 days) than in non-MDR E. coli cases (7 ± 0 days) (P < 0.048). Adjunctive therapy was prescribed more frequently in MDR E. coli (20%) than non-MDR E. coli cases (8.3%). The presence of MDR E. coli was high in this study. High resistance to commonly used antimicrobial drugs and treatment complications was observed in this study.

African Swine Fever Vaccine Development: Current Status And Challenges Ahead, Sezim Monoldorova, Galina Koltsova, Ilya Titov, Inkyu Yoo, Andrey Gogin, Jonguk Jeong, Hyeon-Seop Byeon, Seungri Yun, Yunhee Chang, Shin-Seok Kang, Denis Kolbasov, Bo-Young Jeon

The Thai Journal of Veterinary Medicine

African swine fever (ASF) is a contagious, hemorrhagic and highly lethal viral disease in swine. Following the initial report of ASF in Kenya in 1921 it spread to East Asia through Western Europe and Russia (including Eastern Europe). Many efforts have been dedicated to controlling ASF but the struggle to eradicate this disease continues. Thus far, the efforts to develop an effective vaccine to control ASF have been unsuccessful. A previous inactivated ASF vaccine, developed by traditional methods, failed to protect pigs from ASF virus (ASFV) infection. Neutralizing antibodies were not effective in inducing protective immunity and it appears that …

Segmental Colitis Associated With Diverticulosis Masquerading As Polyploid-Appearing Mucosa In The Rectosigmoid Area On Endoscopy And As Focal Thickening On Imaging, Eugene C. Nwankwo Jr, Gebran Khneizer, Gregory Sayuk, Jill Elwing, Necat Havlioglu, Michael Presti

Open Access Publications

Segmental colitis associated with diverticulosis (SCAD) is an inflammatory disease affecting segments of the large bowel with diverticular disease. SCAD presents several challenges in diagnoses and treatment because it often mimics a range of disorders including inflammatory bowel disease and malignancy. Here, we present the case of a 72-year-old man with lower abdominal pain and bloody stools whose initial abdominal workup showed nonspecific large bowel thickening and concerns for malignancy. Ultimately, the patient was diagnosed with mild SCAD and treated conservatively with a resolution of symptoms. He had no symptoms at the three-month and 1-year follow-ups. This case highlights the …

Predictors Of Anticoagulation Adherence In Patients With Acute Pulmonary Embolism, Karim Merchan, Parth V. Desai, Stephen Morris, Sovik De Sirkar, Dalila Masic, Parth Shah, Nicolas Krepostman, Matthew Collins, Kevin Walsh, Nathalie Antonios, Lucas Chan, Sorcha Allen, Ahmad Manshad, Shannon Kuhrau, Alexandru Marginea, Ahmed Elkaryoni, Jawed Fareed, Yevgeniy Brailovsky, Amir Darki

Division of Cardiology Faculty Papers

Background: Anticoagulation (AC) adherence after acute pulmonary embolism (PE) is vital to prevent mortality and future recurrence of venous thromboembolism (VTE). We aimed to analyze factors affecting AC adherence after acute PE. Methods: Consecutive adult patients with CT angiography or V/Q scan confirmed acute PE were included in a single-center retrospective study from April 2016 to May 2020. Adherence data, including AC refill dates, were collected from pharmacies, and adherence measures including Continuous Measure of Medication Acquisition (CMA), Proportion of Days Covered (PDC), and Optimal Medication Adherence (OMA) were calculated per standardized formulas. Univariable and multivariable linear and logistic regression …

Perspective On Newborn Screening (Nbs): Evidence Sharing On Conditions To Be Included In Nbs In Pakistan, Hafsa Majid, Lena Jafri, Sibtain Ahmed, Khadija Humayun, Salman Kirmani, Natasha Bahadur Ali, Bushra Moiz, Aysha Habib, Bushra Afroze

Department of Pathology and Laboratory Medicine

Newborn screening aims at detecting treatable disorders early so that the treatment can be initiated to prevent mortality and morbidity. Such programmes are well established in most developed countries, and all newborns are screened for selected metabolic, endocrine and other disorders based on disease epidemiology, testing and treatment availability, efficiency and cost-effectiveness. Even in developing countries, such screening programmes are initiated using heel prick capillary blood collected on filter paper. The current narrative review was planned to provide a perspective with evidence in favour of starting newborn screening for different disorders. The programme project should be initiated nationwide, taking one …

Comparison Of Emla Cream Versus Mucosal Vibration Or Pre-Cooling Systems As Topical Anesthetic Agents In Children, Esraa M. Eissa, Ahmed H. Wahba, Salwa M. Awad

Mansoura Journal of Dentistry

Objective: Comparing EMLA cream versus mucosal vibration or pre-cooling systems as preanesthetic techniques to reduce pain associated with dental injection in children. Materials and Methods: Fifty children categorized as positive or definitely positive according to Frankl scale (behavior rating scale) and aged from 5-7 years were selected. They were indicated for bilateral inferior alveolar nerve block for dental treatment and selected from the pediatric dental clinic, Faculty of Dentistry, Mansoura University. Children were randomly divided into two equal groups, in which the injection site was prepared using mucosal vibration with electric tooth brush in group (A) and pre-cooling with iced …

Impact Of Soy-Based Versus Composite Lipid Emulsion (Soybean, Medium Chain Triglycerides, Olive And Fish Oil) In Critically Ill Patients, Sandra Kless, Lisa Hall Zimmerman, Olaf Kroneman

Posters

No abstract provided.

Diagnosis Of Dental Cracks By Digital Bitewing Imaging: A Laboratory Study, Safa A. Al-Shami, Bassant H. Mowafey, Hamdi H. Hamdan, Jilan M. Youssef

Mansoura Journal of Dentistry

Objective: The purpose of this study was to evaluate the diagnostic accuracy of using digital bitewing imaging technique for the diagnosis of dental cracks. Materials and Methods: In this study, 60 specimens of extracted human teeth were collected. Teeth were divided into two equal groups; control group and study group. Cracks were artificially created on the study group by repeated thermal cycling method using boiled water and liquid nitrogen. Then teeth were mixed in a random manner and then placed in a waxed arch block to simulate the human geometrical pattern in imaging. The roots of the teeth were embedded …

Viral Pneumonia Screening On Chest X-Rays Using Confidence-Aware Anomaly Detection, Jianpeng Zhang, Yutong Xie, Guansong Pang, Zhibin Liao, Johan Verjans, Wenxing Li, Zongji Sun, Jian He, Yi Li, Chunhua Shen, Yong Xia

Research Collection School Of Computing and Information Systems

Clusters of viral pneumonia occurrences over a short period may be a harbinger of an outbreak or pandemic. Rapid and accurate detection of viral pneumonia using chest X-rays can be of significant value for large-scale screening and epidemic prevention, particularly when other more sophisticated imaging modalities are not readily accessible. However, the emergence of novel mutated viruses causes a substantial dataset shift, which can greatly limit the performance of classification-based approaches. In this paper, we formulate the task of differentiating viral pneumonia from non-viral pneumonia and healthy controls into a one-class classification-based anomaly detection problem. We therefore propose the confidence-aware …

Cultural Competence In The Care Of Muslim Women Patients, Ayah Ayesh

Honors Projects

Delivering high-quality care to female patients of the Muslim faith requires knowledge of the differences in cultural and spiritual values. Important differences include diet, ideas of modesty, privacy, and touch restrictio. Globally, Muslims represent substantial portions of society and remain the fastest-growing religion in the world. The Muslim faith encompasses several ethnicities with diverse views regarding illness and healthcare. As a result, the care of Muslim patients provides challenges for many non-Muslim healthcare providers. The Islamic faith can influence decision-making, family dynamics, health practices, risks, and the use of healthcare. This paper describes the care of Muslim patients taking into …

Untargeted Metabolomic Identification Of Diagnostic Biomarkers In Ectopic Pregnancy, Onur Turkoglu, Robert Quinn, Stewart F. Graham, Ray Bahado-Singh

Conference Presentation Abstracts

Introduction: Ectopic pregnancy (EP) is a potentially life-threatening condition and early diagnosis still remains a challenge, causing a delay in management leading to tubal rupture. Targeted metabolomics has been shown to identify novel biomarkers for the detection of ectopic pregnancy. Using untargeted metabolomics approach, we sought to identify putative plasma biomarkers for the detection of tubal EP compared to intrauterine pregnancies. Methods: This case-control study included prospective recruitment of 50 tubal EP cases and 50 early intrauterine pregnancy controls. Plasma samples were biochemically profiled using tandem liquid chromatographymass (MS/MS) spectrometry with untargeted metabolomics approach. To avoid over-fitting, datasets were randomly …

Harm Reduction In The Heartland: Public Knowledge And Beliefs About Naloxone In Nebraska, Usa, Allison Schlosser, Patrick Habecker, Rick A. Bevins

Department of Psychology: Faculty Publications

Background: Opioid-related overdose deaths have been increasing in the United States (U.S.) in the last twenty years, creating a public health challenge. Take-home naloxone is an effective strategy for preventing opioid-related overdose death, but its widespread use is particularly challenging in smaller cities, towns, and rural areas where it may be stigmatized and/or poorly understood.

Methods: We analyzed data on knowledge and beliefs about drug use and naloxone among the general public in Nebraska, a largely rural state in the Great Plains region of the U.S., drawing on the 2020 Nebraska Annual Social Indicators Survey.

Results: Respondents reported negative beliefs …

Penicillin Allergy Assessment And Medical Referral To Promote Antibiotic Stewardship, Elaine Bailey Pharmd, Mackenzie Connell, Marie Fluent Dds, Erinne Kennedy Dds, Mph, Mmsc

The Journal of the Michigan Dental Association

Antibiotic stewardship is an integral practice for the dental team to ensure a safe dental visit for patients. Now, with clinical practice guidelines and state toolkits, more dentists are aware of and actively practicing antibiotic stewardship. With the application of antibiotic stewardship practices, dentists are identifying the need for additional tools to enhance practice. For example, one need that has been identified is a tool for screening patients for true penicillin allergies. The Penicillin Allergy Assessment Tool (PAAT) is a decision-making tool that can be used chairside to screen patients who report an allergy to penicillin. After screening, dentists can …