Medicine and Health Sciences Commons^™

Sex-Based Differences In Functional Brain Activity During Working Memory In Survivors Of Pediatric Acute Lymphoblastic Leukemia, Kellen Gandy, Matthew A Scoggins, Nicholas Phillips, Ellen Van Der Plas, Slim Fellah, Lisa M Jacola, Ching-Hon Pui, Melissa M Hudson, Wilburn E Reddick, Ranganatha Sitaram, Kevin R Krull

2020-Current year OA Pubs

BACKGROUND: Long-term survivors of pediatric acute lymphoblastic leukemia are at elevated risk for neurocognitive deficits and corresponding brain dysfunction. This study examined sex-based differences in functional neuroimaging outcomes in acute lymphoblastic leukemia survivors treated with chemotherapy alone.

METHODS: Functional magnetic resonance imaging (fMRI) and neurocognitive testing were obtained in 123 survivors (46% male; median [min-max] age = 14.2 years [8.3-26.5 years]; time since diagnosis = 7.7 years [5.1-12.5 years]) treated on the St. Jude Total XV treatment protocol. Participants performed the n-back working memory task in a 3 T scanner. Functional neuroimaging data were processed (realigned, slice time corrected, normalized, …

Audicor Remote Patient Monitoring: Fda Breakthrough Device And Technology For Heart Failure Management, Marat Fudim Md, Mhs, Michael Mirro Md, Facc, Fhrs, Faha, Hao-Ming Cheng Md

Parkview Heart Institute

Research Letter: The impact of heart failure (HF) on patients, physicians, and hospital systems remains despite recent successes in pharmacologic and device-based treatments. Chronic HF represents one of the nation’s top health issues, leading to reduced patient quality of life, increased risks of hospitalization, increased health care utilization, and high incidence of patient morbidity and mortality. Titration of guideline directed medical therapy and prevention of HF hospitalizations have been identified as key targets in the management of HF. Remote monitoring provides the opportunity to address both issues and has gained significant momentum during the COVID-19 pandemic. Device-based solutions to manage …

Perceptions Of Physical Therapy Clinicians Regarding The Impact Of Covid 19 On Patients’ Mental Health, Brandy Chase, Amy L. Barnett

Faculty Articles & Research

• Research shows that the COVID 19 outbreak can negatively affect a person’s mental health, especially those at a higher risk with debilitating conditions (Javed, Sarwer, & Soto, 2020).
• This alludes to the need to take a closer look at the impact of COVID 19 on physical therapy patients and the amount of mental health training needed by physical therapy clinicians.

2022-03-01_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Rapid Assessment Of Opisthorchis Viverrini Igg Antibody In Serum: A Potential Diagnostic Biomarker To Predict Risk Of Cholangiocarcinoma In Regions Endemic For Opisthorchiasis., Rutchanee Rodpai, Vor Luvira, Lakkhana Sadaow, Wattana Sukeepaisarnjaroen, Amnat Kitkhuandee, Krisada Paonariang, Oranuch Sanpool, Wannaporn Ittiprasert, Victoria H. Mann, Pewpan M Intapan, Paul J. Brindley, Wanchai Maleewong

Microbiology, Immunology, and Tropical Medicine Faculty Publications

BACKGROUND: Opisthorchiasis is caused by an infection with fish-borne liver flukes of the genus Opisthorchis. Opisthorchiasis frequently leads to chronic inflammation in the biliary tract and is classified as a group 1 biological carcinogen by the International Agency for Research on Cancer: a definitive risk for cholangiocarcinoma (CCA).

METHODS: We used the rapid immunochromatographic test (ICT) to detect anti-Opisthorchis viverrini IgG and IgG4 subclass antibodies in sera of patients with CCA. The ICT kits were developed based on soluble antigens excreted and secreted by O. viverrini adult worms.

RESULTS: ICT indicated sera was positive for IgG and IgG4 antibodies, respectively, …

Predictors Of Job Satisfaction Among Pharmacists: A Regional Workforce Survey, Rotana M. Radwan, John P. Bentley, Julie A. Patterson, Dave L. Dixon

Faculty and Student Publications

Background: Job satisfaction affects organizational outcomes including performance and retention. The pharmacy job satisfaction literature points to several predictors of job satisfaction, but educational debt and various work settings have not been previously examined. Objectives: To identify predictors of Virginia pharmacists' job satisfaction. Methods: This cross-sectional study used data from the 2018 Virginia Pharmacist Workforce Survey. Of 15,424 registered pharmacists, 13,962 (90.5%) completed the survey. Pharmacists who reported being employed and working in Virginia in the previous year (2017) were included in the analysis (n = 6042). Data were summarized using descriptive statistics. Multiple logistic regression identified predictors of job …

In Silico Tools For Analysis Of Single-Nucleotide Polymorphisms In The Bovine Transferrin Gene, Aarif Ali, Muneeb U. Rehman, Syed Mudasir Ahmad, Tabish Mehraj

Faculty and Student Publications

Dairy cattle with a high milk yield are susceptible to many infectious diseases, such as mastitis. Subclinical mastitis (SCM) is the most prevalent form of mastitis that predominantly affects animal health, and causes adverse effects on the quality and quantity of milk. In dairy animals, subclinical mastitis often remains undetected, as no gross changes in udder characteristics are visible. In the present study, 135 Holstein Friesian dairy animals were selected and screened as healthy (n = 25) and mastitic (n = 110) based on diagnostic tests such as the California mastitis test, pH, electrical conductivity, and somatic cell count. In …

Real-World, Multicentre Evaluation Of The Incidence And Risk Factors For Non-Susceptible Stenotrophomonas Maltophilia Isolates, Bruce M. Jones, Jamie L. Wagner, Daniel B. Chastain, P. Brandon Bookstaver

Faculty and Student Publications

Background: Stenotrophomonas maltophilia is a cause of infection most commonly in the opportunistic host. Trimethoprim-sulfamethoxazole and levofloxacin are considered first-line treatment agents. With reports of increasing resistance to these first-line agents, it is important to determine risk factors associated with a non-susceptible isolate. Methods: This was a real-world, multicentre, retrospective case-control study from five centres in the southeast United States evaluating S. maltophilia. The primary outcome was risk factors associated with non-susceptibility of S. maltophilia isolates to ≥1 antimicrobial agents. Secondary outcomes include incidence of S. maltophilia non-susceptibility, all-cause mortality, and 30-day readmission rates. Results: There were 325 patients included …

Chemical Composition Analysis, Cytotoxic, Antimicrobial And Antioxidant Activities Of Physalis Angulata L.: A Comparative Study Of Leaves And Fruit, Jayachithra Ramakrishna Pillai, Adil Farooq Wali, Godfred Antony Menezes, Muneeb U. Rehman

Faculty and Student Publications

Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration-and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract …

Safety And Pharmacokinetics Of Intranasally Administered Heparin, Hannah M. Harris, Katherine L. Boyet, Hao Liu, Rohini Dwivedi

Faculty and Student Publications

Purpose: Intranasally administered unfractionated heparin (UFH) and other sulfated polysaccharides are potential prophylactics for COVID-19. The purpose of this research was to measure the safety and pharmacokinetics of clearance of intranasally administered UFH solution from the nasal cavity. Methods: Double-blinded daily intranasal dosing in C57Bl6 mice with four doses (60 ng to 60 μg) of UFH was carried out for fourteen consecutive days, with both blood coagulation measurements and subject adverse event monitoring. The pharmacokinetics of fluorescent-labeled UFH clearance from the nasal cavity were measured in mice by in vivo imaging. Intranasal UFH at 2000 U/day solution with nasal spray …

Letter From The Editors, Administrative Issues Journal Editors

Administrative Issues Journal

No abstract provided.

The Transformational Leader In Nursing Practice – An Approach To Retain Nursing Staff, Anita C. Reinhardt, Teresa G. Leon, Linda Ochart Summers

Administrative Issues Journal

Transformational leaders have been shown to influence positive work environments and support the retention of nursing staff. While exemplars have been found in upper-level management, the implementation of these characteristics in unit-based leaders is less explained. The elements of the transformational leader on followers and the organization—individual consideration, individual stimulation, inspirational motivation, and idealized influence—can engage nursing staff to remain in an organization which will promote positive patient outcomes. This article will review the elements of the transformational leader and share two exemplars of the transformational metanarrative as demonstrated in nursing care units. Both exemplars demonstrate how the transformational leader …

Pre-Service Teachers’ Perceptions Of Preparedness And Self-Efficacy In Instructing Students From Diverse Cultural And Linguistic Backgrounds, Babafunso Adegbola

Administrative Issues Journal

This study aims to determine a connection between the pre-service teachers’ perception of preparedness and their self-efficacy in instructing students from culturally and linguistically diverse backgrounds. The researcher was guided by three research questions: 1) What are pre-service teachers' perceptions of their abilities to teach culturally and linguistically diverse students? 2) To what degree do pre-service teachers believe their teacher education program prepared them to teach culturally and linguistically diverse students? 3) To what extent do pre-service teachers' self-efficacy influence culturally and linguistically diverse students?

Participants were pre-service teachers (education undergraduates in their last year or last semester of graduation), …

Youth Throwing Athletes Do Not Show Bilateral Differences In Medial Elbow Width Or Flexor Tendon Thickness, Rudolph M. Morrow, Gary Mcilvain, Jenifer Johnson, Mark Timmons

Kinesiology Faculty Research

Background: Medial elbow laxity develops in throwing athletes due to valgus forces. Medial elbow instability in professional, collegiate, and high school athletes is well documented; however, the medial elbow of young throwing athletes has received less attention. This study investigated the medial elbow and common flexor tendon during applied elbow valgus stress of youth baseball players.

Methods: The study included 15 participants. The medial elbow width and thickness of the common flexor tendon were measured on ultrasound images.

Results: No significant side differences in medial elbow width or common flexor tendon were found at rest or under applied valgus stress. …

Intersecting Disadvantages For Married Adolescents: Life After Marriage Pre- And Post-Covid-19 In Contexts Of Displacement., Sarah Baird, Maureen Murphy, Jennifer Seager, Nicola Jones, Anju Malhotra, Sarah Alheiwidi, Guday Emirie, Sabina Rashid, Maheen Sultan

Global Health Faculty Publications

PURPOSE: Although there is a growing evidence base on the drivers of child marriage, comparatively little is known about the experiences of married girls in refugee settings and how their development trajectories diverge from those of their nonmarried peers, particularly in the context of the COVID-19 pandemic. Drawing on cross-national panel data from Bangladesh and Jordan, this article explores diversity in child marriage experiences in contexts affected by forced displacement, highlighting how married girls' well-being differs from that of their unmarried peers, and how COVID-19 has reinforced these differences.

METHODS: We analyzed longitudinal survey data-collected pre- and post-COVID-19-from the Gender …

Preventative Practices And Effects Of The Covid-19 Pandemic On Caregivers Of Children With Pediatric Pulmonary Hypertension, Ella Cook, Megan Pierce, Samara Nelson, Ashley Bangerter Seelos, Rebecca Brown, Heather Stickle, Michael Johansen, Erik J. Nelson

Library/Life Sciences Undergraduate Poster Competition 2022

• Pediatric Pulmonary Hypertension (PH) is characterized by issues of lung growth and development prenatally and postnatally.¹
• COVID-19 causes endothelial dysfunction, hypoxia and vasoconstriction. Children living with PH are especially vulnerable to severe complications from the virus due to these additive affects on a cardiorespiratory system that is already stressed by their underlying disease²
• Parents/Caregivers of children with PH have a great burden to prevent COVID-19 infection.

Prostate-Specific Antigen Screening According To Health Professional Counseling And Age In The United States, Seth A. Otto, Ray M. Merrill

Library/Life Sciences Undergraduate Poster Competition 2022

To determine the prevalence of PSA testing in men according to age, reasons for undergoing testing, and whether a discussion about harms and benefits took place with a doctor prior to testing.

Staying On Track: Air Pollution & Exercise On Campus, Selah Willis, Sabina Williams, Nicole Lyons, Karly Anderson, Haley Mcbride, Jim Johnston

Library/Life Sciences Undergraduate Poster Competition 2022

Which exercise location on campus has the lowest levels of PM_2.5 & PM₁₀? What time of day is the lowest concentration of pollutants?

Analytics Monthly, Lehigh Valley Health Network

LVHN documents

No abstract provided.

Complex Class Ii Bulk-Fill Resin Composite Restoration: Cuspal Deflection And Effect Of Water Storage On Microleakage: A Laboratory Study, Kareema E. Elshawaf, Marmar A. Montaser, Ashraf A. Ibrahim

Mansoura Journal of Dentistry

Objective: Objective: To evaluate cuspal deflection and microleakage of complex class II cavities filled with bulk fill and incremental resin composite. Also, asses effect of water storage on microleakage. Materials and methods: 120 maxillary premolars were collected, prepared into standardized (MOD) cavities, then teeth were divided as the following:- Forty tooth of the 120 prepared teeth were randomly assigned for cuspal deflection test which were randomly divided into four groups (n=10) according to restorative materials used (Filtek z350,Filtek bulk fill, Fill-up bulk fill , Beautifil bulk fill). The remaining 80 tooth were used for microleakage test, randomly divided into four …

Effect Of Two Post Space Depths On The Accuracy Of The Scan, Ahmed A. Hegazi, Maged M. Zohdy, Tarek S. Morsi

Mansoura Journal of Dentistry

Objective: This study aims to measure the accuracy of post space scans using 2 post space depths 1.7millimeters 2.10millimeters. Materials and Methods: A total of 14 human mandibular premolar teeth with similar root form and root canal shape averaging cervico-occlusal length of the crown about 8+/-0.5 mm and 14.5+/-0.5 mm for root length were collected for this study , endodontic treatment was performed for all teeth followed by coronal decapitation 2mm above CEJ and post space preparation , After the preparation of each root, the corresponding teeth were allocated randomly to two groups (n=7/ group) according to the depth of …

Studying Stimuli And Smoking Behaviors Among Self-Identified Gifted Smokers And Strategies For Customizing Cessation Support, Danae Deligeorges, Michele Kane, Paraskevi Katsaounou

Special Education Faculty Publications

The aim of the study was to examine smoking habits and triggers among self-identified gifted (inner experiences and awareness qualitatively different from the norm in terms of asynchronous development, advanced cognitive abilities, and heightened intensity) adults in order to customize smoking cessation support.

Effect Of Repeated Eccentric Exercise On Muscle Damage Markers And Motor Unit Control Strategies In Arm And Hand Muscle, Sunggun Jeon, Xin Ye, William M. Miller, Jun Seob Song

Faculty and Student Publications

To examine the contralateral repeated bout effect (CL-RBE) on muscle damage markers and motor unit (MU) control strategies, seventeen healthy adults performed two bouts of 60 eccentric contractions with elbow flexor (EF group; n ​= ​9) or index finger abductor (IA group; n ​= ​8) muscles, separated by 1 week. All participants randomly performed eccentric exercise on either the right or left arm or hand muscles, and muscle damage markers and submaximal trapezoid contraction tests were conducted pre, post, 1- and 2-day post eccentric protocol. One week after the first bout, the same exercise protocol and measurements were performed on …

Assessing Burnout And Resiliency In Online Degree Advancement Respiratory Care Students During A Pandemic, Kristen L. Mchenry, Thomas J. Wing, Jody Lester, Lanny Inabnit, Yong Gao

Respiratory Therapy Faculty Publications and Presentations

Purpose: The purpose of this study was to identify and quantify the presence of burnout in online degree advancement Respiratory Care students during a pandemic and characteristics/strategies of resiliency. Method: The design of the study was quantitative; non-experimental, descriptive, cross-sectional survey research. The Maslach Burnout Inventory for Medical Personnel (MBI-HSS (MP) and Brief Resilience Scale (BRS) were used to measure these constructs. Results: One hundred and twenty-nine (129) students completed components of the survey for a response rate of approximately 28%. Relevant findings include a somewhat higher level of depersonalization for those who practice in adult acute care. Emotional exhaustion …

The Harold B. Lee Library, A Safe Place To Study? An Examination Of Carbon Dioxide And Cognitive Function, Braken Snyder, Connor Krause, Dantly Wilcox, Dustin Hansen, Esther Erickson, James D. Johnston

Library/Life Sciences Undergraduate Poster Competition 2022

High levels of Carbon Dioxide (CO2) above 1000 parts per million can negatively impact cognitive function and decision-making (Bowen et. al). Our study is based on a research article on Indoor Air Quality. If CO2 concentrations get too high, it depletes the oxygen your brain needs.

The Unseen Burdens Of Pediatric Pulmonary Hypertension: Treatment Side Effects And Access To Care, Rebecca Brown, Megan Pierce, Samara Nelson, Ashley Bangerter Seelos, Ella Cook, Heather Stickle, Michael Johansen, Erik J. Nelson

Library/Life Sciences Undergraduate Poster Competition 2022

• Pulmonary hypertension (PH) is a serious and life-threatening disease characterized by an elevation in mean pulmonary artery pressure and pulmonary vascular resistance, leading to right heart failure and death.^1,2
• PH has primarily been studied among adults and therefore clinical therapies have also aimed at treating this population.^3-5
• Several pharmaceutical treatments are available and approved for use in adults, however, the effectiveness among children has yet to be sufficiently determined though they are considered the standard treatment regimen in children.
• Accessing specialized pediatric PH care providers who are versant in these therapies is difficult.

Effects Of Perceived Racism And Socioeconomic Status On Family Health, Tatiana Pryor, Sariah Villalon, Aliceann Crandall

Library/Life Sciences Undergraduate Poster Competition 2022

Family health is strongly associated with lifelong health and development¹ and one’s experiences in childhood may have an impact on their family health in adulthood². Of the research conducted on family health in the United States, little information can be found that directly discusses health disparities and childhood socioeconomic status as predictors of family health. Recent research shows that current household income is positively associated with family health in adulthood, meaning that SES affects access to care and health practices³.

Association Of Electronic Medical Records And Opioid Prescription, Archana Suwal, Jemimah Okonjo, Stacie Deslich, Alberto Coustasse

Management Faculty Research

A Prescription Drug Monitoring Program (PDMP) is an electronic database that tracks controlled substance prescriptions in a state. PDMPs can provide health authorities timely information about prescribing and patient behaviors that contribute to the epidemic and facilitate an agile and directed response. Electronic Prescribing for Controlled Substances (EPCS) aimed to eliminate paper prescriptions by allowing clinical prescribers to write prescriptions electronically, making them digital and trackable for both the prescriber and the pharmacist and has been an essential part of any health information technology system, as well as a requirement for 'meaningful use' (Blumenthal & Tavenner, 2010). However, one of …

The Perceptions Of Educators On Transition Planning & The Postsecondary Transition Readiness Outcomes Of Students With Disabilities, Marisa Duarte

Dissertations

The purpose of this quantitative descriptive research was to gain the perspective of educators on transition planning for students with disabilities in two public school districts in the state of Kentucky. The Individual Disabilities Education Act and Workforce Innovation Opportunities Act are laws requiring students with disabilities to be transition ready upon their graduation from high school. A sample of 12 educators, representing two Kentucky districts, who participate in transitioning students with disabilities, completed The Secondary Educator Transition Questionnaire survey. Data from the districts’ state report cards indicated students with disabilities were not transition ready in comparison with students without …

The Importance Of Health Literacy: A Student-Led Workshop On Lay Communication, Sarah Jean Kamp, Jafra D. Thomas

Kinesiology and Public Health

The purpose of this experiential senior project workshop was to advance the knowledge and practice of health communication by (a) delivering a training workshop to Cal Poly undergraduate students and (b) by exploring the relationship between health literacy and effective communication through completion of a rapid review of the literature. The reviewed literature served the purpose of helping the student further design the workshop to elicit a foundational understanding of the elements of effective communication of health information as well as the history and evolution of health literacy as a concept. The workshop revised and delivered by the student was …