Medicine and Health Sciences Commons^™

The Quality Of Life In Neoadjuvant Versus Adjuvant Therapy Of Esophageal Cancer Treatment Trial (Quintett): Randomized Parallel Clinical Superiority Trial, Richard Malthaner, Edward Yu, Michael Sanatani, Debra Lewis, Andrew Warner, A. Dar, Brian Yaremko, Joel Bierer, David Palma, Dalilah Fortin, Richard Inculet, Eric Frechette, Jacques Raphael, Steward Gaede, Sara Kuruvilla, Jawaid Younus, Mark Vincent, George Rodrigues

Data and Test Instruments

Background: We compared the health-related quality of life (HRQOL) in patientsundergoing trimodality therapy for resectable stage I-III esophageal cancer.Methods: A total of 96 patients were randomized to standard neoadjuvant cisplatinand 5-fluorouracil chemotherapy plus radiotherapy (neoadjuvant) followed by surgicalresection or adjuvant cisplatin, 5-fluorouracil, and epirubicin chemotherapy with concurrentextended volume radiotherapy (adjuvant) following surgical resection.Results: There was no significant difference in the functional assessment of cancertherapy-esophageal (FACT-E) total scores between arms at 1 year (p = 0.759) with36% versus 41% (neoadjuvant vs. adjuvant), respectively, showing an increase of ≥15points compared to pre-treatment (p = 0.638). The HRQOL was significantly inferiorat 2 months …

A Vaccine Education Module For University Students: Vaccine Concerns And Knowledge Gained, Joslyn D. Wilson

Theses and Dissertations

Purpose: The purposes of this research are to evaluate the effectiveness of a vaccine education module (VEM) in 1) contributing to new vaccine knowledge of university freshmen; and 2) identifying common vaccine concerns of university freshmen before and after completing the VEM. Methods: A VEM, including information about vaccine-preventable diseases, benefits of vaccines, principles of community or herd immunity, and where to go to get vaccinated, was created for freshman students. Student vaccine concerns were identified using a pretest/posttest quasi-experimental design using an online questionnaire before and after completing the VEM. After the VEM, participants were also asked to identify …

Student Intentions To Engage Instructors In Mental Health-Related Conversations: An Application Of The Theory Of Planned Behavior, Allie White, Hannah Ball, Sara Labelle

Communication Faculty Articles and Research

Objective

Considering that college students experience mental health issues and college counseling centers are overwhelmed, this study identifies instructors as a potential mental health resource for students. This study utilizes the theory of planned behavior to investigate the relationship between students’ attitudes, injunctive and descriptive norms, perceived behavioral control, and their intentions to engage their instructors in mental health conversations.

Participants

Participants were 311 undergraduate students at a small, private university in Southern California.

Methods

Participants were recruited through a Communication subject pool and completed an online survey about engaging instructors in these conversations.

Results

Results of a regression analysis …

Sources And Types Of Social Supports And Their Association With Mental Health Symptoms And Life Satisfaction Among Young Adults With A History Of Out-Of-Home Care, Rhiannon Evans, Colleen C. Katz, Anthony Fulginiti, Heather N. Taussig

Graduate School of Social Work: Faculty Scholarship

Young adults with a history of out-of-home care report poorer mental health and life satisfaction compared to non-care-experienced peers. Social support is a known protective factor for mental health. There is limited evidence, however, on the relationship between sources (e.g., family members) and types (e.g., information) of social support and mental health symptoms and life satisfaction in this population. Reporting cross-sectional survey data from 215 young adults aged 18–22 years with a history of out-of-home care, the current study conducted descriptive, bivariate, and linear regression analysis to examine the different sources and types of support young adults receive and their …

2022-04-06_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, …

Evaluating Simulation-Based Tobacco Treatment Scenarios For Providers Delivering Treatment For People Living With Mental Illnesses, Chizimuzo T. C. Okoli, Janet Otachi, Sarret Seng, Bassema Abufarsakh, Lovoria B. Williams

Clinical and Translational Science Faculty Publications

Background: People living with mental illnesses (PMI) experience elevated tobacco use and related morbidity and mortality. Despite the availability of effective and safe tobacco treatments along with evidence that PMI are motivated and able to quit successfully, few Mental and behavioral healthcare providers (MHPs) engage PMI in such treatment. MHPs may lack the confidence or skills to engage their clients in tobacco treatment. Currently, there are limited training modalities to prepare MHPs in delivering tobacco treatment for PMI. However, animated scenario-based simulated encounters can bridge this gap to effectively provide tailored MHP training to enhance treatment delivery. Hence, the purpose …

Following The Science: The Role Of The Academic Medical Center In The Covid-19 Pandemic, Richard L. Summers, Leslie Musshafen, Gailen Marshall, John Bates, Sarika Jain, Jake Johnston, Alexandra Castillo, Krishna Ayyalasomayajula, Ramona Sandlin, I. J. Frame, Seth Lirette, Saurabh Chandra, Ashley Robinson, Michael R. Garrett

Journal of Public Health in the Deep South

This article reviews the experience and role of an academic medical center in a response to the COVID-19 pandemic.

Case Report Of Myopericarditis Post Covid-19 Vaccinations In The First Female Young Adult In Ms, Vipina Nair Md, Paul Byers Md, Kathryn G. Taylor Md

Journal of Public Health in the Deep South

Background: The advent of COVID-19 vaccinations saw a rise in myopericarditis cases among young adults all over the United States, especially among males. As of June 11, 2021, 21.5 million second doses of COVID-19 vaccines have been administered in the age group 12 to 29, with 455 reported cases of myocarditis. Purpose: This report outlines a case of myopericarditis diagnosed in the first female young adult in the state of Mississippi after administering the second dose of the Pfizer- BioNTech BNT162b2 mRNA COVID-19 vaccine. The purpose of this case report is to discuss the presentation of myocarditis in a female …

The Effects Of A Periodized Strength And Conditioning Program On Overhand Throwing Velocity, Underhand Throwing Velocity And Off The Bat Velocity In Diii Collegiate Athletes, Sage Jenkins

Undergraduate Distinction Papers

Overhand throwing velocity, underhand throwing velocity and off the bat velocity are measures that impact performance of softball athletes. The purpose of strength and conditioning programs is to improve athletic performance for athletes. Strength and conditioning coaches can achieve this through programming. One aspect of programming that this study looked at is periodization. The purpose of this study was to examine the effects of a periodized strength and conditioning program on these performance measurements in NCAA DIII collegiate softball athletes. Sixteen (n=16) NCAA DIII softball athletes were selected based on their participation on the Otterbein softball team. The athletes underwent …

Public Health Policy: Internet Access To Advance Health Equity, Juanita Graham Dnp-Rn, Frsph, Victor Sutton Phd

Journal of Public Health in the Deep South

Internet access could be the 21st century’s great equalizer, interrupting access barriers that negatively impact health. Mississippi reigns as the poorest state in the nation (CB, 2020), with some of the country’s worst health outcomes (UHF, 2022), particularly among rural populations. The Community Engagement Center (CEC), one of three Jackson Heart Study (JHS) centers, leverages community partnerships and connections to improve public health. In these times of public health crises, connections are relevant - that is, internet connections. Internet, or broadband, access is the far upstream approach needed to improve the social determinants that negatively impact Mississippians’ health. The National …

Educational Guides To Assistive Technology And Digital Literacy For Older Adults And Caregivers, Cheney D. Hess

OTD Capstone Projects

This capstone project consisted of the development of a variety of educational resources to assistive technology and digital literacy for older adults and caregivers to aid this population in the process researching, selecting, and accessing assistive technology.

Technology Use In Schizotypy Utilizing The Domains Of Technology Use Survey (Dotus), Devin Massaro

Theses and Dissertations

The diathesis stress model for schizophrenia posits that genetics and prenatal factors confer vulnerability (diathesis) for mental illness which then may be activated through exposure to environmental stressors during life. One component of our contemporary environment involves technology use which has demonstrated risk and beneficial capabilities in regards to the schizophrenia spectrum. Using an online and in-person survey, this study aimed to elucidate the manner in which time spent on technology related to schizotypy, problematic technology use (PTU), and health behaviors in 227 undergraduate students (aged 18-30). We hypothesized that levels of schizotypy, as well as time spent on social …

The Anxiety, Depression, And Perceived Stress Levels Of Hospice Care Personnel In Georgia, Emily Bauman

Honors College Theses

Working in hospice comes with a variety of unique tasks and stressors that other jobs typically do not require. While this workplace stress can act as a catalyst, too much can be threatening to an individual’s mental state and life in general. Moreover, anxiety and depression can be detrimental to an individual’s life and career. Research has shown positive correlations between stress, anxiety, and depression. The purpose of this study is to use quantitative measures to examine the anxiety, depression, and perceived stress levels of hospice care professionals in Georgia. 12 hospice care workers were quantitatively surveyed regarding their perceived …

The Imperfect Structure Of General Education, Bella Slack

Student Research Symposium

Hello my name is Bella Slack, and I completed this Research Project for my English 2010 class. Every student attending an American College is required to complete their General Education before moving further into career programs. Students spend tens of thousands of dollars on these classes, increasing the funds needed to obtain a college education and prolonging the number of years they are in college before their career. I used Library and Internet resources to find primary and secondary research, as well as a personally conducted survey that was used to inform my argument. Through careful analysis of my sources …

Hur Plays A Role In Double-Strand Break Repair In Pancreatic Cancer Cells And Regulates Functional Brca1-Associated-Ring-Domain-1(Bard1) Isoforms, Aditi Jain, Matthew Mccoy, Carolyn Coats, Samantha Z Brown, Sankar Addya, Carl Pelz, Rosalie C Sears, Charles Yeo, Jonathan R Brody

Department of Surgery Faculty Papers

Human Antigen R (HuR/ELAVL1) is known to regulate stability of mRNAs involved in pancreatic ductal adenocarcinoma (PDAC) cell survival. Although several HuR targets are established, it is likely that many remain currently unknown. Here, we identified BARD1 mRNA as a novel target of HuR. Silencing HuR caused a >70% decrease in homologous recombination repair (HRR) efficiency as measured by the double-strand break repair (pDR-GFP reporter) assay. HuR-bound mRNAs extracted from RNP-immunoprecipitation and probed on a microarray, revealed a subset of HRR genes as putative HuR targets, including the BRCA1-Associated-Ring-Domain-1 (BARD1) (p < 0.005). BARD1 genetic alterations are infrequent in PDAC, and its context-dependent upregulation is poorly understood. Genetic silencing (siRNA and CRISPR knock-out) and pharmacological targeting of HuR inhibited both full length (FL) BARD1 and its functional isoforms (α, δ, Φ). Silencing BARD1 sensitized cells to olaparib and oxaliplatin; caused G2-M cell cycle arrest; and increased DNA-damage while decreasing HRR efficiency in cells. Exogenous overexpression of BARD1 in HuR-deficient cells partially rescued the HRR dysfunction, independent of an HuR pro-oncogenic function. Collectively, our findings demonstrate for the first time that BARD1 is a bona fide HuR target, which serves as an important regulatory point of the transient DNA-repair response in PDAC cells.

Professional Quality Of Life In Respiratory Therapists: A Cross-Sectional Study Of The Prevalence And Predictors For Compassion Satisfaction, Burnout, And Secondary Traumatic Stress, Sarah Pehlke

Graduate Theses, Dissertations, and Capstones

Background: Research on professional quality of life (QOL) variables in healthcare providers proliferated following the onset of the COVID-19 pandemic. Evidence suggests that caregiving careers have positive and negative effects (Beck, 2011). Insufficient research describes these effects in respiratory therapists (RTs), a group of healthcare practitioners who often work in high-stress situations and provide care to high-acuity patient populations.

Purpose: This study evaluated the prevalence and predictors of professional QOL factors, compassion satisfaction (CS), burnout, and secondary traumatic stress (STS), in staff RTs in the United States.

Methods: RTs were invited to participate in a cross-sectional survey evaluating demographics, workplace …

A Discrete Choice Experiment Investigating Hiv Testing Preferences In South Africa, P. Chiwire, A. C. Muhlbacher, S. M. Evers, H. Mahomed, Jan Ostermann Ph.D., M. Hiligsmann

Faculty Publications

Background

South Africa (SA) has the world’s highest burden of HIV infection, with an estimated 13.7% of the population living with HIV (PLWH/Persons Living With HIV). The early identification of PLWH and rapid engagement of them in HIV treatment are indispensable tools in the fight against HIV transmission. Understanding client preferences for HIV testing may help improve uptake. This study aimed to elicit client preferences for key characteristics of HIV testing options.

Methods

A discrete-choice experiment (DCE) was conducted among individuals presenting for HIV testing at two public primary healthcare facilities in Cape Town, South Africa. Participants were asked to …

Dietetic Intervention In Psoriatic Arthritis: The Dieta Trial, Beatriz F. Leite, Melissa A. Morimoto, Carina M. F. Gomes, Barbara N.C. Klemz, Patrícia S. Genaro, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Nágila R.T. Damasceno, Marcelo M. Pinheiro

Faculty Publications

Aim To evaluate whether dietary pattern changes, antioxidant supplementation or 5-10% weight loss could improve disease activity (skin and joint) in patients with psoriatic arthritis (PsA). Methods A total of 97 PsA patients were enrolled in this 12-week randomized, double-blinded, placebo-controlled trial. Patients were randomized into three groups: Diet-placebo (hypocaloric diet + placebo supplementation); Diet-fish (hypocaloric diet + 3 g/day of omega-3 supplementation; and Placebo. Food intake (3-day registry, Healthy Eating Index (HEI), and the Dietary Inflammatory Index (DII)), body composition (whole-body dual-energy X-ray absorptiometry (DXA), weight and waist circumference) and disease activity (PASI, BSA, BASDAI, DAS28-ESR, DAS28-CRP and MDA) …

Gestational Age Variation In Human Placental Drug Transporters, Laura Goetzl, Nune Darbinian, Nana Merabova, Lindsay C Devane, Sammanda Ramamoorthy

Faculty, Staff and Student Publications

Patient and providers' fear of fetal exposure to medications may lead to discontinuation of treatment, disease relapse, and maternal morbidity. Placental drug transporters play a critical role in fetal exposure through active transport but the majority of data are limited to the 3rd trimester, when the majority of organogenesis has already occurred. Our objective was to define gestational age (GA) dependent changes in protein activity, expression and modifications of five major placental drug transporters: SERT, P-gp, NET, BCRP and MRP3. Apical brush border membrane fractions were prepared from fresh 1st, 2nd and 3rd trimester human placentas collected following elective pregnancy …

Nursing Students’ Perspectives On The Covid-19 Vaccines: Moderna, Pfizer, And Johnson And Johnson, Savannah M. Workman

Honors College Theses

There are very few things that everyone in the world shares in common, but there is one thing that has recently plagued our entire world and has impacted each person’s life. The first case of COVID-19 occurred in the United States in January of 2020. In the United States during March of 2020, life as we knew it changed. Restrictions were put in place, schools closed, food and supply chain shortages occurred, travel was banned, and we were warned to stay away from others as they could be symptomatically or asymptomatically carrying the novel coronavirus. Since the time of quarantine …

Quality Of Life Impact And Recovery After Ureteroscopy And Stent Insertion: Insights From Daily Surveys In Stents, Jonathan D Harper, Alana C Desai, Jodi A Antonelli, Gregory E Tasian, Justin B Ziemba, Hussein R Al-Khalidi, H Henry Lai, Naim M Maalouf, Peter P Reese, Hunter B Wessells, Ziya Kirkali, Charles D Scales, Niddk Urinary Stone Disease Research Network (Usdrn)

2020-Current year OA Pubs

BACKGROUND: Our objective was to describe day-to-day evolution and variations in patient-reported stent-associated symptoms (SAS) in the STudy to Enhance uNderstanding of sTent-associated Symptoms (STENTS), a prospective multicenter observational cohort study, using multiple instruments with conceptual overlap in various domains.

METHODS: In a nested cohort of the STENTS study, the initial 40 participants having unilateral ureteroscopy (URS) and stent placement underwent daily assessment of self-reported measures using the Brief Pain Inventory short form, Patient-Reported Outcome Measurement Information System measures for pain severity and pain interference, the Urinary Score of the Ureteral Stent Symptom Questionnaire, and Symptoms of Lower Urinary Tract …

Hsp90-Cdc37 Functions As A Chaperone For The Oncogenic Fgfr3-Tacc3 Fusion, Tao Li, Farideh Mehraein-Ghomi, M Elizabeth Forbes, Sanjeev V Namjoshi, E Ashley Ballard, Qianqian Song, Ping-Chieh Chou, Xuya Wang, Brittany C Parker Kerrigan, Frederick F Lang, Glenn Lesser, Waldemar Debinski, Xuejun Yang, Wei Zhang

Faculty, Staff and Student Publications

The FGFR3-TACC3 (F3-T3) fusion gene was discovered as an oncogenic molecule in glioblastoma and bladder cancers, and has subsequently been found in many cancer types. Notably, F3-T3 was found to be highly expressed in both untreated and matched recurrence glioblastoma under the concurrent radiotherapy and temozolomide (TMZ) treatment, suggesting that targeting F3-T3 is a valid strategy for treatment. Here, we show that the F3-T3 protein is a client of heat shock protein 90 (HSP90), forming a ternary complex with the cell division cycle 37 (CDC37). Deprivation of HSP90 or CDC37 disrupts the formation of the ternary complex, which destabilizes glycosylated …

A False Sense Of Security: The Perceptions Of Threat And Efficacy Contributing To Vaccine Hesitancy In The Gulf States, Braden Hale Bagley

Journal of Public Health in the Deep South

Background: Since the release of the COVID-19 vaccine, vaccine hesitancy has been an issue in the southern states. Public health officials and communication experts have since been tasked with creating messages aimed at eliminating vaccine hesitancy.Purpose: The purpose of this study was to identify which perceptions regarding threat and efficacy are contributing to vaccine hesitancy in the Gulf States.Method: 226 participants from two groups, including the Gulf States and remaining U.S. states, responded to a survey measuring threat and efficacy perceptions, as well as vaccination status. Binary logistic regression was used to identify differences between the two groups.Results: Significant differences …

Assessment Of College Students In Understanding Beliefs, Behaviors, And Key Levels Of Influence Regarding Covid-19 Vaccine Uptake, Olivia Rosemary Hernandez, Antonio J. Gardner, Leah B. P. Pylate, Barry P. Hunt

Journal of Public Health in the Deep South

Background: As Covid-19 causes increased morbidity and mortality, vaccination status is at the forefront of preventive action. However, approximately 52% of residents still need to be vaccinated in Mississippi. These rates are even higher among the 18–24-year-old demographic, where only 38% have reported full vaccination.Purpose: This study aimed to assess the underlying reasons for COVID-19 vaccination hesitancy among college students in the 18-24-year-old demographic.Methods: A 21-item survey was administered to college students at a large southeastern university to assess their beliefs and vaccination status regarding COVID-19.Results: Regarding safety, intention, and severity of COVID-19, statistical significance was found between those college …

Making Covid-19-Related Decisions: A Qualitative Study Of University Students, Jamie Methvin, Antonio J. Gardner, Leah B. P. Pylate, Barry P. Hunt, Holli H. Seitz, Regina Young Hyatt

Journal of Public Health in the Deep South

Background: SARS-Cov-2 (Coronavirus Disease or COVID-19) has impacted society greatly since its arrival to the United States. More specifically, college students have had to modify their behaviors on campus to minimize the spread of the virus.Purpose: The purpose of this study was to identify benefits and barriers to testing, reporting, and quarantining of undergraduate college students attending a large southeastern university.Methods: Undergraduate students were asked to complete an open-ended Qualtrics survey to share their perceived benefits and barriers to engage in behaviors to detect and prevent the spread of COVID-19. Data was analyzed via Grounded Theory techniques to determine codes …

Launching A Human Papillomavirus Vaccination (Hpv) Campaign On A College Campus During The Covid-19 Pandemic, Eric Pittman, M. Allison Ford, Marie Barnard, Emily Tschumpter, Sally Earl, Joshua Gautreaux

Journal of Public Health in the Deep South

No abstract provided.

Influencers Of Covid-19 Vaccine Acceptance In The Deep South, Katie C. Hall, Angela Duck, Tara Price

Journal of Public Health in the Deep South

Background: Within the Deep South, vaccine ratings fall between 48.5-58% of the state’s population being fully vaccinated against COVID-19. Therefore, half of the population is at risk for the negative mortality and morbidity outcomes associated with COVID-19.Purpose: The aim of this study was to describe key influencers for accepting the COVID-19 vaccine for individuals living within the Deep South region of the US.Methods: A descriptive, secondary analysis of quantitative data was conducted from an online survey entitled COVID-19 Vaccine Acceptance Survey. A total of 421 participants identified as living in the Deep South, were ≥ 18 years of age, and …

Individual Correlates Of Covid-19 Concerns, Prevention Behaviors, And Experiences Among College Students, Samantha Cohen-Winans Ms, Kaitlyn Armstrong Ms, M. Allison Ford Phd, Hannah K. Allen Phd

Journal of Public Health in the Deep South

Background. The COVID-19 pandemic continues to be a public health crisis, and college campuses and areas in the southern U.S. are high-risk environments for disease spread. Purpose. This study examined variation in COVID-19 concerns, prevention behaviors, and related experiences among college students at a large, public university in the southeast region of the U.S. Methods. A sample of 544 undergraduate students completed an online survey in the final weeks of the Fall 2020 academic semester. Subgroup variation in level of COVID-19 concern by history of COVID-19 diagnosis and associations between individual correlates and COVID-19 outcomes were explored. Results. Students were …

Covid-19 Related Awareness Among Healthcare Professionals And Students At The Medical Center In The Southern United States, Eldrin Bhanat Md, Mph, Vinayak K. Nahar Md, Phd, Ms, Thomas Dobbs Md, Kenneth R. Butler Phd, Josny Thimothee Ms, Rinkuben Parmar Mbbs, Md, Mph, Patrick Bergin Md, George Russell Md, Alan Jones Md, Bhagyashri D. Navalkele Md

Journal of Public Health in the Deep South

Background: In late 2019, the novel COVID-19 was reported to cause severe viral pneumonia in Wuhan, China. It has spread worldwide, resulting in a pandemic that has now infected more than 123 million people, causing more than 2.7 million deaths globally. Mississippi has become one of the hotspots for spreading the virus with a very high positivity rate. As of 6/09/2021, there were a total of 318,685 cases, and 7,347 deaths have been reported in Mississippi.Purpose: This study aimed to assess the COVID-19 related knowledge among faculty and staff working in our healthcare system. We also assessed if there are …

Mendelian Randomization Supports Bidirectional Causality Between Telomere Length And Clonal Hematopoiesis Of Indeterminate Potential, Tetsushi Nakao, Alexander G. Bick, Margaret A. Taub, Seyedeh M. Zekavat, Md M. Uddin, Abhishek Niroula, Juan M. Peralta, Joanne E. Curran, John Blangero

School of Medicine Publications

Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD. TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus for CHIP in genome-wide association studies. Here, we investigated the relationship between CHIP, LTL, and CAD in the Trans-Omics for Precision Medicine (TOPMed) program (n = 63,302) and UK Biobank (n = 47,080). Bidirectional Mendelian randomization studies …